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        "resumen" => "<span class="elsevierStyleSectionTitle">OBJECTIVE</span><p class="elsevierStyleSimplePara elsevierViewall">Brain metastases are common in patients with lung cancer and influence both prognosis and treatment decisions&#46; The aim of this study was to evaluate the incidence of silent brain metastasis during the initial staging of lung cancer using cranial computed tomography &#40;CT&#41; and magnetic resonance imaging &#40;MRI&#41;&#46;</p> <span class="elsevierStyleSectionTitle">PATIENTS AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective analysis of lung cancer patients with no neurologic signs or symptoms who were evaluated by cranial CT&#44; MRI&#44; or both at the time of diagnosis&#46; Results were checked using data obtained during systematic monitoring of progression&#46; The incidence of brain metastasis was analyzed by sex&#44; age&#44; histology&#44; and TNM stage&#46;</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">Silent brain metastasis was detected in 8&#46;3&#37; of the 169 patients with lung cancer&#46; The detection rate was 7&#46;9&#37; in the cranial CT group and 11&#46;3&#37; in the cranial MRI group&#46; The percentage of false positives and false negatives was 0&#37; and 1&#46;9&#37;&#44; respectively&#46; Cranial MRI performed better than CT in detecting multiple brain metastases &#40;72&#46;8&#37; vs 50&#37;&#41; and metastases smaller than 1 cm &#40;36&#46;3&#37; vs 16&#46;7&#37;&#41;&#46; The incidence of brain metastasis was lower in patients aged over 70 years and higher in patients with adenocarcinoma &#40;20&#37; compared to 5&#46;3&#37; to 5&#46;9&#37; for other histologic subtypes&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;01&#41;&#46; No association was found with TNM stage&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">The incidence of silent brain metastasis is high in patients under 70 years of age&#44; particularly in patients with adenocarcinomas&#44; even in initial stages&#46; This should be taken into consideration when planning staging procedures&#46; Cranial MRI seems to be more accurate than cranial CT for detecting multiple metastases and small metastases&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">OBJETIVO</span><p class="elsevierStyleSimplePara elsevierViewall">Las met&#225;stasis cerebrales &#40;MC&#41; son frecuentes en el c&#225;ncer de pulm&#243;n &#40;CP&#41; y tienen influencia pron&#243;stica y terap&#233;utica&#46; El objetivo del trabajo ha sido evaluar la incidencia de MC silentes en la estadificaci&#243;n inicial del CP mediante tomograf&#237;a axial computarizada y resonancia magn&#233;tica craneales &#40;TACC y RMC&#41;&#46;</p> <span class="elsevierStyleSectionTitle">PACIENTES Y M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis retrospectivo de los pacientes con CP que ten&#237;an un estudio craneal mediante TACC y&#47;o RMC en ausencia de s&#237;ntomas&#47;signos neurol&#243;gicos en el momento del diagn&#243;stico&#46; Para verificar los resultados se us&#243; como criterio la evoluci&#243;n mediante un seguimiento frecuente&#46; Se compar&#243; la incidencia de MC seg&#250;n sexo&#44; edad&#44; histolog&#237;a y estadio TNM&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se detectaron MC silentes en el 8&#44;3&#37; de 169 pacientes con CP&#58; un 7&#44;9&#37; en el grupo de TACC y un 11&#44;3&#37;&#44; en el de RMC&#46; La tasa de resultados falsos positivos fue del 0&#37; y la de falsos negativos&#44; del 1&#44;9&#37;&#46; La RMC detect&#243; m&#225;s MC m&#250;ltiples &#40;un 72&#44;8 frente a un 50&#37;&#41; y menores de 1 cm &#40;un 36&#44;3 frente a un 16&#44;7&#37;&#41; que la TACC&#46; La incidencia de MC fue menor en mayores de 70 a&#241;os y superior en adenocarcinomas &#40;un 20 frente a un 5&#44;3&#8211;5&#44;9&#37;&#59; p &#61; 0&#44;01&#41;&#46; No hubo relaci&#243;n con el grado de extensi&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">En pacientes menores de 70 a&#241;os y espe cialmente en adenocarcinomas&#44; la incidencia de MC silentes es elevada&#44; incluso en estadios iniciales&#44; lo que deber&#237;a considerarse al planificar las pruebas de estadificaci&#243;n&#46; La RMC parece m&#225;s exacta para detectar MC m&#250;ltiples y de peque&#241;o tama&#241;o&#46;</p>"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "LJ Schouten"
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                            3 => "A Twijnstra"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                      "titulo" => "American Society of Clinical Oncology&#46; Treatment of unresectable non-small cell lung cancer guideline&#58; update 2003"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "DG Pfister"
                            1 => "DH Johnson"
                            2 => "ChG Azzoli"
                            3 => "W Sause"
                            4 => "TJ Smith"
