array:23 ["pii" => "S0300289623003137" "issn" => "03002896" "doi" => "10.1016/j.arbres.2023.09.016" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "3413" "copyright" => "SEPAR" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2024;60:122-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S030028962300409X" "issn" => "03002896" "doi" => "10.1016/j.arbres.2023.12.007" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "3453" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2024;60:124" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "Letter to the Director" "titulo" => "Diagnostic Difficulties in Hemorrhagic Hereditary Telangiectasia Presenting With Respiratory Failure and a De Novo Mutation in ENG Gene" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "124" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alfonso Gutiérrez-Macías, Begoña Salinas-Lasa, Julen Agirre-Castillero" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Alfonso" "apellidos" => "Gutiérrez-Macías" ] 1 => array:2 [ "nombre" => "Begoña" "apellidos" => "Salinas-Lasa" ] 2 => array:2 [ "nombre" => "Julen" "apellidos" => "Agirre-Castillero" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028962300409X?idApp=UINPBA00003Z" "url" => "/03002896/0000006000000002/v3_202406051408/S030028962300409X/v3_202406051408/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289623004167" "issn" => "03002896" "doi" => "10.1016/j.arbres.2023.12.011" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "3457" "copyright" => "The Author(s)" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2024;60:119-21" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "Scientific Letter" "titulo" => "COPD Patients Display Increased Peripheral Blood Somatic Mutations Which Associate With the Prevalence of Co-morbidities" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "119" "paginaFinal" => "121" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3290 "Ancho" => 2925 "Tamanyo" => 578673 ] ] "descripcion" => array:1 [ "en" => "Higher prevalence of somatic mutations in COPD patients compared to healthy controls and associations with COPD co-morbidities. (A) Flow chart of differentially prevalent mutated genes identified in our study. (B) The top-10 genes that displayed the highest differential prevalence of somatic mutations in COPD patients compared to healthy controls. The white bars represent the percentage of the COPD group that had a putative somatic mutation within the gene, the gray bars represent the percentage of mutations within the control group. The delta between percentage mutations in the COPD and control group is depicted above the white bars. (C) The prevalence of gene mutations of HLA-A, LGALS9C, ORT2T or KIF26B in COPD patients (n=165) with or without osteoporosis (n=15), hypertension (n=51) or myocardial infarction (n=11). (D) The gene expression levels of HLA-A and MRPL4 in COPD patients (n=165) with or without osteoporosis (n=15) or hypertension (n=51). The somatic mutation data was obtained from peripheral blood, while the gene expression data was obtained from bronchial biopsies. Statistical differences were tested using a Mann–Whitney U test, nominal p values are shown on top of the graph." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alen Faiz, Valerie R. Wiersma, Jonas B. Salzbrunn, Corry-Anke Brandsma, Wim Timens, Janette K. Burgess, Maarten van den Berge, Dirk-Jan Slebos, Victor Guryev, Simon D. Pouwels" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Alen" "apellidos" => "Faiz" ] 1 => array:2 [ "nombre" => "Valerie R." "apellidos" => "Wiersma" ] 2 => array:2 [ "nombre" => "Jonas B." "apellidos" => "Salzbrunn" ] 3 => array:2 [ "nombre" => "Corry-Anke" "apellidos" => "Brandsma" ] 4 => array:2 [ "nombre" => "Wim" "apellidos" => "Timens" ] 5 => array:2 [ "nombre" => "Janette K." "apellidos" => "Burgess" ] 6 => array:2 [ "nombre" => "Maarten" "apellidos" => "van den Berge" ] 7 => array:2 [ "nombre" => "Dirk-Jan" "apellidos" => "Slebos" ] 8 => array:2 [ "nombre" => "Victor" "apellidos" => "Guryev" ] 9 => array:2 [ "nombre" => "Simon D." "apellidos" => "Pouwels" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289623004167?idApp=UINPBA00003Z" "url" => "/03002896/0000006000000002/v3_202406051408/S0300289623004167/v3_202406051408/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "Letter to the Director" "titulo" => "High-flow Nasal Cannula Ventilatory Modalities" "tieneTextoCompleto" => true "saludo" => "To the Director," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "122" "paginaFinal" => "123" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Salvador Díaz Lobato, José Manuel Carratalá Perales, Guillermo Montiel, José Miguel Alonso Íñigo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Salvador" "apellidos" => "Díaz Lobato" "email" => array:1 [ 0 => "sdiazlobato@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "José Manuel" "apellidos" => "Carratalá Perales" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Guillermo" "apellidos" => "Montiel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "José Miguel" "apellidos" => "Alonso Íñigo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "HLA Hospital Universitario Moncloa, Universidad Europea, Nippon Gases Healthcare, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Corta Estancia, Servicio de Urgencias, Hospital General de Alicante, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anestesiología y Reanimación, Hospital Universitario y Politécnico La Fe, Valencia, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Neumonología, Hospital J.A. Fernández, Buenos Aires, Argentina" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 495 "Ancho" => 1508 "Tamanyo" => 91557 ] ] "descripcion" => array:1 [ "en" => "High-flow nasal cannula ventilatory modalities. HFNC: high-flow nasal cannula." ] ] ] "textoCompleto" => "Currently, high-flow nasal cannula therapy (HFNC) is considered as a non-invasive respiratory support therapy suitable for patients experiencing both hypoxemic and hypercapnic respiratory failure. At first glance, setting HFNC seems to be very simple to use. The main menu of the HFNC devices offers only three key parameters: flow, temperature and FiO2. However, several studies have also shown us that setting HFNC may not be as simple as it initially seems, opening the door to defining HFNC ventilatory modalities similar to those used in non-invasive ventilation.We could categorize the HFNC effects into three groups: 1. humidification and warming effects, which are common to all HFNC patients, impacting mucociliary clearance, patient comfort and tolerance, 2. airway pressurization effects, particularly significant for hypoxemic ARF patients, and 3. CO2 washout effects, relevant for hypercapnic ARF patients. Can HFNC settings be customized to prioritize certain mechanisms over others? Existing evidence suggests that customization is feasible.From the beginnings of HFNC, it has been clear that there is a direct correlation between the administered flow rate and the resultant airway pressure.