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Aseptic sampling of pleural fluids was performed by thoracentesis or endothoracic drainage&#59; the samples underwent microbiological processing including culture&#44; identification using biochemical galleries and mass spectrometry&#44; direct observation by electron microscopy in the case of filamentous fungi&#44; followed by antifungal sensitivity testing using commercial Sensititre<span class="elsevierStyleSup">&#174;</span> Yeast One panels &#40;Thermo Fisher Scientific&#44; UK&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Fungal isolates were obtained from 9 patients &#40;8 males with a median age of 65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 years&#41; characterized by nonspecific symptoms &#40;respiratory failure and dyspnea&#41;&#44; a 5-week mortality rate of 50&#37;&#44; and long hospital stays &#40;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24 days&#41;&#46; Seven yeasts &#40;2 non-<span class="elsevierStyleItalic">Candida albicans</span> species&#41; and 3 <span class="elsevierStyleItalic">Aspergillus fumigatus</span> &#40;<span class="elsevierStyleItalic">A&#46; fumigatus</span>&#41; were isolated&#44; and no resistance was documented&#46; The total rate of antifungal therapy was 55&#37;&#44; the most common being azole derivatives&#44; and the least common&#44; caspofungin or inhaled liposomal amphotericin B&#46; None of the patients had received antifungal prophylaxis prior to the study episode&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> lists the risk factors for fungal infection identified in each patient and the species isolated in each case&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">As in other series with larger numbers of cases&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a> the causative agents associated with fungal empyema that presented a slightly lower mortality rate in our series were <span class="elsevierStyleItalic">Candida</span> spp&#46; followed by <span class="elsevierStyleItalic">A&#46; fumigatus</span>&#46; All patients except one had 1 or more previous immunodeficiency diseases according to the accepted classifications<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a>&#58; cancer&#44; diabetes mellitus&#44; long-term steroid treatment&#44; hepatic cirrhosis&#44; solid organ transplant&#44; alcoholism&#44; human immunodeficiency virus infection&#44; or surgery in the 4 weeks prior to isolation of the fungus&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Clinical suspicion&#44; chest drainage&#44; early introduction of antifungal agents&#44; and long-term treatment are associated with a reduced mortality rate&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> However&#44; the treatment of fungal empyema is not protocolized&#44; and combinations that include several drugs can be used &#40;amphotericin B and voriconazole&#44; echinocandins&#41; due the variable penetration of systemically administered antifungals into the pleural cavity&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#44;4</span></a> The percentage of patients treated with broad-spectrum antibiotic therapy was higher than that of patients treated with antifungal drugs&#44; despite determination of the etiology&#44; and no subsequent antibiotic de-escalation was performed&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The lack of specific antifungal treatment may be due to clinicians&#8217; failure to consider fungi as true pathogens&#46; Each case must be studied on an individual basis and the role of each causative agent must be evaluated in order to optimize treatment&#46; This includes the need for pharmacological prophylaxis in patients at high risk of developing fungal empyema &#40;hemodialysis&#44; post-surgical re-exploration&#44; environmental colonization by <span class="elsevierStyleItalic">Aspergillus</span>&#44; or documented cytomegalovirus infection&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The seriousness of this entity and its devastating consequences in patients should not be underestimated&#46;</p></span>"
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Scientific Letter
Fungal Empyema: An Uncommon Entity With High Mortality
Empiema fúngico: una entidad infrecuente con elevada mortalidad
Blanca de Vega Sáncheza,
Corresponding author
blancadevegasanchez@gmail.com

Corresponding author.
