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                    0 => array:2 [
                      "titulo" => "Changes in heroin self administration by rhesus monkey after morphine immunization"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "KF Bonese"
                            1 => "BH Wainer"
                            2 => "FW Fitch"
                            3 => "RM Rothberg"
                            4 => "CR Shuster"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1974"
                        "volumen" => "252"
                        "paginaInicial" => "708"
                        "paginaFinal" => "710"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4474602"
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                          ]
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                ]
              ]
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              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of passive immunization against morphine on heroin administration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A Killian"
                            1 => "K Bonese"
                            2 => "RM Rothberg"
                            3 => "BH Wainer"
                            4 => "CR Schuster"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacol Biochem Behav&#46;"
                        "fecha" => "1978"
                        "volumen" => "9"
                        "paginaInicial" => "347"
                        "paginaFinal" => "352"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/101989"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La vacuna antinicotina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "JI Granda Orive"
                            1 => "S Solano Reina"
                            2 => "CA Jim&#233;nez Ruiz"
                            3 => "T Guti&#233;rrez Jim&#233;nez"
                            4 => "JM Mart&#237;nez Albiach"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Otoneumoalergia Pr&#225;ctica"
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                        "volumen" => "12"
                        "paginaInicial" => "20"
                        "paginaFinal" => "24"
                      ]
                    ]
                  ]
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              ]
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              "etiqueta" => "4"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Suppression of psychoactive effects of cocaine by active immunization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "MRA Carrera"
                            1 => "JA Ashley"
                            2 => "LH Parsons"
                            3 => "P Wirsching"
                            4 => "GF Koob"
                            5 => "KD Janda"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1038/378727a0"
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                        "tituloSerie" => "Nature"
                        "fecha" => "1995"
                        "volumen" => "378"
                        "paginaInicial" => "727"
                        "paginaFinal" => "730"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7501020"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of a therapeutic cocaine vaccine in rodent models"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "BS Fox"
                            1 => "KM Kantak"
                            2 => "MA Edwards"
                            3 => "KM Black"
                            4 => "BK B&#246;llinger"
                            5 => "AJ Botka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature Medicine"
                        "fecha" => "1996"
                        "volumen" => "2"
                        "paginaInicial" => "1129"
                        "paginaFinal" => "1132"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8837612"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib7"
              "etiqueta" => "7"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Altered disposition of repeated nicotine doses in rats immunized against nicotine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "DA Keyler"
                            1 => "Y Hieda"
                            2 => "JS Peter"
                            3 => "PR Pentel"
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                        ]
                      ]
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                  ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Nicotine Tob Res&#46;"
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                        "paginaInicial" => "241"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11072421"
                            "web" => "Medline"
                          ]
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                  ]
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                          "autores" => array:6 [
                            0 => "Y Hieda"
                            1 => "DE Keyler"
                            2 => "JT Vandervoort"
                            3 => "JK Kane"
                            4 => "CA Ross"
                            5 => "DE Raphael"
                          ]
                        ]
                      ]
                    ]
                  ]
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                      "Revista" => array:5 [
                        "tituloSerie" => "J Pharmacol Experimental Ther&#46;"
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                        "paginaInicial" => "1076"
                        "paginaFinal" => "1081"
                      ]
                    ]
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                          "autores" => array:5 [
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                            1 => "DE Keyler"
                            2 => "S Ennifar"
                            3 => "A Fattom"
                            4 => "PR Pentel"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "paginaInicial" => "809"
                        "paginaFinal" => "819"
                      ]
                    ]
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                0 => array:2 [
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                      "titulo" => "A nicotine conjugate vaccine reduces nicotine distribution to brain and attenuates its behavioral and cardiovascular effects in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "DH Malin"
                            2 => "S Ennifar"
                            3 => "Y Hieda"
                            4 => "DE Keyler"
                            5 => "JR Lake"
                          ]
                        ]
                      ]
                    ]
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                      ]
                    ]
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                          "autores" => array:6 [
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                            2 => "G Kalayanov"
                            3 => "S Gordon"
                            4 => "AM Johansson"
                            5 => "TH Svensson"
                          ]
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                        "paginaInicial" => "254"
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                        "link" => array:1 [
                          0 => array:2 [
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                            2 => "G Kalayanov"
                            3 => "S Gordon"
                            4 => "A Malmerfelt"
                            5 => "AM Johansson"
                          ]
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                            2 => "A Lin"
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                            5 => "ML Irvin"
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                ]
              ]
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                ]
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                0 => array:1 [
