Case Reports
Sarcoidosis Following Combined Ribavirin and Interferon Therapy: a Case Report and Review of the Literature
Read
4706
Timeswas read the article
1879
Total PDF
2827
Total HTML
Share statistics
array:23 [ "pii" => "S1579212906601924" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60192-4" "estado" => "S300" "fechaPublicacion" => "2004-01-01" "aid" => "60192" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "copyrightAnyo" => "2004" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2004;40:45-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2425 "formatos" => array:3 [ "EPUB" => 117 "HTML" => 1680 "PDF" => 628 ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212906601936" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60193-6" "estado" => "S300" "fechaPublicacion" => "2004-01-01" "aid" => "60193" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2004;40:50" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1625 "formatos" => array:3 [ "EPUB" => 87 "HTML" => 998 "PDF" => 540 ] ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the Editor</span>" "titulo" => "Study of Delays in Diagnosing Symptomatic Pulmonary Tuberculosis" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "50" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Casal Román" "autores" => array:1 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Casal Román" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906601936?idApp=UINPBA00003Z" "url" => "/15792129/0000004000000001/v1_201305141816/S1579212906601936/v1_201305141816/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212906601912" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60191-2" "estado" => "S300" "fechaPublicacion" => "2004-01-01" "aid" => "60191" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2004;40:41-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2882 "formatos" => array:3 [ "EPUB" => 91 "HTML" => 1890 "PDF" => 901 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Reports</span>" "titulo" => "Polyradiculitis and Wegener's Granulomatosis" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "41" "paginaFinal" => "44" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Casanova, E. Pérez Amor, R.M. Girón, E. Zamora, M.D. Vélez, J. Ancochea" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Casanova" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Pérez Amor" ] 2 => array:3 [ "preGrado" => "Dr." "nombre" => "R.M." "apellidos" => "Girón" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Zamora" ] 4 => array:2 [ "nombre" => "M.D." "apellidos" => "Vélez" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Ancochea" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906601912?idApp=UINPBA00003Z" "url" => "/15792129/0000004000000001/v1_201305141816/S1579212906601912/v1_201305141816/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Reports</span>" "titulo" => "Sarcoidosis Following Combined Ribavirin and Interferon Therapy: a Case Report and Review of the Literature" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "45" "paginaFinal" => "49" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Alfageme Michavila, M. Merino Sánchez, J. Pérez Ronchel, I. Lara Lara, E. Suárez García, J. López Garrido" "autores" => array:6 [ 0 => array:5 [ "preGrado" => "Dra" "nombre" => "I." "apellidos" => "Alfageme Michavila" "email" => array:1 [ 0 => "ialfageme@telefonica.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Merino Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Pérez Ronchel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Lara Lara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "E." "apellidos" => "Suárez García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 5 => array:3 [ "nombre" => "J." "apellidos" => "López Garrido" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Sección de Neumología, Hospital Universitario de Valme, Sevilla, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario de Valme, Sevilla, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Sección de Digestivo, Hospital Universitario de Valme, Sevilla, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dra. I. Alfageme. Bobby Deglané, 5, 3D. 41001 Sevilla. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-05-19" "fechaAceptado" => "2003-06-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec153098" "palabras" => array:5 [ 0 => "Pulmonary sarcoidosis" 1 => "Hepatitis C" 2 => "Interferon therapy" 3 => "Adverse effects interferon therapy" 4 => "Antiviral agents" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153099" "palabras" => array:5 [ 0 => "Sarcoidosis pulmonar" 1 => "Hepatitis C" 2 => "Tratamiento con interferón" 3 => "Efectos adversos del tratamiento con interferón" 4 => "Agentes antivirales" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Treatment of active chronic viral hepatitis type C with interferon alpha has proved effective and therefore its use is being extended to a large number of patients. Common side effects include respiratory manifestations. One side effect attributable to the immunomodulatory effect of interferon is the possible triggering or exacerbation of systemic or cutaneous sarcoidosis. We report a new case and offer an exhaustive review of the literature.