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] ] 9 => array:2 [ "colaborador" => "Grupo de trabajo del Programa Integrado de Investigación en Tuberculosis (PII-TB)" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn0005" ] ] ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "Unidad de Gestión Clínica Neumología, Hospital Universitario San Agustín, Avilés, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Programa Integrado de Investigación en Tuberculosis (PII-TB) SEPAR, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario de Cruces, Baracaldo, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Moisés Broggi, Sant Joan Despí, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Medicina Interna, Complexo Hospitalario de Pontevedra, Pontevedra, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Sección de Neumología, Hospital Son Llatzer, Palma De Mallorca, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Sección de Neumología, Hospital Carmen y Severo Ochoa, Cangas del Narcea, Spain" "etiqueta" => "g" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio de contactos de pacientes con tuberculosis en España: analisis de costes" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Contacts tracing of tuberculosis (TB) patients involves significant health expenditure, but while several studies have analyzed the cost of diagnosis or treatment of latent tuberculosis infection (LTBI)<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>, few have evaluated cost of the overall process<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>. Furthermore, the most appropriate diagnostic method for LTI is still under debate<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We therefore designed this prospective observational study to determine the cost of TB contacts tracing and to conduct a cost-effectiveness analysis of the diagnostic methods and treatment of LTBI.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Contacts of patients diagnosed with TB between January 2018 and December 2019 were included in the National SEPAR Registry of the Integrated Tuberculosis Research Program (PII-TB) database. Research group members were given a username and password to access the registry. Twelve centers from 6 Spanish autonomous communities participated, and the study was approved by all corresponding Ethics and Research Committees.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The following definitions were established:</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Index case</span>: case recognized as the source of the infection of other patients and/or infected cases<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>.</p><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Secondary case</span>: a contact diagnosed with TB.</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Contact</span>: person with exposure to the index case<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>.</p><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Latent tuberculosis infection (LTBI)</span>: tuberculin skin test (TST) with induration diameter of at least 5 mm and/or positive QuantiFERON TB Gold (QFT) with a cut-off of 0.35 IU/mL<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>, and no evidence of active disease.</p><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Diagnostic strategy</span>: techniques used to diagnose LTBI, according to the sequence established at the discretion of the attending physician. Three options were considered: dual (TST plus QFT combined); TST alone; or QFT alone.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Direct costs were extracted from the data provided by the Health Service of the Principality of Asturias<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and the Catalan Public Health Agency<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>, as shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. Indirect costs for the treatment and follow-up of active TB cases detected in the contact study were Є10,262 per patient<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>. Using these data, we performed a cost-effectiveness analysis of the diagnostic strategy and LTBI treatment. Baseline strategies selected for diagnosis and treatment were TST and a 6-month course of isoniazid (6H), respectively, and the target population consisted of all contacts of the 4832 TB cases diagnosed in Spain in 2018<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>, estimating that each of them would have an average of 4 contacts. The number of TB cases avoided was used as a measure of efficacy, assuming that 10% of infected contacts will develop TB during their lifetime<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>, and that LTBI treatment reduces the overall risk by between 56% and 75%, depending on the regimen used<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>. The incremental cost-effectiveness ratio (ICER) was calculated to compare the different strategies. When a strategy was less expensive and more effective than the baseline strategy, the ICER was not calculated and that strategy was considered dominant.