                  "referenciaCompleta" => "Lindmayer K&#44; Horwith G&#44; Fattom A&#44; Naso R&#44; Fuller S&#44; Muenz L&#44; et al&#46; Results of a phase 1&#44; double blinded&#44; controlled safety and immunogenicity trial of NICVAXTM&#44; a conjugated nicotine vaccine&#46; Proceedings of IV European Conference of the Society for Research on Nicotine and Tobacco &#40;SRNT&#41;&#59; 2002&#44; O ctober&#59; Santander&#46;"
                ]
              ]
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                ]
              ]
            ]
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              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of vaccines to help treat drug dependence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "CJ Bunce"
                            1 => "PT Loudon"
                            2 => "C Akers"
                            3 => "J Dobson"
                            4 => "DM Wood"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Mol Ther&#46;"
                        "fecha" => "2003"
                        "volumen" => "5"
                        "paginaInicial" => "58"
                        "paginaFinal" => "63"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12669472"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tissue dependent effects of immunization with a nicotine conjugate vaccine on the distribution of nicotine in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "SD Satoskar"
                            1 => "DE Keyler"
                            2 => "MG le Sage"
                            3 => "DE Raphael"
                            4 => "C Ross"
                            5 => "PR Pentel"
                          ]
                        ]
                      ]
                    ]
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                      "doi" => "10.1016/S1567-5769(03)00094-8"
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                        "fecha" => "2003"
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                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A vaccine for nicotine dependence&#58; targeting the drug rather than the brain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P Pentel"
                            1 => "D Malin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "63617"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "2002"
                        "volumen" => "69"
                        "paginaInicial" => "193"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12097758"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preclinical development of a vaccine against smoking"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "EH Cerny"
                            1 => "R L&#233;vy"
                            2 => "J Mauel"
                            3 => "M Mpandi"
                            4 => "M Mutter"
                            5 => "C Henzelin-Nkubana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "67433"
                      "Revista" => array:6 [
                        "tituloSerie" => "Onkologie"
                        "fecha" => "2002"
                        "volumen" => "25"
                        "paginaInicial" => "406"
                        "paginaFinal" => "411"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12415193"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunization to nicotine with a peptide-based vaccine composed of a conformationally biased agonist of C5a as a molecular adjuvant"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "SD Sanderson"
                            1 => "SR Cheruku"
                            2 => "MP Padmanilayam"
                            3 => "JL Vennerstrom"
                            4 => "GM Thiele"
                            5 => "MI Palmatier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Immunopharmacol&#46;"
                        "fecha" => "2003"
                        "volumen" => "3"
                        "paginaInicial" => "137"
                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12538044"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Investigation using immunization to attenuate the psychoactive effects of nicotine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "MRA Carrera"
                            1 => "JA Ashley"
                            2 => "TZ Hoffman"
                            3 => "S Isomura"
                            4 => "P Wirsching"
                            5 => "GF Koob"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bioorg Med Chem&#46;"
                        "fecha" => "2004"
                        "volumen" => "12"
                        "paginaInicial" => "563"
                        "paginaFinal" => "570"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14738965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition of cytochrome P450 2A6 increases nicotine&#39;s oral bioavailability and decreases smoking"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "EM Sellers"
                            1 => "HL Kaplan"
                            2 => "RF Tyndale"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mcp.2000.107651"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Pharmacol Ther&#46;"
                        "fecha" => "2000"
                        "volumen" => "68"
                        "paginaInicial" => "35"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10945314"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new strategy for improved nicotine vaccines using conformationally constrained haptens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "MM Meijler"
                            1 => "M Matsushita"
                            2 => "LJ Altobell"
                            3 => "P Wirsching"
                            4 => "KD Janda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1021/ja034805t"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Chem Soc&#46;"
                        "fecha" => "2003"
                        "volumen" => "125"
                        "paginaInicial" => "7164"
                        "paginaFinal" => "7165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12797775"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Respiratory Reviews&#46;com&#46; New approaches to smoking cessation show promise"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "Available from http&#58;&#47;&#47;www&#46;respiratoryreviews&#46;com&#47;mar01&#47;rr&#95;cessation&#46;html"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prospects for immunotherapy in smoking cessation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W Hall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(02)11134-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
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                        "volumen" => "360"
                        "paginaInicial" => "1089"
                        "paginaFinal" => "1091"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12384004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vaccines against nicotine&#58; how effective are they likely to be in preventing smoking&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "FJ Vocci"
                            1 => "CN Chiang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "CNS Drugs"
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                        "paginaInicial" => "505"
                        "paginaFinal" => "514"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11510621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Maternal vaccination against nicotine reduces nicotine distribution to fetal brain in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "DE Keyler"
                            1 => "D Shoeman"
                            2 => "MG Lessge"
                            3 => "AD Calvin"
                            4 => "PR Pentel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1124/jpet.102.046805"
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                        "tituloSerie" => "J Pharmacol Exp Ther&#46;"
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                        "link" => array:1 [
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Editorial
When Will the Nicotine Vaccine Be Ready?
