Importancia de la medición de la interleucina 6 en suero como mediador de inflamación sistémica en pacientes con deficiencia de alfa-1-antitripsina

Vilà, S.; Miravitlles, M.; De La Roza, C.; Morell, F.; Vidal, R.

doi:10.1016/S0300-2896(02)75210-1

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Otero González, M. Blanco Aparicio, C. Montero Martínez, P. Valiño López, H. Verea Hernando" "autores" => array:5 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Otero González" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Blanco Aparicio" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Montero Martínez" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Valiño López" ] 4 => array:2 [ "nombre" => "H." "apellidos" => "Verea Hernando" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289602752095?idApp=UINPBA00003Z" "url" => "/03002896/0000003800000006/v1_201307081532/S0300289602752095/v1_201307081532/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "Importancia de la medición de la interleucina 6 en suero como mediador de inflamación sistémica en pacientes con deficiencia de alfa-1-antitripsina" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "263" "paginaFinal" => "266" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "S. Vilà, M. Miravitlles, C. De La Roza, F. Morell, R. Vidal" "autores" => array:5 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "Vilà" "email" => array:1 [ 0 => "saravv@hg.vhebron.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "¿" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Miravitlles" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "De La Roza" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Morell" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Vidal" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicios de Neumología. Hospital Universitario Vall d'Hebron. Barcelona" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dra. S. Vilà. Servicio de Neumología. Hospital Universitario Vall d'Hebron.P.° Vall d'Hebron, 119–129. 08035 Barcelona" ] ] ] 1 => array:3 [ "autoresLista" => "F. Campos, R. Segura" "autores" => array:2 [ 0 => array:3 [ "nombre" => "F." "apellidos" => "Campos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Segura" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicios de Bioquímica. Hospital Universitario Vall d'Hebron. Barcelona" "etiqueta" => "a" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Importance of serum interleukin-6 as a mediator of systemic inflammation in patients with alpha-1 antitrypsin deficiency" ] ] "miscelanea" => "Este trabajo ha sido financiado en parte con una beca de la Fundació La Marató de TV3. La Dra. Sara Vilà ha recibido una beca “Becario SEPAR” 1998–1999 y una beca de la Societat Catalana de Pneumologia (SOCAP) 1999" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-07-27" "fechaAceptado" => "2002-02-08" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec190569" "palabras" => array:4 [ 0 => "Deficiencia de alfa-l-antitripsina" 1 => "Interleucina 6 (IL-6)" 2 => "Receptor soluble de la interleucina 6 (RSIL-6)" 3 => "Enferme-dad pulmonar obstructiva crónica (EPOC)" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec190570" "palabras" => array:4 [ 0 => "Alpha-1 antitrypsin deficiency" 1 => "Interleukin-6 (IL-6)" 2 => "Soluble receptor of IL-6 (SRIL-6)" 3 => "Chronic obstructive pulmo-nary disease (COPD)" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "El objetivo de este estudio fue conocer si la actividad in-flamatoria sistémica que presentan los enfermos con deficiencia de alfa-l-antitripsina (DAAT) puede estar condicio-nada en parte por concentraciones circulantes elevadas de interleucina (IL) 6 y/o de su receptor soluble (RSIL-6). Con este objetivo se cuantificaron las concentraciones de la IL-6 y del RSIL-6 en suero de 7 pacientes con DAAT en fase estable. La edad media de los pacientes era de 51 años (DE, 5,2) y el volumen espiratorio forzado en el primer segundo (FEV1) medio, del 35,5% (DE, 15%). La concentración de la IL-6 y de su RSIL-6 se comparó con las concentraciones de estas sustacias en un grupo de 23 pacientes con enfermedad pulmonar obstructiva crónica (EPOC) sin DAAT y con similar alteración funcional respiratoria (edad media, 63 años [DE, 10,1], FEV1, del 38,3% [DE, 11%])Los pacientes con DAAT presentaron unos valores medios de IL-6 de 4,7pg/ml (amplitud intercuartil [AI], 4,0) y de RSIL-6 de 29,1ng/ml (AI, 31,5). Los pacientes con EPOC presentaron unos valores de IL-6 de 4,1pg/ml (AI, 4,2) y de RSIL-6 de 140,8ng/ml (AI, 71). No se observaron diferen-cias significativas entre las concentraciones halladas para ambas citocinas entre los pacientes con DAAT y el grupo EPOC (prueba no paramétrica de la U de Mann-Whitney; p > 0,05). Tan sólo un paciente con DAAT presentó concen-traciones de IL-6 por encima de las consideradas normalesEn conclusión, las concentraciones séricas de IL-6 y RSIL-6 en pacientes con DAAT no son diferentes de las halladas en pacientes con EPOC con similar alteración funcional respiratoria y concentraciones normales de alfa-1-antitripsina (AAT). Estos resultados no apoyan el papel de dicha citocina en la es-timulación inflamatoria sistémica en pacientes con DAAT" ] "en" => array:1 [ "resumen" => "The objective of this study was to determine whether high concentrations of circulating interleukin-6 (IL-6) and/or the soluble receptor of IL-6 (SRIL-6) may mediate systemic inflammatory activity in patients with alpha-1 antitrypsin de-ficiency (AATD). To that end we assessed serum concentra-tions of IL-6 and SRIL-6 for 7 patients with AATD in stable phase. The patients' mean age was 51 years (SD 5.2); mean FEV1% was 35.5% (SD 15%). IL-6 and SRIL-6 concentrations were compared with those of 23 non-AATD patients with COPD but with similar changes in lung function (mean age 63 years, SD 10.1; FEV1 % 38.3%, SD 11%)The AADT patients had mean IL-6 concentrations of 4.7pg/mL (interquartile range [IR( 4.0) and RSIL-6 levels of 129.1ng/mL (IR 31.5). The COPD patients had IL-6 concen-trations of 4.1pg/mL (IR 4.2) and SRIL-6 levels of 140.8ng/mL (IR 71). No significant differences between the AADT group and the COPD group were observed for either cytokine (non-parametric Mann Whitney U test, p > 0.05). Only one AADT patient had an IL-6 concentration that was higher than normalIn conclusion, the serum IL-6 and SRIL-6 concentrations of patients with AADT are not different from those of patients with COPD, similarly altered respiratory function and normal alpha-1 antitrypsin levels. These results do not point to a role for alpha-1 antitrypsin in systemic inflamma-tory stimulation in patients with AADT" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alpha-l-antitrypsin deficiency: what next?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.A. 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Archivos de Bronconeumología

