TY - JOUR T1 - Functional Outcomes After Lung Transplant in Chronic Obstructive Pulmonary Disease JO - Archivos de Bronconeumología T2 - AU - Cerón Navarro,José AU - de Aguiar Quevedo,Karol AU - Ansótegui Barrera,Emilio AU - Jordá Aragón,Carlos AU - Peñalver Cuesta,Juan Carlos AU - Mancheño Franch,Nuria AU - Vera Sempere,Francisco José AU - Padilla Alarcón,Jose SN - 15792129 M3 - 10.1016/j.arbr.2014.12.003 DO - 10.1016/j.arbr.2014.12.003 UR - https://archbronconeumol.org/en-functional-outcomes-after-lung-transplant-articulo-S1579212914003772 AB - IntroductionLung transplantation (LT) is a therapeutic option with controversial results in chronic obstructive pulmonary disease (COPD). We aimed to analyze the outcomes of transplantation in terms of lung function and to identify prognostic factors. MethodA retrospective analysis of 107 patients with COPD receiving lung transplants in the La Fe Hospital between 1991 and 2008 was performed. Preoperative variables, functional examinations pre and post-LT, surgical procedure variables and long-term monitoring, expressed as mean or percentage, as applicable, were analyzed. Spirometric results before and after LT were analyzed. Linear or logistic regression was used for multivariate analysis depending on the variable. ResultsNinety-four men (87.9%) and 13 women (12.1%) were transplanted, with a mean age±standard deviation of 52.58±8.05 years; 71% of LTs were double-lung transplantations. Spirometric values improved after LT: FVC: +1.22L (+34.9%), FEV1: +1.66L (+56.7%) and FEF25–75: +1.85L (+50.8%); P=.001. This functional improvement was maintained after 5 years only in the group with BODE score >7 (P=.001). Recipient height, type of LT, use of extracorporeal circulation during the surgical procedure, presence of bronchiolitis obliterans syndrome and the age and cause of death of the donor significantly influenced lung function over time. ConclusionsLT improves lung function in COPD patients. This improvement was maintained at 5years only in patients with BODE>7. Double lung transplantation provides better functional results than single-lung transplantation. ER -