Journal Information
Vol. 61. Issue 4.
Pages 196-202 (April 2025)
Share
Download PDF
More article options
Vol. 61. Issue 4.
Pages 196-202 (April 2025)
Original Article
Effect of N-Acetylcysteine on Bronchiectasis in a Real-life Study. Data From the Spanish RIBRON Registry
Visits
482
Grace Osculloa,b, Raúl Méndeza,b, Casilda Olveirac, Rosa Girónd, Marta García-Clementee, Luis Máizf,g, Oriol Sibilab,h, Rafael Golpei, Juan Rodríguez-Hermosaj, Esther Barreirob,k,l,m, Concepción Pradosn, Juan Luis Rodríguez-Lópezo, David de la Rosa-Carrillob,p, Miguel Ángel Martinez-Garcíaa,b,
Corresponding author
mianmartinezgarcia@gmail.com

Corresponding author.
a Servicio de Neumología e Instituto de Investigación La Fe (IISLAFE), Hospital Universitario y Politécnico La Fe, Valencia, Spain
b Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
c Servicio de Neumología, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA)/Universidad de Málaga, Málaga, Spain
d Servicio de Neumología, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Madrid, Spain
e Servicio de Neumología, Instituto de Investigación Biosanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain
f Servicio de Neumología, Hospital Ramón y Cajal, Madrid, Spain
g Universidad de Alcalá de Henares, Madrid, Spain
h Servicio de Neumología, Hospital Clínic, IDIBAPS, Universitat de Barcelona (UB), Barcelona, Spain
i Servicio de Neumología, Hospital Lucus Augusti, Lugo, Spain
j Pulmonary Department, Research Institute of Hospital Clínico San Carlos (IdISSC), Department of Medicine, Faculty of Medicine, University Complutense of Madrid, Madrid, Spain
k Respiratory Diseases and Lung Cancer Research Group, Hospital del Mar Research Institute (IMIM), Barcelona, Spain
l Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra, Barcelona, Spain
m Pulmonology Department, Hospital del Mar, Barcelona, Spain
n Servicio de Neumología, Hospital La Paz, Madrid, Spain
o Servicio de Neumología, Hospital San Agustín, Avilés, Asturias, Spain
p Servicio de Neumología, Hospital Santa Creu i Sant Pau, Barcelona, Spain
Ver más
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (6)
Show moreShow less
Tables (2)
Table 1. Comparative Characteristics of the N-AC and no N-AC Groups.
Tables
Table 2. Adjusted Effect of NA-C on Yearly Exacerbation and Hospitalization Rates.
Tables
Show moreShow less
Abstract
Introduction

There is scarce information about the most used mucolytic drug in bronchiectasis N-acetylcysteine (N-AC). Our objective was to analyze the effect of N-AC with respect to some outcomes in bronchiectasis.

Methods

Ambispective, longitudinal, observational, multi-center (43 centers) study of a cohort of 2461 adult patients diagnosed with bronchiectasis. Those patients treated in a stable situation with at least 600mg/d of N-AC (368; 15%) for at least 6 months were compared with patients not receiving this treatment. The variables analyzed and compared were those available two years before and after treatment. ANCOVA analysis was used to analyze the effect of N-AC as the inter-group difference of the basal intra-group difference for each variable, adjusted for relevant covariables.

Results

The N-AC group showed a full adjusted improvement of 27% in exacerbations, 17% in hospitalizations, and 31% in total exacerbation rates compared with the no-N-AC group. Moreover, a decrease in the volume of sputum production of 59.7% was observed as well as a decrease of 12% of patients with bronchial infection by Pseudomonas aeruginosa (PA). The use of 1200mg/d (n=116) resulted in only a mild, albeit significative improvement in the exacerbation rate compared with the use of 600mg/d (-11% in absolute number). Both doses were well tolerated.

Conclusion

N-AC (in most cases at a dose of 600mg/d) is safe and effective and sufficient to reduce both the number of exacerbations and hospitalizations and the purulence and volume of sputum, as well as the isolation rate of PA in patients with bronchiectasis.

Keywords:
Bronchiectasis
Mortality
Exacerbations
Hospitalizations
Pseudomonas aeruginosa
Graphical abstract

Article

These are the options to access the full texts of the publication Archivos de Bronconeumología
Member
If you are a member of SEPAR:
  • Go to >>>SEPAR<<< website and sign in.
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?