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Proportions were compared using the Student’s <span class="elsevierStyleItalic">t</span>-test or its non-parametric equivalent, the Mann-Whitney <span class="elsevierStyleItalic">U</span> test A <span class="elsevierStyleItalic">p</span>-value of less than .05 was considered significant.</p><p id="par0060" class="elsevierStylePara elsevierViewall">A total of 1035 contacts of 265 index cases with a mean age of 37.96 ± 20.13 years were identified. The diagnostic strategy was dual in 374 (36.4%), TST in 537 (51.9%), and QFT in 124 (11.7%); the percentage of LTBI in each group was 48.2%, 27.4%, and 40.4%, respectively (<span class="elsevierStyleItalic">P</span> = .01). LTBI was diagnosed in 346 (33.4%) contacts and 295 started treatment: 156 (52.9%) received isoniazid plus rifampicin for 3 months (3HR), 124 (42%) received 6H, 5 (1.9%) received rifampicin for 4 months (4R), and 10 (3.2%) received isoniazid for 9 months; 91.1%, 89.1%, 80%, and 70% completed treatment, respectively (<span class="elsevierStyleItalic">P</span> = .1). Seventeen cases of TB were diagnosed (1.6%).</p><p id="par0065" class="elsevierStylePara elsevierViewall">The total cost was Є545,491.80: Є371,037.80 for direct costs, of which 40.8% was for medical consultations, 26.1% for LTBI treament, and 25.1% for diagnostic studies. The average cost per contact studied was Є548.23 (SD 142.97). Dual and QFT strategies were significantly more expensive than TST but more effective, and the 3HR treatment was dominant over 6H. The costs of diagnosis and LTBI treatment and corresponding ICERs are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">The cost per contact studied was higher than the Є368.23 reported in a German study<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>, but unlike our series, that study did not include the costs of preventive treatment. In another study conducted in Norway<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>, the average cost was Є1934, significantly higher than ours, due to differences in the costs charged, especially for medical consultations. If we extrapolate our results to the approximate number of contacts to be evaluated in Spain<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>, the estimated total cost of contacts study would be Є10.6 million.</p><p id="par0075" class="elsevierStylePara elsevierViewall">With regard to LTBI treatment, the 3HR regimen was less expensive and more effective, confirming that it would be a better choice than 6H. This was also demonstrated in a cost-effectiveness study<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> in which all short regimens, including 3HR, were more cost-effective than 6H, although the authors, unlike us, found that 4R was slightly better; however, our results should be interpreted with caution due to the low representation of 4R in our series.</p><p id="par0080" class="elsevierStylePara elsevierViewall">With regard to diagnosis, the dual strategy and QFT were more expensive but more effective than TST, with an ICER of Є8865.61 and Є8463.57 per TB case avoided, respectively. If we bear in mind that health interventions with an ICER of up to Є30,000 are efficient<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>, both strategies would be cost-effective. To determine the best option, we must analyze the ICER together with the potential health benefit of the intervention, – in this case, identifying contacts with LTBI and offering them treatment to reduce the risk of developing TB as well the environment in which the strategy is implemented. Given that the percentage of LTBI is higher when the dual strategy is used, we believe that this would be the most appropriate in a country with a low incidence of disease, such as Spain.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Several studies conducted in low-incidence countries have shown that the use of both interferon-γ release assays (IGRA) and TST techniques is cost-effective in certain groups such as household contacts<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,15</span></a> and health workers<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>. Spanish clinical guidelines also recommend this approach in children under the age of 5 and in individuals who are immunocompromised, HIV-positive, or receiving biological drugs, while for the contacts study they recommend that TST be complemented by IGRA in BCG-vaccinated individuals with a positive TST<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,17</span></a>. Our study included regular contacts, with exposure time to the index case greater or less than 6 hours a day, and sporadic, who accounted for 36% of the total. The rate of LTBI in both groups was higher when TST and QFT were used, but the difference among sporadic contacts was particularly striking (54.6% versus 19.1% for TST or 30.2% for QFT alone), suggesting that the dual strategy may be the best way of initiating the contacts study, regardless of exposure intensity.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Similarly, Erkens et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> in a series of 10,000 contacts, of which 39% were sporadic, found that adding IGRA to TST modified the diagnosis of LTBI in 40% of contacts. They argue that the higher cost would be balanced by a more accurate indication for preventive treatment, and consider this practice to be the most appropriate in low-prevalence countries.