                            5 => "SH Baker Jr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2004.09.053"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2004"
                        "volumen" => "22"
                        "paginaInicial" => "330"
                        "paginaFinal" => "353"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14691125"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraparenchymal brain metastases&#58; MR Imaging versus contrast-enhanced CT"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G Sze"
                            1 => "J Shin"
                            2 => "G Krol"
                            3 => "C Johnson"
                            4 => "D Liu"
                            5 => "MDF Deck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiology.168.1.3380956"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "1988"
                        "volumen" => "168"
                        "paginaInicial" => "187"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3380956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of brain metastasis in potentially operable non-small cell lung cancer&#46; A comparison of CT and MRI"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K Yokoi"
                            1 => "N Kamiya"
                            2 => "H Matsuguma"
                            3 => "S Machida"
                            4 => "T Hirose"
                            5 => "M Kiyoshi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1999"
                        "volumen" => "115"
                        "paginaInicial" => "714"
                        "paginaFinal" => "719"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10084481"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suspected non-small cell lung cancer&#58; Incidence of occult brain and skeletal metastases and effectiveness of imaging for detection&#46; Pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F Earnest"
                            1 => "JH Ryn"
                            2 => "GM Miller"
                            3 => "PH Luetmer"
                            4 => "LA Foestrom"
                            5 => "OL Burnett"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiology.211.1.r99ap34137"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "1999"
                        "volumen" => "211"
                        "paginaInicial" => "137"
                        "paginaFinal" => "145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189463"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MR-imaging of the brain of neurologic asymptomatic patients with large cell or adenocarcinoma of the lung"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "MMH Hochstenbag"
                            1 => "A Twijnstra"
                            2 => "P Hofman"
                            3 => "EFM Wouters"
                            4 => "M ten Velde G"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Does it influence prognosis and treatment&#63; Lung Cancer"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "paginaInicial" => "189"
                        "paginaFinal" => "193"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Revisions in the International System for staging lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "CF Mountain"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1997"
                        "volumen" => "111"
                        "paginaInicial" => "1710"
                        "paginaFinal" => "1717"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9187198"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral tumor-staging in patients with bronchial carcinoma by computed tomography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R Salbeck"
                            1 => "HC Grau"
                            2 => "H Artmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1990"
                        "volumen" => "66"
                        "paginaInicial" => "2007"
                        "paginaFinal" => "2011"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2224799"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cranial computed tomography as a part of the initial staging procedures for patients with non small cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D Ferrigno"
                            1 => "G Buccheri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1994"
                        "volumen" => "106"
                        "paginaInicial" => "1025"
                        "paginaFinal" => "1029"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7924469"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preoperative computed tomography of the brain in non-small cell bronchogenic carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P Kormas"
                            1 => "JR Bradshaw"
                            2 => "K Jeyasingham"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1992"
                        "volumen" => "47"
                        "paginaInicial" => "106"
