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            13 => array:3 [
              "identificador" => "bib0070"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The dominant negative activity of the human glucocorticoid receptor beta isoform&#58; specificity and mechanism of action"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;H&#46; Oakley"
                            1 => "C&#46;M&#46; Jewell"
                            2 => "M&#46;R&#46; Yudt"
                            3 => "D&#46;M&#46; Bofetiado"
                            4 => "J&#46;A&#46; Cidlowski"
                          ]
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1999"
                        "volumen" => "274"
                        "paginaInicial" => "27857"
                        "paginaFinal" => "27866"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10488132"
                            "web" => "Medline"
                          ]
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                      ]
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                ]
              ]
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              "identificador" => "bib0075"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evidence that the &#946; isoform of the human glucocorticoid receptor does not act as a physiologically significant represor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46; Hecht"
                            1 => "J&#46; Carlstedt-Duke"
                            2 => "P&#46; Stierna"
                            3 => "J&#46;A&#46; Gustafsson"
                            4 => "M&#46; Bron-negard"
                            5 => "A&#46;C&#46; Wikstrom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1997"
                        "volumen" => "272"
                        "paginaInicial" => "26659"
                        "paginaFinal" => "26664"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9334248"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
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                ]
              ]
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            15 => array:3 [
              "identificador" => "bib0080"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of the human glucocorticoid receptor &#945; and &#946; isoforms in human respiratory epithelial cells and their regulation by dexamethasone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Pujols"
                            1 => "J&#46; Mullol"
                            2 => "M&#46; Perez"
                            3 => "J&#46; Roca Ferrer"
                            4 => "M&#46; Juan"
                            5 => "A&#46; Xaubet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/ajrcmb.24.1.4024"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "2001"
                        "volumen" => "24"
                        "paginaInicial" => "49"
                        "paginaFinal" => "57"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11152650"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of gene expression by glucocorticoids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;L&#46; Burnstein"
                            1 => "J&#46;A&#46; Cidlowski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Annu Rev Phisiol"
                        "fecha" => "1989"
                        "volumen" => "51"
                        "paginaInicial" => "683"
                        "paginaFinal" => "699"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gene regulation by steroid hormones"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Beato"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1989"
                        "volumen" => "56"
                        "paginaInicial" => "335"
                        "paginaFinal" => "344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2644044"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional domains of the human glucocorticoid receptor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46; Giguere"
                            1 => "S&#46;M&#46; Hollenberg"
                            2 => "M&#46;G&#46; Rosenfeld"
                            3 => "R&#46;M&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1986"
                        "volumen" => "46"
                        "paginaInicial" => "645"
                        "paginaFinal" => "652"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3742595"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of the human interleukine-2 gene by the alpha and beta isoforms of the glucocorticoid receptor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;M&#46; Bamberger"
                            1 => "T&#46; Else"
                            2 => "A&#46;M&#46; Bamberger"
                            3 => "F&#46;U&#46; Beil"
                            4 => "H&#46;M&#46; Schulte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Mol Cell Endocrinology"
                        "fecha" => "1997"
                        "volumen" => "136"
                        "paginaInicial" => "23"
                        "paginaFinal" => "28"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural variants of the &#946; isoform of the human glucocorticoid receptor do not alter sensitivity to glucocorticoids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; De Lange"
                            1 => "J&#46;W&#46; Koper"
                            2 => "A&#46;O&#46; Brinkmann"
                            3 => "F&#46;H&#46; De Jong"
                            4 => "S&#46;W&#46; Lamberts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Mol Cell Endocrinology"
                        "fecha" => "1999"
                        "volumen" => "153"
                        "paginaInicial" => "163"
                        "paginaFinal" => "168"
                      ]
                    ]
                  ]
                ]
              ]
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            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interaction of glucocorticoid receptor isoforms with transcription factors AP-1 and NF-kappa B&#58; lack of effect of glucocorticoid receptor &#946;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46;J&#46; Brogan"
