array:23 [
  "pii" => "S0300289615310164"
  "issn" => "03002896"
  "doi" => "10.1016/S0300-2896(15)31016-4"
  "estado" => "S300"
  "fechaPublicacion" => "1994-11-01"
  "aid" => "71086"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
  "copyrightAnyo" => "1994"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 1994;30:440-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1420
    "formatos" => array:3 [
      "EPUB" => 63
      "HTML" => 824
      "PDF" => 533
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0300289615310176"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(15)31017-6"
    "estado" => "S300"
    "fechaPublicacion" => "1994-11-01"
    "aid" => "71087"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 1994;30:445-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1638
      "formatos" => array:3 [
        "EPUB" => 81
        "HTML" => 988
        "PDF" => 569
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Efecto del CO<span class="elsevierStyleInf">2</span> sobre el diafragma de rata in vitro"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "445"
          "paginaFinal" => "448"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Impact of CO<span class="elsevierStyleInf">2</span> on the rat diaphragm <span class="elsevierStyleItalic">in vitro</span>"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:2 [
        0 => array:2 [
          "autoresLista" => "M&#46;J&#46; Barranco, M&#46;A&#46; Ciscar, M&#46; Ram&#243;n, G&#46; Juan"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;J&#46;"
              "apellidos" => "Barranco"
            ]
            1 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "Ciscar"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Ram&#243;n"
            ]
            3 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Juan"
            ]
          ]
        ]
        1 => array:2 [
          "autoresLista" => "J&#46; Cortijo"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Cortijo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310176?idApp=UINPBA00003Z"
    "url" => "/03002896/0000003000000009/v1_201509151216/S0300289615310176/v1_201509151216/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0300289615310152"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(15)31015-2"
    "estado" => "S300"
    "fechaPublicacion" => "1994-11-01"
    "aid" => "71085"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 1994;30:433-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1122
      "formatos" => array:3 [
        "EPUB" => 62
        "HTML" => 623
        "PDF" => 437
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Relaci&#243;n entre hiperrespuesta bronquial inespec&#237;fica&#44; variaci&#243;n diaria del flujo espiratorio m&#225;ximo y necesidades de medicaci&#243;n en pacientes con asma leve"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "433"
          "paginaFinal" => "439"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Links between non-specific bronchial hyperreactivity&#44; diurnal variation in peak expiratory flow and dose requirements in patients with mild asthma"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46; Prieto, V&#46; Guti&#233;rrez, J&#46;M&#46; Bert&#243;, B&#46; Camps, M&#46;J&#46; P&#233;rez"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Prieto"
            ]
            1 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Guti&#233;rrez"
            ]
            2 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Bert&#243;"
            ]
            3 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Camps"
            ]
            4 => array:2 [
              "nombre" => "M&#46;J&#46;"
              "apellidos" => "P&#233;rez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310152?idApp=UINPBA00003Z"
    "url" => "/03002896/0000003000000009/v1_201509151216/S0300289615310152/v1_201509151216/es/main.assets"
  ]
  "es" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Patr&#243;n ventilatorio de reposo y respuesta ventilatoria a la estimulaci&#243;n hiperc&#225;pnica tras el trasplante pulmonar"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "440"
        "paginaFinal" => "444"
      ]
    ]
    "autores" => array:2 [
      0 => array:4 [
        "autoresLista" => "P&#46; Morales, P&#46; Cordero, V&#46; Maci&#225;n, V&#46; Marco"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Morales"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "P&#46;"
            "apellidos" => "Cordero"
          ]
          2 => array:2 [
            "nombre" => "V&#46;"
            "apellidos" => "Maci&#225;n"
          ]
          3 => array:2 [
            "nombre" => "V&#46;"
            "apellidos" => "Marco"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicios de Neumolog&#237;a&#46; Hospital Universitario La Fe&#46; Valencia"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "1"
            "correspondencia" => "Correspondencia&#58; Servicio de Neumolog&#237;a&#46; Hospital Universitario La Fe&#46; Avda&#46; Campanar&#44; 21&#46; 46009 Valencia&#46;"
          ]
        ]
      ]
      1 => array:3 [
        "autoresLista" => "J&#46;M&#46; Borro"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "Borro"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Cirug&#237;a Tor&#225;cica&#46; Hospital Universitario La Fe&#46; Valencia"
            "etiqueta" => "&#42;"
