TY - JOUR T1 - Tuberculosis-HIV Co-Infection: Progress and Challenges After Two Decades of Global Antiretroviral Treatment Roll-Out JO - Archivos de Bronconeumología T2 - AU - Letang,Emilio AU - Ellis,Jayne AU - Naidoo,Kogieleum AU - Casas,Esther C. AU - Sánchez,Paquita AU - Hassan-Moosa,Razia AU - Cresswell,Fiona AU - Miró,Jose M. AU - García-Basteiro,Alberto L. SN - 03002896 M3 - 10.1016/j.arbres.2019.11.015 DO - 10.1016/j.arbres.2019.11.015 UR - https://archbronconeumol.org/en-tuberculosis-hiv-co-infection-progress-challenges-after-articulo-S0300289619305897 AB - Despite wide antiretroviral scale-up during the past two decades resulting in declining new infections and mortality globally, HIV-associated tuberculosis remains as a major public health concern. Tuberculosis is the leading HIV-associated opportunistic infection and the main cause of death globally and, particularly, in resource-limited settings. Several challenges exist regarding diagnosis, global implementation of latent tuberculosis treatment, management of active tuberculosis, delivery of optimal patient-centered TB and HIV prevention and care in high burden countries. In this article we review the advances on pathogenesis, diagnosis, and treatment after nearly two decades of global roll-out of antiretroviral therapy and discuss the current challenges for the global control of tuberculosis-HIV co-infection. ER -