TY - JOUR T1 - Small Airway Dysfunction in Children With Controlled Asthma JO - Archivos de Bronconeumología T2 - AU - Azaldegi,Garazi AU - Korta,Javier AU - Sardón,Olaia AU - Corcuera,Paula AU - Pérez-Yarza,Eduardo G. SN - 15792129 M3 - 10.1016/j.arbr.2018.08.007 DO - 10.1016/j.arbr.2018.08.007 UR - https://archbronconeumol.org/en-small-airway-dysfunction-in-children-articulo-S1579212919300527 AB - IntroductionAsthma is characterized by chronic inflammation of the central and distal airways. The aim of this study was to assess the small airway (SA) of children with moderate-severe asthma with normal FEV1. MethodsThis was an open-label, prospective, observational, cross-sectional study with consecutive inclusion of patients with moderate-severe asthma, receiving standard clinical treatment, with normal baseline FEV1. We determined multiflow FEno (CAno), oscillatory resistance and reactance (R5–R20, X5), forced spirometry (FEV1, FEF25–75), total body plethysmography (RV/TLC) and bronchodilation test. SA involvement was defined as: CAno >4.5ppb, R5–R20 >0.147kPa/L/s, X5 <−0.18kPa/L, FEF25–75 <−1.65 z-score, RV/TLC >33%. Poor asthma control was defined as ≤19 points on the ACT questionnaire or ≤20 on the c-ACT. ResultsIn a cohort of 100 cases, 76 had moderate asthma and 24 had severe asthma; 71 children were classified as poorly controlled and 29 were well-controlled. In total, 77.78% of the group with all the correct determinations (n=72) showed ≥ 1 altered SA parameter and 48.61% ≥ 2 parameters. There were no differences between well-controlled or poorly controlled cases. ConclusionsChildren with moderate-severe asthma, with normal FEV1, show a phenotype of dysfunctional SA. In our series, the evaluation of SA using the techniques described above did not provide information on disease control. ER -