                            1 => "I&#46;A&#46; Murray"
                            2 => "G&#46; Cerillo"
                            3 => "M&#46; Needham"
                            4 => "A&#46; White"
                            5 => "J&#46;R&#46; Davis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Mol Cell Endocrinology"
                        "fecha" => "1999"
                        "volumen" => "157"
                        "paginaInicial" => "95"
                        "paginaFinal" => "104"
                      ]
                    ]
                  ]
                ]
              ]
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            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is there a role for glucocorticoid receptor beta in asthma&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Gagliardo"
                            1 => "A&#46;M&#46; Vignola"
                            2 => "M&#46; Mathieu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/rr31"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Res"
                        "fecha" => "2001"
                        "volumen" => "2"
                        "paginaInicial" => "1"
                        "paginaFinal" => "4"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11686858"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of glucocorticoid insensitivity with increased expresion of glucocorticoid receptor &#946;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Leung"
                            1 => "Q&#46; Hamid"
                            2 => "A&#46; Vottero"
                            3 => "S&#46;J&#46; Szefler"
                            4 => "W&#46; Surs"
                            5 => "A&#46; Minshall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1997"
                        "volumen" => "186"
                        "paginaInicial" => "1567"
                        "paginaFinal" => "1573"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9348314"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
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            24 => array:3 [
              "identificador" => "bib0125"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;R&#46; Sousa"
                            1 => "S&#46;J&#46; Lane"
                            2 => "J&#46;A&#46; Cidlowski"
                            3 => "D&#46;Z&#46; Staynov"
                            4 => "T&#46;H&#46; Lee"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mai.2000.106486"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2000"
                        "volumen" => "105"
                        "paginaInicial" => "943"
                        "paginaFinal" => "950"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10808175"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0130"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased glucocorticoid receptor &#946; in airway cells of glucocorticoid- insensitive asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Q&#46; Hamid"
                            1 => "S&#46; Wenzel"
                            2 => "P&#46;J&#46; Hauk"
                            3 => "A&#46; Tsicopoulos"
                            4 => "B&#46; Wallaert"
                            5 => "J&#46; Lafitte"
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.159.5.9804131"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1999"
                        "volumen" => "159"
                        "paginaInicial" => "1600"
                        "paginaFinal" => "1604"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10228133"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0135"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proinflamatory cytokines regulate human glucocorticoid receptor gene expression and lead to the acumulation of the dominant negative &#946; isoform&#58; a mechanism for the generation of glucocorticoid resistance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;C&#46; Webster"
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                            2 => "C&#46;M&#46; Hewell"
                            3 => "J&#46;A&#46; Cidlowsky"
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                    0 => array:2 [
                      "doi" => "10.1073/pnas.121455098"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "2001"
                        "volumen" => "98"
                        "paginaInicial" => "6865"
                        "paginaFinal" => "6870"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11381138"
                            "web" => "Medline"
                          ]
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                ]
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            27 => array:3 [
              "identificador" => "bib0140"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocorticoid insensitivity asthma&#58; a one year clinical follow up pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Demoly"
                            1 => "D&#46; Jaffuel"
                            2 => "M&#46; Mathieu"
                            3 => "H&#46; Sahla"
                            4 => "P&#46; Godard"
                            5 => "F&#46;B&#46; Michel"
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                        ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
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                        "volumen" => "53"
                        "paginaInicial" => "1063"
                        "paginaFinal" => "1065"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10195080"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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              "identificador" => "bib0145"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;Y&#46;M&#46; Leung"
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                            2 => "A&#46; Vottero"
                            3 => "S&#46;J&#46; Szefler"
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                            5 => "E&#46; Minshall"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1997"
