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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The purpose of this study was to explore the association between tuberculin reaction size in contacts with positive tuberculin skin test results and a variety of contact and index patient variables&#46;</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We reviewed the contact investigation records for tuberculosis patients identified by the Tuberculosis Prevention and Control Center of Lleida&#44; Spain&#44; over a period of 7 years&#46; Patients with pulmonary and&#47;or extrapulmonary disease were included&#46; Tuberculosis infection had been diagnosed using the Mantoux skin test with 2 tuberculin units of purified protein derivative RT-23&#44; and tuberculosis disease had been detected on the basis of clinical data&#44; chest radiographs&#44; and cultures&#46; We examined the association between tuberculin reaction size and contact age&#44; close contact with index patients with positive sputum smears&#44; and diagnosis of tuberculosis disease in contacts&#46; Associations were analyzed using the &#967;<span class="elsevierStyleSup">2</span> test for linear trend&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Tuberculin reaction size was 10 mm or greater in 85&#46;9&#37; of the 768 contacts analyzed and 15 mm or greater in 63&#46;8&#37;&#46; The percentage of contacts under 15 years of age &#40;P&#61;&#46;006&#41; who had close contact with an index patient with a positive sputum smear &#40;P&#61;&#46;013&#41; and who were diagnosed with tuberculosis disease &#40;P&#61;&#46;029&#41; increased with tuberculin reaction size&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We found that larger tuberculin reaction size in contacts with positive tuberculin skin test results was most frequently associated with recent infections in the contact&#44; close contact with an index patient with a positive sputum smear&#44; and diagnosis of tuberculosis disease in contact&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">En este trabajo se ha analizado la asociaci&#243;n del tama&#241;o de las reacciones tubercul&#237;nicas con diversas variables del contacto y del caso &#237;ndice en contactos de pacientes tuberculosos con prueba de la tuberculina positiva&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se revisaron los estudios de contactos realizados a pacientes tuberculosos en el Centro de Prevenci&#243;n y Control de la Tuberculosis de Lleida durante un per&#237;odo de 7 a&#241;os&#46; Se incluyeron en el trabajo las revisiones realizadas a pacientes tuberculosos con localizaci&#243;n pulmonar y&#47;o extrapulmonar&#46; Para el diagn&#243;stico de infecci&#243;n tuberculosa se realiz&#243; el test de Mantoux con 2 UT de tuberculina PPD-RT23&#46; Para detectar la enfermedad tuberculosa se examinaron la situaci&#243;n cl&#237;nica&#44; la radiograf&#237;a de t&#243;rax y la bacteriolog&#237;a&#46; Se analiz&#243; la asociaci&#243;n entre el tama&#241;o de la reacci&#243;n tubercul&#237;nica con la edad del contacto&#44; con ser conviviente de un caso &#237;ndice con baciloscopia positiva y con el diagn&#243;stico de enfermedad tuberculosa en el contacto&#46; Para el an&#225;lisis de las asociaciones anteriores se utiliz&#243; la prueba de la &#967;<span class="elsevierStyleSup">2</span> de tendencia lineal&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El 85&#44;9&#37; de los 768 contactos con prueba de la tuberculina positiva presentaron un di&#225;metro de induraci&#243;n de la reacci&#243;n tubercul&#237;nica igual o superior a 10 mm&#44; y el 63&#44;8&#37; una induraci&#243;n igual o superior a 15 mm&#46; Al aumentar el tama&#241;o de la induraci&#243;n tubercul&#237;nica se detect&#243; un incremento del porcentaje de contactos menores de 15 a&#241;os &#40;p &#61; 0&#44;006&#41;&#44; convivientes de caso &#237;ndice con baciloscopia positiva &#40;p &#61; 0&#44;013&#41; y con diagn&#243;stico de enfermedad tuberculosa &#40;p &#61; 0&#44;029&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los contactos con prueba de la tuberculina positiva que presentan reacciones de mayor tama&#241;o se han asociado con mayor frecuencia a contactos con infecciones recientes&#44; a contactos convivientes de caso &#237;ndice con baciloscopia positiva y a contactos con enfermedad tuberculosa&#46;</p>"
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Journal Information
Vol. 43. Issue 3.
Pages 161-164 (January 2007)
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Vol. 43. Issue 3.
Pages 161-164 (January 2007)
Original Articles
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Tuberculin Reaction Size in Tuberculosis Patient Contact
Visits
3987
Miquel Alsedà
Corresponding author
miquel.alseda@gencat.net

