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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "National Asthma Education and Prevention Program Expert Panel Report 2" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Guidelines for the diagnosis and management of asthma" "serieFecha" => "1997" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "British guidelines on asthma management, 1995 review and position statement" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "British Asthma Guidelines Coordinating Committee" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1997" "volumen" => "52" "paginaInicial" => "S1" "paginaFinal" => "S24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9474238" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Where have we been? The history of acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.E. Brenner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Emergency asthma" "paginaInicial" => "1" "paginaFinal" => "31" "serieFecha" => "1999" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "National and international guidelines for the emergency management of adult asthma in North American emergency departments" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.M. Nowak" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Ann Emerg Med" "fecha" => "1999" "volumen" => "34" "paginaInicial" => "S13" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of systemic beta-agonists in acute asthma in North American emergency departments [abstract]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Travers" 1 => "B.H. Rowe" 2 => "S. Clark" 3 => "J.r. Camargo CA" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Ann Emerg Med" "fecha" => "1999" "volumen" => "34" "paginaInicial" => "S13" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intravenous beta2-agonists for acute asthma in the emergency department [Cochrane Review]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Travers" 1 => "A.P. Jones" 2 => "K. Kelly" 3 => "S.J. Barker" 4 => "C.A. J.r. Camargo" 5 => "B.H. Rowe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "The Cochrane Library, Issue 4" "serieFecha" => "2001" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized trial of intravenous albuterol in early management of acute severe asthma in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.J. Browne" 1 => "A.S. Penna" 2 => "X. Phung" 3 => "M. Soo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(96)06358-1" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1997" "volumen" => "349" "paginaInicial" => "301" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9024371" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A prospective, randomized study of continuous versus intermittent nebulized albuterol for severe status asthmaticus in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.C. Papo" 1 => "J. Frank" 2 => "A.E. Thompson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Crit Care Med" "fecha" => "1993" "volumen" => "21" "paginaInicial" => "479" "paginaFinal" => "486" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous vs intermittent nebulized albuterol for emergency management of asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Khine" 1 => "S.M. Fuchs" 2 => "A.L. Saville" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acad Emerg Med" "fecha" => "1996" "volumen" => "3" "paginaInicial" => "1019" "paginaFinal" => "1024" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8922008" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous nebulization of albuterol (Salbutamol) in acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Colacone" 1 => "N. Wolkove" 2 => "E. Stern" 3 => "M. Afilalo" 4 => "T.M. Rosenthal" 5 => "H. Kreisman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1990" "volumen" => "97" "paginaInicial" => "693" "paginaFinal" => "697" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2306971" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous versus intermittent albuterol nebulization in the treatment of acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.Y. Lin" 1 => "D. Sauter" 2 => "T. Newman" 3 => "J. Sirleaf" 4 => "J. Walters" 5 => "M. Ravakol" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Emerg Med" "fecha" => "1993" "volumen" => "22" "paginaInicial" => "1847" "paginaFinal" => "1853" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8239106" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of intermittent and continuously nebulized albuterol for treatment of asthma in an urban emergency department" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.S. Rudnitsky" 1 => "R.S. Eberlein" 2 => "J.M. Schoffstall" 3 => "J.E. Mazur" 4 => "W.H. Spivey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Emerg Med" "fecha" => "1993" "volumen" => "22" "paginaInicial" => "1842" "paginaFinal" => "1846" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8239105" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous versus frequent intermittent nebulization of albuterol in acute asthma: a randomized, prospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Reisner" 1 => "A. Kotch" 2 => "G. Dworkin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "1995" "volumen" => "75" "paginaInicial" => "41" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7621059" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous vs intermittent albuterol, at high and low doses, in the treatment of severe asthma in adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Shrestha" 1 => "K. Bidadi" 2 => "S. Gourlay" 3 => "J. Hayes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1996" "volumen" => "110" "paginaInicial" => "42" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8681661" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous versus intermittent nebulization of Salbutamol in acute severe asthma. A randomized, controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. BesbesOuanes" 1 => "S. Nouira" 2 => "S. Elatrous" 3 => "J. Knani" 4 => "M. Boussarsar" 5 => "F. Abroug" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mem.2000.109169" "Revista" => array:6 [ "tituloSerie" => "Ann Emerg Med" "fecha" => "2000" "volumen" => "36" "paginaInicial" => "198" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10969220" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "State of the art: therapeutic controversies in severe acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.A. Gibbs" 1 => "C.A. Camargo" 2 => "B.H. Rowe" 3 => "R.A. Silverman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Emerg Med" "fecha" => "2000" "volumen" => "7" "paginaInicial" => "800" "paginaFinal" => "815" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Farmacos betaagonistas en el tratamiento del asma bronquial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.A. Quadrelli" 1 => "A.J. Roncoroni" 2 => "D.M. Pinna" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2000" "volumen" => "36" "paginaInicial" => "471" "paginaFinal" => "486" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11004989" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spacer devices used with meter-dose inhalers: breakthrough or gimmick?