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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Describir la distribuci&#243;n celular y el grado de expresi&#243;n de diversas hormonas y receptores de opioides en el desarrollo embrionario y en el pulm&#243;n sano del adulto</p> <span class="elsevierStyleSectionTitle">M&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Seleccionamos tejido pulmonar de las tres etapas del desarrollo fetal &#40;seudoglandular&#44; canalicular y sacular&#44; tres muestras por etapa&#41;&#44; de reci&#233;n nacidos &#40;tres&#41;&#44; ni&#241;os de 10 meses &#40;dos&#41; y adultos &#40;tres&#41; fallecidos sin afecci&#243;n pulmonar&#46; Practicamos tinci&#243;n inmunohistoqu&#237;mica para hormonas espec&#237;ficas &#40;calcitonina&#44; parathormona&#44; serotonina y hormona adrenocorticotropa &#91;ACTH&#93;&#41; y receptores de opioides tipo delta y mu&#46; Valoramos el porcentaje de c&#233;lulas positivas as&#237; como el tipo celular reactivo en cada caso</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La serotonina es la primera en aparecer &#40;estadio seudoglandular en c&#233;lulas neuroendocrinas aisladas&#41; para posteriormente desaparecer&#46; La calcitonina aparece en el estadio canalicular en c&#233;lulas neuroendocrinas y neumocitos&#46; Su expresi&#243;n m&#225;xima es al nacimiento y disminuye en el pulm&#243;n adulto&#46; No hemos encontrado producci&#243;n de ACTH ni de parathormona&#46; Los receptores de opioides aparecen en la fase canalicular y alcanzan el m&#225;ximo grado en el nacimiento&#46; En el adulto s&#243;lo existen receptores para opioides tipo delta en neumocitos&#44; c&#233;lulas musculares bronquiolares y mesoteliales</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La hormonosecreci&#243;n pulmonar es importante durante el desarrollo fetal y alcanza su m&#225;xima expresi&#243;n en el nacimiento&#46; La principal hormona que produce el pulm&#243;n fetal es la calcitonina&#46; Existen receptores opioides durante el desarrollo fetal en diferentes tipos celulares y alcanzan su m&#225;xima expresi&#243;n al nacimiento&#46; El conocimiento de la expresi&#243;n de sustancias activas podr&#237;a tener consecuencias terap&#233;uticas en determinados procesos patol&#243;gicos como el s&#237;ndrome de distr&#233;s respiratorio en el ni&#241;o o el asma bronquial</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To describe the cellular distribution and level of expression of certain hormones and opioid receptors during fetal development and in the lung of the healthy adult</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We sampled lung tissue from fetuses at three stages of development &#40;pseudoglandular&#44; canalicular and saccular&#41; &#40;3 samples per stage&#41;&#44; from newborn infants &#40;3&#41;&#44; from 10-month-old infants &#40;2&#41; and from adults &#40;3&#41; who had died without lung disease&#46; After specific immunohistochemical staining for hormones &#40;calcitonin&#44; parathormone&#44; serotonin and adrenocorticotropic hormone - ACTH&#41; and opioid receptors&#44; we assessed the percentage of positive cells for each cell type in each sample</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Serotonin is the first to appear &#40;pseudoglandular stage in isolated neuroendocrine cells&#41; and it disappears later&#46; Calcitonin appears in the canalicular stage in neuro-endocrine and lung cells&#46; Expression is at its peak at birth and is less in the adult lung&#46; We found no ACTH or parathormone production&#46; Opioid receptors appear in the canalicular stage and peak at birth&#46; In adult lung&#44; bronchiolar muscle and mesothelial cells&#44; only deltatype opioid receptors are present</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Pulmonary hormone secretion is significant during fetal development and peaks at birth&#46; Calcitonin is the main hormone produced in the fetal lung&#46; Opioid receptors are present during fetal development in various types of cells and peak at birth&#46; An understanding of the expression of active substances could have therapeutic relevance in certain conditions&#44; such as bronchial asthma or respiratory distress syndrome in the child</p>"
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Expresión hormonal y de receptores opioides en pulmón fetal y del adulto
Hormone expression and opioid receptors in fetal and adult lung
J.J. Gómez-Romána,
Corresponding author
apagrj@humv.es

Correspondencia: Departamento de Anatomía Patológica. Hospital Universitario Marqués de Valdecilla.Avda. Valdecilla, s/n. 39008 Santander
