Correspondencia: Departamento de Anatomía Patológica. Hospital Universitario Marqués de Valdecilla.Avda. Valdecilla, s/n. 39008 Santander
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Holmgren, M. Córdova, P. Ortúzar, I. Sánchez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "N.L." "apellidos" => "Holmgren" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Córdova" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Ortúzar" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Sánchez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289602752411?idApp=UINPBA00003Z" "url" => "/03002896/0000003800000008/v1_201307081526/S0300289602752411/v1_201307081526/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289602752393" "issn" => "03002896" "doi" => "10.1016/S0300-2896(02)75239-3" "estado" => "S300" "fechaPublicacion" => "2002-08-01" "aid" => "75239" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2002;38:356-61" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5166 "formatos" => array:3 [ "EPUB" => 64 "HTML" => 4528 "PDF" => 574 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Uso y accesibilidad del análisis estadístico en la revista Archivos De Bronconeumología (1970–1999)" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "356" "paginaFinal" => "361" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Use and comprehensibility of statistical analysis in Archivos Debronconeumología(1970–1999)" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "J.I. De Granda Orive, T. Gutiérrez Jiménez, J. Escobar Sacristán, V. Gallego Rodríguez, R. Sáez Valls" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J.I." "apellidos" => "De Granda Orive" ] 1 => array:2 [ "nombre" => "T." "apellidos" => "Gutiérrez Jiménez" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Escobar Sacristán" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Gallego Rodríguez" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Sáez Valls" ] ] ] 1 => array:2 [ "autoresLista" => "F. García Río" "autores" => array:1 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "García Río" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289602752393?idApp=UINPBA00003Z" "url" => "/03002896/0000003800000008/v1_201307081526/S0300289602752393/v1_201307081526/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "Expresión hormonal y de receptores opioides en pulmón fetal y del adulto" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "362" "paginaFinal" => "366" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "J.J. Gómez-Román, J. Fernando Val-Bernal" "autores" => array:2 [ 0 => array:4 [ "nombre" => "J.J." "apellidos" => "Gómez-Román" "email" => array:1 [ 0 => "apagrj@humv.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Fernando Val-Bernal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Departamento de Anatomía Patológica" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Departamento de Anatomía Patológica. Hospital Universitario Marqués de Valdecilla.Avda. Valdecilla, s/n. 39008 Santander" ] ] ] 1 => array:3 [ "autoresLista" => "J.M. Cifrián Martínez, S. Fernández Rozas" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J.M." "apellidos" => "Cifrián Martínez" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Fernández Rozas" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neumología. Hospital Universitario Marqués de Valdecilla. Santander" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hormone expression and opioid receptors in fetal and adult lung" ] ] "miscelanea" => "Este trabajo fue presentado parcialmente como comunicación póster en el Congreso Nacional SEPAR celebrado en La Coruña en 2001" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-09-18" "fechaAceptado" => "2002-03-12" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec190548" "palabras" => array:3 [ 0 => "Hormonas" 1 => "Receptores opioides" 2 => "Pulmón" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec190547" "palabras" => array:3 [ 0 => "Hormones" 1 => "Opioid receptors" 2 => "Lung" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Describir la distribución celular y el grado de expresión de diversas hormonas y receptores de opioides en el desarrollo embrionario y en el pulmón sano del adulto</p> <span class="elsevierStyleSectionTitle">Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Seleccionamos tejido pulmonar de las tres etapas del desarrollo fetal (seudoglandular, canalicular y sacular, tres muestras por etapa), de recién nacidos (tres), niños de 10 meses (dos) y adultos (tres) fallecidos sin afección pulmonar. Practicamos tinción inmunohistoquímica para hormonas específicas (calcitonina, parathormona, serotonina y hormona adrenocorticotropa [ACTH]) y receptores de opioides tipo delta y mu. Valoramos el porcentaje de células positivas así como el tipo celular reactivo en cada caso</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La serotonina es la primera en aparecer (estadio seudoglandular en células neuroendocrinas aisladas) para posteriormente desaparecer. La calcitonina aparece en el estadio canalicular en células neuroendocrinas y neumocitos. Su expresión máxima es al nacimiento y disminuye en el pulmón adulto. No hemos encontrado producción de ACTH ni de parathormona. Los receptores de opioides aparecen en la fase canalicular y alcanzan el máximo grado en el nacimiento. En el adulto sólo existen receptores para opioides tipo delta en neumocitos, células musculares bronquiolares y mesoteliales</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La hormonosecreción pulmonar es importante durante el desarrollo fetal y alcanza su máxima expresión en el nacimiento. La principal hormona que produce el pulmón fetal es la calcitonina. Existen receptores opioides durante el desarrollo fetal en diferentes tipos celulares y alcanzan su máxima expresión al nacimiento. El conocimiento de la expresión de sustancias activas podría tener consecuencias terapéuticas en determinados procesos patológicos como el síndrome de distrés respiratorio en el niño o el asma bronquial</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To describe the cellular distribution and level of expression of certain hormones and opioid receptors during fetal development and in the lung of the healthy adult</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We sampled lung tissue from fetuses at three stages of development (pseudoglandular, canalicular and saccular) (3 samples per stage), from newborn infants (3), from 10-month-old infants (2) and from adults (3) who had died without lung disease. After specific immunohistochemical staining for hormones (calcitonin, parathormone, serotonin and adrenocorticotropic hormone - ACTH) and opioid receptors, we assessed the percentage of positive cells for each cell type in each sample</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Serotonin is the first to appear (pseudoglandular stage in isolated neuroendocrine cells) and it disappears later. Calcitonin appears in the canalicular stage in neuro-endocrine and lung cells. Expression is at its peak at birth and is less in the adult lung. We found no ACTH or parathormone production. Opioid receptors appear in the canalicular stage and peak at birth. In adult lung, bronchiolar muscle and mesothelial cells, only deltatype opioid receptors are present</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Pulmonary hormone secretion is significant during fetal development and peaks at birth. Calcitonin is the main hormone produced in the fetal lung. Opioid receptors are present during fetal development in various types of cells and peak at birth. An understanding of the expression of active substances could have therapeutic relevance in certain conditions, such as bronchial asthma or respiratory distress syndrome in the child</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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Year/Month | Html | Total | |
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2024 November | 5 | 46 | 51 |
2024 October | 52 | 250 | 302 |
