Original articleGeneral thoracicMediastinal Paragangliomas: The Mayo Clinic Experience
Section snippets
Material and Methods
After approval from the Mayo Clinic Institutional Review Board, we identified 14 patients who underwent resection of a mediastinal paraganglioma at our Clinic from 1973 through 2007. Perioperative data were collected using all available medical records from the time of diagnosis to the present time. Follow-up included use of all medical records and a database that included late clinical outcomes obtained through prospective surveys. Survival was ascertained through Accurint (Philadelphia, PA; //www.accurint.com
Results
The median age of these patients was 39 years (range, 27 to 68 years) and 71% were female. All patients had a history of hypertension with varying degrees of control with standard medications. The median preoperative blood pressure was 126/76 mm Hg (range, 95/61 to 175/85 mm Hg). Prior to surgical exploration, patients were prepared with a combination of alpha-adrenergic blockade (n = 12), beta-adrenergic blockade (n = 9), and tyrosine hydroxylase inhibition (n = 7) (Table 1). One patient had a
Comment
Mediastinal paragangliomas are rare tumors and therefore it is not surprising that most publications detailing treatment of mediastinal paragangliomas are single case reports [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. However, physicians at the University of Michigan reported 12 intrapericardial paragangliomas in 1996 [6]. Herein we report the Mayo Clinic experience of 14 patients who had surgical resection of these tumors between 1973 and 2007.
The mediastinal paragangliomas in our study
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