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Koning" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1985" "volumen" => "88" "paginaInicial" => "276" "paginaFinal" => "284" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3893919" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Site of beta-adrenergics receptors in the respiratory tract: use of fenoterol administered by two methods" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.E. Ruffin" 1 => "J.M. Montgomery" 2 => "M.T. Newhouse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1978" "volumen" => "74" "paginaInicial" => "256" "paginaFinal" => "260" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/211011" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patterns of deposition of labeled monodispersed aerosols in obstructive lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Santolicandro" 1 => "C. Giuntini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med Allied Sci" "fecha" => "1979" "volumen" => "23" "paginaInicial" => "115" "paginaFinal" => "127" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/549963" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aerosol characterization and deposition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.E. Morrow" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1974.110.6P2.88" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1979" "volumen" => "110" "paginaInicial" => "88" "paginaFinal" => "99" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4613236" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Deposition of aerosol in the respiratory tract" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.D. Brain" 1 => "P.A. Valberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1979.120.6.1325" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1979" "volumen" => "120" "paginaInicial" => "1325" "paginaFinal" => "1373" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/391112" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimal delivery of aerosols from metered dose inhalers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.B. Dolovich" 1 => "R.E. Ruffin" 2 => "R. Roberts" 3 => "M.T. Newhouse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1981" "volumen" => "80" "paginaInicial" => "911" "paginaFinal" => "915" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7307637" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An evaluation of the physical properties of monodisperse and heterodisperse aerosols used in the assessment of bronchial function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.E. Morrow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "1981" "volumen" => "80" "numero" => "Suppl" "paginaInicial" => "809" "paginaFinal" => "813" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7307615" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of jet nebulizers for lung aerosol therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.M. Clay" 1 => "D. Pavia" 2 => "S.P. Newman" 3 => "S.W. Clarke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1983" "volumen" => "2" "paginaInicial" => "592" "paginaFinal" => "594" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2900978" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors influencing the size distribution of aerosols from jet nebulizers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.M. Clay" 1 => "D. Pavia" 2 => "S.P. Newman" 3 => "T. Lennard-Jones" 4 => "S.W. Clarke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1983" "volumen" => "38" "paginaInicial" => "755" "paginaFinal" => "759" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6648854" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vivo measurements of aerosol dose and distribution: clinical relevance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.L. Laube" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Aerosol Med" "fecha" => "1996" "volumen" => "9" "numero" => "Suppl 1" "paginaInicial" => "S77" "paginaFinal" => "S91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10160061" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Targets for inhaled treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.J. Lipworth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Respir Med" "fecha" => "2000" "volumen" => "94" "numero" => "Suppl D" "paginaInicial" => "S13" "paginaFinal" => "S16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11003169" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Deposition of pressurized aerosols in the human respiratory tract" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.P. Newman" 1 => "D. Pavia" 2 => "F. Moren" 3 => "N.F. Sheahan" 4 => "S.W. Clarke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1981" "volumen" => "36" "paginaInicial" => "52" "paginaFinal" => "55" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7292382" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of various inhalation modes on the deposition of radioactive pressurized aerosols" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.P. Newman" 1 => "D. Pavia" 2 => "N. Garland" 3 => "S.W. Clarke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J Resp Dis" "fecha" => "1982" "volumen" => "119" "paginaInicial" => "57" "paginaFinal" => "65" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aerosol deposition considerations in inhalation therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.P. Newman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1985" "volumen" => "88" "numero" => "Suppl" "paginaInicial" => "s152" "paginaFinal" => "s160" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current concepts: control of asthma by aerosols" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Newhouse" 1 => "M. Dolovich" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198610023151406" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1986" "volumen" => "315" "paginaInicial" => "870" "paginaFinal" => "874" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2875391" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disposable jet nebulizers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.F. Alvine" 1 => "P. Rodgers" 2 => "K.M. Fitzsimmons" 3 => "R.C. Ahrens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "How reliable are they? Chest" "fecha" => "1992" "volumen" => "101" "paginaInicial" => "316" "paginaFinal" => "319" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparison of commercial jet nebulizers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.T. Loffer" 1 => "D. Ikle" 2 => "H.S. Nelson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1994" "volumen" => "106" "paginaInicial" => "1788" "paginaFinal" => "1793" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7988201" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medication nebulizer performance: effects of diluent volume, nebulizer flow, and nebulizer brand" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Hess" 1 => "D. Fisher" 2 => "P. Williams" 3 => "S. Pooler" 4 => "R.M. Kacmarek" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1996" "volumen" => "110" "paginaInicial" => "498" "paginaFinal" => "505" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8697857" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of inspiratory flow rate, particle size, and airway caliber on aerosolized drug delivery to the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.A. Dolovich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2000" "volumen" => "45" "paginaInicial" => "597" "paginaFinal" => "608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10894453" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of