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Our study has some limitations. Firstly, its design has an inherent risk of selection bias. However, it should be noted that one of the main strengths of our study is that all researchers were TB experts who participate regularly in the PII-TB, which we believe ensure the quality of data collection and reduces this possibility of selection bias. Secondly, to determine effectiveness, we estimated that 10% of infected contacts might develop TB over their lifetime, while other studies suggest a rate of 15%<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>; however, we do not believe that this difference reduces the validity of our results. Finally, we did not analyze other indirect costs, such as transport or work absenteeism, so the total cost may be underestimated, but we should remember that this study was conducted in a country with high economic resources, so the likely impact of these factors on the final results would, in our opinion, be marginal.</p><p id="par0100" class="elsevierStylePara elsevierViewall">We conclude that the study of TB contacts generates a significant health expense, derived mainly from diagnostic techniques and the treatment of latent tuberculosis infection. In this respect, we believe that the most appropriate strategy is the sequential use of TST plus QFT in all contacts, and treatment with 3HR.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0105" class="elsevierStylePara elsevierViewall">This study was funded by the <span class="elsevierStyleGrantSponsor" id="gs0005">Instituto de la Salud Carlos III-Fondos FEDER</span> grant <span class="elsevierStyleGrantNumber" refid="gs0005">PI17/00724</span> and by the <span class="elsevierStyleGrantSponsor" id="gs0010">Spanish Society of Pulmonology and Thoracic Surgery (SEPAR)</span> grant <span class="elsevierStyleGrantNumber" refid="gs0010">378/2017</span>.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors state that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interests" ] 2 => array:2 [ "identificador" => "xack642544" "titulo" => "Acknowledgements" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Members of the PII-TB Research Group (Integrated Research Program-TB) are listed in the Appendix.</p>" "identificador" => "fn0005" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:3 [ "etiqueta" => "Appendix" "identificador" => "sec0015" "apendiceSeccion" => array:1 [ 0 => array:3 [ "apendice" => "<p id="par0120" class="elsevierStylePara elsevierViewall">Fernando Álvarez Navascues (Unidad de Gestión Clínica Neumología Hospital Universitario San Agustín, Avilés, Spain). María Somoza-González (Servicio de Neumología Consorcio Sanitario de Terrassa, Terrassa, Spain). Christian Anchorena (Servicio de Neumología, Complexo Hospitalario de Pontevedra, Pontevedra, Spain). Ángel Domínguez-Castellano (Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Seville, Spain). Antón Penas-Truque (Servicio de Neumología, Hospital Universitario Lucus Augusti, Lugo, Spain). Silvia Dorronsoro-Quintana (Sección de Neumología, Hospital de Zumárraga, Zumárraga, Spain). Juan-Francisco Medina-Gallardo (Servicio de Neumología, Hospital Universitario Virgen del Rocío, Seville, Spain). Lander Altube-Urrengoetxea (Servicio de Neumología, Hospital Universitario de Galdakao, Galdakao, Spain). María Otero-Santiago (Hospital Universitario de A Coruña, Corunna, Spain). Concepción Rodríguez-García (Unidad de Gestión Clínica Neumología Hospital Universitario San Agustín, Avilés, Spain). Juan Rodríguez-López (Sección de Neumología Hospital Grande Covián, Arriondas, Spain).</p>" "titulo" => "PII-TB Research Group (Integrated Research Program-TB)" "identificador" => "sec0020" ] ] ] ] ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">LTBI: latent tuberculosis infection.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cost (Є) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Medical consultations</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Initial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">120.30 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Subsequent \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">72.20 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Blood tests (blood count, biochemistry with liver function tests)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.48 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Sputum smear and sputum culture</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19.66 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Plain chest X-ray</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.51 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Tuberculin skin test</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">QuantiFERON TB Gold</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">125 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">LTBI treatment</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cost (Є) per patient \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Isoniazid for 6 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.72 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Isoniazid plus rifampicin for 3 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">71.52 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Rifampicin for 4 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83.71 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Isoniazid for 9 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.08 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Indirect costs.