TY - JOUR T1 - Inflammatory Patterns in Asthmatic Children Based on Alveolar Nitric Oxide Determination JO - Archivos de Bronconeumología T2 - AU - Corcuera-Elosegui,Paula AU - Sardón-Prado,Olaia AU - Aldasoro-Ruiz,Ane AU - Korta-Murua,Javier AU - Mintegui-Aramburu,Javier AU - Emparanza-Knorr,José I. AU - Pérez-Yarza,Eduardo G. SN - 15792129 M3 - 10.1016/j.arbr.2015.02.032 DO - 10.1016/j.arbr.2015.02.032 UR - https://archbronconeumol.org/en-inflammatory-patterns-in-asthmatic-children-articulo-S1579212915000658 AB - IntroductionNitric oxide (NO) levels can be measured at proximal (maximum airway NO flux [J′awNO]) and distal (alveolar NO concentration [CANO]) levels. Four inflammatory patterns have been described in asthmatic individuals, although their relevance has not been well established. The objective was to determine J′awNO and CANO in order to establish four inflammatory categories in asthmatics. Material and methodsCross-sectional study of a sample consisting of healthy and asthmatic children. Exhaled NO was determined at multiple flows. J′awNO and CANO were obtained according to the two-compartment model. The asthma control questionnaire (ACQ) and spirometry were administered to asthmatic children. Patients were categorized as type I (normal J′awNO and CANO), type II (elevated J′awNO and normal CANO), type III (elevated J′awNO and CANO) and type IV (normal J′awNO and elevated CANO). Correlation between FENO,50, J′awNO and CANO was analyzed using Spearman's R Correlation Test. Analysis of variance and paired comparisons were performed using the Bonferroni correction. ResultsOne hundred sixty-two children were studied, of whom 49 (32.23%) were healthy controls and 103 (67.76%) asthmatics. In the control subjects, FENO,50 (ppb) (median and range) was 11.5 (1.6–27.3), J′awNO (pl/s) was 516 (98.3–1470) and CANO (ppb) was 2.2 (0.1–4.5). Forty-four (42.7%) of the asthmatic participants were categorized as type I, 41 (39.8%) as type II, 14 (13.5%) as type III and 4 (3.88%) as type IV. Good correlation was observed between J′awNO and FENO,50 (r=0.97). There was no association between J′awNO and CANO. FEV1/FVC decreased significantly in type III (mean 79.8±7.5). Morbidity was significantly higher in types III and IV. ConclusionsNormal values obtained are similar to those previously reported. Asthmatics with high CANO showed higher morbidity. No correlation was found between proximal and distal inflammation. ER -