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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Exhaled breath condensate represents an alternative to bronchoalveolar lavage for the analysis of markers of inflammation and oxidative stress in patients with adult respiratory distress syndrome &#40;ARDS&#41;&#46; However&#44; analysis of hydrogen peroxide &#40;H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span>&#41; yields variable results that do not correlate with severity of the clinical presentation&#46; In an attempt to explain this variability&#44; the aim of the present study was to assess the possible limitations of the most commonly used technique for analyzing H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> in breath condensate&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> levels were analyzed using the Gallati technique &#40;linear range between 0&#46;3 and 10 &#956;M&#44; <span class="elsevierStyleItalic">r</span> &#61; 0&#46;99&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41; in serial samples of condensate taken from the expiratory tube of a mechanical ventilator in 6 patients with ARDS&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The volume of condensate obtained correlated to minute ventilation &#40;<span class="elsevierStyleItalic">r</span> &#61; 0&#46;96&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46; In 11 out of 23 samples&#44; a spectrophotometer reading was obtained at 450 nm despite the absence of the characteristic color of the reaction and in some of these samples a spontaneous reading was obtained that was indicative of contamination&#46; The absorbance spectrum of these samples did not contain the characteristic peak for H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> at 450 nm and pretreatment of some samples with catalase did not affect the absorbance at 450 nm&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The spectrophotometric method commonly used to measure H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> levels in breath condensate lacks specificity in ARDS due to the presence of variable levels of contaminants in the samples&#44; which lead to false positives&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El condensado del aire espirado es una alternativa al lavado broncoalveolar para estudiar marcadores de inflamaci&#243;n y estr&#233;s oxidativo en pacientes con s&#237;ndrome de distr&#233;s respiratorio del adulto &#40;SDRA&#41;&#46; Sin embargo&#44; el estudio del per&#243;xido de hidr&#243;geno &#40;H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span>&#41; ofrece resultados variables que no se relacionan con la gravedad del cuadro cl&#237;nico&#46; El objetivo del presente estudio ha sido identificar las posibles limitaciones de la t&#233;cnica m&#225;s utilizada para medir el H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> en condensado que expliquen esta variabilidad&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se analizaron muestras seriadas de condensado de la v&#237;a espiratoria del ventilador de 6 pacientes con SDRA mediante la t&#233;cnica de Gallati &#40;lineal entre 0&#44;3-10 &#956;M&#44; r &#61; 0&#44;99&#59; p &#60; 0&#44;05&#41; para H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span>&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El volumen de condensado se relacion&#243; con la ventilaci&#243;n minuto &#40;r &#61; 0&#44;96&#59; p &#60; 0&#44;05&#41;&#46; En 11 de 23 muestras se obtuvo lectura a 450 nm sin el color caracter&#237;stico de la reacci&#243;n y en algunas se obtuvo tambi&#233;n lectura espont&#225;nea indicativa de contaminantes&#46; El espectro de absorci&#243;n de estas muestras no mostr&#243; el pico caracter&#237;stico del H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> a 450 nm y el pretratamiento de algunas muestras con catalasa no modific&#243; la absorbancia a 450 nm&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El m&#233;todo espectrofotom&#233;trico frecuentemente empleado para medir el H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> en condensado es inespec&#237;fico en el SDRA por la presencia en las muestras de cantidades variables de contaminantes que determinan falsos positivos&#46;</p>"
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Original Articles
Limitations of the Technique to Determine Hydrogen Peroxide Levels in Exhaled Breath Condensate From Patients With Adult Respiratory Distress Syndrome
A. Bruhn, L. Liberona, C. Lisboa, G. Borzone
Corresponding author
gborzone@med.puc.cl

Correspondence: Dra. G. Borzone. Departamento de Enfermedades Respiratorias. Pontificia Universidad Católica de Chile. Marcoleta, 345, 4.°. Santiago de Chile. Chile