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Dx: diagnostic strategy; LTIT: latent tuberculous infection treatment.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Total cost: calculated for 19,328 contacts with an LTBI prevalence of 33.4%. Effectiveness: number of TB cases avoided, assuming that 10% of infected contacts will develop the disease over their lifetime. ICER (incremental cost-effectiveness ratio) = [total cost of strategy A1-total cost of strategy A2]/[effectiveness of strategy A1-effectiveness of strategy A2]; 6H: isoniazid for 6 months; 3HR: isoniazid and rifampicin for 3 months; 4R: rifampicin for 4 months; 9H: isoniazid for 9 months.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean cost (per contact) Є \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total cost Є \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Effectiveness (number of TB cases avoided) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">ICER Є \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Dx</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>TST \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">333.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5,861,852.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">530 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-------- \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>TST plus QFT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">486.76<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9,408,097.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">930 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8865.61 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>QFT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">412.82 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7,977,746.52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">780 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8463.57 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">LTBI treatment</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>6H \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">473.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,703,146.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">304 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">--------- \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3HR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">447.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,553,720.96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">376 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dominant \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4R \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">827.45<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">+</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4,726,394.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">344 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50,581.18 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>9H \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">516.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,951,447.52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">262 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="npar0005"><span class="elsevierStyleItalic">P</span> < .05 with respect to the basic strategy (TST).</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "+" "nota" => "<p class="elsevierStyleNotepara" id="npar0010"><span class="elsevierStyleItalic">P</span> < .05 with respect to the basic strategy (6H).</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cost-effectiveness of the diagnostic strategy and latent tuberculous infection treatment.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cost-effectiveness of rifampin for 4 months and isoniazid for 6 months in the treatment of tuberculosis infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.M. Pina" 1 => "L. Clotet" 2 => "A. Ferrer" 3 => "M.R. Sala" 4 => "P. Garrido" 5 => "L. Salleras" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2013.01.017" "Revista" => array:6 [ "tituloSerie" => "Respir Med." "fecha" => "2013" "volumen" => "107" "paginaInicial" => "768" "paginaFinal" => "777" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23490222" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cost of illness of non-multidrug-resistant tuberculosis in Germany: an update" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Diel" 1 => "A. Nienhaus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/23120541.00329-2020" "Revista" => array:3 [ "tituloSerie" => "ERJ Open Res." "fecha" => "2020" "volumen" => "6" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systematic review of cost and cost-effectiveness of different TB-screening strategies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Nienhaus" 1 => "A. Schablon" 2 => "J.T. Costa" 3 => "R. Diel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1472-6963-11-247" "Revista" => array:5 [ "tituloSerie" => "BMC Health Serv Res." "fecha" => "2011" "volumen" => "11" "paginaInicial" => "247" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21961888" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis contact investigation in low- and middle-income countries: standardized definitions and indicators" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Fair" 1 => "C.R. Miller" 2 => "S.E. Ottmani" 3 => "G.J. Fox" 4 => "P.C. Hopewell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5588/ijtld.14.0512" "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis." "fecha" => "2015" "volumen" => "19" "paginaInicial" => "269" "paginaFinal" => "272" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25686131" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Consensus document on prevention and treatment of tuberculosis in patients for biological treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Mir Viladrich" 1 => "E. Daudén Tello" 2 => "G. Solano-López" 3 => "F.J. López Longo" 4 => "C. Taxonera Samso" 5 => "P. Sánchez Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2015.04.016" "Revista" => array:7 [ "tituloSerie" => "Arch Bronconeumol." "fecha" => "2016" "volumen" => "52" "paginaInicial" => "36" "paginaFinal" => "45" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26187708" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0190962219304633" "estado" => "S300" "issn" => "01909622" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Decreto 194/2019, de 31 de octubre, de segunda modificación del decreto 87/2009, de 29 de julio, por el que se establecen los precios públicos a aplicar por el Servicio de Salud del Principado de Asturias por la prestación de servicios sanitarios. Boletín Oficial del Principado de Asturias. Número 219 de 13-XI-2019: 1-7." ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Agencia de Salud Pública de Barcelona. Anuncio sobre la aprobación definitiva de los precios públicos para la Agencia de Salud Pública de Barcelona para el año 2017. Diari Oficial de la Generalitat de Catalunya. Núm. 7325-9.3.2017: 1-12." ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis costs in Spain and related factors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.A. Gullón" 1 => "J.M. García-García" 2 => "M.Á. Villanueva" 3 => "F. Álvarez-Navascues" 4 => "T. Rodrigo" 5 => "M.T. Casals" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2016.05.002" "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol." "fecha" => "2016" "volumen" => "52" "paginaInicial" => "583" "paginaFinal" => "589" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27323653" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Tuberculosis in Spain. Available from: <a target="_blank" href="https://www.mscbs.gob.es/profesionales/saludPublica/prevPromocion/PlanTuberculosis/docs/InfografiaTBSpain2018.pdf">https://www.mscbs.gob.es/profesionales/saludPublica/prevPromocion/PlanTuberculosis/docs/InfografiaTBSpain2018.pdf</a>." ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of tuberculosis after recent exposure. A 10-year follow-up study of contacts in Amsterdam" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Sloot" 1 => "M.F. Schim van der Loeff" 2 => "P.M. Kouw" 3 => "M.W. Borgdorff" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.201406-1159oc" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med." "fecha" => "2014" "volumen" => "190" "paginaInicial" => "1044" "paginaFinal" => "1052" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25265362" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of latent tuberculosis infection: an updated network meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Zenner" 1 => "N. Beer" 2 => "R.J. Harris" 3 => "M.C. Lipman" 4 => "H.R. Stagg" 5 => "M.J. van der Werf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.7326/m17-0609" "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med." "fecha" => "2017" "volumen" => "167" "paginaInicial" => "248" "paginaFinal" => "255" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28761946" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immigrant screening for latent tuberculosis in Norway: a cost-effectiveness analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.S. Haukaas" 1 => "T.M. Arnesen" 2 => "B.A. Winje" 3 => "E. Aas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10198-016-0779-0" "Revista" => array:6 [ "tituloSerie" => "Eur J Health Econ." "fecha" => "2017" "volumen" => "18" "paginaInicial" => "405" "paginaFinal" => "415" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26970772" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cost-effectiveness of 3 months of weekly rifapentine and isoniazid compared with other standard treatment regimens for latent tuberculosis infection: a decision analysis study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.N. Doan" 1 => "G.J. Fox" 2 => "M.T. Meehan" 3 => "N. Scott" 4 => "R. Ragonnet" 5 => "K. Viney" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jac/dky403" "Revista" => array:6 [ "tituloSerie" => "J Antimicrob Chemother." "fecha" => "2019" "volumen" => "74" "paginaInicial" => "218" "paginaFinal" => "227" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30295760" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Grupo