<a class="elsevierStyleCrossRef" href="#bib0030">1</a> However, factors beyond flow rate can also influence pressurization. The first one is related to the degree of elastance of the rib cage (with a constant flow, elastance that determines the airway pressure). Secondly, the size of the cannula (larger cannulas covering a larger nares surface area increase airway pressure<a class="elsevierStyleCrossRef" href="#bib0035">2</a>). Thirdly, the patient's breathing pattern (the pressure is higher with mouth-closed breathing<a class="elsevierStyleCrossRef" href="#bib0040">3</a>). Fourthly, the type of gas used (lower-density inspired gas as helium–oxygen mixture, leads to lower airway pressure<a class="elsevierStyleCrossRef" href="#bib0045">4</a>). Finally, the airway access (pressure is lower when HFNC is administered through tracheostomy vs nasal cannula). Studies conducted during the COVID-19 pandemic have also highlighted additional HFNC optimization techniques, including prone maneuvers and surgical mask placement.<a class="elsevierStyleCrossRef" href="#bib0050">5</a>Conversely, certain circumstances enhance CO2 washout. Different studies have shown that CO2 washout increase when the patient breathes with an open mouth<a class="elsevierStyleCrossRef" href="#bib0040">3</a> or when smaller cannulas leave more space in the nostrils.<a class="elsevierStyleCrossRef" href="#bib0035">2</a> It is worth noting that the density of the inspired gas, whether it is ambient air, O2 or a helium–O2 mixture, does not alter CO2 washout.In summary, we could clearly differentiate three ventilatory strategies or modalities when setting up a HFNC (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). In hypoxemic ARF patients it would be advisable to use high-flow rates and cannulas covering more than 50% of the nares, encourage mouth-closed breathing, avoid low-density gases, and consider mask placement and prone maneuvers for oxygenation. In hypercapnic ARF patients, lower flow rates and cannulas that occlude less than 50% of the nares should be more appropriate. Advise open-mouth breathing and consider low-density gas mixtures if needed. Finally, for patients with compromised mucociliar clearance, high flows are unnecessary, and the focus should primarily be on gas humidification and warming.<elsevierMultimedia ident="fig0005"></elsevierMultimedia>To our knowledge, this is the first time that ventilatory modalities applied to HFNC have been described. Future studies are necessary to enhance our understanding of HFNC and the impact of different HFNC settings on clinical outcomes.Conflict of InterestThe authors do not have any conflict of interest related to this manuscript." "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 495 "Ancho" => 1508 "Tamanyo" => 91557 ] ] "descripcion" => array:1 [ "en" => "High-flow nasal cannula ventilatory modalities. HFNC: high-flow nasal cannula." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nasal high-flow therapy delivers low level positive airway pressure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Parke" 1 => "S. McGuinness" 2 => "M. Eccleston" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/bja/aep280" "Revista" => array:5 [ "tituloSerie" => "Br J Anaesth" "fecha" => "2009" "volumen" => "103" "paginaInicial" => "886" "paginaFinal" => "890" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of flow and cannula size on generated pressure during nasal high flow" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Pinkham" 1 => "S. Tatkov" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13054-020-02980-w" "Revista" => array:5 [ "tituloSerie" => "Crit Care" "fecha" => "2020" "volumen" => "24" "paginaInicial" => "248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32448344" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A high-flow nasal cannula system with relatively low flow effectively washes out CO2 from the anatomical dead space in a sophisticated respiratory model made by a 3D printer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. Onodera" 1 => "R. Akimoto" 2 => "H. Suzuki" 3 => "M. Okada" 4 => "M. Nakane" 5 => "K. Kawamae" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s40635-018-0172-7" "Revista" => array:4 [ "tituloSerie" => "Intensive Care Med Exp" "fecha" => "2018" "volumen" => "6" "paginaInicial" => "7" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High flow nasal cannula: influence of gas type and flow rate on airway pressure and CO2 clearance in adult nasal airway replicas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.P. Moore" 1 => "I.M. Katz" 2 => "M. Pichelin" 3 => "G. Caillibotte" 4 => "W.H. Finlay" 5 => "A.R. Martin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clinbiomech.2019.04.004" "Revista" => array:6 [ "tituloSerie" => "Clin Biomech (Bristol, Avon)" "fecha" => "2019" "volumen" => "65" "paginaInicial" => "73" "paginaFinal" => "80" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30991233" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical mask on top of high-flow nasal cannula improves oxygenation in critically ill COVID-19 patients with hypoxemic respiratory failure" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Montiel" 1 => "A. Robert" 2 => "A. Robert" 3 => "A. Nabaoui" 4 => "T. Marie" 5 => "N.M. Mestre" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13613-020-00744-x" "Revista" => array:5 [ "tituloSerie" => "Ann Intensive Care" "fecha" => "2020" "volumen" => "10" "paginaInicial" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32990864" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000006000000002/v3_202406051408/S0300289623003137/v3_202406051408/en/main.assets" "Apartado" => array:4 [ "identificador" => "94562" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Letters to the Director" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000006000000002/v3_202406051408/S0300289623003137/v3_202406051408/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289623003137?idApp=UINPBA00003Z"]