                        "volumen" => "196"
                        "paginaInicial" => "1567"
                        "paginaFinal" => "1574"
                      ]
                    ]
                  ]
                ]
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            29 => array:3 [
              "identificador" => "bib0150"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Steroid-resistant asthma&#58; cellular mechanisms contributing to inadequate response to glucocorticoid therapy"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;R&#46; Sher"
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                            2 => "W&#46; Surs"
                            3 => "J&#46;C&#46; Kam"
                            4 => "G&#46; Zieg"
                            5 => "A&#46;K&#46; Kamada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI116963"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1994"
                        "volumen" => "93"
                        "paginaInicial" => "33"
                        "paginaFinal" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8282803"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            30 => array:3 [
              "identificador" => "bib0155"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dysregulation of interleukine 4&#44; interleukine 5&#44; and interferon gamma gene expression in steroid-resistant asthma"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "R&#46;J&#46; Martin"
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                            3 => "E&#46;R&#46; Sher"
                            4 => "S&#46; Ying"
                            5 => "A&#46;B&#46; Kay"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1995"
                        "volumen" => "181"
                        "paginaInicial" => "33"
                        "paginaFinal" => "40"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7807013"
                            "web" => "Medline"
                          ]
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                      ]
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                ]
              ]
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            31 => array:3 [
              "identificador" => "bib0160"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A novel action of IL-13&#58; induction of diminished monocyte glucocorticoid receptor-binding affinity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Spahn"
                            1 => "S&#46;J&#46; Szefler"
                            2 => "W&#46; Surs"
                            3 => "D&#46;E&#46; Doherty"
                            4 => "S&#46;R&#46; Nimmagadda"
                            5 => "D&#46;Y&#46;M&#46; Leung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Immunol"
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Respuesta al tratamiento glucocorticoideo en el asma. Papel de las isoformas α y β del receptor glucocorticoideo
A. Torregoa,b,
Corresponding author
atorrego@clinic.ub.es

Correspondencia: Servei de Pneumologia. Hospital Clínic.Villarroel, 170. 08036 Barcelona
, L. Pujolsa, C. Picadoa,b
a Servei de Pneumologia. Institut Clínic de Pneumologia i Cirurgia Toràcica
b Idibaps. Hospital Clínic. Universitat de Barcelona
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                        "link" => array:1 [
                          0 => array:2 [
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              "referencia" => array:1 [
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                        "paginaInicial" => "2435"
                        "paginaFinal" => "2441"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                        "paginaFinal" => "9559"
                        "link" => array:1 [
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                        "paginaFinal" => "5038"
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                          "autores" => array:5 [
                            0 => "C&#46;M&#46; Bamberger"
                            1 => "A&#46;M&#46; Bamberger"
                            2 => "M&#46; Wald"
                            3 => "G&#46;P&#46; Chrousos"
                            4 => "H&#46;M&#46; Schulte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Steroid Biochem Mol Biol"
                        "fecha" => "1997"
                        "volumen" => "60"
                        "paginaInicial" => "43"
                        "paginaFinal" => "50"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9182857"
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                      "titulo" => "The non-ligand binding &#946;-isoform of the human glucocorticoid receptor &#40;hGR&#946;&#41;&#58; tissue levels&#44; mechanism of action&#44; and potential physiologic role"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "S&#46; Elliot"
                            2 => "T&#46; Kino"
                            3 => "C&#46; Bamberger"
                            4 => "M&#46; Karl"
                            5 => "E&#46; Webster"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Med"
                        "fecha" => "1996"
                        "volumen" => "2"
                        "paginaInicial" => "597"
                        "paginaFinal" => "607"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8898375"
                            "web" => "Medline"
                          ]
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                ]
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            10 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Shahidi"
                            1 => "A&#46; Vottero"
                            2 => "C&#46;A&#46; Stratakis"
                            3 => "S&#46;E&#46; Taymans"
                            4 => "M&#46; Karl"
                            5 => "C&#46;A&#46; Longui"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Biochem Biophys Res Commun"
                        "fecha" => "1999"
                        "volumen" => "254"
                        "paginaInicial" => "555"
                        "paginaFinal" => "565"
                      ]
