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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO assess the prognostic value of a series of clinicopathological variables in stage I nonsmall cell lung cancer&#44; for tumors up to 3 cm in diameter&#46;</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p class="elsevierStyleSimplePara elsevierViewall">The study included 271 patients&#46; Survival was analyzed with the Kaplan-Meier method&#46; The Cox model was used for multivariate analysis&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Five- and ten-year survival were 78&#46;63&#37; and 67&#46;59&#37;&#44; respectively&#46; Survival did not significantly depend on sex&#44; age&#44; extent of resection&#44; histology&#44; visceral pleural invasion&#44; level of bronchial invasion or T1 versus T2&#46; The decade in which resection was performed did affect survival &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;0037&#41;&#46; Five-year survival was 58&#37; for operations between 1970 and 1980&#44; 77&#37; for operations between 1981 and 1990&#44; and 84&#37; for operations between 1991 and 2000&#46; Tumor size also affected survival &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;0046&#41;&#44; which was 86&#37; for patients with tumors of less than or equal to 2 cm in diameter and 73&#37; for those with tumors of more than 2 cm in diameter&#46; In the multivariate analysis both variables entered into regression&#44; remaining predictive of survival&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">We found evidence for a prognostic stage migration &#40;Will Rogers phenomenon&#41; according to the decade in which resection was performed and that tumor size affected survival in our population&#46; Finally&#44; the current system of TNM staging fails in conforming groups of patients with a homogenous prognosis&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Valorar el papel pron&#243;stico de una serie de variables cl&#237;nico-patol&#243;gicas en el carcinoma broncog&#233;nico no anapl&#225;sico de c&#233;lulas peque&#241;as con un tama&#241;o m&#225;ximo de 3 cm y clasificado en estadio I&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes Y M&#233;todo</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 271 pacientes&#46; La supervivencia se analiz&#243; con el m&#233;todo de Kaplan-Meier&#46; Para el an&#225;lisis multivariante se utiliz&#243; el modelo de Cox&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La supervivencia fue del 78&#44;63 y el 67&#44;59&#37; a los 5 y 10 a&#241;os&#44; respectivamente&#46; El sexo&#44; la edad&#44; la amplitud de ex&#233;resis&#44; la estirpe histol&#243;gica&#44; la invasi&#243;n de la pleura visceral&#44; el grado de invasi&#243;n bronquial y T1-T2 no influyeron significativamente en la supervivencia&#46; La d&#233;cada en que el paciente fue operado condicion&#243; la supervivencia &#40;p &#61; 0&#44;0037&#41;&#44; que a los 5 a&#241;os fue del 58&#37; para los intervenidos entre 1970 y 1980&#44; del 77&#37; para los operados entre 1981 y 1990 y del 84&#37; para los sometidos a la intervenci&#243;n entre 1991 y 2000&#46; El tama&#241;o tumoral tambi&#233;n condicion&#243; la supervivencia &#40;p &#61; 0&#44;0046&#41;&#44; que fue del 86&#37; para los pacientes con tumores con un di&#225;metro inferior o igual a 2 cm y del 73&#37; para los que ten&#237;an tumores con di&#225;metro de m&#225;s de 2 cm&#46; Ambas variables entraron en regresi&#243;n cuando se utiliz&#243; el an&#225;lisis multivariante&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos comprobado una migraci&#243;n pron&#243;stica &#40;fen&#243;meno de Will Rogers&#41; en relaci&#243;n con la d&#233;cada en que el paciente fue operado &#40;<span class="elsevierStyleItalic">time trend</span>&#41; y que el tama&#241;o tumoral condicion&#243; la supervivencia de nuestra serie&#46; Por &#250;ltimo&#44; el sistema vigente de estadificaci&#243;n TNM es deficiente en la configuraci&#243;n de grupos de pacientes con un pron&#243;stico homog&#233;neo&#46;</p>"
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Original Articles
Stage I Nonsmall Cell Lung Cancer up to 3 cm in Diameter: Prognostic Factors
J. Padilla
Corresponding author
jpadilla@comv.es

Correspondence: Dr. J. Padilla Alarcón. Servicio de Cirugía Torácica. Hospital Universitario La Fe. Avda. de Campanar, 21. 46009 Valencia. España
, V. Calvo, J.C. Peñalver, C. Jordá, J. Escrivá, A. García Zarza, J. Pastor, E. Blasco
Servicio de Cirugía Torácica, Hospital Universitario La Fe, Valencia, Spain
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Article information
ISSN: 15792129
Original language: English
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