Inhaled steroids and the prevention of lung cancer
Esteroides inhalados y prevención del cáncer de pulmón
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Hospital Universitario 12 de Octubre. Madrid. Spain." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Esteroides inhalados y prevención del cáncer de pulmón" ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold"> To the Editor:</span> For some years, chronic obstructive pulmonary disease (COPD) has been considered a risk factor for the development of lung cancer, independent of smoking<span class="elsevierStyleSup">1</span>.</p><p class="elsevierStylePara"> Several randomized controlled trials of inhaled steroids in COPD have been published recently<span class="elsevierStyleSup">2-4</span>. Together, these studies have enrolled 2,683 COPD patients randomly assigned to receive inhaled steroid therapy or not.</p><p class="elsevierStylePara">At the same time, results from experimental studies have suggested that inhaled steroids may have a protective effect against pulmonary carcinogenesis<span class="elsevierStyleSup">5,6</span>.</p><p class="elsevierStylePara">Now that several years have passed since the start of clinical trials, it might be time to seek an answer to this question: is it possible to follow the evolution of these 2683 patients long enough to detect a possible chemopreventive effect?</p>" "pdfFichero" => "260v39n07a13046513pdf001.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Airways obstruction and the risk for lung cancer." 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"idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Pauwels RA" 1 => "Lofdahl CG" 2 => "Laitinen LA" 3 => "Schouten JP" 4 => "Postma DS" 5 => "Pride NB" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199906243402503" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "340" "paginaInicial" => "1948" "paginaFinal" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10379018" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial." 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ISSN: 15792129Original language: English
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