                    ]
                  ]
                ]
              ]
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            11 => array:3 [
              "identificador" => "bib0060"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocorticoid receptor &#945; and &#946; in glucocorticoid dependent asthma"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Gagliardo"
                            1 => "P&#46; Chanez"
                            2 => "A&#46;M&#46; Vignola"
                            3 => "J&#46; Bousquet"
                            4 => "I&#46; Vachier"
                            5 => "P&#46; Godard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.162.1.9911032"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "162"
                        "paginaInicial" => "7"
                        "paginaFinal" => "13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10903212"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
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            12 => array:3 [
              "identificador" => "bib0065"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of glucocorticoid receptor &#946; in lymphocites of patients with glucocorticoid-resistant ulcerative colitis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Honda"
                            1 => "F&#46; Orii"
                            2 => "T&#46; Ayabe"
                            3 => "S&#46; Imai"
                            4 => "T&#46; Ashida"
                            5 => "T&#46; Obara"
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                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2000"
                        "volumen" => "118"
                        "paginaInicial" => "859"
                        "paginaFinal" => "866"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10784585"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
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            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The dominant negative activity of the human glucocorticoid receptor beta isoform&#58; specificity and mechanism of action"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;H&#46; Oakley"
                            1 => "C&#46;M&#46; Jewell"
                            2 => "M&#46;R&#46; Yudt"
                            3 => "D&#46;M&#46; Bofetiado"
                            4 => "J&#46;A&#46; Cidlowski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1999"
                        "volumen" => "274"
                        "paginaInicial" => "27857"
                        "paginaFinal" => "27866"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10488132"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            14 => array:3 [
              "identificador" => "bib0075"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evidence that the &#946; isoform of the human glucocorticoid receptor does not act as a physiologically significant represor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46; Hecht"
                            1 => "J&#46; Carlstedt-Duke"
                            2 => "P&#46; Stierna"
                            3 => "J&#46;A&#46; Gustafsson"
                            4 => "M&#46; Bron-negard"
                            5 => "A&#46;C&#46; Wikstrom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1997"
                        "volumen" => "272"
                        "paginaInicial" => "26659"
                        "paginaFinal" => "26664"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9334248"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            15 => array:3 [
              "identificador" => "bib0080"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of the human glucocorticoid receptor &#945; and &#946; isoforms in human respiratory epithelial cells and their regulation by dexamethasone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Pujols"
                            1 => "J&#46; Mullol"
                            2 => "M&#46; Perez"
                            3 => "J&#46; Roca Ferrer"
                            4 => "M&#46; Juan"
                            5 => "A&#46; Xaubet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/ajrcmb.24.1.4024"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "2001"
                        "volumen" => "24"
                        "paginaInicial" => "49"
                        "paginaFinal" => "57"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11152650"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of gene expression by glucocorticoids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;L&#46; Burnstein"
                            1 => "J&#46;A&#46; Cidlowski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Annu Rev Phisiol"
                        "fecha" => "1989"
                        "volumen" => "51"
                        "paginaInicial" => "683"
                        "paginaFinal" => "699"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gene regulation by steroid hormones"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Beato"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1989"
                        "volumen" => "56"
                        "paginaInicial" => "335"
                        "paginaFinal" => "344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2644044"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional domains of the human glucocorticoid receptor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46; Giguere"
                            1 => "S&#46;M&#46; Hollenberg"
                            2 => "M&#46;G&#46; Rosenfeld"
                            3 => "R&#46;M&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1986"
                        "volumen" => "46"
                        "paginaInicial" => "645"
                        "paginaFinal" => "652"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3742595"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of the human interleukine-2 gene by the alpha and beta isoforms of the glucocorticoid receptor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;M&#46; Bamberger"
                            1 => "T&#46; Else"
