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Journal Information
Vol. 31. Issue 1.
Pages 37-39 (January 1995)
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Vol. 31. Issue 1.
Pages 37-39 (January 1995)
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Afectación intersticial pulmonar por hemocromatosis como forma de presentación de la enfermedad
Interstitial pulmonary involvement due to hemochromatosis as a presenting sign of disease
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M.E. Pereiro Alonso1, J.M. García García, M.A. Martínez Muñiz
Sección de Neumología. Hospital San Agustín. Avilés, Asturias
J.M. Alonso de la Campa*
* Servicio de Anatomía Patológica. Hospital San Agustín. Avilés, Asturias
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Presentamos un caso de hemocromatosis cuya primera manifestación fue el hallazgo casual de un patrón intersticial en la radiografía de tórax y en cuya biopsia transbronquial se demostró la presencia de hierro (Fe) en los macrófagos alveolares y material septal, lo que nos llevó a la búsqueda de depósitos en otras localizaciones, confirmándose su existencia en la biopsia hepática que mostró un Fe en peso seco de cilindro hepático (+): 6.964 μg.

Se ha revisado la literatura médica por el sistema CDROM Medline, año 1989 y hasta mayo de 1994, sin haber encontrado ninguna referencia al respecto.

Palabras clave:
Hemocromatosis
Patrón intersticial

We present a patient with hemochromatosis whose first sign of disease was an accidental finding of interstitial patterns on a chest film and whose transbronchial biopsy showed traces of iron (Fe) in alveolar macrophages and septal matter. We then looked for deposits in other locations, finding Fe ([+]: 6.964 μg) in the dry weight of a cylindrical sample of liver tissue.

A Medline search on CD-ROM for 1989 through May of 1994 revealed no references to similar cases.

Key words:
Hemochromatosis
Interstitial pattern
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Bibliografía
[1.]
G.M. Nichols, B.R. Bacon.
Hereditary hemochromatosis: pathogenesis and clinical features of a common disease.
Am J Gastroenterology, 84 (1989), pp. 851-862
[2.]
K.K. Kidd.
Genetic linkage hemochromatosis.
N Engl J Med, 301 (1979), pp. 209-210
[3.]
M. Simon, R. Fauchet, J.P. Hespel, et al.
Idiopathic hemochromatosis: a study of biochemical expression in 247 heterozygous members of 63 families: evidence of a single major HLA-linked gene.
Gastroenterology, 78 (1980), pp. 703-708
[4.]
M. Simon, M. Baurel, B. Genetet, et al.
Idiopathic hemochromatosis and iron overload in alcoholic liver disease: differentiation by HLA phenotype.
Gastroenterology, 73 (1977), pp. 655-658
[5.]
M. Simon, M. Baurel, R. Fauchet, et al.
Association of HLA-A3 and HLA-B14 antigens with idiopathic hemochromatosis.
Gut, 17 (1976), pp. 332-334
[6.]
M. Simon, M. Bourel, B. Genetet, et al.
Idiopathic hemochro matosis.
Demonstration of recessive transmission and early detection of family HLA typing. N Engl J Med, 297 (1977), pp. 1.017-1.021
[7.]
P. Brissot, M. Bourel, D. Henry, et al.
Assesment of liver iron contenting 271 patients a re-evaluation of direct and indirect methods.
Gastroenterology, 80 (1981), pp. 557-565
[8.]
P. Fishman Alfred.
Pulmonary diseases and disorders Vol. I.
2.a ed., McGraw Hill Interamericana, (1988), pp. 847-848
[9.]
Zakim David, P. Boyer Thomas.
Hepatology a textbook of liver disease.
1.a ed., W.B. Saunders Co, (1982), pp. 1.166-1.167
[10.]
A. Bomford, R. Williams.
Long term results of venesection therapy in idiopathic hemochromatosis.
Q J Med, 45 (1976), pp. 611-623
[11.]
M.S. Milder, J.D. Cook, S. Stray, et al.
Idiopathic hemochromatosis, an interim report.
Medicine, 59 (1980), pp. 34-49
[12.]
A.E. Stocks, L.W. Powell.
Carbohydrate intolerance in idiopathic hemochromatosis and cirrhosis of the liver.
Q J Med, 42 (1973), pp. 733-749
[13.]
L.M. Buja, W.C. Roberts.
Iron in the heart. Etiology and clinical significance.
Am J Med, 51 (1971), pp. 209-221
[14.]
I.W. Dymock, E.B.D. Hamilton, J.W. Laws, et al.
Arthropathy of hemochromatosis; clinical and radiological analysis of 63 patients with iron overload.
Ann Rheum Dis, 29 (1970), pp. 469-476
Copyright © 1995. Sociedad Española de Neumología y Cirugía Torácica
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