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Vol. 58. Issue 1.
Pages T1-T2 (January 2022)
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Vol. 58. Issue 1.
Pages T1-T2 (January 2022)
Editorial
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[Translated article] GesEPOC 2021 and GOLD 2021. Closer together or further apart?
GesEPOC 2021 y GOLD 2021. ¿Más cerca o más lejos?
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Marc Miravitlles
Servicio de Neumología, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Spain
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Arch Bronconeumol. 2022;58:1-210.1016/j.arbres.2021.04.009
Marc Miravitlles
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The recent publication of the new 2021 update of the Spanish COPD Guidelines (GesEPOC 2021)1 prompts the perennial question: do we really need national guidelines if a global document like the Global Initiative for Objective Lung Disease (GOLD) is available?2 The answer is very simple and can be found in the GOLD document itself: GOLD is a global strategy that must be adapted to the needs and characteristics of each country or region. This is what GesEPOC aspires to, and most of its recommendations coincide with or are clearly derived from those of GOLD.

The definition of the disease and most of the treatment recommendations in both documents are practically identical, since they are drawn from the evaluation of the same evidence. GesEPOC even proposes the same blood eosinophil cut-off points for recommending the use of inhaled corticosteroids (ICS). Two notable differences are perhaps the following: firstly, GOLD continues to make no specific recommendation for use of mucolytics/antioxidants in COPD2. This contrasts not only with GesEPOC1, but also with the guidelines drawn up by the European Respiratory Society/American Thoracic Society3 and the American College of Chest Physicians, and the Canadian Thoracic Society4, all of which, after evaluating the evidence, recommend the use of mucolytics/antioxidants for the prevention of COPD exacerbations. Secondly, GOLD recommends the use of ICS in patients with blood eosinophil levels of 100−300 cells/µL who have at least 1 moderate exacerbation per year despite adequate bronchodilator therapy. GesEPOC, on the other hand, is more restrictive and recommends that the frequency and etiology of exacerbations, active smoking, and history or risk factors for pneumonia are considered in these patients before prescribing ICS.

Nevertheless, the most important differences between both documents lie in the way patients are classified for treatment initiation and follow-up. GesEPOC recommends classifying patients into 2 risk levels according to 3 variables: dyspnea level; exacerbations in the previous year; and lung function. High-risk patients are then classified into 3 phenotypes: non-exacerbator, eosinophilic exacerbator, and non-eosinophilic exacerbator. GOLD, in contrast, classifies patients into 4 categories, A–D, according to the frequency of exacerbations and the level of symptoms. If we omit lung function, low-risk patients according to GesEPOC would be equivalent to GOLD A, and high-risk non-exacerbators would be GOLD B. However, we believe that lung function is important because, for example, the same approach should not be taken in a GOLD B patient with an mMRC of 3 or a COPD Assessment Test (CAT) of 25 if their FEV1 (%) is 30% or 65%: in the first case, maximum bronchodilation is clearly needed, but in the second, symptoms may not be purely due to respiratory causes, and other factors, such as comorbidities, may need to be investigated and treated. This and other considerations have led us to include FEV1 in the treatment decision algorithm5,6. GesEPOC categorizes patients at high risk of exacerbation as eosinophilic or non-eosinophilic and recommends a single treatment alternative for each group: LABA/ICS or LABA/LAMA, respectively. GOLD, on the other hand, classifies exacerbators as C or D according to their symptom burden, meaning the most common group, D, is not offered a specific treatment, and LAMA, LABA/LAMA or LABA/ICS are recommended as first choice in these patients. In other words, classifying a patient as D is not associated with any particular treatment, but instead requires a subclassification to define the most appropriate option. In the GOLD D treatment schedule, the various options are indicated with asterisks: LABA/LAMA in highly symptomatic patients and LABA/ICS in individuals with >300 eosinophils/µl, while LAMA is indicated as the first choice for the rest. However, just as GOLD proposes 3 initial treatment options for the D category, a LAMA appears as the first treatment option for 3 of the initial GOLD categories, B, C, and D; this, in fact, could be true of all 4 categories, because “a bronchodilator” which could also be a LAMA is also recommended for category A. Taking this reasoning to the extreme, we might suggest that patients do not need to be classified as A, B, C, or D from the outset, since the administration of a LAMA covers treatment recommendations under all circumstances. The GesEPOC 2021 classification has been modified to make the recommendation more specific; in the previous edition, exacerbators were classified as emphysema or chronic bronchitis types, but the initial inhaled treatment was the same7. This classification has therefore been replaced by the 2 exacerbator groups, eosinophilic and non-eosinophilic, because this characteristic differentiates between the use or non-use of ICS.

For maintenance treatment, GOLD no longer uses the A–D classification; instead, it recommends several options depending on whether the underlying problem is dyspnea or exacerbations. It also recommends reviewing and adjusting treatment at each follow-up visit. GesEPOC maintains the same classification used for initial treatment and recommends a second therapeutic step for each patient type. Evaluation of treatable traits and second-line or non-inhaled therapy is only recommended in patients whose problems persist despite optimizing inhaled treatment. Furthermore, for the first time GesEPOC 2021 recommends assessing clinical control in COPD to evaluate the need for escalating or deescalating treatment8,9.

In fact, the two different approaches to organizing treatment recommendations are simply two routes to the same destination. Following the recommendations in both documents to the letter, we will mostly, if not always, arrive at the same treatment; the diffierences lie in the path followed. The guidelines should attempt to strike a balance between clarity and rigor, while always avoiding ambiguous recommendations as far as possible. In summary, the treatment of COPD could boil down to 3 principles: 1) optimize bronchodilation to alleviate symptoms and reduce the risk of exacerbations; 2) add ICS if, despite bronchodilation, exacerbations persist and the patient is eosinophilic, and 3) if, despite optimal inhaled treatment, symptoms or exacerbations persist, evaluate treatable traits and the need for second-line treatments. The guidelines must convey this message as clearly and unequivocally as possible, without adding unnecessary complexity. Only the end users of the guidelines will be able to tell whether these documents have managed to help improve the treatment of COPD in this new decade10.

Conflict of interests

Marc Miravitlles is the coordinator of GesEPOC, the Spanish COPD Guidelines. He has received honoraria for speaking engagements from AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, Menarini, Rovi, Bial, Sandoz, Zambon, CSL Behring, Grifols and Novartis; consultancy fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Ferrer, GlaxoSmithKline, Bial, Gebro Pharma, CSL Behring, Laboratorios Esteve, Ferrer, Mereo Biopharma, Verona Pharma, Spin Therapeutics, pH Pharma, Novartis, Sanofi and Grifols; and research grants from Grifols.

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Arch Bronconeumol., 58 (2022), pp. 69-81
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J.J. Soler-Cataluña, B. Alcázar, M. Miravitlles.
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M. Miravitlles, P. Sliwinski, C.K. Rhee, R.W. Costello, V. Carter, J.H.Y. Tan, et al.
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Arch Bronconeumol., 57 (2021), pp. 122-129
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COPD in Spain at the start of a new decade.
Arch Bronconeumol., 57 (2021), pp. 1-2

Please cite this article as: Miravitlles M. GesEPOC 2021 y GOLD 2021. ¿Más cerca o más lejos? Arch Bronconeumol. 2022;58:1–2.

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Archivos de Bronconeumología

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