                        "paginaFinal" => "108"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1549816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extrathoracic staging of bronchogenic carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A Salvatierra"
                            1 => "C Baamonde"
                            2 => "JM Llamas"
                            3 => "F Cruz"
                            4 => "J L&#243;pez-Pujol"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1990"
                        "volumen" => "97"
                        "paginaInicial" => "1052"
                        "paginaFinal" => "1058"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2184992"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic accuracy of MRI compared to CCT in patients with brain metastases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "PD Schellinger"
                            1 => "HM Meinck"
                            2 => "A Thron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurooncol"
                        "fecha" => "1999"
                        "volumen" => "44"
                        "paginaInicial" => "275"
                        "paginaFinal" => "281"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10720207"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M Mehta"
                            1 => "IW Tremont-Lukats"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Evaluation and management of brain metastasis&#46; En&#58; 2002 Educational Book&#46; 38th Annual Meeting of American Society of Clinical Oncology"
                        "paginaInicial" => "375"
                        "paginaFinal" => "382"
                        "serieFecha" => "2002"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Resectable brain metastases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "MA Vogelbaum"
                            1 => "JH Suh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2005.04.6235"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2006"
                        "volumen" => "24"
                        "paginaInicial" => "1289"
                        "paginaFinal" => "1294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16525184"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer in Spain&#46; Last epidemiological trends concerning age&#44; gender&#44; smoking prevalence and histological types &#40;abstract only&#44; 11th World Conference on Lung Cancer&#44; July 2005&#46; Barcelona&#44; Spain&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J S&#225;nchez de Cos"
                            1 => "L Miravet"
                            2 => "A N&#250;&#241;ez"
                            3 => "J Hern&#225;ndez"
                            4 => "J Abal"
                            5 => "C Montero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lung Cancer"
                        "fecha" => "2005"
                        "volumen" => "49"
                        "numero" => "Suppl"
                        "paginaInicial" => "197"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgical management of non-small cell lung cancer with synchronous brain metastases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P Bonnette"
                            1 => "P Puyo"
                            2 => "C Gabriel"
                            3 => "R Giudicelli"
                            4 => "JF Regnard"
                            5 => "M Riquet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2001"
                        "volumen" => "119"
                        "paginaInicial" => "1469"
                        "paginaFinal" => "1475"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11348955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases&#58; phase III results of the RTOG 9508 randomised trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "DW Andrews"
                            1 => "CB Scott"
                            2 => "PW Sperduto"
                            3 => "AE Flanders"
                            4 => "LE Gaspar"
                            5 => "MC Schell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(04)16250-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2004"
                        "volumen" => "363"
                        "paginaInicial" => "1665"
                        "paginaFinal" => "1672"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15158627"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
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Vol. 43. Issue 7.
Pages 386-391 (January 2007)
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Vol. 43. Issue 7.
Pages 386-391 (January 2007)
Original Articles
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Silent Brain Metastasis in the Initial Staging of Lung Cancer: Evaluation by Computed Tomography and Magnetic Resonance Imaging
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Julio Sánchez de Cos Escuína,
Corresponding author
jsd01cc@saludalia.com

