Elsevier

Lung Cancer

Volume 161, November 2021, Pages 1-8
Lung Cancer

Infectious complications of EBUS-TBNA: A nested case-control study using 10-year registry data

https://doi.org/10.1016/j.lungcan.2021.08.016Get rights and content
Under a Creative Commons license
open access

Highlights

  • Infectious complications of EBUS-TBNA are rare.

  • Infectious complications are associated with necrotic target lesion and EUS-B-FNA.

  • Infectious complications might be related to refusal of cancer treatment.

Abstract

Objectives

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become a standard procedure, but little is known about its infectious complications. The aim of this study is to evaluate the incidence and risk factors of infectious complications of EBUS-TBNA and its clinical course, including effects on anti-cancer treatment.

Methods

This is a nested case-control study of patients who received EBUS-TBNA and were followed for at least 2 months at Samsung Medical Center from August 2009 to April 2019. Patients with clinical symptoms of infection and correlating chest images were defined as the infection group (n = 33). The controls were randomly selected from patients without infectious complication. Multivariate logistic regression with backward selection was used to identify the risk factors of infectious complications.

Results

Of the 6826 patients, 33 (0.48%) infectious complications were identified, comprising pneumonia (n = 20) and mediastinal infections (n = 13). Target lesions with necrotic features on chest computed tomography (CT) scan (adjusted odds ratio [aOR], 3.08; 95% confidence interval [CI], 1.49–6.40; P = 0.002) and procedures that were performed via the esophagus (aOR, 3.19; 95% CI, 1.47–6.88; P = 0.003) were independently associated with infectious complications. Among patients ultimately diagnosed with cancer, the infection group tended to refuse anti-cancer treatment compared to controls (32/459, 7.0% vs. 5/30, 16.7%; P = 0.066). However, among the patients who received anti-cancer treatment, there was no delay in onset of treatment.

Conclusions

Infectious complications of EBUS-TBNA are rare; however, attention should be paid if the target lesion appears necrotic on chest CT or if the procedure is performed via the esophagus. Although it was not conclusive due to its rarity, patients with infectious complications tended not to receive anti-cancer treatment.

Abbreviations

aOR
adjusted odds ratio
CI
confidence interval
CT
computed tomography
EBUS-TBNA
endobronchial ultrasound-guided transbronchial needle aspiration
EUS-B-FNA
transesophageal bronchoscopic ultrasound-guided fine-needle aspiration
IQR
interquartile range

Keywords

EBUS-TBNA
EUS-B-FNA
Complication
Mediastinitis

Cited by (0)