            "identificador" => "aff0010"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Breathing pattern at rest and ventilatory response to hypercapnia after lung transplantation"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "1993-11-29"
    "fechaAceptado" => "1994-04-12"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec569884"
          "palabras" => array:4 [
            0 => "Trasplante pulmonar"
            1 => "Di&#243;xido de carbono"
            2 => "Centros respiratorios"
            3 => "Patr&#243;n ventilatorio"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec569885"
          "palabras" => array:4 [
            0 => "Lung transplantation"
            1 => "Carbon dioxide"
            2 => "Respiratory centres"
            3 => "Breathing pattern"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El objetivo del presente trabajo ha sido la evaluaci&#243;n del patr&#243;n ventilatorio de reposo &#40;PVR&#41;&#44; de la presi&#243;n de oclusi&#243;n a los 100 primeros milisegundos &#40;P<span class="elsevierStyleInf">0&#44;1</span>&#41; y de la respuesta ventilatoria a la estimulaci&#243;n hiperc&#225;pnica tras el trasplante pulmonar&#46; Se estudiaron 7 pacientes trasplantados pulmonares y se compararon con un grupo control de 7 sujetos sanos&#46; El PVR en los pacientes trasplantados se caracteriz&#243; por presentar un incremento significativo de la ventilaci&#243;n minuto &#40;V<span class="elsevierStyleInf">E</span>&#41; a expensas de un aumento del volumen corriente &#40;V<span class="elsevierStyleInf">T</span>&#41; y sobre todo del flujo inspiratorio medio &#40;V<span class="elsevierStyleInf">T</span>&#47;Ti&#41;&#46; La respuesta ventilatoria a la estimulaci&#243;n hiperc&#225;pnica no evidenci&#243; diferencias significativas respecto al grupo control&#44; aunque las pendientes de respuesta de V<span class="elsevierStyleInf">E</span> y V<span class="elsevierStyleInf">T</span> al CO<span class="elsevierStyleInf">2</span> mostraron una tendencia a estar disminuidas&#46; Estos resultados se explican por la situaci&#243;n mec&#225;nica respiratoria de algunos de los sujetos estudiados y por el efecto de la denervaci&#243;n pulmonar sobre el control de la ventilaci&#243;n&#46;</p></span>"
      ]
      "en" => array:1 [
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We aimed to assess breathing pattern at rest by studying occlusion pressure after the first 100 miliseconds &#40;P<span class="elsevierStyleInf">0&#44;1</span>&#41; and ventilatory response to hypercapnia after lung transplantation&#46; Seven transplanted patients were compared with a control group of 7 healthy subjects&#46; The breathing pattern at rest after transplantation included a significant increase in minute volume &#40;V<span class="elsevierStyleInf">E</span>&#41; at the expense of an increase in tidal volume &#40;V<span class="elsevierStyleInf">T</span>&#41; and above all of mean inspiratory flow &#40;V<span class="elsevierStyleInf">T</span>&#47;Ti&#41;&#46; There were no significant differences in ventilatory response to hypercapnia between the 2 groups&#44; although the response curves of both V<span class="elsevierStyleInf">E</span> and V<span class="elsevierStyleInf">T</span> to C0<span class="elsevierStyleInf">2</span> tended to slope downward&#46; These results can be explained by the mechanics of ventilation in some subjects studied and by the effect of pulmonary denervation on ventilatory control&#46;</p></span>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:19 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The cough response to ultrasonically nebulized distilled water in heart-lung transplantation patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46; Higenbottam"
                            1 => "M&#46; Jackson"
                            2 => "P&#46; Woolman"
                            3 => "R&#46; Lowry"
                            4 => "R&#46;J&#46; Wallwork"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/140.1.58"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1989"
                        "volumen" => "140"
                        "paginaInicial" => "58"
                        "paginaFinal" => "61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2502056"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of pulmonary restriction on hypercapnic responses of heart-lung transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;R&#46; Duncan"
                            1 => "F&#46;T&#46; Kagawa"
                            2 => "M&#46;R&#46; Kramer"
                            3 => "V&#46;A&#46; Starnes"
                            4 => "J&#46; Theodore"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "1991"
                        "volumen" => "71"
                        "paginaInicial" => "322"
                        "paginaFinal" => "327"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1917757"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evidence of an altered pattern ofbreathing during exercise in recipients of heart-lung transplants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "F&#46;C&#46; Sciurba"
                            1 => "G&#46;R&#46; Owens"
                            2 => "M&#46;H&#46; Sanders"
                            3 => "B&#46;P&#46; Griffith"
                            4 => "R&#46;L&#46; Hardesty"
                            5 => "I&#46;L&#46; Paradis"
                            6 => "J&#46;P&#46; Constantino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198812293192604"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1988"
