Journal Information
Download PDF
More article options
Special article
Available online 15 September 2022
Hypoxic Burden in Obstructive Sleep Apnea: Present and Future
Miguel A. Martinez-Garciaa,b,
Corresponding author

Corresponding author.
, Manuel Sánchez-de-la-Torreb,c, David P. Whited, Ali Azarbarzind
a Respiratory Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain
b Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain
c Precision Medicine in Chronic Diseases, Hospital Universitari Arnau de Vilanova-Santa Maria, IRB Lleida, Department of Nursing and Physiotherapy, Faculty of Nursing and Physiotherapy, University of Lleida, Lleida, Spain
d Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States
Received 15 July 2022. Accepted 12 August 2022
Article information
Full Text
Download PDF
Figures (2)

Conventional measures of obstructive sleep apnea (OSA) severity, such as the apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) are commonly used to quantify OSA severity and guide therapeutical decision-making processes. However, it is widely recognized that both AHI and ODI have important limitations and novel physiologically-informed metrics are needed to better capture the severity of OSA and characterize its physiological consequences, particularly the severity of recurrent nocturnal hypoxemia, ensuing the respiratory events. According to recent studies, the sleep apnea-specific “hypoxic burden (HB)”, defined as the sum of individual areas under the oxygen desaturation curve, has shown some promise in identifying high risk individuals with OSA. In addition to the frequency of respiratory events, HB capture the depth and duration of OSA-related hypoxemia that may prove to be important disease characterizing features, not captured by the conventional “frequency-based” metrics, such as AHI and ODI. In this “perspective” paper the methods to quantify the HB, its characteristics, associations with health outcomes, and its limitations will be discussed.

Hypoxic burden
Cardiovascular diseases
Heart failure
Ischemic heart disease
Blood pressure
Chronic kidney disease


These are the options to access the full texts of the publication Archivos de Bronconeumología
Si es usted socio de la SEPAR siga los siguientes pasos:
  • Diríjase desde aquí a la web de la >>>SEPAR<<< e inicie sesión mediante el formulario que se encuentra en la barra lateral derecha de la web de la sociedad.

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Archivos de Bronconeumología

Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Archivos de Bronconeumología

Subscribe to our newsletter

Article options

Are you a health professional able to prescribe or dispense drugs?