2024 September | 50 | 204 | 254 |
2024 August | 56 | 126 | 182 |
2024 July | 60 | 86 | 146 |
2024 June | 73 | 148 | 221 |
2024 May | 70 | 279 | 349 |
2024 April | 39 | 142 | 181 |
2024 March | 48 | 223 | 271 |
2024 February | 46 | 146 | 192 |
2024 January | 0 | 68 | 68 |
2023 December | 0 | 46 | 46 |
2023 November | 0 | 125 | 125 |
2023 October | 0 | 153 | 153 |
2023 September | 0 | 99 | 99 |
2023 August | 0 | 2 | 2 |
2023 July | 0 | 29 | 29 |
2023 June | 0 | 15 | 15 |
2023 May | 0 | 7 | 7 |
2023 April | 0 | 1 | 1 |
2023 March | 11 | 40 | 51 |
2023 February | 83 | 71 | 154 |
2023 January | 59 | 58 | 117 |
2022 December | 55 | 71 | 126 |
2022 November | 116 | 144 | 260 |
2022 October | 91 | 132 | 223 |
2022 September | 133 | 154 | 287 |
2022 August | 64 | 110 | 174 |
2022 July | 52 | 50 | 102 |
2022 June | 45 | 90 | 135 |
2022 May | 74 | 97 | 171 |
2022 April | 88 | 116 | 204 |
2022 March | 72 | 78 | 150 |
2022 February | 55 | 55 | 110 |
2022 January | 66 | 111 | 177 |
2021 December | 55 | 68 | 123 |
2021 November | 105 | 81 | 186 |
2021 October | 142 | 96 | 238 |
2021 September | 107 | 85 | 192 |
2021 August | 69 | 91 | 160 |
2021 July | 53 | 41 | 94 |
2021 June | 65 | 63 | 128 |
2021 May | 77 | 72 | 149 |
2021 April | 66 | 113 | 179 |
2021 March | 130 | 41 | 171 |
2021 February | 84 | 43 | 127 |
2021 January | 52 | 57 | 109 |
2020 December | 64 | 54 | 118 |
2020 November | 69 | 34 | 103 |
2020 October | 73 | 53 | 126 |
2020 September | 47 | 36 | 83 |
2020 August | 69 | 56 | 125 |
2020 July | 49 | 45 | 94 |
2020 June | 50 | 74 | 124 |
2020 May | 81 | 62 | 143 |
2020 April | 50 | 70 | 120 |
2020 March | 60 | 49 | 109 |
2020 February | 51 | 64 | 115 |
2020 January | 31 | 127 | 158 |
2019 December | 42 | 108 | 150 |
2019 November | 22 | 120 | 142 |
2019 October | 27 | 809 | 836 |
2019 September | 24 | 81 | 105 |
2019 August | 31 | 60 | 91 |
2019 July | 24 | 87 | 111 |
2019 June | 14 | 67 | 81 |
2019 May | 23 | 84 | 107 |
2019 April | 48 | 63 | 111 |
2019 March | 16 | 33 | 49 |
2019 February | 9 | 13 | 22 |
2019 January | 5 | 21 | 26 |
2018 December | 7 | 23 | 30 |
2018 November | 28 | 33 | 61 |
2018 October | 25 | 19 | 44 |
2018 September | 17 | 12 | 29 |
2018 May | 6 | 9 | 15 |
2018 April | 6 | 7 | 13 |
2018 March | 7 | 13 | 20 |
2018 February | 6 | 11 | 17 |
2018 January | 5 | 10 | 15 |
2017 December | 13 | 19 | 32 |
2017 November | 7 | 17 | 24 |
2017 October | 9 | 13 | 22 |
2017 September | 3 | 13 | 16 |
2017 August | 11 | 10 | 21 |
2017 July | 6 | 6 | 12 |
2017 June | 14 | 13 | 27 |
2017 May | 16 | 12 | 28 |
2017 April | 8 | 5 | 13 |
2017 March | 5 | 40 | 45 |
2017 February | 3 | 11 | 14 |
2017 January | 8 | 7 | 15 |
2016 December | 13 | 10 | 23 |
2016 November | 28 | 18 | 46 |
2016 October | 29 | 19 | 48 |
2016 September | 30 | 27 | 57 |
2016 August | 22 | 9 | 31 |
2016 July | 27 | 13 | 40 |
2016 June | 24 | 12 | 36 |
2016 May | 23 | 3 | 26 |
2016 April | 11 | 2 | 13 |
2016 March | 7 | 4 | 11 |
2016 February | 19 | 2 | 21 |
2016 January | 27 | 15 | 42 |
2015 December | 22 | 11 | 33 |
2015 November | 26 | 6 | 32 |
2015 October | 185 | 1 | 186 |
2015 September | 169 | 0 | 169 |
2015 August | 136 | 0 | 136 |
2015 July | 122 | 0 | 122 |
2015 June | 100 | 0 | 100 |
2015 May | 164 | 0 | 164 |
2015 April | 138 | 0 | 138 |
2015 March | 112 | 0 | 112 |
2015 February | 109 | 0 | 109 |
2015 January | 97 | 0 | 97 |
2014 December | 108 | 0 | 108 |
2014 November | 147 | 0 | 147 |
2014 October | 148 | 0 | 148 |
2014 September | 137 | 0 | 137 |
2014 August | 97 | 0 | 97 |
2014 July | 47 | 0 | 47 |
2014 June | 95 | 0 | 95 |
2014 May | 124 | 0 | 124 |
2014 April | 81 | 0 | 81 |
2014 March | 116 | 0 | 116 |
2014 February | 65 | 0 | 65 |
2014 January | 61 | 0 | 61 |
2013 December | 75 | 0 | 75 |
2013 November | 116 | 0 | 116 |
2013 October | 108 | 0 | 108 |
2013 September | 67 | 0 | 67 |
2013 August | 90 | 0 | 90 |
2013 July | 91 | 0 | 91 |
2013 June | 67 | 0 | 67 |
2013 May | 86 | 0 | 86 |
2013 April | 41 | 0 | 41 |
2013 March | 11 | 0 | 11 |
2000 January | 3230 | 0 | 3230 |