nebulized aerosol deposition in the lungs of healthy adults following oral and nasal inhalation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.L. Everald" 1 => "J.G. Hardy" 2 => "A.D. Milner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1993" "volumen" => "48" "paginaInicial" => "1045" "paginaFinal" => "1046" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8256235" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapeutic aerosols 1. Physical and practical considerations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.P. Newman" 1 => "S.W. Clarke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1983" "volumen" => "38" "paginaInicial" => "881" "paginaFinal" => "886" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6364439" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cost-benefit comparison of aerosol bronchodilator delivery methods in hospitalized patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.C. Jasper" 1 => "Z. Mohsenifar" 2 => "S. Kahan" 3 => "H.S. Goldberg" 4 => "S.K. Koerner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1987" "volumen" => "91" "paginaInicial" => "614" "paginaFinal" => "618" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3103989" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Substitution of metered- dose inhalers for hand-held nebulizers. Success and cost savings in a large acute-care hospital" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.L. Bowton" 1 => "W.M. Goldsmith" 2 => "E.F. Haponik" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1992" "volumen" => "101" "paginaInicial" => "305" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1346514" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vitro performance of plastic spacer devices [review]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. O'Collaghan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Aerosol Med" "fecha" => "1997" "volumen" => "10" "numero" => "Suppl 1" "paginaInicial" => "S31" "paginaFinal" => "S35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10165121" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the nebuhaler" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.W. Barry" 1 => "C. O'Callaghan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Clin Pharmacol" "fecha" => "1995" "volumen" => "40" "paginaInicial" => "76" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8527272" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhalation therapy in asthma: nebulizer or pressurized meter-dose inhaler with holding chamber? In vivo comparison of lung deposition in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.H. Wildhaber" 1 => "N.D. Dore" 2 => "J.M. Wilson" 3 => "S.G. Devadason" 4 => "P.N. LeSoef" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Pediatr" "fecha" => "1999" "volumen" => "136" "paginaInicial" => "28" "paginaFinal" => "33" ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchodilator delivery in acute airflow obstruction. A meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.O. Turner" 1 => "A. Patel" 2 => "S. Ginsburg" 3 => "J.M. FitzGerald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arc Intern Med" "fecha" => "1997" "volumen" => "157" "paginaInicial" => "1736" "paginaFinal" => "1744" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib00205" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.J. Cates" 1 => "B.H. Rowe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Holding chambers versus nebulisers for betaagonist treatment of acute asthma [Cochrane Review]. The Cochrane Library, Issue 4" "serieFecha" => "2001" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of salbutamol delivered by nebulizer or metereddose inhaler with a pear-shaped spacer in acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Rodrigo" 1 => "C. Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Ther Res" "fecha" => "1993" "volumen" => "54" "paginaInicial" => "797" "paginaFinal" => "808" ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Salbutamol treatment of acute severe asthma in the ED: MDI versus hand-held nebulizer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Rodrigo" 1 => "G. Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Emerg Med" "fecha" => "1998" "volumen" => "16" "paginaInicial" => "637" "paginaFinal" => "642" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9827736" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma therapy with aerosols: are nebulizers obsolete? A continuing controversy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.T. Newhouse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1999" "volumen" => "135" "paginaInicial" => "5" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10393594" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Consensus statement: Aerosols and delivery devices" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Association for Respiratory Care and the American Respiratory Care Foundation" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2000" "volumen" => "45" "paginaInicial" => "589" "paginaFinal" => "596" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10894452" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamiento de la crisis asmatica: comparacion entre fenoterol y Salbutamol en altas dosis administradas mediante inhalador de dosis medida con inhalocamara y aminofilina intravenosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Rodrigo" 1 => "C. Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pac Critico" "fecha" => "1991" "volumen" => "4" "paginaInicial" => "194" "paginaFinal" => "209" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of the patient with acute asthma in the emergency department: a factor analytic study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Rodrigo" 1 => "C. Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1993" "volumen" => "104" "paginaInicial" => "1325" "paginaFinal" => "1328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8222781" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new indez for early prediction of hospitalization in patients with acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Rodrigo" 1 => "C. Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Emerg Med" "fecha" => "1997" "volumen" => "15" "paginaInicial" => "8" "paginaFinal" => "13" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9002561" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early prediction of poor response acute asthma patients in the emergency department" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Rodrigo" 1 => "C. Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1999" "volumen" => "114" "paginaInicial" => "1016" "paginaFinal" => "1021" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9792570" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhaled beta-agonists and acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.M. Nowak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0735-6757(95)90262-7" "Revista" => array:6 [ "tituloSerie" => "Am J Emerg Med" "fecha" => "1995" "volumen" => "13" "paginaInicial" => "94" "paginaFinal" => "96" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7832966" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimal dose of Salbutamol respiratory solution: comparison of three doses with plasma levels" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E.H. Walters" 1 => "A. Cockroft" 2 => "T. Griffiths" 3 => "K. Rocchiccioli" 4 => "B.H. Davies" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1981" "volumen" => "36" "paginaInicial" => "625" "paginaFinal" => "626" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7031974" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Betaadrenoceptor responses to high doses of inhaled Salbutamol in patients with bronchial asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B.J. Lipworth" 1 => "R.A. Clark" 2 => "D.P. Dhillon" 3 => "R.A. Brown" 4 => "D.G. McDevitt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Clin Pharmacol" "fecha" => "1988" "volumen" => "26" "paginaInicial" => "527" "paginaFinal" => "533" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2849969" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High doses of sympathomimetics in severe bronchial asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.C. Stanescu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1989" "volumen" => "2" "paginaInicial" => "597" "paginaFinal" => "598" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2570716" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of cumulative and noncumulative techniques to measure dose-response curves for beta-agonists in patients with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Britton" 1 => "A. Tattersfield" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1984" "volumen" => "39" "paginaInicial" => "597" "paginaFinal" => "599" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6474387" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metered dose inhaler Salbutamol treatment of asthma in the ED: comparison of two doses with plasma levels" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Rodrigo" 1 => "C. Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0735-6757(96)90121-7" "Revista" => array:6 [ "tituloSerie" => "Am J Emerg Med" "fecha" => "1996" "volumen" => "14" "paginaInicial" => "144" "paginaFinal" => "150" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8924135" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0300" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Observations on the effects of aerosolized albuterol in acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Strauss" 1 => "R. Hejal" 2 => "O. Galan" 3 => "L. Dixon" 4 => "J.r. McFadden ER" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.155.2.9032178" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1997" "volumen" => "155" "paginaInicial" => "454" "paginaFinal" => "458" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9032178" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0305" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapeutic response pattern to high and cumulative doses of Salbutamol in acute severe asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Rodrigo" 1 => "G. Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1998" "volumen" => "113" "paginaInicial" => "593" "paginaFinal" => "598" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9515830" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0310" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dizon L Comparison of rwo dosage regimen of albuterol in acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.R. McFadden" 1 => "L. Strauss" 2 => "R. Hejal" 3 => "G. Galan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1998" "volumen" => "105" "paginaInicial" => "12" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9688015" "web" => "Medline" ] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0315" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Should inhaled anticholinergics be added to β2 agonists for treating acute childhood and adolescent asthma? A systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.H. Plotnick" 1 => "F.M. Ducharme" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Bmj" "fecha" => "1998" "volumen" => "317" "paginaInicial" => "971" "paginaFinal" => "977" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9765164" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0320" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ipratropium bromide in acute adult severe asthma: a meta-analysis of randomized controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.J. Rodrigo" 1 => "C. Rodrigo" 2 => "O. Burschtin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1999" "volumen" => "107" "paginaInicial" => "363" "paginaFinal" => "370" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10527039" "web" => "Medline" ] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0325" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First-line therapy for adults acute asthma patients with a multiple dose protocol of ipratropium bromide plus albuterol on the emergency department" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.J. Rodrigo" 1 => "C. Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.161.6.9908115" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "161" "paginaInicial" => "1862" "paginaFinal" => "1868" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10852758" "web" => "Medline" ] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0330" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhaled flunisolide for acute severe asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Rodrigo" 1 => "C. Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.157.3.9704022" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1998" "volumen" => "157" "paginaInicial" => "698" "paginaFinal" => "703" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9517578" "web" => "Medline" ] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0335" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "S-albuterol exacerbates calcium responses to carbacol in airway smooth muscle cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Yanmaguchi" 1 => "J.R. McCullough" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF02772202" "Revista" => array:6 [ "tituloSerie" => "Clin Rev Allergy Immunol" "fecha" => "1996" "volumen" => "14" "paginaInicial" => "47" "paginaFinal" => "55" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8866171" "web" => "Medline" ] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0340" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stereoselective metabolism of RS-albuterol in humans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Walle" 1 => "E.A. Eaton" 2 => "U.K. Walle" 3 => "G. Pesola" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF02772206" "Revista" => array:6 [ "tituloSerie" => "Clin Rev Allergy Immunol" "fecha" => "1996" "volumen" => "14" "paginaInicial" => "101" "paginaFinal" => "113" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8866175" "web" => "Medline" ] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0345" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improved bronchodilation with levalbuterol compared with racemic albuterol in patients with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.S. Nelson" 1 => "G. Bensch" 2 => "W.W. Pleskow" 3 => "R. DiSantostefano" 4 => "S. DeGraw" 5 => "D.S. Reasner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "1998" "volumen" => "102" "paginaInicial" => "943" "paginaFinal" => "952" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9847435" "web" => "Medline" ] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0350" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchodilating effects and side effects of beta-adrenoreceptor stimulants by different modes of administration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Larsson" 1 => "N. Svedmyr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1977.116.5.861" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1977" "volumen" => "116" "paginaInicial" => "861" "paginaFinal" => "869" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/921062" "web" => "Medline" ] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0355" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic cardiovascular and metabolic effects associated with the inhalation of an increased dose of albuterol: influence of mouth rinsing and gargling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Kung" 1 => "S.W. Croley" 2 => "B.A. Phillips" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1987" "volumen" => "91" "paginaInicial" => "382" "paginaFinal" => "387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3816316" "web" => "Medline" ] ] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib0360" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of a rapid-sequence metaproterenol protocol in the treatment of acute adult asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.A. Jerrad" 1 => "J. Olshhaker" 2 => "E. Welebob" 3 => "V. Caraballo" 4 => "F. Hooper" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0735-6757(95)90121-3" "Revista" => array:6 [ "tituloSerie" => "Am J Emerg Med" "fecha" => "1995" "volumen" => "13" "paginaInicial" => "392" "paginaFinal" => "395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7605520" "web" => "Medline" ] ] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib0365" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arterial oxygen desaturation following salbutamol inhalation in acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Tal" 1 => "H. Pasterkamp" 2 => "F. Leahy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1984" "volumen" => "86" "paginaInicial" => "868" "paginaFinal" => "869" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6499548" "web" => "Medline" ] ] ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib0370" "etiqueta" => "74." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serial relationships between ventilation-perfusion inequality and spirometry in acute severe asthma requiring hospitalization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Roca" 1 => "L.l. Ramis" 2 => "R. Rodríguez Roisin" 3 => "E. Ballester" 4 => "J.M. Montserrat" 5 => "P.D. Wagner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/137.5.1055" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1988" "volumen" => "137" "paginaInicial" => "1055" "paginaFinal" => "1061" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3195803" "web" => "Medline" ] ] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib0375" "etiqueta" => "75." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "acute severe asthma: pathophysiology and pathobiology of gas exchange abnormalities" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Rodríguez Roisin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1997" "volumen" => "10" "paginaInicial" => "1359" "paginaFinal" => "1371" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9192945" "web" => "Medline" ] ] ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib0380" "etiqueta" => "76." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypokalemia from beta2-receptor stimulation by circulating epinephrine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.I. Brown" 1 => "D.C. Brown" 2 => "M.B. Murphy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198312083092303" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1983" "volumen" => "309" "paginaInicial" => "1414" "paginaFinal" => "1419" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6314140" "web" => "Medline" ] ] ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib0385" "etiqueta" => "77." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypokalemia and other nonbronchial effects of inhaled fenoterol and Salbutamol: a placebo controlled dose-response study in healthy volunteers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Scheinin" 1 => "M. Koulu" 2 => "E. Larikainene" 3 => "H. Allonen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Clin Pharmacol" "fecha" => "1987" "volumen" => "24" "paginaInicial" => "645" "paginaFinal" => "653" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2829953" "web" => "Medline" ] ] ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib0390" "etiqueta" => "78." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular and hypokalaemic effects of inhaled Salbutamol fenoterol and isoprenaline" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Crane" 1 => "C. Burguess" 2 => "R. 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Journal Information
Vol. 38. Issue 7.
Pages 322-328 (July 2002)
Vol. 38. Issue 7.
Pages 322-328 (July 2002)
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Controversias sobre el uso de los agonistas beta en el tratamiento del asma aguda
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G.J. Rodrigoa,
, C. Rodrigob
Corresponding author
gurodrig@adinet.com.uy
Correspondencia: Dr. G.J. Rodrigo. Departamento de Emergencia. Hospital Central de las FF.AA. Avda. 8 de Octubre, 3020. 11600 Montevideo. Uruguay
Correspondencia: Dr. G.J. Rodrigo. Departamento de Emergencia. Hospital Central de las FF.AA. Avda. 8 de Octubre, 3020. 11600 Montevideo. Uruguay
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Bibliografía
[1.]
National Asthma Education and Prevention Program Expert Panel Report 2.
Guidelines for the diagnosis and management of asthma,
[2.]
British Asthma Guidelines Coordinating Committee.
British guidelines on asthma management, 1995 review and position statement.
Thorax, 52 (1997), pp. S1-S24
[3.]
B.E. Brenner.
Where have we been? The history of acute asthma.
Emergency asthma, pp. 1-31
[4.]
R.M. Nowak.
National and international guidelines for the emergency management of adult asthma in North American emergency departments.
Ann Emerg Med, 34 (1999), pp. S13
[5.]
A. Travers, B.H. Rowe, S. Clark, J.r. Camargo CA.
The use of systemic beta-agonists in acute asthma in North American emergency departments [abstract].
Ann Emerg Med, 34 (1999), pp. S13
[6.]
A. Travers, A.P. Jones, K. Kelly, S.J. Barker, C.A. J.r. Camargo, B.H. Rowe.
Intravenous beta2-agonists for acute asthma in the emergency department [Cochrane Review].
The Cochrane Library, Issue 4,
[7.]
G.J. Browne, A.S. Penna, X. Phung, M. Soo.
Randomized trial of intravenous albuterol in early management of acute severe asthma in children.
Lancet, 349 (1997), pp. 301-305
[8.]
M.C. Papo, J. Frank, A.E. Thompson.
A prospective, randomized study of continuous versus intermittent nebulized albuterol for severe status asthmaticus in children.
Crit Care Med, 21 (1993), pp. 479-486
[9.]
H. Khine, S.M. Fuchs, A.L. Saville.
Continuous vs intermittent nebulized albuterol for emergency management of asthma.
Acad Emerg Med, 3 (1996), pp. 1019-1024
[10.]
A. Colacone, N. Wolkove, E. Stern, M. Afilalo, T.M. Rosenthal, H. Kreisman.
Continuous nebulization of albuterol (Salbutamol) in acute asthma.