, J. Fernando Val-Bernala
a Departamento de Anatomía Patológica
J.M. Cifrián Martínez, S. Fernández Rozas
Servicio de Neumología. Hospital Universitario Marqués de Valdecilla. Santander
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Describir la distribuci&#243;n celular y el grado de expresi&#243;n de diversas hormonas y receptores de opioides en el desarrollo embrionario y en el pulm&#243;n sano del adulto</p> <span class="elsevierStyleSectionTitle">M&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Seleccionamos tejido pulmonar de las tres etapas del desarrollo fetal &#40;seudoglandular&#44; canalicular y sacular&#44; tres muestras por etapa&#41;&#44; de reci&#233;n nacidos &#40;tres&#41;&#44; ni&#241;os de 10 meses &#40;dos&#41; y adultos &#40;tres&#41; fallecidos sin afecci&#243;n pulmonar&#46; Practicamos tinci&#243;n inmunohistoqu&#237;mica para hormonas espec&#237;ficas &#40;calcitonina&#44; parathormona&#44; serotonina y hormona adrenocorticotropa &#91;ACTH&#93;&#41; y receptores de opioides tipo delta y mu&#46; Valoramos el porcentaje de c&#233;lulas positivas as&#237; como el tipo celular reactivo en cada caso</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La serotonina es la primera en aparecer &#40;estadio seudoglandular en c&#233;lulas neuroendocrinas aisladas&#41; para posteriormente desaparecer&#46; La calcitonina aparece en el estadio canalicular en c&#233;lulas neuroendocrinas y neumocitos&#46; Su expresi&#243;n m&#225;xima es al nacimiento y disminuye en el pulm&#243;n adulto&#46; No hemos encontrado producci&#243;n de ACTH ni de parathormona&#46; Los receptores de opioides aparecen en la fase canalicular y alcanzan el m&#225;ximo grado en el nacimiento&#46; En el adulto s&#243;lo existen receptores para opioides tipo delta en neumocitos&#44; c&#233;lulas musculares bronquiolares y mesoteliales</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La hormonosecreci&#243;n pulmonar es importante durante el desarrollo fetal y alcanza su m&#225;xima expresi&#243;n en el nacimiento&#46; La principal hormona que produce el pulm&#243;n fetal es la calcitonina&#46; Existen receptores opioides durante el desarrollo fetal en diferentes tipos celulares y alcanzan su m&#225;xima expresi&#243;n al nacimiento&#46; El conocimiento de la expresi&#243;n de sustancias activas podr&#237;a tener consecuencias terap&#233;uticas en determinados procesos patol&#243;gicos como el s&#237;ndrome de distr&#233;s respiratorio en el ni&#241;o o el asma bronquial</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To describe the cellular distribution and level of expression of certain hormones and opioid receptors during fetal development and in the lung of the healthy adult</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We sampled lung tissue from fetuses at three stages of development &#40;pseudoglandular&#44; canalicular and saccular&#41; &#40;3 samples per stage&#41;&#44; from newborn infants &#40;3&#41;&#44; from 10-month-old infants &#40;2&#41; and from adults &#40;3&#41; who had died without lung disease&#46; After specific immunohistochemical staining for hormones &#40;calcitonin&#44; parathormone&#44; serotonin and adrenocorticotropic hormone - ACTH&#41; and opioid receptors&#44; we assessed the percentage of positive cells for each cell type in each sample</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Serotonin is the first to appear &#40;pseudoglandular stage in isolated neuroendocrine cells&#41; and it disappears later&#46; Calcitonin appears in the canalicular stage in neuro-endocrine and lung cells&#46; Expression is at its peak at birth and is less in the adult lung&#46; We found no ACTH or parathormone production&#46; Opioid receptors appear in the canalicular stage and peak at birth&#46; In adult lung&#44; bronchiolar muscle and mesothelial cells&#44; only deltatype opioid receptors are present</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Pulmonary hormone secretion is significant during fetal development and peaks at birth&#46; Calcitonin is the main hormone produced in the fetal lung&#46; Opioid receptors are present during fetal development in various types of cells and peak at birth&#46; An understanding of the expression of active substances could have therapeutic relevance in certain conditions&#44; such as bronchial asthma or respiratory distress syndrome in the child</p>"
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ISSN: 03002896
Original language: Spanish
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