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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los resultados obtenidos con el medidor del flujo m&#225;ximo &#40;PF&#41; se compararon con los de la capacidad vital &#40;CV&#41;&#44; y los del volumen expirado m&#225;ximo en un segundo &#40;VEMS&#41; en relaci&#243;n con la concentraci&#243;n en plasma de methylsulfato thiazinamium&#44; utilizado como ejemplo de broncodilatador&#44; despu&#233;s de su administraci&#243;n oral&#46; Se investigaron dos dosis orales &#40;300 y 900 mg&#41;&#46; Se concluy&#243; que la informaci&#243;n proporcionada por el PF es &#250;til para comprobar el efecto terap&#233;utico de methylsulfato thiazinamium en enfermos pulmonares cr&#243;nicos obstructivos no espec&#237;ficos&#46; Adem&#225;s suministra los datos necesarios para decidir la hora adecuada del d&#237;a en que se debe tomar el medicamento broncodilatador&#46; Con ello se consigue el m&#225;ximo efecto terap&#233;utico con la dosis m&#237;nima&#46; Lo cual permite reducir los efectos secundarios no terap&#233;uticos&#46;</p></span>"
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Journal Information
Vol. 17. Issue 5.
Pages 201-204 (September - October 1981)
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Vol. 17. Issue 5.
Pages 201-204 (September - October 1981)
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Utilidad de las medidas del punto maximo del flujo para la aplicacion terapeutica de broncodilatadores en enfermos pulmonares cronicos obstructivos no especificos
Usefulness of the peak flow meter for the therapeutic use of bronchodilators in non specific obstructive chronic pulmonary diseases
Visits
2978
F. Gimeno, L.E. Van Bork, W.Chr. Berg, H.J. Sluiter
Departamento de Asma y Laboratorio de Investigación Funcional Pulmonar de «Beatrixoord» (Director: Dr. B. van Dijk). Departamento de Enfermedades Pulmonares de la Clínica de Medicina Interna de la Universidad de Groningen (Prof. Dr. H. J. Sluiter). Holanda
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Resumen

Los resultados obtenidos con el medidor del flujo máximo (PF) se compararon con los de la capacidad vital (CV), y los del volumen expirado máximo en un segundo (VEMS) en relación con la concentración en plasma de methylsulfato thiazinamium, utilizado como ejemplo de broncodilatador, después de su administración oral. Se investigaron dos dosis orales (300 y 900 mg). Se concluyó que la información proporcionada por el PF es útil para comprobar el efecto terapéutico de methylsulfato thiazinamium en enfermos pulmonares crónicos obstructivos no específicos. Además suministra los datos necesarios para decidir la hora adecuada del día en que se debe tomar el medicamento broncodilatador. Con ello se consigue el máximo efecto terapéutico con la dosis mínima. Lo cual permite reducir los efectos secundarios no terapéuticos.

Summary

The results obtained with the peak flow meter were compared with the results of measurement of the vital capacity, and forced expiratory volume in one second in relation to plasma concentrations after oral administration of thiazinamium methylsulphate, as example of bronchodilators drugs. The results of two oral administrations (300 and 900 mg) were investigated. It is concluded that the peak flow measurements yields a good estímate concerning the effect of thiazinamium methylsulphate in patients with chronic non-specific lung disease, and therefore might provide the necessary information for choosing the best time of the day for bronchodilation drug administration to enhance a therapeutic effect with the minimal dose; by which measure the chance on unpleasant side effects in minimized.

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Bibliografia
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A. Bouhuys, J. Ortega.
Improvement of irreversible airway obstruction by thiazinamium (Multergan).
Pneumonologie, 153 (1976),
Copyright © 1981. Sociedad Española de Neumología y Cirugía Torácica
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