J.I. de Granda Orive
Corresponding author
igo01m@saludalia.com

Correspondence: Dr. J.I. de Granda Orive. Cavanilles, 43, 7.° E. 28007 Madrid. España
Servicio de Neumología, Hospital General Básico de la Defensa de Valencia, Valencia, Spain
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      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in heroin self administration by rhesus monkey after morphine immunization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "KF Bonese"
                            1 => "BH Wainer"
                            2 => "FW Fitch"
                            3 => "RM Rothberg"
                            4 => "CR Shuster"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1974"
                        "volumen" => "252"
                        "paginaInicial" => "708"
                        "paginaFinal" => "710"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4474602"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of passive immunization against morphine on heroin administration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A Killian"
                            1 => "K Bonese"
                            2 => "RM Rothberg"
                            3 => "BH Wainer"
                            4 => "CR Schuster"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacol Biochem Behav&#46;"
                        "fecha" => "1978"
                        "volumen" => "9"
                        "paginaInicial" => "347"
                        "paginaFinal" => "352"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/101989"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La vacuna antinicotina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "JI Granda Orive"
                            1 => "S Solano Reina"
                            2 => "CA Jim&#233;nez Ruiz"
                            3 => "T Guti&#233;rrez Jim&#233;nez"
                            4 => "JM Mart&#237;nez Albiach"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Otoneumoalergia Pr&#225;ctica"
                        "fecha" => "2003"
                        "volumen" => "12"
                        "paginaInicial" => "20"
                        "paginaFinal" => "24"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Granda Orive JI&#46; El tabaquismo como enfermedad adictiva cr&#243;nica&#46; In&#58; Jim&#233;nez Ruiz CA&#44; Fagerstr&#246;m K&#44; editors&#46; Tratado de tabaquismo&#46; Grupo Aula M&#233;dica&#46; In press&#46; 2004&#46;"
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suppression of psychoactive effects of cocaine by active immunization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "MRA Carrera"
                            1 => "JA Ashley"
                            2 => "LH Parsons"
                            3 => "P Wirsching"
                            4 => "GF Koob"
                            5 => "KD Janda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/378727a0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1995"
                        "volumen" => "378"
                        "paginaInicial" => "727"
                        "paginaFinal" => "730"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7501020"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of a therapeutic cocaine vaccine in rodent models"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "BS Fox"
                            1 => "KM Kantak"
                            2 => "MA Edwards"
                            3 => "KM Black"
                            4 => "BK B&#246;llinger"
                            5 => "AJ Botka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature Medicine"
                        "fecha" => "1996"
                        "volumen" => "2"
                        "paginaInicial" => "1129"
                        "paginaFinal" => "1132"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8837612"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Altered disposition of repeated nicotine doses in rats immunized against nicotine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "DA Keyler"
                            1 => "Y Hieda"
                            2 => "JS Peter"
                            3 => "PR Pentel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nicotine Tob Res&#46;"
                        "fecha" => "1999"
                        "volumen" => "1"
                        "paginaInicial" => "241"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11072421"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Active immunization alters the plasma nicotine concentration in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y Hieda"
                            1 => "DE Keyler"
                            2 => "JT Vandervoort"
                            3 => "JK Kane"
                            4 => "CA Ross"
                            5 => "DE Raphael"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Pharmacol Experimental Ther&#46;"
                        "fecha" => "1997"
                        "volumen" => "283"
                        "paginaInicial" => "1076"
                        "paginaFinal" => "1081"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vaccination against nicotine during continued nicotine administration in rats&#58; immunogenicity of the vaccine and effects on nicotine distribution to brain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y Hieda"
                            1 => "DE Keyler"
                            2 => "S Ennifar"
                            3 => "A Fattom"
                            4 => "PR Pentel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Inmunopharmacol&#46;"
                        "fecha" => "2000"
                        "volumen" => "22"
                        "paginaInicial" => "809"
                        "paginaFinal" => "819"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A nicotine conjugate vaccine reduces nicotine distribution to brain and attenuates its behavioral and cardiovascular effects in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "PR Pentel"
                            1 => "DH Malin"
