AJM onlineClinical research studyDepression and Health-Related Quality of Life in Chronic Obstructive Pulmonary Disease
Section snippets
Participants
The Function, Living, Outcomes, and Work study is an ongoing cohort study of patients with COPD and matched referents without COPD.14 The cohort was derived from members of Kaiser Permanente (KP). Previously, patient recruitment has been described in detail.14 Briefly, we identified all adult KP members living within a 30-mile radius of our research clinic who were treated recently for COPD.14 The age range was restricted to 40-65 years because an important focus of the Function, Living,
Patient Characteristics
By design, patients with and without COPD were similar in age, sex, and race (Table 1). Compared with referents, patients with COPD had a higher prevalence of all examined comorbidities, higher average BMI, and greater prevalence of depressive symptoms (P <.001 for all).
COPD and the Risk of Depressive Symptoms
In multivariate analysis adjusting for sociodemographics and comorbidities, depressive symptoms were much more common in patients with COPD than in referents (OR 3.6; 95% CI 2.1-6.1; P <.001). In addition, when COPD subjects
Discussion
In a population-based sample, COPD was associated with a greater risk of depressive symptoms compared with a matched referent group. The fact that increasing COPD severity is associated with an increasing likelihood of depressive symptoms provides further evidence for an association between COPD and depression. Depressive symptoms also appeared to negatively impact quality of life, highlighting the importance of depression in these patients. Targeting depression in COPD could therefore be an
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2019, EClinicalMedicineCitation Excerpt :A population-based cohort study was carried out using the continuous electronic health record database, Optimum Patient Care Research Database (OPCRD) which contains anonymised routine, patient-level diagnostic, clinical and prescribing information on approximately 5·8 million patients from over 700 primary care centres across the UK (http://opcrd.co.uk/). OPCRD has received a favourable opinion from the NHS Health Research Authority for anonymous research use (REC reference: 15/EM/0150). Governance is provided and study protocol was approved by the Anonymised Data Ethics and Protocols Transparency (ADEPT) committee (ADEPT0918), an independent body of experts and regulators commissioned by the Respiratory Effectiveness Group (REG, http://www.effectivenessevaluation.org/).
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Funding: Dr. Omachi was supported by the Agency for Healthcare Research and Quality, Grant number F32 HS017664. Dr. Eisner was supported by R01HL077618 from the National Heart, Lung, and Blood Institute, National Institutes of Health, and UCSF Bland Lane FAMRI Center of Excellence on Secondhand Smoke CoE2007.
Conflict of Interest: None.
Authorship: All authors had access to the data and a role in writing the manuscript.