Correspondence: Dr. M. Alsedà. Camp de Mart, 39, 3.º, 2.ª. 25004 Lleida. España
, Pere Godoy
Sección de Epidemiología, Delegación Territorial del Departamento de Sanidad y Seguridad Social de Lleida, Facultad de Medicina, Universidad de Lleida, Lleida, Spain
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Objective

The purpose of this study was to explore the association between tuberculin reaction size in contacts with positive tuberculin skin test results and a variety of contact and index patient variables.

Patients and Methods

We reviewed the contact investigation records for tuberculosis patients identified by the Tuberculosis Prevention and Control Center of Lleida, Spain, over a period of 7 years. Patients with pulmonary and/or extrapulmonary disease were included. Tuberculosis infection had been diagnosed using the Mantoux skin test with 2 tuberculin units of purified protein derivative RT-23, and tuberculosis disease had been detected on the basis of clinical data, chest radiographs, and cultures. We examined the association between tuberculin reaction size and contact age, close contact with index patients with positive sputum smears, and diagnosis of tuberculosis disease in contacts. Associations were analyzed using the χ2 test for linear trend.

Results

Tuberculin reaction size was 10 mm or greater in 85.9% of the 768 contacts analyzed and 15 mm or greater in 63.8%. The percentage of contacts under 15 years of age (P=.006) who had close contact with an index patient with a positive sputum smear (P=.013) and who were diagnosed with tuberculosis disease (P=.029) increased with tuberculin reaction size.

Conclusions

We found that larger tuberculin reaction size in contacts with positive tuberculin skin test results was most frequently associated with recent infections in the contact, close contact with an index patient with a positive sputum smear, and diagnosis of tuberculosis disease in contact.

Key words:
Tuberculosis
Contacts
Tuberculin reaction
Objetivo

En este trabajo se ha analizado la asociación del tamaño de las reacciones tuberculínicas con diversas variables del contacto y del caso índice en contactos de pacientes tuberculosos con prueba de la tuberculina positiva.

Pacientes y Métodos

Se revisaron los estudios de contactos realizados a pacientes tuberculosos en el Centro de Prevención y Control de la Tuberculosis de Lleida durante un período de 7 años. Se incluyeron en el trabajo las revisiones realizadas a pacientes tuberculosos con localización pulmonar y/o extrapulmonar. Para el diagnóstico de infección tuberculosa se realizó el test de Mantoux con 2 UT de tuberculina PPD-RT23. Para detectar la enfermedad tuberculosa se examinaron la situación clínica, la radiografía de tórax y la bacteriología. Se analizó la asociación entre el tamaño de la reacción tuberculínica con la edad del contacto, con ser conviviente de un caso índice con baciloscopia positiva y con el diagnóstico de enfermedad tuberculosa en el contacto. Para el análisis de las asociaciones anteriores se utilizó la prueba de la χ2 de tendencia lineal.

Resultados

El 85,9% de los 768 contactos con prueba de la tuberculina positiva presentaron un diámetro de induración de la reacción tuberculínica igual o superior a 10 mm, y el 63,8% una induración igual o superior a 15 mm. Al aumentar el tamaño de la induración tuberculínica se detectó un incremento del porcentaje de contactos menores de 15 años (p = 0,006), convivientes de caso índice con baciloscopia positiva (p = 0,013) y con diagnóstico de enfermedad tuberculosa (p = 0,029).

Conclusiones

Los contactos con prueba de la tuberculina positiva que presentan reacciones de mayor tamaño se han asociado con mayor frecuencia a contactos con infecciones recientes, a contactos convivientes de caso índice con baciloscopia positiva y a contactos con enfermedad tuberculosa.

Palabras clave:
Tuberculosis
Contactos
Reacción tuberculínica
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