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Vol. 30. Issue 9.
Pages 440-444 (November 1994)
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Vol. 30. Issue 9.
Pages 440-444 (November 1994)
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Patrón ventilatorio de reposo y respuesta ventilatoria a la estimulación hipercápnica tras el trasplante pulmonar
Breathing pattern at rest and ventilatory response to hypercapnia after lung transplantation
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P. Morales1, P. Cordero, V. Macián, V. Marco
Servicios de Neumología. Hospital Universitario La Fe. Valencia
J.M. Borro*
* Cirugía Torácica. Hospital Universitario La Fe. Valencia
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El objetivo del presente trabajo ha sido la evaluación del patrón ventilatorio de reposo (PVR), de la presión de oclusión a los 100 primeros milisegundos (P0,1) y de la respuesta ventilatoria a la estimulación hipercápnica tras el trasplante pulmonar. Se estudiaron 7 pacientes trasplantados pulmonares y se compararon con un grupo control de 7 sujetos sanos. El PVR en los pacientes trasplantados se caracterizó por presentar un incremento significativo de la ventilación minuto (VE) a expensas de un aumento del volumen corriente (VT) y sobre todo del flujo inspiratorio medio (VT/Ti). La respuesta ventilatoria a la estimulación hipercápnica no evidenció diferencias significativas respecto al grupo control, aunque las pendientes de respuesta de VE y VT al CO2 mostraron una tendencia a estar disminuidas. Estos resultados se explican por la situación mecánica respiratoria de algunos de los sujetos estudiados y por el efecto de la denervación pulmonar sobre el control de la ventilación.

Palabras clave:
Trasplante pulmonar
Dióxido de carbono
Centros respiratorios
Patrón ventilatorio

We aimed to assess breathing pattern at rest by studying occlusion pressure after the first 100 miliseconds (P0,1) and ventilatory response to hypercapnia after lung transplantation. Seven transplanted patients were compared with a control group of 7 healthy subjects. The breathing pattern at rest after transplantation included a significant increase in minute volume (VE) at the expense of an increase in tidal volume (VT) and above all of mean inspiratory flow (VT/Ti). There were no significant differences in ventilatory response to hypercapnia between the 2 groups, although the response curves of both VE and VT to C02 tended to slope downward. These results can be explained by the mechanics of ventilation in some subjects studied and by the effect of pulmonary denervation on ventilatory control.

Key words:
Lung transplantation
Carbon dioxide
Respiratory centres
Breathing pattern
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Copyright © 1994. Sociedad Española de Neumología y Cirugía Torácica
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