A 68-year-old man referred to pulmonary consult with a 6-month history of increase shortness of breath and dry cough. He has worked in a copper mine north of Chile for almost 40 years. On physical examination, breath sounds were reduced bilaterally along with mild crackles. Laboratory studies revealed erythrocytosis with hematocrit 54% and hemoglobin 18.5g per deciliter (reference range, 13.5–17.5). Chest-CT scan showed mass-like lesions and bronchial narrowing in both upper lobes. Flexible bronchoscopy demonstrated mucosa dark pigmentation from both main stem bronchi and bronchus intermedius together with segmental bronchi obliteration of both upper lobes (Fig. 1A and Video). Bronchial mucosa biopsy revealed coal dust and acicular crystalline material observed under polarized light (40×) (Fig. 1B). Anthracofibrosis results from carbon particles deposition but other organic and inorganic substances,1,2 like silica in this case, can also cause this pigmentation.2 Commonly reported radiological features includes central peribronchial soft tissue thickening, intraparenchymal peribronchial cuffing or bronchial narrowing, such our case.1 Definitive diagnosis included a bronchoscopic examination that revealed a dark pigmentation in airway and biopsy samples revealed infiltration of non-specific mononuclear inflammatory cells, mostly polymorphonuclears with a normal epithelium.2 Unfortunately, there is no treatment for this condition rather than avoid exposure.
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(b) Bronchial mucosa biopsy demonstrates silica crystalline material under polarized light (40×).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 68-year-old man referred to pulmonary consult with a 6-month history of increase shortness of breath and dry cough. He has worked in a copper mine north of Chile for almost 40 years. On physical examination, breath sounds were reduced bilaterally along with mild crackles. Laboratory studies revealed erythrocytosis with hematocrit 54% and hemoglobin 18.5<span class="elsevierStyleHsp" style=""></span>g per deciliter (reference range, 13.5–17.5). Chest-CT scan showed mass-like lesions and bronchial narrowing in both upper lobes. Flexible bronchoscopy demonstrated mucosa dark pigmentation from both main stem bronchi and bronchus intermedius together with segmental bronchi obliteration of both upper lobes (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A and <a class="elsevierStyleCrossRef" href="#sec0010">Video</a>). Bronchial mucosa biopsy revealed coal dust and acicular crystalline material observed under polarized light (40×) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). Anthracofibrosis results from carbon particles deposition but other organic and inorganic substances,<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">1,2</span></a> like silica in this case, can also cause this pigmentation.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> Commonly reported radiological features includes central peribronchial soft tissue thickening, intraparenchymal peribronchial cuffing or bronchial narrowing, such our case.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> Definitive diagnosis included a bronchoscopic examination that revealed a dark pigmentation in airway and biopsy samples revealed infiltration of non-specific mononuclear inflammatory cells, mostly polymorphonuclears with a normal epithelium.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> Unfortunately, there is no treatment for this condition rather than avoid exposure.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0015" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0010" ] ] ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 529 "Ancho" => 1500 "Tamanyo" => 164012 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Flexible bronchoscopy shows extensive dark airway pigmentation with bronchial obliteration of both upper lobes. 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Kahkouee" 1 => "R. Pourghorban" 2 => "M. Bitarafan" 3 => "K. Najafizadeh" 4 => "S.S. Makki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch. Bronconeumol." "fecha" => "2015" "volumen" => "51" "paginaInicial" => "322" "paginaFinal" => "327" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0020" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What do we know about anthracofibrosis? A literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Jamaati" 1 => "A. Sharifi" 2 => "M.S. Mirenayat" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Tanaffos" "fecha" => "2017" "volumen" => "16" "paginaInicial" => "175" "paginaFinal" => "189" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000005400000012/v1_201812020626/S0300289618302801/v1_201812020626/en/main.assets" "Apartado" => array:4 [ "identificador" => "45361" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Imagen clínica" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005400000012/v1_201812020626/S0300289618302801/v1_201812020626/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289618302801?idApp=UINPBA00003Z" ]