ISSN: 0300-2896

Archivos de Bronconeumologia is an international journal that publishes original studies whose content is based upon results of research initiatives dealing with several aspects of respiratory medicine including epidemiology, respiratory physiology, pathophysiology of respiratory diseases, clinical management, thoracic surgery, pediatric lung diseases, respiratory critical care, respiratory allergy and basic research. Other types of articles such as editorials, reviews, and different types of letters are also published in the journal. Additionally, the journal expresses the voice of the following scientific societies: the Spanish Respiratory Society of Pneumology and Thoracic Surgery (SEPAR; https://www.separ.es/), the Latin American Thoracic Society (ALAT; https://alatorax.org/), and the Iberian American Association of Thoracic Surgery (AIACT; http://www.aiatorax.com/).

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Vol. 38. Issue 6.

Pages 263-266 (June 2002)

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Pages 263-266 (June 2002)

DOI: 10.1016/S0300-2896(02)75210-1

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Importancia de la medición de la interleucina 6 en suero como mediador de inflamación sistémica en pacientes con deficiencia de alfa-1-antitripsina

Importance of serum interleukin-6 as a mediator of systemic inflammation in patients with alpha-1 antitrypsin deficiency

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S. Vilà

Corresponding author

saravv@hg.vhebron.es

Correspondencia: Dra. S. Vilà. Servicio de Neumología. Hospital Universitario Vall d'Hebron.P.° Vall d'Hebron, 119–129. 08035 Barcelona

