ReviewThe evolving landscape of biomarker testing for non-small cell lung cancer in Europe
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Abbreviations
ALK
anaplastic lymphoma kinase
AMP
Association for Molecular Pathology
ASCO
American Society of Clinical Oncology
BRAF
B-Raf proto-oncogene
CAP
College of American Pathologists
ctDNA
circulating tumour cell DNA
ddPCR
digital droplet PCR
EGFR
epidermal growth factor receptor
EMQN
European Molecular Genetics Quality Network
EQA
external quality assessment
ERBB2
Erb-B2 receptor tyrosine kinase 2
ESCAT
ESMO Scale of Clinical Actionability of Molecular Targets
ESMO
European Society for Medical Oncology
FDA
Food and Drug Administration
FGFR
fibroblast growth factor receptor
FISH
fluorescence in situ hybridisation
FNA
fine needle aspiration
HER
human epidermal growth factor receptor
IASLC
International Association for the Study of Lung Cancer
ICC
immunocytochemistry
IHC
immunohistochemistry
ISH
in situ hybridisation
KRAS
Kirsten rat sarcoma viral oncogene homolog
MEK
mitogen-activated protein kinase kinase
MET
hepatocyte growth factor receptor
MTB
molecular tumour board
NCCN
National Comprehensive Cancer Network
NEQAS
National External Quality Assessment Service
NGS
next-generation sequencing
NRG1
neuregulin-1
NSCLC
non-small cell lung cancer
NTRK
neurotrophic tyrosine receptor kinase
OncoKB
Oncology Knowledge Base
PCR
polymerase chain reaction
PD-1
programmed cell death protein 1
PD-L1
programmed cell death protein ligand 1
qPCR
quantitative PCR
QuIP
Quality Initiative for Pathology
RET
rearranged during transfection
ROS1
ROS proto-oncogene 1
ROSE
rapid on-site evaluation
RT-PCR
real-time polymerase chain reaction
SGT
single-gene testing
SOC
standard of care
SOP
standard operating procedures
TAT
turnaround time
TMB
tumour mutational burden
VAF
variant allele frequency
Keywords
Precision medicine
Predictive molecular pathology
Targeted therapies
Next-generation sequencing
Oncogenic driver mutations
NSCLC
Cited by (0)
- 1
Employed by Amgen at initiation of the manuscript.
© 2021 The Authors. Published by Elsevier B.V.