                            2 => "S Ennifar"
                            3 => "Y Hieda"
                            4 => "DE Keyler"
                            5 => "JR Lake"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pharmacol Biochem Behv&#46;"
                        "fecha" => "2000"
                        "volumen" => "65"
                        "paginaInicial" => "191"
                        "paginaFinal" => "198"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Active immunization against nicotine prevents reinstatement of nicotine-seeking behavior in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N Lindblom"
                            1 => "SHL de Villiers"
                            2 => "G Kalayanov"
                            3 => "S Gordon"
                            4 => "AM Johansson"
                            5 => "TH Svensson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "63629"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "2002"
                        "volumen" => "69"
                        "paginaInicial" => "254"
                        "paginaFinal" => "260"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12097770"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Active immunization against nicotine-induced dopamine release in the rats nucleus accumbens shell"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "SHL de Villiers"
                            1 => "N Lindhom"
                            2 => "G Kalayanov"
                            3 => "S Gordon"
                            4 => "A Malmerfelt"
                            5 => "AM Johansson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "63628"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "2002"
                        "volumen" => "69"
                        "paginaInicial" => "247"
                        "paginaFinal" => "253"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12097769"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Passive immunization against nicotine prevents nicotine alleviation of nicotine abstinence syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "DH Malin"
                            1 => "JR Lake"
                            2 => "A Lin"
                            3 => "M Saldana"
                            4 => "L Balch"
                            5 => "ML Irvin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacol Biochem Behav&#46;"
                        "fecha" => "2001"
                        "volumen" => "68"
                        "paginaInicial" => "87"
                        "paginaFinal" => "92"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11274712"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "TA-NIC nicotine vaccine"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "Available from www&#46;xenova&#46;co&#46;uk&#47;dc&#95;ta&#95;nic&#46;html"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Clair Roberts JS&#44; Dobson J&#44; Wood D&#44; Settles M&#46; Safety and immunogenicity of nicotine conjugate vaccine&#46; Proceedings of Annual Meeting of the College on Problems of Drug Dependence CPDD&#59; 2002&#44; June&#59; Quebec City&#46;"
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Clair Roberts JS&#44; Akers CVR&#44; Vanhinsbergh L&#44; McKenna KA&#44; Wood DM&#44; Jack L&#44; et al&#46; Longitudinal safety and immunogenicity data of TA-NIC&#44; a novel nicotine vaccine&#46; Proceedings of Annual Meeting of the Society for Research on Nicotine and Tobacco &#40;SRNT&#41;&#59; 2003&#44; November&#59; Padua&#46;"
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Lindmayer K&#44; Horwith G&#44; Fattom A&#44; Naso R&#44; Fuller S&#44; Muenz L&#44; et al&#46; Results of a phase 1&#44; double blinded&#44; controlled safety and immunogenicity trial of NICVAXTM&#44; a conjugated nicotine vaccine&#46; Proceedings of IV European Conference of the Society for Research on Nicotine and Tobacco &#40;SRNT&#41;&#59; 2002&#44; O ctober&#59; Santander&#46;"
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Lindmayer K&#44; Horwith G&#44; Fattom A&#44; Naso R&#44; Fuller S&#44; Muenz L&#44; et al&#46; Results of a phase 1&#44; double blinded&#44; controlled safety and immunogenicity trial of NICVAXTM&#44; a conjugated nicotine vaccine&#46; Proceedings of IV European Conference of the Society for Research on Nicotine and Tobacco &#40;SRNT&#41;&#59; 2003&#44; November&#59; Padua&#46;"
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of vaccines to help treat drug dependence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "CJ Bunce"
                            1 => "PT Loudon"
                            2 => "C Akers"
                            3 => "J Dobson"
                            4 => "DM Wood"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Mol Ther&#46;"
                        "fecha" => "2003"
                        "volumen" => "5"
                        "paginaInicial" => "58"
                        "paginaFinal" => "63"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12669472"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tissue dependent effects of immunization with a nicotine conjugate vaccine on the distribution of nicotine in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "SD Satoskar"
                            1 => "DE Keyler"
                            2 => "MG le Sage"
                            3 => "DE Raphael"
                            4 => "C Ross"
                            5 => "PR Pentel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1567-5769(03)00094-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Immunopharmacol&#46;"
                        "fecha" => "2003"
                        "volumen" => "3"
                        "paginaInicial" => "957"
                        "paginaFinal" => "970"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12810353"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A vaccine for nicotine dependence&#58; targeting the drug rather than the brain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P Pentel"
                            1 => "D Malin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "63617"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "2002"
