Original articleRisk Factors For Rate of Decline in Forced Expiratory Volume in One Second in Children and Adolescents with Cystic Fibrosis
Section snippets
Methods
Patients 6 to 17 years old were included if they had at least 3 spirometry measurements obtained at times of clinical stability after enrollment in ESCF. The first measurement was defined as the baseline spirometry. A 1-year lead-in period followed, during which baseline clinical characteristics were assessed. The subsequent 5.5 years comprised the observation period. To ensure adequate long-term follow-up, spirometry must have been performed at times of clinical stability at least once during
Results
Of the 4923 patients who met the inclusion criteria, 4866 (98.8%) had data available for all of the final risk factors and were included in the final model. Baseline and lead-in year characteristics are shown in Table I. Progression of lung disease is evident on the basis of a cross-sectional analysis of baseline FEV1, which was highest in the 6- to 8-year-old group and lowest in the 13- to 17-year-old group. The percentage of patients with a positive respiratory tract culture for P aeruginosa
Discussion
In this analysis, we characterized the rate of FEV1 decline in children and adolescents with CF who participated in a large, prospective observational study. The rates of FEV1 decline that we estimated were either of the same magnitude or less than those previously published from studies assessing FEV1 decline in individuals with CF.1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 Moreover, we identified many of the same risk factors for FEV1 decline. Both of these observations
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