ECOMED. Analysis of costs and results of the economic assessment of health interventions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Prieto" 1 => "J.A. Sacristán" 2 => "J.L. Pinto" 3 => "X. Badia" 4 => "F. Antoñanzas" 5 => "J. del Llano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0025-7753(04)74260-8" "Revista" => array:6 [ "tituloSerie" => "Med Clin (Barc)." "fecha" => "2004" "volumen" => "122" "paginaInicial" => "423" "paginaFinal" => "429" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15066252" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Pooran" 1 => "H. Booth" 2 => "R.F. Miller" 3 => "G. Scott" 4 => "M. Badri" 5 => "J.F. Huggett" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2466-10-7" "Revista" => array:5 [ "tituloSerie" => "BMC Pulm Med." "fecha" => "2010" "volumen" => "10" "paginaInicial" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20170555" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cost-effectiveness of different screening strategies (single or dual) for the diagnosis of tuberculosis infection in healthcare workers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.T. Del Campo" 1 => "H. Fouad" 2 => "M.M. Solís-Bravo" 3 => "M.A. Sánchez-Uriz" 4 => "I. Mahíllo-Fernández" 5 => "J. Esteban" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/668436" "Revista" => array:6 [ "tituloSerie" => "Infect Control Hosp Epidemiol." "fecha" => "2012" "volumen" => "33" "paginaInicial" => "1226" "paginaFinal" => "1234" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23143360" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sumario ejecutivo de la guía de práctica clínica sobre el uso de las pruebas de liberación de interferón-gamma para el diagnóstico de infección tuberculosa" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Santin" 1 => "J.M. García-García" 2 => "D. Rigau" 3 => "N. Altet" 4 => "L. Anibarro" 5 => "I. Casas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2016.02.020" "Revista" => array:7 [ "tituloSerie" => "Arch Bronconeumol." "fecha" => "2016" "volumen" => "52" "paginaInicial" => "477" "paginaFinal" => "481" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27424071" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S2352512621005348" "estado" => "S300" "issn" => "23525126" ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Added value of interferon-gamma release assays in screening for tuberculous infection in the Netherlands" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.G. Erkens" 1 => "A.G. Dinmohamed" 2 => "M. Kamphorst" 3 => "S. Toumanian" 4 => "R. van Nispen-Dobrescu" 5 => "M. Alink" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5588/ijtld.13.0589" "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis." "fecha" => "2014" "volumen" => "18" "paginaInicial" => "413" "paginaFinal" => "420" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24670695" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of active tuberculosis in the five years following infection… 15%?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.M. Trauer" 1 => "N. Moyo" 2 => "E.L. Tay" 3 => "K. Dale" 4 => "R. Ragonnet" 5 => "E.S. McBryde" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.chest.2015.11.017" "Revista" => array:7 [ "tituloSerie" => "Chest." "fecha" => "2016" "volumen" => "149" "paginaInicial" => "516" "paginaFinal" => "525" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26867835" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0022347617317481" "estado" => "S300" "issn" => "00223476" ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack642544" "titulo" => "Acknowledgements" "texto" => "<p id="par0115" class="elsevierStylePara elsevierViewall">The authors thank Prof. Roland Diel for his critical review of the final version of the manuscript.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000005800000005/v2_202212170819/S0300289622000953/v2_202212170819/en/main.assets" "Apartado" => array:4 [ "identificador" => "93642" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific Letters/Cartas científicas" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005800000005/v2_202212170819/S0300289622000953/v2_202212170819/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289622000953?idApp=UINPBA00003Z" ]
Year/Month | Html | Total | |
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2024 October | 75 | 24 | 99 |
2024 September | 108 | 19 | 127 |
2024 August | 82 | 44 | 126 |
2024 July | 59 | 16 | 75 |
2024 June | 71 | 23 | 94 |
2024 May | 74 | 25 | 99 |
2024 April | 40 | 20 | 60 |
2024 March | 50 | 19 | 69 |
2024 February | 59 | 24 | 83 |
2024 January | 63 | 25 | 88 |
2023 December | 66 | 23 | 89 |
2023 November | 63 | 19 | 82 |
2023 October | 82 | 34 | 116 |
2023 September | 72 | 32 | 104 |
2023 August | 38 | 26 | 64 |
2023 July | 60 | 27 | 87 |
2023 June | 58 | 15 | 73 |
2023 May | 46 | 24 | 70 |
2023 April | 91 | 35 | 126 |
2023 March | 48 | 29 | 77 |
2023 February | 45 | 23 | 68 |
2023 January | 37 | 54 | 91 |
2022 December | 65 | 47 | 112 |
2022 November | 57 | 29 | 86 |
2022 October | 66 | 31 | 97 |
2022 September | 51 | 35 | 86 |
2022 August | 47 | 51 | 98 |
2022 July | 45 | 52 | 97 |
2022 June | 122 | 79 | 201 |
2022 May | 85 | 21 | 106 |