                        "volumen" => "319"
                        "paginaInicial" => "1&#46;186"
                        "paginaFinal" => "1&#46;192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3205267"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of human heart-lung transplantation upon breathing at rest and during sleep"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "S&#46;A&#46; Shea"
                            1 => "R&#46; Horner"
                            2 => "N&#46;R&#46; Banner"
                            3 => "E&#46; Mckenzie"
                            4 => "R&#46; Heaton"
                            5 => "M&#46;H&#46; Yacoub"
                            6 => "A&#46; Guz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Physiol"
                        "fecha" => "1988"
                        "volumen" => "72"
                        "paginaInicial" => "131"
                        "paginaFinal" => "150"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3131860"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory control of heart-lung transplant recipients during CO<span class="elsevierStyleInf">2</span> rebreathing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;R&#46; Duncan"
                            1 => "F&#46;T&#46; Kagawa"
                            2 => "S&#46;R&#46; Chaplan"
                            3 => "V&#46;A&#46; Starnes"
                            4 => "J&#46; Theodore"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1989"
                        "volumen" => "139"
                        "paginaInicial" => "240"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "FIypercapnic ventilatory response in recipients of double-lung transplants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;E&#46; Frost"
                            1 => "N&#46; Zamel"
                            2 => "P&#46; McClean"
                            3 => "R&#46; Grossman"
                            4 => "G&#46;A&#46; Patterson"
                            5 => "J&#46;R&#46; Maurer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/146.6.1582"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1992"
                        "volumen" => "146"
                        "paginaInicial" => "1&#46;610"
                        "paginaFinal" => "1&#46;612"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1456579"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ventilation and breathing pattern during Progressive hypercapnia and hupoxia after human heart-lung transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;F&#46;I&#46; Sanders"
                            1 => "G&#46;R&#46; Owens"
                            2 => "F&#46;C&#46; Sciurba"
                            3 => "R&#46;M&#46; Rogers"
                            4 => "I&#46;L&#46; Paradis"
                            5 => "B&#46;P&#46; Griffith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/140.1.38"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1989"
                        "volumen" => "140"
                        "paginaInicial" => "38"
                        "paginaFinal" => "44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2502053"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spirometric reference val&#250;es from a mediterranean population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Roca"
                            1 => "J&#46; Sanchis"
                            2 => "A&#46; Agust&#237;-Vidal"
                            3 => "F&#46; Segarra"
                            4 => "D&#46; Navajas"
                            5 => "R&#46; Rodriguez-Roisin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Eur Physiopathol Respir"
                        "fecha" => "1986"
                        "volumen" => "22"
                        "paginaInicial" => "217"
                        "paginaFinal" => "224"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3730638"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory function tests&#58; Normal values at median altitudes and the prediction of normal results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;I&#46; Goldman"
                            1 => "M&#46;R&#46; Becklake"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Rev of Tub"
                        "fecha" => "1959"
                        "volumen" => "79"
                        "paginaInicial" => "457"
                        "paginaFinal" => "467"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The alveolar-arterial oxygen difference&#58; its size and components in normal man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46; Mellemgaard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1748-1716.1966.tb03281.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Physiol Scand"
                        "fecha" => "1966"
                        "volumen" => "67"
                        "paginaInicial" => "10"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5963295"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A clinical method for assessing the ventilatory response to carb&#243;n dioxide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;J&#46;C&#46; Read"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Austr Ann Med"
                        "fecha" => "1966"
                        "volumen" => "16"
                        "paginaInicial" => "20"