, Irene López Ramosb, Raúl Ortiz de Lejarazub, Carlos Disdier Vicentea,c
a Servicio de Neumología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
b Servicio de Microbiología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
c CIBERES (Centro de Investigación en Red Enfermedades Respiratorias), Valladolid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Fungal infections have increased in the last few decades as a result of the widespread use of broad-spectrum antibiotics and the growing number of immunocompromised patients in our clinics&#44; which have led to changes in the saprophytic microorganisms usually isolated&#46; Even so&#44; fungal empyemas are still rare entities&#44; with a mortality rate of over 70&#37;&#46; The most common ways for fungi to reach the pleural cavity are via lung infections&#44; complications of pre-existing chronic empyemas&#44; esophageal-bronchial fistulas&#44; or repeated thoracentesis&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> so in patients with risk factors&#44; the possibility of a fungal etiology must be taken into account&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report a retrospective analysis of exclusively fungal pleural effusions diagnosed in our hospital between 2005 and 2016&#46; Aseptic sampling of pleural fluids was performed by thoracentesis or endothoracic drainage&#59; the samples underwent microbiological processing including culture&#44; identification using biochemical galleries and mass spectrometry&#44; direct observation by electron microscopy in the case of filamentous fungi&#44; followed by antifungal sensitivity testing using commercial Sensititre<span class="elsevierStyleSup">&#174;</span> Yeast One panels &#40;Thermo Fisher Scientific&#44; UK&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Fungal isolates were obtained from 9 patients &#40;8 males with a median age of 65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 years&#41; characterized by nonspecific symptoms &#40;respiratory failure and dyspnea&#41;&#44; a 5-week mortality rate of 50&#37;&#44; and long hospital stays &#40;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24 days&#41;&#46; Seven yeasts &#40;2 non-<span class="elsevierStyleItalic">Candida albicans</span> species&#41; and 3 <span class="elsevierStyleItalic">Aspergillus fumigatus</span> &#40;<span class="elsevierStyleItalic">A&#46; fumigatus</span>&#41; were isolated&#44; and no resistance was documented&#46; The total rate of antifungal therapy was 55&#37;&#44; the most common being azole derivatives&#44; and the least common&#44; caspofungin or inhaled liposomal amphotericin B&#46; None of the patients had received antifungal prophylaxis prior to the study episode&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> lists the risk factors for fungal infection identified in each patient and the species isolated in each case&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">As in other series with larger numbers of cases&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a> the causative agents associated with fungal empyema that presented a slightly lower mortality rate in our series were <span class="elsevierStyleItalic">Candida</span> spp&#46; followed by <span class="elsevierStyleItalic">A&#46; fumigatus</span>&#46; All patients except one had 1 or more previous immunodeficiency diseases according to the accepted classifications<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a>&#58; cancer&#44; diabetes mellitus&#44; long-term steroid treatment&#44; hepatic cirrhosis&#44; solid organ transplant&#44; alcoholism&#44; human immunodeficiency virus infection&#44; or surgery in the 4 weeks prior to isolation of the fungus&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Clinical suspicion&#44; chest drainage&#44; early introduction of antifungal agents&#44; and long-term treatment are associated with a reduced mortality rate&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> However&#44; the treatment of fungal empyema is not protocolized&#44; and combinations that include several drugs can be used &#40;amphotericin B and voriconazole&#44; echinocandins&#41; due the variable penetration of systemically administered antifungals into the pleural cavity&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#44;4</span></a> The percentage of patients treated with broad-spectrum antibiotic therapy was higher than that of patients treated with antifungal drugs&#44; despite determination of the etiology&#44; and no subsequent antibiotic de-escalation was performed&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The lack of specific antifungal treatment may be due to clinicians&#8217; failure to consider fungi as true pathogens&#46; Each case must be studied on an individual basis and the role of each causative agent must be evaluated in order to optimize treatment&#46; This includes the need for pharmacological prophylaxis in patients at high risk of developing fungal empyema &#40;hemodialysis&#44; post-surgical re-exploration&#44; environmental colonization by <span class="elsevierStyleItalic">Aspergillus</span>&#44; or documented cytomegalovirus infection&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The seriousness of this entity and its devastating consequences in patients should not be underestimated&#46;</p></span>"
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                            0 => "S&#46;C&#46; Ko"
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                            2 => "P&#46;R&#46; Hsueh"
                            3 => "K&#46;T&#46; Luh"
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Article information
ISSN: 15792129
Original language: English
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