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Vol. 21. Issue 3.
Pages 118-123 (May - June 1985)
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Vol. 21. Issue 3.
Pages 118-123 (May - June 1985)
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Alveolitis alergica extrinseca. Retrospectiva y perspectiva
Perspective and retrospective analysis of extrinc allergic alveolitis
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M. Selman Lama, R. Chapela Mendoza, L. Teran Ortiz, C. Hernandez Perez, J. Salas Hernandez, N. Barquin Alvarez, E. Martinez Cordero
Instituto Nacional de Enfermedades Respiratorias. Tlalpan. México, D.F
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En este trabajo se reportan los principales hallazgos observados en pacientes con alveolitis alérgica extrínseca inducida por antígeno aviario, estudiados en los dos últimos años. En términos generales desde los puntos de vista clínico, radiológico, funcional y morfológico, nuestros resultados son similares a los reportados en la literatura. Sin embargo, en nuestra serie destacan: 1) Una gran predilección por el sexo femenino (5:1) y una alta asociación con el puerperio. 2) Factor reumatoide positivo a títulos muy elevados en más de la mitad de los pacientes; incremento de los fenotipos HLA-B 15 y HLA-DR 7 y disminución de la actividad supresora, que en conjunto sugieren la presencia de fenómenos autoinmu-nes. 3) Datos morfológicos y bioquímicos de fibrosis en el 25% de los casos estudiados, lo que demuestra que ésta no es una enfermedad «inocente» como habitualmente se considera.

In this paper we report the most important findings observed in patients with extrinsic allergic alveolitis induced by avian antigen, studied in the last two years. Our results, from the clinical, radiological, functional and morphological stand points are similar to those described elsewhere. However, in our serie stand out: 1) High predilection for females (5:1) and high association with puerpery. 2) Elevated titers of rheumatoid factor; increase of HLA-B 15 and HLA-DR 7 phenotypes; decrease of suppressor activity; these findings suggest the presence of autoimmune phenomena. 3) In 25% of the patients we detected presence of fibrosis measured morphologically and biochemically, which suggests that this is not an «innocent» disease as usually has been considered.

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Copyright © 1985. Sociedad Española de Neumología y Cirugía Torácica
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