                        "paginaFinal" => "32"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The regulation of ventilation in diffuse pulmonary fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;V&#46; Lourenco"
                            1 => "G&#46;M&#46; Turino"
                            2 => "L&#46;A&#46;G&#46; Davidson"
                            3 => "A&#46;P&#46; Fishman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1965"
                        "volumen" => "38"
                        "paginaInicial" => "199"
                        "paginaFinal" => "216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14256716"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory regulation during pulmonary restriction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;G&#46; Thompson"
                            1 => "D&#46;J&#46;C&#46; Read"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Austr Ann Med"
                        "fecha" => "1968"
                        "volumen" => "17"
                        "paginaInicial" => "193"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pattern of breathing in diffuse lung fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Renzi"
                            1 => "J&#46; Milic-Emili"
                            2 => "A&#46;E&#46; Grassino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Eur Physiopathol Respir"
                        "fecha" => "1982"
                        "volumen" => "18"
                        "paginaInicial" => "461"
                        "paginaFinal" => "472"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7074242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Studies on the vagus nerves in man&#58; their role in respiratory and circulatory control"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Guz"
                            1 => "M&#46;I&#46;M&#46; Noble"
                            2 => "D&#46; Trenchard"
                            3 => "H&#46;L&#46; Cochrane"
                            4 => "A&#46;R&#46; Makey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Sci"
                        "fecha" => "1964"
                        "volumen" => "27"
                        "paginaInicial" => "293"
                        "paginaFinal" => "304"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14220908"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Post-transplant obliterative bronchiolitis and other late sequelae in human heart-lung transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;M&#46; Burke"
                            1 => "J&#46; Theodore"
                            2 => "D&#46;K&#46; Dawkins"
                            3 => "S&#46;A&#46; Yousen"
                            4 => "N&#46; Blank"
                            5 => "M&#46;E&#46; Billingham"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1984"
                        "volumen" => "86"
                        "paginaInicial" => "824"
                        "paginaFinal" => "829"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6437751"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physiologic aspects of human heart-lung transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Theodore"
                            1 => "S&#46;W&#46; Jamieson"
                            2 => "C&#46;M&#46; Burke"
                            3 => "B&#46;A&#46; Reitz"
                            4 => "E&#46;D&#46; Stinsen"
                            5 => "A&#46; Wan Kessel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1984"
                        "volumen" => "86"
                        "paginaInicial" => "349"
                        "paginaFinal" => "357"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6432455"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human heart-lung transplantation&#58; physiological aspects of denervated lung and post-transplant obliterative bronchiolitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Estenne"
                            1 => "P&#46; Ketelbant"
                            2 => "G&#46; Primo"
                            3 => "J&#46;C&#46; Yernault"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1987"
                        "volumen" => "135"
                        "paginaInicial" => "976"
                        "paginaFinal" => "978"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3105374"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathologic pulmonary alterations in long-term human heart-lung transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;A&#46; Yousem"
                            1 => "C&#46;M&#46; Burke"
                            2 => "M&#46;E&#46; Billingham"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Pathol"
                        "fecha" => "1985"
                        "volumen" => "6"
                        "paginaInicial" => "1"
                        "paginaFinal" => "923"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1110079"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/03002896/0000003000000009/v1_201509151216/S0300289615310164/v1_201509151216/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9277"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03002896/0000003000000009/v1_201509151216/S0300289615310164/v1_201509151216/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310164?idApp=UINPBA00003Z"
]
Share
Journal Information
Vol. 30. Issue 9.
