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Letter to the Editor
Primary Lung Adenocarcinoma With Enteric Morphology Associated With Primary Colon Adenocarcinoma
Adenocarcinoma primario de pulmón con morfología entérica asociado a un adenocarcinoma primario de colon
Mohammed-Massine El Hammoumia,c,
Corresponding author
hamoumimassine@hotmail.fr

Corresponding author.
, Reda El Ochib, El Hassane Kabiria,c
a Servicio de Cirugía Torácica, Mohamed V Military University Hospital, Rabat, Morocco
b Servicio de Anatomía Patológica, Mohamed V Military University Hospital, Rabat, Morocco
c Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Primary lung adenocarcinoma with enteric morphology is an extremely rare variant of primary invasive adenocarcinoma&#46; It is characterized by predominant colorectal-like components &#40;&#62;50&#37;&#41; and the tumor cells must be negative for all immunohistochemical enteric differentiation markers&#44; such as CK20&#44; CDX2&#44; and mucin 2 &#40;MUC2&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report an exceptional case of a lung adenocarcinoma with enteric morphology associated with a primary colon adenocarcinoma&#46; To our knowledge&#44; no similar case has been reported in the literature&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A 50-year-old man presented 2 months previously with severe anemia&#46; Colonoscopy revealed moderately differentiated colon adenocarcinoma of the right colon with positive cytokeratine CK 7 and CK 20 and negative TTF-1 &#40;thyroid transcription factor 1&#41; on immunohistochemistry&#46; Surgical resection of the digestive tumor&#44; classified as T3N0M0&#44; was performed through right colectomy and ileo-transverse side-to-side anastomosis&#46; Simultaneously&#44; in the lung&#44; chest computed tomography revealed a 3&#46;5<span class="elsevierStyleHsp" style=""></span>cm mass in the right lower lobe&#46; Scan-guided biopsy showed a primitive lung adenocarcinoma with positive TTF-1 in the right lower lobe&#46; The lung tumor was classified as T2N0M0&#46; A lower right lobectomy with lymphadenectomy was performed successfully&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Morphologically&#44; the lung tumor was described as whitish or gray-white with some focal areas of hemorrhage and necrosis&#46; Histologically&#44; prominent components of colorectal carcinoma-like glands with typical papillary structures were observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#44; b&#41;&#46; On immunohistochemistry&#44; anti-CK 7 and TTF-1 were positive&#46; Anti-CK20 antibody&#44; MUC2 and CDX2 were negative &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>c&#41;&#46; Resected lymph nodes were negative for malignancy&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The patient did not receive adjuvant therapy and progress was uneventful until the ninth month&#44; when he presented with isolated sternal metastasis from the surgically resected lung adenocarcinoma&#46; Scheduled chemotherapy was reasonably well tolerated and toxicity was minimal&#46; He continues to progress well after 6 months&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">When lung tumor cells are negative for any intestinal protein markers&#44; the entity is called &#8220;lung adenocarcinoma with enteric morphology&#8221;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Other morphological types&#44; including the lepidic pattern&#44; can suggest a differential diagnosis of colon cancer&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">On immunohistochemistry&#44; anti-CK7 is generally positive&#46; TTF-1 is positive in 50&#37; of cases&#46; Enteric differentiation is confirmed by positivity of at least 1 of the following markers&#58; CK20&#44; CDX2 and MUC2&#46; If these 3 markers are negative&#44; morphology is considered enteric&#46; Other markers such as villin can be useful&#46; Therefore&#44; no EGFR&#44; K-Ras and ALK gene mutation has ever been reported&#44; in contrast to colon adenocarcinoma and other subtypes of lung adenocarcinoma<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In our particular case&#44; the first challenge was to differentiate the primary lung adenocarcinoma with enteric morphology from colon adenocarcinoma metastasis&#46; Meticulous&#44; repeated examinations were performed and second opinions were obtained by the pathology team&#46; The second challenge was the therapeutic strategy or the use of chemotherapy in the postoperative course&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">This association causes problems for diagnosing lung adenocarcinoma with enteric morphology&#44; especially in cases where the immunohistochemical study would be superimposed on that of pulmonary metastasis of colon adenocarcinoma&#44; and offers opportunities for molecular diagnostics&#44; such as EGFR mutation&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; El Hammoumi M&#46;-M&#46;&#44; El Ochi R&#46;&#44; Kabiri E&#46;H&#46; Adenocarcinoma primario de pulm&#243;n con morfolog&#237;a ent&#233;rica asociado a un adenocarcinoma primario de colon&#46; Arch Bronconeumol&#46; 2016&#59;52&#58;221&#46;</p>"
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ISSN: 15792129
Original language: English
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