Programa de Doctorado en Ciencias Médicas, Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Exhaled breath condensate represents an alternative to bronchoalveolar lavage for the analysis of markers of inflammation and oxidative stress in patients with adult respiratory distress syndrome &#40;ARDS&#41;&#46; However&#44; analysis of hydrogen peroxide &#40;H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span>&#41; yields variable results that do not correlate with severity of the clinical presentation&#46; In an attempt to explain this variability&#44; the aim of the present study was to assess the possible limitations of the most commonly used technique for analyzing H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> in breath condensate&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> levels were analyzed using the Gallati technique &#40;linear range between 0&#46;3 and 10 &#956;M&#44; <span class="elsevierStyleItalic">r</span> &#61; 0&#46;99&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41; in serial samples of condensate taken from the expiratory tube of a mechanical ventilator in 6 patients with ARDS&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The volume of condensate obtained correlated to minute ventilation &#40;<span class="elsevierStyleItalic">r</span> &#61; 0&#46;96&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46; In 11 out of 23 samples&#44; a spectrophotometer reading was obtained at 450 nm despite the absence of the characteristic color of the reaction and in some of these samples a spontaneous reading was obtained that was indicative of contamination&#46; The absorbance spectrum of these samples did not contain the characteristic peak for H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> at 450 nm and pretreatment of some samples with catalase did not affect the absorbance at 450 nm&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The spectrophotometric method commonly used to measure H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> levels in breath condensate lacks specificity in ARDS due to the presence of variable levels of contaminants in the samples&#44; which lead to false positives&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El condensado del aire espirado es una alternativa al lavado broncoalveolar para estudiar marcadores de inflamaci&#243;n y estr&#233;s oxidativo en pacientes con s&#237;ndrome de distr&#233;s respiratorio del adulto &#40;SDRA&#41;&#46; Sin embargo&#44; el estudio del per&#243;xido de hidr&#243;geno &#40;H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span>&#41; ofrece resultados variables que no se relacionan con la gravedad del cuadro cl&#237;nico&#46; El objetivo del presente estudio ha sido identificar las posibles limitaciones de la t&#233;cnica m&#225;s utilizada para medir el H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> en condensado que expliquen esta variabilidad&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se analizaron muestras seriadas de condensado de la v&#237;a espiratoria del ventilador de 6 pacientes con SDRA mediante la t&#233;cnica de Gallati &#40;lineal entre 0&#44;3-10 &#956;M&#44; r &#61; 0&#44;99&#59; p &#60; 0&#44;05&#41; para H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span>&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El volumen de condensado se relacion&#243; con la ventilaci&#243;n minuto &#40;r &#61; 0&#44;96&#59; p &#60; 0&#44;05&#41;&#46; En 11 de 23 muestras se obtuvo lectura a 450 nm sin el color caracter&#237;stico de la reacci&#243;n y en algunas se obtuvo tambi&#233;n lectura espont&#225;nea indicativa de contaminantes&#46; El espectro de absorci&#243;n de estas muestras no mostr&#243; el pico caracter&#237;stico del H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> a 450 nm y el pretratamiento de algunas muestras con catalasa no modific&#243; la absorbancia a 450 nm&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El m&#233;todo espectrofotom&#233;trico frecuentemente empleado para medir el H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span> en condensado es inespec&#237;fico en el SDRA por la presencia en las muestras de cantidades variables de contaminantes que determinan falsos positivos&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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2017 July 3 10 13
2017 June 4 24 28
2017 May 6 13 19
2017 April 0 6 6
2017 March 4 27 31
2017 February 2 2 4
2017 January 3 6 9
2016 December 7 6 13
2016 November 9 7 16
2016 October 10 12 22
2016 September 6 10 16
2016 August 6 2 8
2016 July 2 4 6
2016 March 1 0 1
2016 February 1 0 1
2015 December 2 0 2
2015 October 25 1 26
2015 September 25 14 39
2015 August 18 10 28
2015 July 26 9 35
2015 June 31 10 41
2015 May 41 13 54
2015 April 26 12 38
2015 March 34 9 43
2015 February 28 5 33
2015 January 28 9 37
2014 December 32 8 40
2014 November 27 9 36
2014 October 31 21 52
2014 September 15 10 25
2014 August 27 11 38
2014 July 21 11 32
2014 June 27 13 40
2014 May 40 18 58
2014 April 39 15 54
2014 March 40 14 54
2014 February 36 16 52
2014 January 16 9 25
2013 December 27 15 42
2013 November 19 6 25
2013 October 19 17 36
2013 September 22 7 29
2013 August 25 9 34
2013 July 39 25 64
2013 June 15 9 24
2013 May 23 4 27
2013 April 12 10 22
2013 March 8 3 11
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