Archivos de Bronconeumología

ISSN: 0300-2896

Archivos de Bronconeumologia is an international journal that publishes original studies whose content is based upon results of research initiatives dealing with several aspects of respiratory medicine including epidemiology, respiratory physiology, pathophysiology of respiratory diseases, clinical management, thoracic surgery, pediatric lung diseases, respiratory critical care, respiratory allergy and basic research. Other types of articles such as editorials, reviews, and different types of letters are also published in the journal. Additionally, the journal expresses the voice of the following scientific societies: the Spanish Respiratory Society of Pneumology and Thoracic Surgery (SEPAR; https://www.separ.es/), the Latin American Thoracic Society (ALAT; https://alatorax.org/), and the Iberian American Association of Thoracic Surgery (AIACT; http://www.aiatorax.com/).

It is a monthly journal in which all manuscripts are sent to peer-review and handled by the editor or an associate editor from the team and the final decision is made on the basis of the comments from the expert reviewers and the editors. The journal is published solely in English. All the published data is composed of novel manuscripts not previously published in any other journal and not being in consideration for publication in any other journal..

The journal is indexed at Science Citation Index Expanded, Medline/Pubmed, Embase and SCOPUS. Access to any published article is possible through the journal's web page as well as from Pubmed, ScienceDirect, and other international databases. Furthermore, the journal is also present in X, Facebook and Linkedin. Manuscripts can be submitted electronically using the following web site: https://www.editorialmanager.com/ARBR/.

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Current Contents/Clinical Medicine, JCR SCI-Expanded, Index Medicus/Medline, Excerpta Medica/EMBASE, IBECS, IME, SCOPUS, IBECS

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© Clarivate Analytics, Journal Citation Reports 2022

Impact factor 2023

8.7

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Citescore 2023

3.5

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SJR 2023

0.464

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SNIP 2023

0.482

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