                            2 => "A&#46;M&#46; Bamberger"
                            3 => "F&#46;U&#46; Beil"
                            4 => "H&#46;M&#46; Schulte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Mol Cell Endocrinology"
                        "fecha" => "1997"
                        "volumen" => "136"
                        "paginaInicial" => "23"
                        "paginaFinal" => "28"
                      ]
                    ]
                  ]
                ]
              ]
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            20 => array:3 [
              "identificador" => "bib0105"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural variants of the &#946; isoform of the human glucocorticoid receptor do not alter sensitivity to glucocorticoids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; De Lange"
                            1 => "J&#46;W&#46; Koper"
                            2 => "A&#46;O&#46; Brinkmann"
                            3 => "F&#46;H&#46; De Jong"
                            4 => "S&#46;W&#46; Lamberts"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Mol Cell Endocrinology"
                        "fecha" => "1999"
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                        "paginaInicial" => "163"
                        "paginaFinal" => "168"
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                    ]
                  ]
                ]
              ]
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            21 => array:3 [
              "identificador" => "bib0110"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interaction of glucocorticoid receptor isoforms with transcription factors AP-1 and NF-kappa B&#58; lack of effect of glucocorticoid receptor &#946;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "I&#46;A&#46; Murray"
                            2 => "G&#46; Cerillo"
                            3 => "M&#46; Needham"
                            4 => "A&#46; White"
                            5 => "J&#46;R&#46; Davis"
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Mol Cell Endocrinology"
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                        "paginaInicial" => "95"
                        "paginaFinal" => "104"
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              ]
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            22 => array:3 [
              "identificador" => "bib0115"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is there a role for glucocorticoid receptor beta in asthma&#63;"
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                          "etal" => false
                          "autores" => array:3 [
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                    0 => array:2 [
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                        "tituloSerie" => "Respir Res"
                        "fecha" => "2001"
                        "volumen" => "2"
                        "paginaInicial" => "1"
                        "paginaFinal" => "4"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11686858"
                            "web" => "Medline"
                          ]
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              ]
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            23 => array:3 [
              "identificador" => "bib0120"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of glucocorticoid insensitivity with increased expresion of glucocorticoid receptor &#946;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "Q&#46; Hamid"
                            2 => "A&#46; Vottero"
                            3 => "S&#46;J&#46; Szefler"
                            4 => "W&#46; Surs"
                            5 => "A&#46; Minshall"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1997"
                        "volumen" => "186"
                        "paginaInicial" => "1567"
                        "paginaFinal" => "1573"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9348314"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0125"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform"
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                          "etal" => false
                          "autores" => array:5 [
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2000"
                        "volumen" => "105"
                        "paginaInicial" => "943"
                        "paginaFinal" => "950"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10808175"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0130"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased glucocorticoid receptor &#946; in airway cells of glucocorticoid- insensitive asthma"
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                          "etal" => true
                          "autores" => array:6 [
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                            2 => "P&#46;J&#46; Hauk"
                            3 => "A&#46; Tsicopoulos"
                            4 => "B&#46; Wallaert"
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                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1999"
                        "volumen" => "159"
                        "paginaInicial" => "1600"
                        "paginaFinal" => "1604"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10228133"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0135"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proinflamatory cytokines regulate human glucocorticoid receptor gene expression and lead to the acumulation of the dominant negative &#946; isoform&#58; a mechanism for the generation of glucocorticoid resistance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                    0 => array:2 [
                      "doi" => "10.1073/pnas.121455098"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "2001"
                        "volumen" => "98"
                        "paginaInicial" => "6865"
                        "paginaFinal" => "6870"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11381138"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocorticoid insensitivity asthma&#58; a one year clinical follow up pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Demoly"
