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Vol. 58. Issue 10.
Pages 715 (October 2022)
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Vol. 58. Issue 10.
Pages 715 (October 2022)
Clinical Image
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Disseminated Tuberculosis
Javier Alejandro Teco-Cortes
Corresponding author

Corresponding author.
, Minerva Lazos-Ochoa
Departamento de Patología, Hospital General de México «Dr. Eduardo Liceaga», Secretaría de Salud, Dr. Balmis No. 148 Colonia Doctores, Delegación Cuauhtémoc, CP 06720 Mexico City, Mexico
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We report the case of a 58-year-old man with no history of interest, who presented with asthenia, adynamia, drowsiness, and dyslalia. Laryngoscopy showed diffuse and ulcerated transglottal lesions, and carcinoma was suspected. A chest X-ray was performed, which revealed bilateral fibrothorax of undetermined etiology (Fig. 1A). The patient died suddenly from no clearly defined cause. Due to his rapid deterioration and fatal outcome, no serological or immunological studies were possible.

Fig. 1

Autopsy revealed pulmonary tuberculosis with histological criteria of activity and acino-nodular, cavitated, and miliary patterns (Fig. 1B) spreading to the larynx, which showed a diffusely ulcerated surface with a crazy-paving appearance (Fig. 1C); in the gastrointestinal tract, oval ulcers were observed perpendicular to the longitudinal axis of the intestine (Fig. 1D), bone marrow, spleen, and mediastinal and mesenteric lymph nodes. Granulomatous inflammation (Fig. 1E) and the presence of acid-alcohol-resistant bacilli were confirmed microscopically with Ziehl-Neelsen staining (Fig. 1F). The patient died due to peritonitis secondary to a perforated ulcer in the ileocecal junction.

The diagnosis of tuberculosis can be challenging, especially in low-incidence regions or in the case of an atypical clinical picture, such as ours, in which laryngeal carcinoma was suspected, but due to the lack of etiological diagnosis and targeted treatment, the outcome was the unexpected death of the patient.1,2


None declared.

Conflict of interest


Y.E. Smulders, B.J. De Bondt, M. Lacko, J.A. Hodge, K.W. Kross.
Laryngeal tuberculosis presenting as a supraglottic carcinoma: a case report and review of the literature.
J Med Case Rep, 3 (2009), pp. 9288
H.A. Vázquez-Sánchez, F. González-Loranca, E.G. Jiménez-Villanueva, O.A. Marroquín-García, D. Castro-Martínez.
Septic shock from disseminated tuberculosis with splenic tuberculous abscess.
Cir Cir, 89 (2021), pp. 33-36
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