</p><p class="elsevierStyleSimplePara elsevierViewall">A 49-year-old man with type C chronic, active hepatitis developed new respiratory symptoms and pulmonary infiltrates with hilar and mediastinal adenopathy after 4 months of treatment with pegylated interferon and ribavirin. The transbronchial biopsy showed multiple sarcoid granulomas. When the patient was diagnosed, he had already taken the total dose of interferon and no specific treatment was started. His hepatitis did not respond to therapy and his viral load and transaminase levels remained high.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El tratamiento con interferón alfa en la hepatitis crónica activa por el virus C tiene una eficacia demostrada, por ello se está generalizando su uso a gran número de pacientes. Entre los efectos secundarios, las manifestaciones respiratorias banales son muy frecuentes. Un efecto secundario atribuible al efecto inmunomodulador del interferón es la posibilidad de agravar o desencadenar una sarcoidosis cutánea o sistémica. Presentamos un nuevo caso y hacemos una exhaustiva revisión de la bibliografía.</p><p class="elsevierStyleSimplePara elsevierViewall">Se comunica el caso de un varón de 49 años con hepatitis crónica activa por el virus C que a los 4 meses de tratamiento con interferón pegilado más ribavirina presentó sintomatología respiratoria que no tenía previamente e infiltrados pulmonares con adenopatías hiliares y mediastínicas. En la biopsia transbronquial se apreciaron abundantes granulomas sarcoideos. Cuando se diagnosticó, el paciente había finalizado toda la dosis de interferón y no se instauró ningún tratamiento específico. La hepatitis no respondió a la terapia, permaneciendo elevada la carga viral y las transaminasas.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunology of sarcoidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "YP Kataria" 1 => "JF Holter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chest Med" "fecha" => "1997" "volumen" => "18" "paginaInicial" => "719" "paginaFinal" => "739" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9413655" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of subcutaneous sarcoid nodules induced by interferon-alpha" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I Ohhata" 1 => "T Ochi" 2 => "S Kurebayashi" 3 => "H Masutani" 4 => "M Kikui" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nihon yobu Shikkan Gakkai Zasshi" "fecha" => "1994" "volumen" => "32" "paginaInicial" => "996" "paginaFinal" => "1000" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrence of sarcoidosis following interferon alpha therapy for chronic hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M Nakajima" 1 => "Y Kubota" 2 => "N Miyashita" 3 => "Y Niki" 4 => "T Matsushima" 5 => "T Manabe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Intern Med" "fecha" => "1996" "volumen" => "35" "paginaInicial" => "376" "paginaFinal" => "379" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8797050" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis after interferon therapy for chronic active hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H Teragawa" 1 => "T Hondo" 2 => "K Takahashi" 3 => "H Watanabe" 4 => "H Ohe" 5 => "N Hattori" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Intern Med" "fecha" => "1996" "volumen" => "35" "paginaInicial" => "19" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8652926" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis in interferon-alpha therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "HG Otte" 1 => "C Hartig" 2 => "R Stadler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hautarzt" "fecha" => "1997" "volumen" => "48" "paginaInicial" => "482" "paginaFinal" => "487" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9333628" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis associated with interferon-alpha therapy for chronic hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "RM Hoffmann" 1 => "MC Jung" 2 => "R Motz" 3 => "C Gossl" 4 => "HP Emslander" 5 => "R Zachoval" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "1998" "volumen" => "28" "paginaInicial" => "1058" "paginaFinal" => "1063" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9672184" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous sarcoid foreign body granulomas developing in sites of previous skin injury after systemic interferon-alpha treatment for chronic hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B Eberlein-König" 1 => "R Hein" 2 => "D Abeck" 3 => "R Engst" 4 => "J Ring" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1999" "volumen" => "140" "paginaInicial" => "370" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10233247" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonal sarcoidosis: a rare side effect of interferon-alpha treatment for chronic hepatitis C infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J Pohl" 1 => "W Stremmel" 2 => "B Kallinowski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-2000-10023" "Revista" => array:6 [ "tituloSerie" => "Z Gastroenterol" "fecha" => "2000" "volumen" => "38" "paginaInicial" => "951" "paginaFinal" => "955" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11194885" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Probable cutaneous sarcoidosis associated with combined ribavirin and interferon-alpha therapy for chronic hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G Savoye" 1 => "O Goria" 2 => "S Herve" 3 => "G Riachi" 4 => "I Noblesse" 5 => "L Bastien" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gastroenterol Clin Biol" "fecha" => "2000" "volumen" => "24" "paginaInicial" => "679" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10962394" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic sarcoidosis during interferon-alpha therapy for chronic hepatitis C virus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P Cacoub" 1 => "A Sbai" 2 => "C Frances" 3 => "C Genesti" 4 => "P Hausfater" 5 => "JC Piette" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterol Clin Biol" "fecha" => "2000" "volumen" => "24" "paginaInicial" => "364" "paginaFinal" => "366" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10804348" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis and IFN-(alpha) treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "NJ Vander Els" 1 => "H Gedes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2000" "volumen" => "117" "paginaInicial" => "294" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10631240" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of cutaneous sarcoidosis in a patient with chronic hepatitis C treated with interferon alpha 2b" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V Neglia" 1 => "S Sookoian" 2 => "M Herrera" 3 => "A Abeldano" 4 => "MC Kien" 5 => "E Chouela" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Med Surg" "fecha" => "2001" "volumen" => "5" "paginaInicial" => "406" "paginaFinal" => "408" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11915769" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis during the treatment of hepatitis C by interferon-alpha and ribavirin: 2 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L Leveque" 1 => "A De Boulard" 2 => "P Bielefeld" 3 => "C Sgro" 4 => "P Hillon" 5 => "T Gabreau" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Med Interne" "fecha" => "2001" "volumen" => "22" "paginaInicial" => "1248" "paginaFinal" => "1252" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11794896" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis and comorbidity: retrospective study of 32 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F Bonnet" 1 => "J Dubuc" 2 => "P Morlat" 3 => "X Delbrel" 4 => "MS Doutre" 5 => "S De Witte" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Med Intern" "fecha" => "2001" "volumen" => "22" "paginaInicial" => "619" "paginaFinal" => "623" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis after interferon-alpha treatment in hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H Krehmeier" 1 => "EH Egberts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dtsch Med Wochenschr" "fecha" => "2001" "volumen" => "126" "paginaInicial" => "460" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11360451" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis induced by interferon therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "JG Ravenel" 1 => "HP McAdams" 2 => "JF Plankeel" 3 => "KJ Butnor" 4 => "TA Sporn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2214/ajr.177.1.1770199" "Revista" => array:6 [ "tituloSerie" => "AJR Am J Roentgenol" "fecha" => "2001" "volumen" => "177" "paginaInicial" => "199" "paginaFinal" => "201" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11418426" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis during combined interferon-alfa and ribavirin therapy in 2 patients with chronic hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J Wendling" 1 => "V Descamps" 2 => "M Grossin" 3 => "P Marcellin" 4 => "P Le Bozec" 5 => "S Belaich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2002" "volumen" => "138" "paginaInicial" => "546" "paginaFinal" => "547" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11939833" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic sarcoidosis presenting as a granulomatous tattoo reaction secondary to interferon-alpha treatment for chronic hepatitis C and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A Nawras" 1 => "MM Alsolaiman" 2 => "S Mehboob" 3 => "C Bartholomew" 4 => "B Maliakkal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dig Dis Sci" "fecha" => "2002" "volumen" => "47" "paginaInicial" => "1627" "paginaFinal" => "1631" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12141827" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "O Cogrel" 1 => "MS Doutre" 2 => "V Marliere" 3 => "M Beylot-Barry" 4 => "P Couzigou" 5 => "C Beylot" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2002" "volumen" => "146" "paginaInicial" => "320" "paginaFinal" => "324" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11903249" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Various sarcoid lesions in a patient induced by interferon therapy for chronic hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K Noguchi" 1 => "M Enjoji" 2 => "M Nakamuta" 3 => "R Sugimoto" 4 => "K Coto" 5 => "H Nawata" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Gastroenterol" "fecha" => "2002" "volumen" => "35" "paginaInicial" => "282" "paginaFinal" => "284" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12192210" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manifestation of sarcoidosis during interferon and ribavirin therapy for chronic hepatitis C: a report of two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N Gitlin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Gastroenterol Hepatol" "fecha" => "2002" "volumen" => "14" "paginaInicial" => "883" "paginaFinal" => "885" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12172411" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis in two patients with chronic hepatitis C treated with interferon, ribavirin and amantadine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R Pérez-álvarez" 1 => "R Pérez-López" 2 => "JL Lombrana" 3 => "M Rodríguez" 4 => "L Rodrigo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Viral Hepat" "fecha" => "2002" "volumen" => "9" "paginaInicial" => "75" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11851906" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reactivation of sarcoidosis during interferon therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "SD Li" 1 => "S Yong" 2 => "D Srinivas" 3 => "T Van" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Gastroenterol." "fecha" => "2002" "volumen" => "37" "paginaInicial" => "50" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12109666" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis, natural history, treatment, and prevention of hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "TJ Liang" 1 => "B Rehermann" 2 => "LB Seeff" 3 => "JH Hoofnagle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "2000" "volumen" => "132" "paginaInicial" => "296" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10681285" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interferon alfa 2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "JG McHutchison" 1 => "SC Gordon" 2 => "ER Schiff" 3 => "ML Shiffman" 4 => "WM Lee" 5 => "V Rustgi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "1998" "volumen" => "339" "paginaInicial" => "1485" "paginaFinal" => "1492" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomised trial of interferon a2b plus ribavirin for 48 weeks or for 24 weeks versus interferon a2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T Poynard" 1 => "P Marcellin" 2 => "SS Lee" 3 => "C Miederau" 4 => "GS Minuk" 5 => "G Ideo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1998" "volumen" => "352" "paginaInicial" => "1426" "paginaFinal" => "1432" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomized trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "MP Manus" 1 => "JG McHutchison" 2 => "SC Gordon" 3 => "VK Rustgi" 4 => "M Shiffman" 5 => "R Reindollar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2001" "volumen" => "358" "paginaInicial" => "958" "paginaFinal" => "965" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11583749" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Side effects of therapy of hepatitis C and their management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "MW