Chest, 97 (1990), pp. 693-697
[11.]
R.Y. Lin, D. Sauter, T. Newman, J. Sirleaf, J. Walters, M. Ravakol.
Continuous versus intermittent albuterol nebulization in the treatment of acute asthma.
Ann Emerg Med, 22 (1993), pp. 1847-1853
[12.]
G.S. Rudnitsky, R.S. Eberlein, J.M. Schoffstall, J.E. Mazur, W.H. Spivey.
Comparison of intermittent and continuously nebulized albuterol for treatment of asthma in an urban emergency department.
Ann Emerg Med, 22 (1993), pp. 1842-1846
[13.]
C. Reisner, A. Kotch, G. Dworkin.
Continuous versus frequent intermittent nebulization of albuterol in acute asthma: a randomized, prospective study.
Ann Allergy Asthma Immunol, 75 (1995), pp. 41-47
[14.]
M. Shrestha, K. Bidadi, S. Gourlay, J. Hayes.
Continuous vs intermittent albuterol, at high and low doses, in the treatment of severe asthma in adults.
Chest, 110 (1996), pp. 42-47
[15.]
L. BesbesOuanes, S. Nouira, S. Elatrous, J. Knani, M. Boussarsar, F. Abroug.
Continuous versus intermittent nebulization of Salbutamol in acute severe asthma. A randomized, controlled trial.
Ann Emerg Med, 36 (2000), pp. 198-203
[16.]
M.A. Gibbs, C.A. Camargo, B.H. Rowe, R.A. Silverman.
State of the art: therapeutic controversies in severe acute asthma.
Am Emerg Med, 7 (2000), pp. 800-815
[17.]
S.A. Quadrelli, A.J. Roncoroni, D.M. Pinna.
Farmacos betaagonistas en el tratamiento del asma bronquial.
Arch Bronconeumol, 36 (2000), pp. 471-486
[18.]
P. Koning.
Spacer devices used with meter-dose inhalers: breakthrough or gimmick?.
Chest, 88 (1985), pp. 276-284
[19.]
R.E. Ruffin, J.M. Montgomery, M.T. Newhouse.
Site of beta-adrenergics receptors in the respiratory tract: use of fenoterol administered by two methods.
Chest, 74 (1978), pp. 256-260
[20.]
A. Santolicandro, C. Giuntini.
Patterns of deposition of labeled monodispersed aerosols in obstructive lung disease.
J Nucl Med Allied Sci, 23 (1979), pp. 115-127
[21.]
P.E. Morrow.
Aerosol characterization and deposition.
Am Rev Respir Dis, 110 (1979), pp. 88-99
[22.]
J.D. Brain, P.A. Valberg.
Deposition of aerosol in the respiratory tract.
Am Rev Respir Dis, 120 (1979), pp. 1325-1373
[23.]
M.B. Dolovich, R.E. Ruffin, R. Roberts, M.T. Newhouse.
Optimal delivery of aerosols from metered dose inhalers.
Chest, 80 (1981), pp. 911-915
[24.]
P.E. Morrow.
An evaluation of the physical properties of monodisperse and heterodisperse aerosols used in the assessment of bronchial function.
Chest, 80 (1981), pp. 809-813
[25.]
M.M. Clay, D. Pavia, S.P. Newman, S.W. Clarke.
Assessment of jet nebulizers for lung aerosol therapy.
Lancet, 2 (1983), pp. 592-594
[26.]
M.M. Clay, D. Pavia, S.P. Newman, T. Lennard-Jones, S.W. Clarke.
Factors influencing the size distribution of aerosols from jet nebulizers.
Thorax, 38 (1983), pp. 755-759
[27.]
B.L. Laube.
In vivo measurements of aerosol dose and distribution: clinical relevance.
J Aerosol Med, 9 (1996), pp. S77-S91
[29.]
S.P. Newman, D. Pavia, F. Moren, N.F. Sheahan, S.W. Clarke.
Deposition of pressurized aerosols in the human respiratory tract.
Thorax, 36 (1981), pp. 52-55
[30.]
S.P. Newman, D. Pavia, N. Garland, S.W. Clarke.
Effects of various inhalation modes on the deposition of radioactive pressurized aerosols.
Eur J Resp Dis, 119 (1982), pp. 57-65
[31.]
S.P. Newman.
Aerosol deposition considerations in inhalation therapy.
Chest, 88 (1985), pp. s152-s160
[32.]
M. Newhouse, M. Dolovich.
Current concepts: control of asthma by aerosols.
N Engl J Med, 315 (1986), pp. 870-874
[33.]
G.F. Alvine, P. Rodgers, K.M. Fitzsimmons, R.C. Ahrens.
Disposable jet nebulizers.
How reliable are they? Chest, 101 (1992), pp. 316-319
[34.]
D.T. Loffer, D. Ikle, H.S. Nelson.
A comparison of commercial jet nebulizers.
Chest, 106 (1994), pp. 1788-1793
[35.]