Correspondence: Dr. J. Sánchez de Cos Escuín. Isla de Hierro, 2, 3.°C. 10001 Cáceres. España
, Diego Masjoans Mennab, M. Agustín Sojo Gonzáleza, José Zamorano Quirantesc, Carlos Disdier Vicentea, María Cristina Pérez Calvod
a Sección de Neumología, Hospital San Pedro de Alcántara, Cáceres, Spain
b Unidad de Resonancia Magnética, Clínica San Francisco, Cáceres, Spain
c Unidad de Investigación Clínica, Hospital San Pedro de Alcántara, Cáceres, Spain
d Servicio de Radiología, Hospital San Pedro de Alcántara, Cáceres, Spain
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OBJECTIVE

Brain metastases are common in patients with lung cancer and influence both prognosis and treatment decisions. The aim of this study was to evaluate the incidence of silent brain metastasis during the initial staging of lung cancer using cranial computed tomography (CT) and magnetic resonance imaging (MRI).

PATIENTS AND METHODS

We performed a retrospective analysis of lung cancer patients with no neurologic signs or symptoms who were evaluated by cranial CT, MRI, or both at the time of diagnosis. Results were checked using data obtained during systematic monitoring of progression. The incidence of brain metastasis was analyzed by sex, age, histology, and TNM stage.

RESULTS

Silent brain metastasis was detected in 8.3% of the 169 patients with lung cancer. The detection rate was 7.9% in the cranial CT group and 11.3% in the cranial MRI group. The percentage of false positives and false negatives was 0% and 1.9%, respectively. Cranial MRI performed better than CT in detecting multiple brain metastases (72.8% vs 50%) and metastases smaller than 1 cm (36.3% vs 16.7%). The incidence of brain metastasis was lower in patients aged over 70 years and higher in patients with adenocarcinoma (20% compared to 5.3% to 5.9% for other histologic subtypes, P=.01). No association was found with TNM stage.

CONCLUSIONS

The incidence of silent brain metastasis is high in patients under 70 years of age, particularly in patients with adenocarcinomas, even in initial stages. This should be taken into consideration when planning staging procedures. Cranial MRI seems to be more accurate than cranial CT for detecting multiple metastases and small metastases.

Key words:
Lung cancer
Silent brain metastasis
Computed tomography
Magnetic resonance imaging
OBJETIVO

Las metástasis cerebrales (MC) son frecuentes en el cáncer de pulmón (CP) y tienen influencia pronóstica y terapéutica. El objetivo del trabajo ha sido evaluar la incidencia de MC silentes en la estadificación inicial del CP mediante tomografía axial computarizada y resonancia magnética craneales (TACC y RMC).

PACIENTES Y MÉTODOS

Análisis retrospectivo de los pacientes con CP que tenían un estudio craneal mediante TACC y/o RMC en ausencia de síntomas/signos neurológicos en el momento del diagnóstico. Para verificar los resultados se usó como criterio la evolución mediante un seguimiento frecuente. Se comparó la incidencia de MC según sexo, edad, histología y estadio TNM.

RESULTADOS

Se detectaron MC silentes en el 8,3% de 169 pacientes con CP: un 7,9% en el grupo de TACC y un 11,3%, en el de RMC. La tasa de resultados falsos positivos fue del 0% y la de falsos negativos, del 1,9%. La RMC detectó más MC múltiples (un 72,8 frente a un 50%) y menores de 1 cm (un 36,3 frente a un 16,7%) que la TACC. La incidencia de MC fue menor en mayores de 70 años y superior en adenocarcinomas (un 20 frente a un 5,3–5,9%; p = 0,01). No hubo relación con el grado de extensión.

CONCLUSIONES

En pacientes menores de 70 años y espe cialmente en adenocarcinomas, la incidencia de MC silentes es elevada, incluso en estadios iniciales, lo que debería considerarse al planificar las pruebas de estadificación. La RMC parece más exacta para detectar MC múltiples y de pequeño tamaño.