                        "volumen" => "69"
                        "paginaInicial" => "193"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12097758"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preclinical development of a vaccine against smoking"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "EH Cerny"
                            1 => "R L&#233;vy"
                            2 => "J Mauel"
                            3 => "M Mpandi"
                            4 => "M Mutter"
                            5 => "C Henzelin-Nkubana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "67433"
                      "Revista" => array:6 [
                        "tituloSerie" => "Onkologie"
                        "fecha" => "2002"
                        "volumen" => "25"
                        "paginaInicial" => "406"
                        "paginaFinal" => "411"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12415193"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunization to nicotine with a peptide-based vaccine composed of a conformationally biased agonist of C5a as a molecular adjuvant"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "SD Sanderson"
                            1 => "SR Cheruku"
                            2 => "MP Padmanilayam"
                            3 => "JL Vennerstrom"
                            4 => "GM Thiele"
                            5 => "MI Palmatier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Immunopharmacol&#46;"
                        "fecha" => "2003"
                        "volumen" => "3"
                        "paginaInicial" => "137"
                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12538044"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Investigation using immunization to attenuate the psychoactive effects of nicotine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "MRA Carrera"
                            1 => "JA Ashley"
                            2 => "TZ Hoffman"
                            3 => "S Isomura"
                            4 => "P Wirsching"
                            5 => "GF Koob"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bioorg Med Chem&#46;"
                        "fecha" => "2004"
                        "volumen" => "12"
                        "paginaInicial" => "563"
                        "paginaFinal" => "570"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14738965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition of cytochrome P450 2A6 increases nicotine&#39;s oral bioavailability and decreases smoking"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "EM Sellers"
                            1 => "HL Kaplan"
                            2 => "RF Tyndale"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mcp.2000.107651"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Pharmacol Ther&#46;"
                        "fecha" => "2000"
                        "volumen" => "68"
                        "paginaInicial" => "35"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10945314"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new strategy for improved nicotine vaccines using conformationally constrained haptens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "MM Meijler"
                            1 => "M Matsushita"
                            2 => "LJ Altobell"
                            3 => "P Wirsching"
                            4 => "KD Janda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1021/ja034805t"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Chem Soc&#46;"
                        "fecha" => "2003"
                        "volumen" => "125"
                        "paginaInicial" => "7164"
                        "paginaFinal" => "7165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12797775"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Respiratory Reviews&#46;com&#46; New approaches to smoking cessation show promise"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "Available from http&#58;&#47;&#47;www&#46;respiratoryreviews&#46;com&#47;mar01&#47;rr&#95;cessation&#46;html"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prospects for immunotherapy in smoking cessation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W Hall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(02)11134-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2002"
                        "volumen" => "360"
                        "paginaInicial" => "1089"
                        "paginaFinal" => "1091"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12384004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vaccines against nicotine&#58; how effective are they likely to be in preventing smoking&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "FJ Vocci"
                            1 => "CN Chiang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "CNS Drugs"
                        "fecha" => "2001"
                        "volumen" => "15"
                        "paginaInicial" => "505"
                        "paginaFinal" => "514"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11510621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Maternal vaccination against nicotine reduces nicotine distribution to fetal brain in rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "DE Keyler"
                            1 => "D Shoeman"
                            2 => "MG Lessge"
                            3 => "AD Calvin"
                            4 => "PR Pentel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1124/jpet.102.046805"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pharmacol Exp Ther&#46;"
                        "fecha" => "2003"
                        "volumen" => "305"
                        "paginaInicial" => "587"
                        "paginaFinal" => "592"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12606612"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
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ISSN: 15792129
Original language: English
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