, M. Miravitlles, C. De La Roza, F. Morell, R. Vidal

Servicios de Neumología. Hospital Universitario Vall d'Hebron. Barcelona

F. Camposa, R. Seguraa

a Servicios de Bioquímica. Hospital Universitario Vall d'Hebron. Barcelona

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El objetivo de este estudio fue conocer si la actividad in-flamatoria sistémica que presentan los enfermos con deficiencia de alfa-l-antitripsina (DAAT) puede estar condicio-nada en parte por concentraciones circulantes elevadas de interleucina (IL) 6 y/o de su receptor soluble (RSIL-6). Con este objetivo se cuantificaron las concentraciones de la IL-6 y del RSIL-6 en suero de 7 pacientes con DAAT en fase estable. La edad media de los pacientes era de 51 años (DE, 5,2) y el volumen espiratorio forzado en el primer segundo (FEV1) medio, del 35,5% (DE, 15%). La concentración de la IL-6 y de su RSIL-6 se comparó con las concentraciones de estas sustacias en un grupo de 23 pacientes con enfermedad pulmonar obstructiva crónica (EPOC) sin DAAT y con similar alteración funcional respiratoria (edad media, 63 años [DE, 10,1], FEV1, del 38,3% [DE, 11%])

Los pacientes con DAAT presentaron unos valores medios de IL-6 de 4,7pg/ml (amplitud intercuartil [AI], 4,0) y de RSIL-6 de 29,1ng/ml (AI, 31,5). Los pacientes con EPOC presentaron unos valores de IL-6 de 4,1pg/ml (AI, 4,2) y de RSIL-6 de 140,8ng/ml (AI, 71). No se observaron diferen-cias significativas entre las concentraciones halladas para ambas citocinas entre los pacientes con DAAT y el grupo EPOC (prueba no paramétrica de la U de Mann-Whitney; p > 0,05). Tan sólo un paciente con DAAT presentó concen-traciones de IL-6 por encima de las consideradas normales

En conclusión, las concentraciones séricas de IL-6 y RSIL-6 en pacientes con DAAT no son diferentes de las halladas en pacientes con EPOC con similar alteración funcional respiratoria y concentraciones normales de alfa-1-antitripsina (AAT). Estos resultados no apoyan el papel de dicha citocina en la es-timulación inflamatoria sistémica en pacientes con DAAT

Palabras clave:

Deficiencia de alfa-l-antitripsina

Interleucina 6 (IL-6)

Receptor soluble de la interleucina 6 (RSIL-6)

Enferme-dad pulmonar obstructiva crónica (EPOC)

The objective of this study was to determine whether high concentrations of circulating interleukin-6 (IL-6) and/or the soluble receptor of IL-6 (SRIL-6) may mediate systemic inflammatory activity in patients with alpha-1 antitrypsin de-ficiency (AATD). To that end we assessed serum concentra-tions of IL-6 and SRIL-6 for 7 patients with AATD in stable phase. The patients' mean age was 51 years (SD 5.2); mean FEV1% was 35.5% (SD 15%). IL-6 and SRIL-6 concentrations were compared with those of 23 non-AATD patients with COPD but with similar changes in lung function (mean age 63 years, SD 10.1; FEV1 % 38.3%, SD 11%)

The AADT patients had mean IL-6 concentrations of 4.7pg/mL (interquartile range [IR( 4.0) and RSIL-6 levels of 129.1ng/mL (IR 31.5). The COPD patients had IL-6 concen-trations of 4.1pg/mL (IR 4.2) and SRIL-6 levels of 140.8ng/mL (IR 71). No significant differences between the AADT group and the COPD group were observed for either cytokine (non-parametric Mann Whitney U test, p > 0.05). Only one AADT patient had an IL-6 concentration that was higher than normal

In conclusion, the serum IL-6 and SRIL-6 concentrations of patients with AADT are not different from those of patients with COPD, similarly altered respiratory function and normal alpha-1 antitrypsin levels. These results do not point to a role for alpha-1 antitrypsin in systemic inflamma-tory stimulation in patients with AADT

Keywords:

Alpha-1 antitrypsin deficiency

Interleukin-6 (IL-6)

Soluble receptor of IL-6 (SRIL-6)

Chronic obstructive pulmo-nary disease (COPD)

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