Anticuerpos monoclonales en la terapéutica neumológica
Therapeutic use of monoclonal antibodies in pneumology
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Hospital Universitario Dr. Negrín. Las Palmas de Gran Canaria. Las Palmas. España." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Therapeutic use of monoclonal antibodies in pneumology" ] ] "pdfFichero" => "6v42nSupl.2a13097275pdf001.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec191363" "palabras" => array:6 [ 0 => "Monoclonales" 1 => "Neumología" 2 => "Asma" 3 => "Cáncer de pulmón" 4 => "Omalizumab" 5 => "Xolair®" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec191364" "palabras" => array:6 [ 0 => "Monoclonal antibodies" 1 => "Pneumology" 2 => "Asthma" 3 => "Lung cancer" 4 => "Omalizumab" 5 => "Xolair®" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "La tecnología desarrollada en los últimos 20 años con los anticuerpos monoclonales, inicialmente para su uso como marcadores de laboratorio, ha llevado recientemente a la creación de una nueva serie de fármacos de vanguardia, altamente selectivos. En la actualidad las publicaciones médicas de mayor prestigio están informando, con gran profusión, de sus resultados clínicos. Dentro de la neumología, sólo uno de estos fármacos ¿el omalizumab (Xolair®)¿ ha sido autorizado para el tratamiento del asma, aunque se han publicado diversos estudios con otros anticuerpos monoclonales que inciden en las vías etiopatogénicas del asma. La investigación de estos fármacos en el carcinoma de pulmón está menos desarrollada, pero no es menos prometedora. En esta revisión se analizan los fundamentos del tratamiento con anticuerpos monoclonales y se actualiza la investigación que se está desarrollando en el campo de la neumología." ] "en" => array:1 [ "resumen" => "The technology developed in the last 20 years with monoclonal antibodies, initially for their use as laboratory markers, has led to the recent creation of a novel series of highlyselective drugs. Currently, a large number of publications in high-prestige medical journals are reporting the results of the clinical use of these drugs. Within pneumology, only one of these drugs ¿ omalizumab (Xolair®) ¿ has been authorized for the treatment of asthma, although several studies of other monoclonal antibodies that affect the etiopathogenic pathways of asthma have been published. Research into the use of these drugs in lung cancer is less well developed but no less promising. The present review analyzes the bases for monoclonal antibody therapy and provides an update on the research being carried out in the field of pneumology." ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/00000042000000S2/v0_201307090905/13097275/v0_201307090905/es/main.assets" "Apartado" => array:4 [ "identificador" => "14582" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "''Hot topics'' 2006 en neumología" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/00000042000000S2/v0_201307090905/13097275/v0_201307090905/es/6v42nSupl.2a13097275pdf001.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/13097275?idApp=UINPBA00003Z" ]
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