Pages 440-444 (November 1994)
Share
Share
Download PDF
More article options
Vol. 30. Issue 9.
Pages 440-444 (November 1994)
Full text access
Patrón ventilatorio de reposo y respuesta ventilatoria a la estimulación hipercápnica tras el trasplante pulmonar
Breathing pattern at rest and ventilatory response to hypercapnia after lung transplantation
Visits
3846
P. Morales1, P. Cordero, V. Macián, V. Marco
Servicios de Neumología. Hospital Universitario La Fe. Valencia
J.M. Borro*
* Cirugía Torácica. Hospital Universitario La Fe. Valencia
This item has received
Article information

El objetivo del presente trabajo ha sido la evaluación del patrón ventilatorio de reposo (PVR), de la presión de oclusión a los 100 primeros milisegundos (P0,1) y de la respuesta ventilatoria a la estimulación hipercápnica tras el trasplante pulmonar. Se estudiaron 7 pacientes trasplantados pulmonares y se compararon con un grupo control de 7 sujetos sanos. El PVR en los pacientes trasplantados se caracterizó por presentar un incremento significativo de la ventilación minuto (VE) a expensas de un aumento del volumen corriente (VT) y sobre todo del flujo inspiratorio medio (VT/Ti). La respuesta ventilatoria a la estimulación hipercápnica no evidenció diferencias significativas respecto al grupo control, aunque las pendientes de respuesta de VE y VT al CO2 mostraron una tendencia a estar disminuidas. Estos resultados se explican por la situación mecánica respiratoria de algunos de los sujetos estudiados y por el efecto de la denervación pulmonar sobre el control de la ventilación.

Palabras clave:
Trasplante pulmonar
Dióxido de carbono
Centros respiratorios
Patrón ventilatorio

We aimed to assess breathing pattern at rest by studying occlusion pressure after the first 100 miliseconds (P0,1) and ventilatory response to hypercapnia after lung transplantation. Seven transplanted patients were compared with a control group of 7 healthy subjects. The breathing pattern at rest after transplantation included a significant increase in minute volume (VE) at the expense of an increase in tidal volume (VT) and above all of mean inspiratory flow (VT/Ti). There were no significant differences in ventilatory response to hypercapnia between the 2 groups, although the response curves of both VE and VT to C02 tended to slope downward. These results can be explained by the mechanics of ventilation in some subjects studied and by the effect of pulmonary denervation on ventilatory control.

Key words:
Lung transplantation
Carbon dioxide
Respiratory centres
Breathing pattern
Full text is only aviable in PDF
Bibliografía
[1.]
T. Higenbottam, M. Jackson, P. Woolman, R. Lowry, R.J. Wallwork.
The cough response to ultrasonically nebulized distilled water in heart-lung transplantation patients.
Am Rev Respir Dis, 140 (1989), pp. 58-61
[2.]
S.R. Duncan, F.T. Kagawa, M.R. Kramer, V.A. Starnes, J. Theodore.
Effects of pulmonary restriction on hypercapnic responses of heart-lung transplant recipients.
J Appl Physiol, 71 (1991), pp. 322-327
[3.]
F.C. Sciurba, G.R. Owens, M.H. Sanders, B.P. Griffith, R.L. Hardesty, I.L. Paradis, J.P. Constantino.
Evidence of an altered pattern ofbreathing during exercise in recipients of heart-lung transplants.
N Engl J Med, 319 (1988), pp. 1.186-1.192
[4.]