                            1 => "D&#46; Jaffuel"
                            2 => "M&#46; Mathieu"
                            3 => "H&#46; Sahla"
                            4 => "P&#46; Godard"
                            5 => "F&#46;B&#46; Michel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1998"
                        "volumen" => "53"
                        "paginaInicial" => "1063"
                        "paginaFinal" => "1065"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10195080"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;Y&#46;M&#46; Leung"
                            1 => "Q&#46; Hamid"
                            2 => "A&#46; Vottero"
                            3 => "S&#46;J&#46; Szefler"
                            4 => "W&#46; Surs"
                            5 => "E&#46; Minshall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1997"
                        "volumen" => "196"
                        "paginaInicial" => "1567"
                        "paginaFinal" => "1574"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Steroid-resistant asthma&#58; cellular mechanisms contributing to inadequate response to glucocorticoid therapy"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;R&#46; Sher"
                            1 => "D&#46;Y&#46;M&#46; Leung"
                            2 => "W&#46; Surs"
                            3 => "J&#46;C&#46; Kam"
                            4 => "G&#46; Zieg"
                            5 => "A&#46;K&#46; Kamada"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1172/JCI116963"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1994"
                        "volumen" => "93"
                        "paginaInicial" => "33"
                        "paginaFinal" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8282803"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Dysregulation of interleukine 4&#44; interleukine 5&#44; and interferon gamma gene expression in steroid-resistant asthma"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "R&#46;J&#46; Martin"
                            2 => "S&#46;J&#46; Szefler"
                            3 => "E&#46;R&#46; Sher"
                            4 => "S&#46; Ying"
                            5 => "A&#46;B&#46; Kay"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1995"
                        "volumen" => "181"
                        "paginaInicial" => "33"
                        "paginaFinal" => "40"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7807013"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            31 => array:3 [
              "identificador" => "bib0160"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "A novel action of IL-13&#58; induction of diminished monocyte glucocorticoid receptor-binding affinity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Spahn"
                            1 => "S&#46;J&#46; Szefler"
                            2 => "W&#46; Surs"
                            3 => "D&#46;E&#46; Doherty"
                            4 => "S&#46;R&#46; Nimmagadda"
                            5 => "D&#46;Y&#46;M&#46; Leung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "1996"
                        "volumen" => "181"
                        "paginaInicial" => "33"
                        "paginaFinal" => "40"
                      ]
                    ]
                  ]
                ]
              ]
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            32 => array:3 [
              "identificador" => "bib0165"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Induction of corticosteroid insensitivity in human PBMCs by microbial superantigens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;J&#46; Hauk"
                            1 => "G&#46;P&#46; Hamid QA Chrousos"
                            2 => "D&#46;Y&#46;M&#46; Leung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mai.2000.105807"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2000"
                        "volumen" => "105"
                        "paginaInicial" => "782"
                        "paginaFinal" => "787"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10756230"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Clinical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoidresistant bronchial asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;J&#46; Lane"
                            1 => "J&#46;P&#46; Arm"
                            2 => "D&#46;Z&#46; Staynov"
                            3 => "T&#46;H&#46; Lee"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/ajrcmb.11.1.8018337"
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                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "1994"
                        "volumen" => "11"
                        "paginaInicial" => "42"
                        "paginaFinal" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8018337"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0175"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "GR&#946; expression in nasal polyp inflamatory cells and its relationship to the anti-inflammatory effects of intranasal fluticasone"
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                          "etal" => true
                          "autores" => array:6 [
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                            1 => "D&#46;Y&#46;M&#46; Leung"
                            2 => "S&#46; Muro"
                            3 => "A&#46;M&#46; Kahn"
                            4 => "S&#46;S&#46; Hamilos"
                            5 => "S&#46;E&#46; Thawley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mai.2001.116428"
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                        "tituloSerie" => "J Allergy Clin Immunol"
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                        "paginaInicial" => "59"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11447383"
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ISSN: 03002896
Original language: Spanish
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