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Original Article
Functional and Compositional Shifts in Lung and Gut Microbiota after One Year of Treatment with Highly Effective CFTR Modulators in Cystic Fibrosis
Natalia Bastón-Paza, Carmen García-Duránb, Doĝukan Bayraktarc, Esther Palaciosa, Ana Moreno-Blancod,e, Janetta Topc, María Garrigaf, Luis Máizg, Saioa Vicente-Santamaríah, Antonio Oliverd,i, Jesús Oteo-Iglesiasd,j, Rafael Cantóna,d, Concha Gilb,k, Anita C. Schürchc, Rosa del Campod,l,
, Juan de Dios Caballeroa,d
Corresponding author
a Department of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute (IRYCIS), 28034 Madrid, Spain
b Department of Microbiology and Parasitology, Complutense University of Madrid, 28040 Madrid, Spain
c Division Laboratories and Pharmacy, Department of Medical Microbiology of University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
d Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), 28029 Madrid, Spain
e Department of Microbiology and Immunology, Carver College of Medicine, 52242, Iowa, United States
f Department of Endocrinology and Nutrition, Cystic Fibrosis Unit, Ramón y Cajal University Hospital, 28034 Madrid, Spain
g Department of Pulmonology, Cystic Fibrosis Unit, Ramón y Cajal University Hospital, University of Alcalá, 28034 Madrid, Spain
h Department of Pediatrics, Cystic Fibrosis Unit, 12 de Octubre University Hospital, 28041 Madrid, Spain
i Department of Microbiology, Son Espases University Hospital, Balearic Islands Health Research Institute (IdISBa), Palma de Mallorca, Spain
j Reference and Research Laboratory on Antibiotic Resistance, National Microbiology Center, Carlos III Health Institute, Madrid, Spain
k Proteomics Unit, Complutense University of Madrid, 28040 Madrid, Spain
l Health Sciences Faculty, La Rioja University, 26006 Logroño, Spain
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