Short Communication
The impact of SARS-CoV-2 on the cystic fibrosis foundation therapeutics development network

https://doi.org/10.1016/j.jcf.2020.12.007Get rights and content
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Highlights

  • The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) global pandemic has significantly impacted CF clinical research.

  • An electronic survey was sent to Therapeutic Development Network (TDN) sites to monitor the impact.

  • SARS-CoV-2 had an early impact on participant enrollment, research team stability, and procedures such as spirometry and sputum induction.

  • Trends steadily improved over the months as research activities began to recover across the TDN.

  • SARS-CoV-2 highlights new opportunities to expand CF research focusing on data collection outside of research centers and increased access for remote participation.

Abstract

The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) global pandemic significantly impacted CF clinical research within the Cystic Fibrosis Foundation Therapeutics Development Network (CFF TDN). A Research Electronic Data Capture (REDCap) survey was developed and sent to network sites to monitor and understand the impact on research teams, ongoing and anticipated clinical research, and specific clinical and research procedures. Key findings indicated an early impact on participant enrollment, research team stability, and procedures such as spirometry and sputum induction. These trends steadily improved over the months as research activities began to recover across the TDN. While SARS-CoV-2 created a significant challenge it also highlights new opportunities to expand CF research with greater focus on data collection outside of research centers and increased access for remote participation.

Keywords

Cystic fibrosis
Clinical research
Coronavirus
SARS-CoV-2

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