Journal Information
Vol. 60. Issue 2.
Pages 88-94 (February 2024)
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Vol. 60. Issue 2.
Pages 88-94 (February 2024)
Original Article
Comparison of Clinical and Genetic Characteristics Between Younger and Older Lung Cancer Patients
Cristina Candal-Pedreiraa,b, Alberto Ruano-Ravinaa,b,c,
Corresponding author

Corresponding author.
, Virginia Calvo de Juand, Manuel Coboe, José Manuel Trigoe, Delvys Rodríguez-Abreuf, Anna Estivalf, Enric Carcerenyg, Marc Cucurullg, Rafael López Castroh, Andrea Medinah, Rosario García Campeloi, Patricia Cordeiro Gonzálezi, Amparo Sánchez-Gastaldoj, Joaquim Bosch-Barrerak, Bartomeu Massutíl, Manuel Dóminem, Carlos Campsn, Ana Laura Ortegao, Alfredo Sánchez-Hernándezp..., María Guirado Risueñoq, Edel del Barco Morillor, Alberto Garrido Fernándezs, Mariano ProvenciodVer más
a Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain
b Health Research Institute of Santiago de Compostela (Instituto de Investigación Sanitaria de Santiago de Compostela-IDIS), Santiago de Compostela, Galicia, Spain
c Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain
d Oncology Department, Puerta de Hierro University Teaching Hospital, Majadahonda, Spain
e UGC Medical Oncology Intercenters, Regional and Virgen de la Victoria University Teaching Hospitals, Malaga, IBIMA, Malaga, Spain
f Gran Canaria Island Hospital, Las Palmas de Gran Canaria, Spain
g Medical Oncology Department, Catalonian Oncology Institute, Badalona-Germans Trias i Pujol Hospital, B-ARGO Group, Spain
h Medical Oncology Section, Valladolid University Clinical Teaching Hospital, Spain
i Department of Oncology, A Coruña University Teaching Hospital Complex, Coruña, Spain
j Virgen del Rocio University Teaching Hospital, Seville, Spain
k Catalonian Oncology Institute, Dr. Josep Trueta University Teaching Hospital, Girona, Spain
l Dr. Balmis University Teaching Hospital, Alicante Health Research and Biomedical Institute (ISABIAL), Alicante, Spain
m Jiménez Díaz Foundation University Hospital, IIS-FJD, Madrid, Spain
n Department of Medical Oncology, Catalan Institute of Oncology, Doctor Josep Trueta University Hospital and Precision Oncology Group (OncoGIR-Pro), Girona Biomedical Research Institute (IDIBGI), Girona, Spain
o Jaén Hospital Complex, Jaén, Spain
p Castellón Provincial Hospital, Castellón, Spain
q Department of Oncology, Elche University General Teaching Hospital, Elche, Spain
r Medical Oncology Department, Salamanca University Healthcare Complex-IBSAL, Salamanca, Spain
s Álvaro Cunqueiro University Teaching Hospital, Vigo, Spain
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Tables (5)
Table 1. Clinical Characteristics of Subjects, Both Overall and by Age Group at Diagnosis.
Table 2. Number of Subjects With Positive Molecular Determinations (Alterations) and Percent Positivity,a by Age Group at Diagnosis.
Table 3. Multivariate Logistic Regression of the Clinical Characteristics of Subjects: Subjects Under the Age of 50 Years Compared With Subjects Aged 50 Years and Older.
Table 4. Multivariate Logistic Regression of Genetic Characteristicsa: Subjects Under the Age of 50 Years Compared With Subjects Aged 50 Years and Older.
Table 5. Description of the Sample by Age at Diagnosis: Subjects Under the Age of 35 Years Compared With Subjects Aged 35 Years and Older.
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Figures (1)

The aim of this study was to analyze the clinical and genetic characteristics of young lung cancer cases, and to compare them with those of older cases.


We used the Thoracic Tumors Registry (TTR) as a data source representative of lung cancer cases diagnosed in Spain, and included all cases registered until 9/01/2023 which had information on age at diagnosis or the data needed to calculate it. We performed a descriptive statistical analysis and fitted logistic regressions to analyze how different characteristics influenced being a younger lung cancer patient.


A total of 26,336 subjects were included. Lung cancer cases <50 years old had a higher probability of being women (OR: 1.38; 95% CI: 1.21–1.57), being in stage III or IV (OR: 1.32; 95% CI: 1.08–1.62), not having comorbidities (OR: 5.21; 95% CI: 4.59–5.91), presenting with symptoms at diagnosis (OR: 1.53; 95% CI: 1.29–1.81), and having ALK translocation (OR: 7.61; 95% CI: 1.25–46.32) and HER2 mutation (OR: 5.71; 95% CI: 1.34–24.33), compared with subjects ≥50 years. Among subjects <35 years old (n=61), our study observed a higher proportion of women (59.0% vs. 26.6%; p<0.001), never smokers (45.8% vs. 10.3%; p<0.001), no comorbidities (21.3% vs. 74.0%; p<0.001); ALK translocation (33.3% vs. 4.4%; p<0.001) and ROS1 mutation (14.3% vs. 2.3%; p=0.01), compared with subjects ≥35 years.


Lung cancer displays differences by age at diagnosis which may have important implications for its clinical management.

Genetic alterations
Lung cancer
Young patients
Epidermal growth factor receptor
Anaplastic lymphoma kinase


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