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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio fue conocer si la actividad in-flamatoria sist&#233;mica que presentan los enfermos con deficiencia de alfa-l-antitripsina &#40;DAAT&#41; puede estar condicio-nada en parte por concentraciones circulantes elevadas de interleucina &#40;IL&#41; 6 y&#47;o de su receptor soluble &#40;RSIL-6&#41;&#46; Con este objetivo se cuantificaron las concentraciones de la IL-6 y del RSIL-6 en suero de 7 pacientes con DAAT en fase estable&#46; La edad media de los pacientes era de 51 a&#241;os &#40;DE&#44; 5&#44;2&#41; y el volumen espiratorio forzado en el primer segundo &#40;FEV<span class="elsevierStyleInf">1</span>&#41; medio&#44; del 35&#44;5&#37; &#40;DE&#44; 15&#37;&#41;&#46; La concentraci&#243;n de la IL-6 y de su RSIL-6 se compar&#243; con las concentraciones de estas sustacias en un grupo de 23 pacientes con enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; sin DAAT y con similar alteraci&#243;n funcional respiratoria &#40;edad media&#44; 63 a&#241;os &#91;DE&#44; 10&#44;1&#93;&#44; FEV<span class="elsevierStyleInf">1</span>&#44; del 38&#44;3&#37; &#91;DE&#44; 11&#37;&#93;&#41;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con DAAT presentaron unos valores medios de IL-6 de 4&#44;7<span class="elsevierStyleHsp" style=""></span>pg&#47;ml &#40;amplitud intercuartil &#91;AI&#93;&#44; 4&#44;0&#41; y de RSIL-6 de 29&#44;1<span class="elsevierStyleHsp" style=""></span>ng&#47;ml &#40;AI&#44; 31&#44;5&#41;&#46; Los pacientes con EPOC presentaron unos valores de IL-6 de 4&#44;1<span class="elsevierStyleHsp" style=""></span>pg&#47;ml &#40;AI&#44; 4&#44;2&#41; y de RSIL-6 de 140&#44;8<span class="elsevierStyleHsp" style=""></span>ng&#47;ml &#40;AI&#44; 71&#41;&#46; No se observaron diferen-cias significativas entre las concentraciones halladas para ambas citocinas entre los pacientes con DAAT y el grupo EPOC &#40;prueba no param&#233;trica de la U de Mann-Whitney&#59; p &#62; 0&#44;05&#41;&#46; Tan s&#243;lo un paciente con DAAT present&#243; concen-traciones de IL-6 por encima de las consideradas normales</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En conclusi&#243;n&#44; las concentraciones s&#233;ricas de IL-6 y RSIL-6 en pacientes con DAAT no son diferentes de las halladas en pacientes con EPOC con similar alteraci&#243;n funcional respiratoria y concentraciones normales de alfa-1-antitripsina &#40;AAT&#41;&#46; Estos resultados no apoyan el papel de dicha citocina en la es-timulaci&#243;n inflamatoria sist&#233;mica en pacientes con DAAT</p>"
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        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The objective of this study was to determine whether high concentrations of circulating interleukin-6 &#40;IL-6&#41; and&#47;or the soluble receptor of IL-6 &#40;SRIL-6&#41; may mediate systemic inflammatory activity in patients with alpha-1 antitrypsin de-ficiency &#40;AATD&#41;&#46; To that end we assessed serum concentra-tions of IL-6 and SRIL-6 for 7 patients with AATD in stable phase&#46; The patients&#39; mean age was 51 years &#40;SD 5&#46;2&#41;&#59; mean FEV<span class="elsevierStyleInf">1</span>&#37; was 35&#46;5&#37; &#40;SD 15&#37;&#41;&#46; IL-6 and SRIL-6 concentrations were compared with those of 23 non-AATD patients with COPD but with similar changes in lung function &#40;mean age 63 years&#44; SD 10&#46;1&#59; FEV<span class="elsevierStyleInf">1</span> &#37; 38&#46;3&#37;&#44; SD 11&#37;&#41;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The AADT patients had mean IL-6 concentrations of 4&#46;7<span class="elsevierStyleHsp" style=""></span>pg&#47;mL &#40;interquartile range &#91;IR&#40; 4&#46;0&#41; and RSIL-6 levels of 129&#46;1<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;IR 31&#46;5&#41;&#46; The COPD patients had IL-6 concen-trations of 4&#46;1<span class="elsevierStyleHsp" style=""></span>pg&#47;mL &#40;IR 4&#46;2&#41; and SRIL-6 levels of 140&#46;8<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;IR 71&#41;&#46; No significant differences between the AADT group and the COPD group were observed for either cytokine &#40;non-parametric Mann Whitney U test&#44; p &#62; 0&#46;05&#41;&#46; Only one AADT patient had an IL-6 concentration that was higher than normal</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In conclusion&#44; the serum IL-6 and SRIL-6 concentrations of patients with AADT are not different from those of patients with COPD&#44; similarly altered respiratory function and normal alpha-1 antitrypsin levels&#46; These results do not point to a role for alpha-1 antitrypsin in systemic inflamma-tory stimulation in patients with AADT</p>"
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Vol. 38. Issue 6.
Pages 263-266 (June 2002)
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Vol. 38. Issue 6.
Pages 263-266 (June 2002)
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Importancia de la medición de la interleucina 6 en suero como mediador de inflamación sistémica en pacientes con deficiencia de alfa-1-antitripsina
Importance of serum interleukin-6 as a mediator of systemic inflammation in patients with alpha-1 antitrypsin deficiency
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S. Vilà
Corresponding author
saravv@hg.vhebron.es