D. Hess, D. Fisher, P. Williams, S. Pooler, R.M. Kacmarek.
Medication nebulizer performance: effects of diluent volume, nebulizer flow, and nebulizer brand.
Chest, 110 (1996), pp. 498-505
[36.]
M.A. Dolovich.
Influence of inspiratory flow rate, particle size, and airway caliber on aerosolized drug delivery to the lung.
Respir Care, 45 (2000), pp. 597-608
[37.]
M.L. Everald, J.G. Hardy, A.D. Milner.
Comparison of nebulized aerosol deposition in the lungs of healthy adults following oral and nasal inhalation.
Thorax, 48 (1993), pp. 1045-1046
[38.]
S.P. Newman, S.W. Clarke.
Therapeutic aerosols 1. Physical and practical considerations.
Thorax, 38 (1983), pp. 881-886
[39.]
A.C. Jasper, Z. Mohsenifar, S. Kahan, H.S. Goldberg, S.K. Koerner.
Cost-benefit comparison of aerosol bronchodilator delivery methods in hospitalized patients.
Chest, 91 (1987), pp. 614-618
[40.]
D.L. Bowton, W.M. Goldsmith, E.F. Haponik.
Substitution of metered- dose inhalers for hand-held nebulizers. Success and cost savings in a large acute-care hospital.
Chest, 101 (1992), pp. 305-308
[41.]
C. O'Collaghan.
In vitro performance of plastic spacer devices [review].
J Aerosol Med, 10 (1997), pp. S31-S35
[42.]
P.W. Barry, C. O'Callaghan.
The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the nebuhaler.
Br J Clin Pharmacol, 40 (1995), pp. 76-78
[43.]
J.H. Wildhaber, N.D. Dore, J.M. Wilson, S.G. Devadason, P.N. LeSoef.
Inhalation therapy in asthma: nebulizer or pressurized meter-dose inhaler with holding chamber? In vivo comparison of lung deposition in children.
J Pediatr, 136 (1999), pp. 28-33
[44.]
M.O. Turner, A. Patel, S. Ginsburg, J.M. FitzGerald.
Bronchodilator delivery in acute airflow obstruction. A meta-analysis.
Arc Intern Med, 157 (1997), pp. 1736-1744
[45.]
C.J. Cates, B.H. Rowe.
Holding chambers versus nebulisers for betaagonist treatment of acute asthma [Cochrane Review]. The Cochrane Library, Issue 4,
[46.]
G. Rodrigo, C. Rodrigo.
Comparison of salbutamol delivered by nebulizer or metereddose inhaler with a pear-shaped spacer in acute asthma.
Curr Ther Res, 54 (1993), pp. 797-808
[47.]
C. Rodrigo, G. Rodrigo.
Salbutamol treatment of acute severe asthma in the ED: MDI versus hand-held nebulizer.
Am J Emerg Med, 16 (1998), pp. 637-642
[48.]
M.T. Newhouse.
Asthma therapy with aerosols: are nebulizers obsolete? A continuing controversy.
J Pediatr, 135 (1999), pp. 5-8
[49.]
American Association for Respiratory Care and the American Respiratory Care Foundation.
Consensus statement: Aerosols and delivery devices.
Respir Care, 45 (2000), pp. 589-596
[50.]
G. Rodrigo, C. Rodrigo.
Tratamiento de la crisis asmatica: comparacion entre fenoterol y Salbutamol en altas dosis administradas mediante inhalador de dosis medida con inhalocamara y aminofilina intravenosa.
Pac Critico, 4 (1991), pp. 194-209
[51.]
G. Rodrigo, C. Rodrigo.
Assessment of the patient with acute asthma in the emergency department: a factor analytic study.
Chest, 104 (1993), pp. 1325-1328
[52.]
G. Rodrigo, C. Rodrigo.
A new indez for early prediction of hospitalization in patients with acute asthma.
Am J Emerg Med, 15 (1997), pp. 8-13
[53.]
G. Rodrigo, C. Rodrigo.
Early prediction of poor response acute asthma patients in the emergency department.
Chest, 114 (1999), pp. 1016-1021
[54.]
R.M. Nowak.
Inhaled beta-agonists and acute asthma.
Am J Emerg Med, 13 (1995), pp. 94-96
[55.]
E.H. Walters, A. Cockroft, T. Griffiths, K. Rocchiccioli, B.H. Davies.
Optimal dose of Salbutamol respiratory solution: comparison of three doses with plasma levels.
Thorax, 36 (1981), pp. 625-626
[56.]
B.J. Lipworth, R.A. Clark, D.P. Dhillon, R.A. Brown, D.G. McDevitt.
Betaadrenoceptor responses to high doses of inhaled Salbutamol in patients with bronchial asthma.
Br J Clin Pharmacol, 26 (1988), pp. 527-533
[57.]
D.C. Stanescu.
High doses of sympathomimetics in severe bronchial asthma.
Eur Respir J, 2 (1989), pp. 597-598
[58.]
J. Britton, A. Tattersfield.
Comparison of cumulative and noncumulative techniques to measure dose-response curves for beta-agonists in patients with asthma.
