Corticoides inhalados y supervivencia en la EPOC
Inhaled corticosteroids and survival in COPD
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Fundación Caubet-CIMERA (Centro Internacional de Medicina Respiratoria Avanzada). Bunyola. Illes Balears. España." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Inhaled corticosteroids and survival in COPD" ] ] "pdfFichero" => "6v42nSupl.2a13097280pdf001.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec191389" "palabras" => array:4 [ 0 => "Corticoides inhalados" 1 => "EPOC" 2 => "Supervivencia" 3 => "Tratamiento combinado" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec191390" "palabras" => array:4 [ 0 => "Inhaled corticosteroids" 1 => "COPD" 2 => "Survival" 3 => "Combination therapy" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "El tratamiento de la enfermedad pulmonar obstructiva crónica (EPOC), hasta hace poco considerado de efecto sólo sintomático, se ha modificado recientemente gracias a nuevos descubrimientos respecto a su fisiopatología. La descripción de la EPOC como una enfermedad inflamatoria ha provocado una búsqueda acelerada para demostrar los posibles efectos beneficiosos del tratamiento antiinflamatorio en la EPOC. Al principio se ensayaron los corticoides inhalados aisladamente, y luego en combinación con agonistas β de acción prolongada; es el denominado ¿tratamiento combinado¿. Sucesivos ensayos clínicos, progresivamente de creciente tamaño y duración, demostraron beneficios clínicos del tratamiento antiinflamatorio en la EPOC respecto a los objetivos de reducción de síntomas e incluso su abolición, mejoría de la función pulmonar y calidad de vida, y descenso de la frecuencia y gravedad de las exacerbaciones. La controversia respecto a una modificación de la historia natural de la EPOC y una mejora de la supervivencia ha generado multitud de debates, algunos aún abiertos y con posturas polarizadas. Por último, los largamente esperados resultados del estudio TORCH empiezan a ¿destilarse¿ durante 2006." ] "en" => array:1 [ "resumen" => "Treatment of chronic obstructive pulmonary disease (COPD) was considered to be only symptomatic until recently, but this has changed due to new findings on the physiopathology of this disease. The description of COPD as an inflammatory disease has provoked an accelerated search to demonstrate the possible beneficial effects of antiinflammatory therapy in this disease. Initially, inhaled corticosteroids (IC) alone were tested, followed by IC in combination with long-acting beta2-agonists, known as combination therapy. Successive clinical trials, of increasing size and duration, to demonstrate the potential beneficial effects of anti-inflammatory therapy in COPD regarding goals of a reduction and even disappearance of symptoms, an improvement in pulmonary function and quality of life, and a decrease in the frequency and severity of exacerbations. The controversy regarding modification of the natural history of COPD and improved survival led to a multitude of debates, some still ongoing, and polarized attitudes. Finally, the longawaited results of the TORCH study are beginning to be known in 2006." ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/00000042000000S2/v0_201307090905/13097280/v0_201307090905/es/main.assets" "Apartado" => array:4 [ "identificador" => "14582" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "''Hot topics'' 2006 en neumología" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/00000042000000S2/v0_201307090905/13097280/v0_201307090905/es/6v42nSupl.2a13097280pdf001.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/13097280?idApp=UINPBA00003Z" ]
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