Correspondencia: Dra. S. Vilà. Servicio de Neumología. Hospital Universitario Vall d'Hebron.P.° Vall d'Hebron, 119–129. 08035 Barcelona
, M. Miravitlles, C. De La Roza, F. Morell, R. Vidal
Servicios de Neumología. Hospital Universitario Vall d'Hebron. Barcelona
F. Camposa, R. Seguraa
a Servicios de Bioquímica. Hospital Universitario Vall d'Hebron. Barcelona
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Article information

El objetivo de este estudio fue conocer si la actividad in-flamatoria sistémica que presentan los enfermos con deficiencia de alfa-l-antitripsina (DAAT) puede estar condicio-nada en parte por concentraciones circulantes elevadas de interleucina (IL) 6 y/o de su receptor soluble (RSIL-6). Con este objetivo se cuantificaron las concentraciones de la IL-6 y del RSIL-6 en suero de 7 pacientes con DAAT en fase estable. La edad media de los pacientes era de 51 años (DE, 5,2) y el volumen espiratorio forzado en el primer segundo (FEV1) medio, del 35,5% (DE, 15%). La concentración de la IL-6 y de su RSIL-6 se comparó con las concentraciones de estas sustacias en un grupo de 23 pacientes con enfermedad pulmonar obstructiva crónica (EPOC) sin DAAT y con similar alteración funcional respiratoria (edad media, 63 años [DE, 10,1], FEV1, del 38,3% [DE, 11%])

Los pacientes con DAAT presentaron unos valores medios de IL-6 de 4,7pg/ml (amplitud intercuartil [AI], 4,0) y de RSIL-6 de 29,1ng/ml (AI, 31,5). Los pacientes con EPOC presentaron unos valores de IL-6 de 4,1pg/ml (AI, 4,2) y de RSIL-6 de 140,8ng/ml (AI, 71). No se observaron diferen-cias significativas entre las concentraciones halladas para ambas citocinas entre los pacientes con DAAT y el grupo EPOC (prueba no paramétrica de la U de Mann-Whitney; p > 0,05). Tan sólo un paciente con DAAT presentó concen-traciones de IL-6 por encima de las consideradas normales

En conclusión, las concentraciones séricas de IL-6 y RSIL-6 en pacientes con DAAT no son diferentes de las halladas en pacientes con EPOC con similar alteración funcional respiratoria y concentraciones normales de alfa-1-antitripsina (AAT). Estos resultados no apoyan el papel de dicha citocina en la es-timulación inflamatoria sistémica en pacientes con DAAT

Palabras clave:
Deficiencia de alfa-l-antitripsina
Interleucina 6 (IL-6)
Receptor soluble de la interleucina 6 (RSIL-6)
Enferme-dad pulmonar obstructiva crónica (EPOC)

The objective of this study was to determine whether high concentrations of circulating interleukin-6 (IL-6) and/or the soluble receptor of IL-6 (SRIL-6) may mediate systemic inflammatory activity in patients with alpha-1 antitrypsin de-ficiency (AATD). To that end we assessed serum concentra-tions of IL-6 and SRIL-6 for 7 patients with AATD in stable phase. The patients' mean age was 51 years (SD 5.2); mean FEV1% was 35.5% (SD 15%). IL-6 and SRIL-6 concentrations were compared with those of 23 non-AATD patients with COPD but with similar changes in lung function (mean age 63 years, SD 10.1; FEV1 % 38.3%, SD 11%)

The AADT patients had mean IL-6 concentrations of 4.7pg/mL (interquartile range [IR( 4.0) and RSIL-6 levels of 129.1ng/mL (IR 31.5). The COPD patients had IL-6 concen-trations of 4.1pg/mL (IR 4.2) and SRIL-6 levels of 140.8ng/mL (IR 71). No significant differences between the AADT group and the COPD group were observed for either cytokine (non-parametric Mann Whitney U test, p > 0.05). Only one AADT patient had an IL-6 concentration that was higher than normal

In conclusion, the serum IL-6 and SRIL-6 concentrations of patients with AADT are not different from those of patients with COPD, similarly altered respiratory function and normal alpha-1 antitrypsin levels. These results do not point to a role for alpha-1 antitrypsin in systemic inflamma-tory stimulation in patients with AADT

Keywords:
Alpha-1 antitrypsin deficiency
Interleukin-6 (IL-6)
Soluble receptor of IL-6 (SRIL-6)
Chronic obstructive pulmo-nary disease (COPD)
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Copyright © 2002. Sociedad Española de Neumología y Cirugía Torácica
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