Palabras clave:
Cáncer de pulmón
Metástasis cerebrales silentes
Tomografía computarizada
Resonancia magnética
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REFERENCES
[1]
RA Patchell.
Treatment of brain metastasis.
2002 Educational Book. 38th Annual Meeting of American Society of Clinical Oncology, pp. 383-391
[2]
LJ Schouten, J Rutten, HAM Huveneers, A Twijnstra.
Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma.
Cancer, 94 (2002), pp. 2698-2705
[3]
GA Silvestri, B Littenberg, GL Colice.
The clinical evaluation for detecting metastatic lung cancer. A metaanalysis.
Am J Respir Crit Care Med, 152 (1995), pp. 225-230
[4]
The American Thoracic Society and The European Respiratory Society.
Pretreatment evaluation of non-small cell lung cancer.
Am J Respir Crit Care Med, 156 (1997), pp. 320-332
[5]
GA Silvestri, LT Tanoue, ML Margolis, J Barker, F Detterbeck.
The noninvasive staging of non-small cell lung cancer.
Chest, 123 (2003), pp. 147S-156S
[6]
EM Toloza, L Harpole, DC McCrory.
Noninvasive staging of non-small cell lung cancer. A review of the current evidence.
Chest, 123 (2003), pp. 137S-146S
[7]
DG Pfister, DH Johnson, ChG Azzoli, W Sause, TJ Smith, SH Baker Jr, et al.
American Society of Clinical Oncology. Treatment of unresectable non-small cell lung cancer guideline: update 2003.
J Clin Oncol, 22 (2004), pp. 330-353
[8]
G Sze, J Shin, G Krol, C Johnson, D Liu, MDF Deck.
Intraparenchymal brain metastases: MR Imaging versus contrast-enhanced CT.
Radiology, 168 (1988), pp. 187-194
[9]
K Yokoi, N Kamiya, H Matsuguma, S Machida, T Hirose, M Kiyoshi, et al.
Detection of brain metastasis in potentially operable non-small cell lung cancer. A comparison of CT and MRI.
Chest, 115 (1999), pp. 714-719
[10]
F Earnest, JH Ryn, GM Miller, PH Luetmer, LA Foestrom, OL Burnett, et al.
Suspected non-small cell lung cancer: Incidence of occult brain and skeletal metastases and effectiveness of imaging for detection. Pilot study.
[11]
MMH Hochstenbag, A Twijnstra, P Hofman, EFM Wouters, M ten Velde G.
MR-imaging of the brain of neurologic asymptomatic patients with large cell or adenocarcinoma of the lung.
Does it influence prognosis and treatment? Lung Cancer, 42 (2003), pp. 189-193
[12]
CF Mountain.
Revisions in the International System for staging lung cancer.
Chest, 111 (1997), pp. 1710-1717
[13]
R Salbeck, HC Grau, H Artmann.
Cerebral tumor-staging in patients with bronchial carcinoma by computed tomography.
Cancer, 66 (1990), pp. 2007-2011
[14]
D Ferrigno, G Buccheri.
Cranial computed tomography as a part of the initial staging procedures for patients with non small cell lung cancer.
Chest, 106 (1994), pp. 1025-1029
[15]
P Kormas, JR Bradshaw, K Jeyasingham.
Preoperative computed tomography of the brain in non-small cell bronchogenic carcinoma.
Thorax, 47 (1992), pp. 106-108
[16]
A Salvatierra, C Baamonde, JM Llamas, F Cruz, J López-Pujol.
Extrathoracic staging of bronchogenic carcinoma.
Chest, 97 (1990), pp. 1052-1058
[17]
PD Schellinger, HM Meinck, A Thron.
Diagnostic accuracy of MRI compared to CCT in patients with brain metastases.
J Neurooncol, 44 (1999), pp. 275-281
[18]
M Mehta, IW Tremont-Lukats.
Evaluation and management of brain metastasis. En: 2002 Educational Book. 38th Annual Meeting of American Society of Clinical Oncology, pp. 375-382
[19]
MA Vogelbaum, JH Suh.
Resectable brain metastases.
J Clin Oncol, 24 (2006), pp. 1289-1294
[20]
J Sánchez de Cos, L Miravet, A Núñez, J Hernández, J Abal, C Montero, et al.
Lung cancer in Spain. Last epidemiological trends concerning age, gender, smoking prevalence and histological types (abstract only, 11th World Conference on Lung Cancer, July 2005. Barcelona, Spain).
Lung Cancer, 49 (2005), pp. 197
[21]
P Bonnette, P Puyo, C Gabriel, R Giudicelli, JF Regnard, M Riquet, et al.
Surgical management of non-small cell lung cancer with synchronous brain metastases.
Chest, 119 (2001), pp. 1469-1475
[22]
DW Andrews, CB Scott, PW Sperduto, AE Flanders, LE Gaspar, MC Schell, et al.
Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial.
Lancet, 363 (2004), pp. 1665-1672
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