TY - JOUR T1 - The Efficacy and Safety of Different Sericin Doses for Pleurodesis JO - Archivos de Bronconeumología T2 - AU - Yazicioglu,Alkin AU - Sahinoglu,Tuba AU - Uysal,Serkan AU - Subasi,Mahmut AU - Demirag,Funda AU - Yekeler,Erdal SN - 03002896 M3 - 10.1016/j.arbres.2019.06.012 DO - 10.1016/j.arbres.2019.06.012 UR - https://archbronconeumol.org/en-the-efficacy-safety-different-sericin-articulo-S030028961930287X AB - BackgroundThe aim of present study is to compare the effectiveness, side-effect potential of different doses of sericin pleurodesis. MethodsAdult, male, 12-week-old, Wistar-albino rats (n=52), were randomly-divided into four-groups, referred to A, B, C and D. Sericin was administrated at different doses through left thoracotomy, with 15mg sericin to Group-A, 30mg to Group-B and 45mg to Group-C. Group-D was assigned as control group. The rats were sacrificed 12 days later. Left-hemithorax, heart, liver and kidney were examined pathologically. ResultsNo foreign body reaction in the parenchyma was observed in any of the rats, while emphysema was least common in Group-B (P<.05). Multi-layer mesothelium of both pleura was most common in Group-B, while fibrosis and fibrin organization within the visceral-pleura was more successful in all of sericin treated groups than in control group (P<.05), with neither Group-A, Group-B nor Group-C being superior to each other. In the examination of collagen fibers using Masson's trichrome, “dense collagen fibers” were found in all three sericin treated groups, and differences between Groups-A, -B, -C and the control group were significant (P<.05). The probability of observing pyknotic nucleus and balloon degeneration in liver increased with increasing sericin doses (P<.05). Glomerular degeneration in kidney and the findings of pericarditis were most common in Group-C (P<.05). ConclusionThe target should be to maximize efficacy while minimizing the likelihood of side-effects. The intrapleural administration of sericin 30mg performs better due to multi-layer mesothelial reaction being higher and emphysema being lower in Group-B, to the fewer side-effects affecting the kidney and heart, and liver toxicity not being higher. ER -