TY - JOUR T1 - Effects of Controlled Voluntary Increase in the Ventilatory Demand on Respiratory System Resistance in Healthy and Non-Cystic Fibrosis Bronchiectasis Subjects: A Cross-Sectional Study JO - Archivos de Bronconeumología T2 - AU - Moroli,Ricardo Grassi AU - Santos,Daniele Oliveira dos AU - Souza,Hugo Celso Dutra de AU - Perossi,Larissa AU - Ribeiro,Maytê Assunção AU - Perossi,Jéssica AU - Baddini-Martinez,José Antônio AU - Gastaldi,Ada Clarice SN - 03002896 M3 - 10.1016/j.arbres.2020.04.008 DO - 10.1016/j.arbres.2020.04.008 UR - https://archbronconeumol.org/en-effects-controlled-voluntary-increase-in-articulo-S0300289620301253 AB - IntroductionBronchiectasis patients may present a reduced functional capacity due to an increase in the ventilatory demand during exercise. ObjectiveTo evaluate the effects of controlled voluntary hyperinflation and increased respiratory rate on the mechanics of the respiratory system, simulating what happens during exercise, in bronchiectasis and healthy subjects. MethodsBronchiectasis (n=30) and healthy (n=16) subjects were evaluated by impulse oscillometry (IOS) during a baseline condition, and in controlled conditions with baseline (b) tidal volume (V) and hyperinflation (H), with respiratory rates at 30(R30) and 40(R40) bpm, in a random order. The mixed effects and a significance level at 0.05 were used for comparisons. ResultsResistance at 5Hz (R5), and at minus 20Hz (R5–R20), in kPa/L/s, were higher in subjects with bronchiectasis in all experimental conditions (p<0.05). For the bronchiectasis group, R5 and R5-20 increased with R increase at V (VRb versus VR30 and VR40; VR30 versus VR40; R5, R20 and R5-20 increased with R increase at H (HRb versus HR40; HR30 versus HR40). For the same R, there was a decrease with H compared to V (HRb versus VR30 and VR40; and HR30 versus VR30 and VR40). For the healthy group, only R20 showed differences (HR30 versus HR40; HR40 versus VR40). ConclusionThe tachypnea increases the resistance and reactance of the respiratory system in bronchiectasis patients, and the voluntary hyperinflation caused attenuates this increase. These results can guide the development of strategies to reduce the limitation of physical activity in patients with bronchiectasis. ER -