Fried" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/jhep.2002.36810" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2002" "volumen" => "36" "paginaInicial" => "S237" "paginaFinal" => "SS44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12407599" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normal after exposure to recombinant interferons α A, β and γ and 1,25-dihydroxyvitamin D3" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "AOS Fels" 1 => "DF Nathan" 2 => "ZA Cohn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI113083" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1987" "volumen" => "80" "paginaInicial" => "381" "paginaFinal" => "386" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2440910" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004000000001/v1_201305141816/S1579212906601924/v1_201305141816/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004000000001/v1_201305141816/S1579212906601924/v1_201305141816/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906601924?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 5 | 12 |
| 2024 October | 34 | 22 | 56 |
| 2024 September | 22 | 10 | 32 |
| 2024 August | 44 | 53 | 97 |
| 2024 July | 31 | 21 | 52 |
| 2024 June | 31 | 22 | 53 |
| 2024 May | 37 | 28 | 65 |
| 2024 April | 18 | 22 | 40 |
| 2024 March | 19 | 15 | 34 |
| 2024 February | 22 | 23 | 45 |
| 2023 March | 4 | 3 | 7 |
| 2023 February | 18 | 21 | 39 |
| 2023 January | 17 | 27 | 44 |
| 2022 December | 28 | 25 | 53 |
| 2022 November | 16 | 14 | 30 |
| 2022 October | 51 | 33 | 84 |
| 2022 September | 54 | 31 | 85 |
| 2022 August | 40 | 33 | 73 |
| 2022 July | 23 | 38 | 61 |
| 2022 June | 52 | 26 | 78 |
| 2022 May | 28 | 33 | 61 |
| 2022 April | 24 | 25 | 49 |
| 2022 March | 24 | 52 | 76 |
| 2022 February | 19 | 27 | 46 |
| 2022 January | 17 | 28 | 45 |
| 2021 December | 17 | 51 | 68 |
| 2021 November | 20 | 44 | 64 |
| 2021 October | 17 | 49 | 66 |
| 2021 September | 23 | 50 | 73 |
| 2021 August | 21 | 33 | 54 |
| 2021 July | 17 | 28 | 45 |
| 2021 June | 33 | 40 | 73 |
| 2021 May | 22 | 41 | 63 |
| 2021 April | 76 | 69 | 145 |
| 2021 March | 33 | 42 | 75 |
| 2021 February | 21 | 20 | 41 |
| 2021 January | 25 | 21 | 46 |
| 2020 December | 12 | 17 | 29 |
| 2020 November | 13 | 13 | 26 |
| 2020 October | 13 | 10 | 23 |
| 2020 September | 11 | 12 | 23 |
| 2020 August | 7 | 11 | 18 |
| 2020 July | 19 | 14 | 33 |
| 2020 June | 13 | 5 | 18 |
| 2020 May | 20 | 19 | 39 |
| 2020 April | 16 | 11 | 27 |
| 2020 March | 14 | 12 | 26 |
| 2020 February | 14 | 13 | 27 |
| 2020 January | 16 | 10 | 26 |
| 2019 December | 28 | 23 | 51 |
| 2019 November | 13 | 11 | 24 |
| 2019 October | 10 | 11 | 21 |
| 2019 September | 8 | 7 | 15 |
| 2019 August | 13 | 8 | 21 |
| 2019 July | 13 | 19 | 32 |
| 2019 June | 4 | 13 | 17 |
| 2019 May | 7 | 16 | 23 |
| 2019 April | 8 | 40 | 48 |
| 2019 March | 10 | 14 | 24 |
| 2019 February | 18 | 14 | 32 |
| 2019 January | 8 | 13 | 21 |
| 2018 December | 9 | 11 | 20 |
| 2018 November | 14 | 7 | 21 |
| 2018 October | 12 | 16 | 28 |
| 2018 September | 14 | 11 | 25 |
| 2018 May | 7 | 0 | 7 |
| 2018 April | 6 | 4 | 10 |
| 2018 March | 3 | 4 | 7 |
| 2018 February | 3 | 3 | 6 |
| 2018 January | 2 | 6 | 8 |
| 2017 December | 7 | 6 | 13 |
| 2017 November | 1 | 3 | 4 |
| 2017 October | 6 | 9 | 15 |
| 2017 September | 4 | 4 | 8 |
| 2017 August | 8 | 7 | 15 |
| 2017 July | 2 | 5 | 7 |
| 2017 June | 11 | 9 | 20 |
| 2017 May | 14 | 9 | 23 |
| 2017 April | 36 | 7 | 43 |
| 2017 March | 6 | 2 | 8 |
| 2017 February | 5 | 12 | 17 |
| 2017 January | 6 | 5 | 11 |
| 2016 December | 14 | 8 | 22 |
| 2016 November | 17 | 14 | 31 |
| 2016 October | 16 | 8 | 24 |
| 2016 September | 11 | 4 | 15 |
| 2016 August | 7 | 4 | 11 |
| 2016 July | 3 | 3 | 6 |
| 2016 May | 1 | 0 | 1 |
| 2016 April | 3 | 0 | 3 |
| 2016 March | 5 | 0 | 5 |
| 2016 February | 3 | 0 | 3 |
| 2016 January | 1 | 0 | 1 |
| 2015 December | 5 | 0 | 5 |
| 2015 November | 1 | 1 | 2 |
| 2015 October | 45 | 1 | 46 |
| 2015 September | 29 | 6 | 35 |
| 2015 August | 47 | 9 | 56 |
| 2015 July | 40 | 7 | 47 |
| 2015 June | 37 | 6 | 43 |
| 2015 May | 44 | 10 | 54 |
| 2015 April | 35 | 7 | 42 |
| 2015 March | 28 | 8 | 36 |
| 2015 February | 32 | 5 | 37 |
| 2015 January | 26 | 8 | 34 |
| 2014 December | 25 | 5 | 30 |
| 2014 November | 35 | 6 | 41 |
| 2014 October | 58 | 8 | 66 |
| 2014 September | 39 | 6 | 45 |
| 2014 August | 36 | 10 | 46 |
| 2014 July | 32 | 9 | 41 |
| 2014 June | 52 | 8 | 60 |
| 2014 May | 62 | 8 | 70 |
| 2014 April | 52 | 10 | 62 |
| 2014 March | 72 | 8 | 80 |
| 2014 February | 54 | 7 | 61 |
| 2014 January | 32 | 6 | 38 |
| 2013 December | 42 | 12 | 54 |
| 2013 November | 26 | 6 | 32 |
| 2013 October | 36 | 10 | 46 |
| 2013 September | 42 | 9 | 51 |
| 2013 August | 41 | 10 | 51 |
| 2013 July | 57 | 11 | 68 |
| 2013 June | 35 | 7 | 42 |
| 2013 May | 35 | 7 | 42 |
| 2013 April | 19 | 4 | 23 |
| 2013 March | 6 | 2 | 8 |
Show all
