Article information
Resumen
Se estudia el efecto broncodilatador de un nuevo preparado derivado atropínico en 18 enfermos afectos de bronconeumopatía crónica obstructiva y en comparación con la isoprenalina.
Los resultados indican que el Sch-1000 tiene un efecto positivo comprobado por un aumento de FEV, disminución de resistencias aéreas y del volumen de gas intratorácico.
Las modificaciones en broncodilatación son semejantes a las obtenidas con isoprenalina.
Hay que destacar la ausencia de efectos secundarios anticolinérgicos.
Summary
The authors study the bronchodilating effect of a new atropinic derived preparation in 18 patients affected with chronic obstructive bronchopneumopathy and in comparison to isoprenaline. The results indicate that Sch-1000 has a verified positive effect by an increase of FEV, decrease of air resistences and of the volume of intrathoracic gas. Modification in bronchodilatation is similar to that obtained with isoprenaline.
The absence of anticholingeric secondary effects is worthy of note.
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Bibliografia
[1.]
P.T. Macklem, J. Mead.
Resistance of central and peripheral airways measured by a retrograde catheter.
J. Appl. PhysioL, 64 (1967), pp. 395
[2.]
G.A. Cabezas, P.D. Graf, J.A. Nadel.
Sympathetic versus parasympatethic regulation of airways in dogs.
J. Appl. PhysioL, 31 (1971), pp. 651
[3.]
M.A. De Kock, J.A. Nadel, S. Zwi, H.J.H. Colebacht, C.R. Olsen.
New method for perfusing bronchial arteries: histamine bronchoconstriction and apnea.
J. Appl. PhysioL, 21 (1966), pp. 185
[4.]
W.T. Ulmer, K. Lanser, M.S. e islam.
La regulation de la motricité bronchiale aux divers niveaux de l’arbre bronchique.
Les Bronches, 25 (1975), pp. 1
[5.]
E.D. Adrian.
Afferent impulses in the vagus and their effect on respiration.
J. Physiol, 79 (1933), pp. 332
[6.]
G.C. Knowlton, M.G. Larrabee.
A unitary analysis of pulmonary volume receptors.
Am. J. Physiol, 151 (1946), pp. 547
[7.]
J.G. Widdicombe.
The site pulmonary stretch receptor in the cat.
J. PhysioL, 125 (1954), pp. 336
[8.]
R. Peset, P.H.H. Quanjer, G.J. Tammeling.
Bronchodilation estimated by bodyplethysmography Comparison between the panting and spontaneous breathing methods.
Progr. Resp. Res., 4 (1969), pp. 215
[9.]
R. Bauer, F.S. Kuhn, K. Stockhaus, K. Wick.
Magensekretions hemmer und Spasmolyticum CH. Boehringer Sohn Ingelheim am Rhein.
Biologische ForschungPharmacologie, (1968),
[10.]
P. Gayrard, L. Orehek, J. Charpin.
Effects bronchodilatateurs d’un anticholinergique en aerosol (Sch-1000).
Etude preliminaire. Marseille Med., 11 (1972), pp. 689
[11.]
P. Gayrard, J. Orehek, J. Charpin.
Effects bronchodilatateurs d’un atropinique de synthese: Sch-1000, aerosol doseur.
Rev. Franc. Mal. Resp., 1 (1973), pp. 481
[12.]
P.L. Kamburoff.
Estudio de titulación de dosis en pacientes con neumopatía obstructiva Dosier Sch-1000. Información.
Dept. Med. C.H. Boehringer Sohn Ingelheim, (1971),
[13.]
H. Poppius, Y. Salorinne, A.A. Viljanen.
Comparative trial of salbutamol and anticholinergic drug Sch-1000, in prevention of exercise induced asthma.
Scand. J. Resp. Dis., 54 (1973), pp. 142
[14.]
R. Schindl.
Atropinderivat ais Dosier Aerosol fur die inhalative Therapie des Asthma bronciale.
Med. Welt., 24 (1973), pp. 603
[16.]
N.J. Gross.
A new anticholinergic bronchodilator.
Am. Rev. Resp. Dis., 112 (1975), pp. 823
[17.]
H. Poppius, Y. Salorinne, A.A. Viljanen.
Inhalation of a new anticholinergic drug Sch-1000 in asthma and chronic bronchitis: effect on airway resistance, thoracic gas volume, blood gases and exercise induced asthma.
Bull. Physiopath. Resp., 8 (1972), pp. 643
[18.]
S. Spector, R.E. Ball.
Bronchodilating effects of aerosolized Sch-1000 and atropine sulfate in asthmatics.
Chest., 68 (1975), pp. 426
[19.]
W.W. Storms, G.A. Dopico, C.M.E. Reed.
Aerosol Sch-1000: An anticholinergic bronchodilator.
Am. Rev. Resp. Dis., 111 (1975), pp. 419
[20.]
J.M. Verstraeten.
L’influence de l’association d’un parasympathicolityque dans l’asthme et la bronchite chronique spastique.
Poumon et Coeur, 31 (1975), pp. 79
[21.]
A. Baronti, A. Grieco.
Etude comparative des effets bronchodilatateurs du fenoterol et du Sch-1000 dans la bronchite chronique.
Bull. Physiopath. Resp., 12 (1976), pp. 533
[22.]
A.B. Dubois, S.Y. Botelho, G.N. Bedell, R. Marsahall, J.H. Comroe Jr..
A rapid plethysmographic method for measuring thoracic gas volume. A comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects.
J. Clin, invest., 35 (1956), pp. 322
[23.]
A.B. Dubois, S.Y. Botelho, J.H. Comroe Jr..
A new method for measuring airway resistance in man using a body plethysmograph: valúes in normal subjects and in patients with respiratory disease.
J. Clin. Invest., 35 (1956), pp. 327
[24.]
J.E. Cotes.
SI Units in Respiratory Medicine.
Am. Rev. Resp. Dis., 112 (1975), pp. 753
[25.]
A. Bouhuys, K.P. Van de woestijne.
Respiratory mechanies and dust exposure in byssinosis.
J. Clin. Invest., 49 (1970), pp. 106
[26.]
S.F. Bouh.
The use of expiratory forced flows for determining response to bronchodilator drugs.
Chest., 62 (1972), pp. 534
[27.]
Commision de Normalisation des epreuves respiratoires de la Haute Autorité de la CECA.
Louxembourg. Aide memoire pour la pratique de Fexamen de la fonction ventilatoire par la spirographie.
Masson et Cie, (1961),
[28.]
R.M. Cherniack, M.B. Raber.
Normal standards for ventilatory function using an automated Wedge spirometer.
Am. Rev. Resp. Dis., 106 (1972), pp. 38
[29.]
R. Amrein, R. Keller, H. Joos, H. Herzog.
Neue Normalwerte fur die Lungenfunktionsprufung mit der Ganzkorperplethysmographie.
Deutsch. Med. Wrchs., 94 (1969), pp. 1785
[30.]
G.W. Snedecor.
Statistical Methods.
The Colegíate Press, (1956),
[31.]
Committee on Emphysema of the ACCP.
Criteria for the Assesment of Reversibility in Air-ways Obstruction.
Chest., 65 (1974), pp. 552
[32.]
V. Lopez Merino, M. Ferris Santes.
Acerca de la acción bronquiolítica de la aleudrina.
Folia Clin. Intern., 8 (1958), pp. 75
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