Thorax, 39 (1984), pp. 597-599
[59.]
G. Rodrigo, C. Rodrigo.
Metered dose inhaler Salbutamol treatment of asthma in the ED: comparison of two doses with plasma levels.
Am J Emerg Med, 14 (1996), pp. 144-150
[60.]
L. Strauss, R. Hejal, O. Galan, L. Dixon, J.r. McFadden ER.
Observations on the effects of aerosolized albuterol in acute asthma.
Am J Respir Crit Care Med, 155 (1997), pp. 454-458
[61.]
C. Rodrigo, G. Rodrigo.
Therapeutic response pattern to high and cumulative doses of Salbutamol in acute severe asthma.
Chest, 113 (1998), pp. 593-598
[62.]
E.R. McFadden, L. Strauss, R. Hejal, G. Galan.
Dizon L Comparison of rwo dosage regimen of albuterol in acute asthma.
Am J Med, 105 (1998), pp. 12-17
[63.]
L.H. Plotnick, F.M. Ducharme.
Should inhaled anticholinergics be added to β2 agonists for treating acute childhood and adolescent asthma? A systematic review.
Bmj, 317 (1998), pp. 971-977
[64.]
G.J. Rodrigo, C. Rodrigo, O. Burschtin.
Ipratropium bromide in acute adult severe asthma: a meta-analysis of randomized controlled trials.
Am J Med, 107 (1999), pp. 363-370
[65.]
G.J. Rodrigo, C. Rodrigo.
First-line therapy for adults acute asthma patients with a multiple dose protocol of ipratropium bromide plus albuterol on the emergency department.
Am J Respir Crit Care Med, 161 (2000), pp. 1862-1868
[66.]
G. Rodrigo, C. Rodrigo.
Inhaled flunisolide for acute severe asthma.
Am J Respir Crit Care Med, 157 (1998), pp. 698-703
[67.]
H. Yanmaguchi, J.R. McCullough.
S-albuterol exacerbates calcium responses to carbacol in airway smooth muscle cells.
Clin Rev Allergy Immunol, 14 (1996), pp. 47-55
[68.]
T. Walle, E.A. Eaton, U.K. Walle, G. Pesola.
Stereoselective metabolism of RS-albuterol in humans.
Clin Rev Allergy Immunol, 14 (1996), pp. 101-113
[69.]
H.S. Nelson, G. Bensch, W.W. Pleskow, R. DiSantostefano, S. DeGraw, D.S. Reasner, et al.
Improved bronchodilation with levalbuterol compared with racemic albuterol in patients with asthma.
J Allergy Clin Immunol, 102 (1998), pp. 943-952
[70.]
S. Larsson, N. Svedmyr.
Bronchodilating effects and side effects of beta-adrenoreceptor stimulants by different modes of administration.
Am Rev Respir Dis, 116 (1977), pp. 861-869
[71.]
M. Kung, S.W. Croley, B.A. Phillips.
Systemic cardiovascular and metabolic effects associated with the inhalation of an increased dose of albuterol: influence of mouth rinsing and gargling.
Chest, 91 (1987), pp. 382-387
[72.]
D.A. Jerrad, J. Olshhaker, E. Welebob, V. Caraballo, F. Hooper.
Efficacy and safety of a rapid-sequence metaproterenol protocol in the treatment of acute adult asthma.
Am J Emerg Med, 13 (1995), pp. 392-395
[73.]
A. Tal, H. Pasterkamp, F. Leahy.
Arterial oxygen desaturation following salbutamol inhalation in acute asthma.
Chest, 86 (1984), pp. 868-869
[74.]
J. Roca, L.l. Ramis, R. Rodríguez Roisin, E. Ballester, J.M. Montserrat, P.D. Wagner.
Serial relationships between ventilation-perfusion inequality and spirometry in acute severe asthma requiring hospitalization.
Am Rev Respir Dis, 137 (1988), pp. 1055-1061
[75.]
R. Rodríguez Roisin.
acute severe asthma: pathophysiology and pathobiology of gas exchange abnormalities.
Eur Respir J, 10 (1997), pp. 1359-1371
[76.]
M.I. Brown, D.C. Brown, M.B. Murphy.
Hypokalemia from beta2-receptor stimulation by circulating epinephrine.
N Engl J Med, 309 (1983), pp. 1414-1419
[77.]
M. Scheinin, M. Koulu, E. Larikainene, H. Allonen.
Hypokalemia and other nonbronchial effects of inhaled fenoterol and Salbutamol: a placebo controlled dose-response study in healthy volunteers.
Br J Clin Pharmacol, 24 (1987), pp. 645-653
[78.]
J. Crane, C. Burguess, R. Beasley.
Cardiovascular and hypokalaemic effects of inhaled Salbutamol fenoterol and isoprenaline.
Thorax, 44 (1989), pp. 136-140
[79.]
R.Y. Lin, A.J. Smith, P. Hergenroeder.
High serum albuterol levels and tachycardia in adult ashtmatics treated with high-dose continuously aerosolized albuterol.
Chest, 103 (1993), pp. 221-225
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