S.A. Shea, R. Horner, N.R. Banner, E. Mckenzie, R. Heaton, M.H. Yacoub, A. Guz.
The effect of human heart-lung transplantation upon breathing at rest and during sleep.
Respir Physiol, 72 (1988), pp. 131-150
[5.]
S.R. Duncan, F.T. Kagawa, S.R. Chaplan, V.A. Starnes, J. Theodore.
Respiratory control of heart-lung transplant recipients during CO2 rebreathing.
Am Rev Respir Dis, 139 (1989), pp. 240
[6.]
A.E. Frost, N. Zamel, P. McClean, R. Grossman, G.A. Patterson, J.R. Maurer.
FIypercapnic ventilatory response in recipients of double-lung transplants.
Am Rev Respir Dis, 146 (1992), pp. 1.610-1.612
[7.]
M.F.I. Sanders, G.R. Owens, F.C. Sciurba, R.M. Rogers, I.L. Paradis, B.P. Griffith, et al.
Ventilation and breathing pattern during Progressive hypercapnia and hupoxia after human heart-lung transplantation.
Am Rev Respir Dis, 140 (1989), pp. 38-44
[8.]
J. Roca, J. Sanchis, A. Agustí-Vidal, F. Segarra, D. Navajas, R. Rodriguez-Roisin, et al.
Spirometric reference valúes from a mediterranean population.
Bull Eur Physiopathol Respir, 22 (1986), pp. 217-224
[9.]
H.I. Goldman, M.R. Becklake.
Respiratory function tests: Normal values at median altitudes and the prediction of normal results.
Am Rev of Tub, 79 (1959), pp. 457-467
[10.]
K. Mellemgaard.
The alveolar-arterial oxygen difference: its size and components in normal man.
Acta Physiol Scand, 67 (1966), pp. 10-20
[11.]
D.J.C. Read.
A clinical method for assessing the ventilatory response to carbón dioxide.
Austr Ann Med, 16 (1966), pp. 20-32
[12.]
R.V. Lourenco, G.M. Turino, L.A.G. Davidson, A.P. Fishman.
The regulation of ventilation in diffuse pulmonary fibrosis.
Am J Med, 38 (1965), pp. 199-216
[13.]
J.G. Thompson, D.J.C. Read.
Respiratory regulation during pulmonary restriction.
Austr Ann Med, 17 (1968), pp. 193
[14.]
G. Renzi, J. Milic-Emili, A.E. Grassino.
The pattern of breathing in diffuse lung fibrosis.
Bull Eur Physiopathol Respir, 18 (1982), pp. 461-472
[15.]
A. Guz, M.I.M. Noble, D. Trenchard, H.L. Cochrane, A.R. Makey.
Studies on the vagus nerves in man: their role in respiratory and circulatory control.
Clin Sci, 27 (1964), pp. 293-304
[16.]
C.M. Burke, J. Theodore, D.K. Dawkins, S.A. Yousen, N. Blank, M.E. Billingham, et al.
Post-transplant obliterative bronchiolitis and other late sequelae in human heart-lung transplantation.
Chest, 86 (1984), pp. 824-829
[17.]
J. Theodore, S.W. Jamieson, C.M. Burke, B.A. Reitz, E.D. Stinsen, A. Wan Kessel, et al.
Physiologic aspects of human heart-lung transplantation.
Chest, 86 (1984), pp. 349-357
[18.]
M. Estenne, P. Ketelbant, G. Primo, J.C. Yernault.
Human heart-lung transplantation: physiological aspects of denervated lung and post-transplant obliterative bronchiolitis.
Am Rev Respir Dis, 135 (1987), pp. 976-978
[19.]
S.A. Yousem, C.M. Burke, M.E. Billingham.
Pathologic pulmonary alterations in long-term human heart-lung transplantation.
Hum Pathol, 6 (1985), pp. 1-923
Copyright © 1994. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?