Afinidad de la hemoglobina para el oxigeno en la hipoxemia de los obstructivos
Affinity of hemoblogin for oxygen in hypoxemia of obstructive patients
* Jefe Servicio Fisiología Respiratoria. Instituto Nacional de Silicosis. Oviedo
** Médico adjunto Laboratorio de Bioquímica. Instituto Nacional de Silicosis. Oviedo
*** Medico adjunto Fisiología Respiratoria. Instituto Nacional de Silicosis. Oviedo
**** Jefe Laboratorio Clínico. Instituto Nacional de Silicosis. Oviedo
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Marín, S. Ruso, J. Custardoy, A. Losada, M. González, Manuel Valdés Ruiz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Marín" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Ruso" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Custardoy" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Losada" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "González" ] 5 => array:2 [ "nombre" => "Manuel Valdés" "apellidos" => "Ruiz" ] ] ] 1 => array:2 [ "autoresLista" => "P. Vergara, J.L. López" "autores" => array:2 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Vergara" ] 1 => array:2 [ "nombre" => "J.L." "apellidos" => "López" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615325928?idApp=UINPBA00003Z" "url" => "/03002896/0000001400000004/v1_201509151328/S0300289615325928/v1_201509151328/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Afinidad de la hemoglobina para el oxigeno en la hipoxemia de los obstructivos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "149" "paginaFinal" => "153" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "L. Palenciano, M.C. Rodríguez, F. Payo, A. de Vega, M. Corrales, G. Ocio" "autores" => array:6 [ 0 => array:3 [ "nombre" => "L." "apellidos" => "Palenciano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "M.C." "apellidos" => "Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "F." "apellidos" => "Payo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "de Vega" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "M." "apellidos" => "Corrales" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "G." "apellidos" => "Ocio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">****</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Jefe Servicio Fisiología Respiratoria. Instituto Nacional de Silicosis. Oviedo" "etiqueta" => "*" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Médico adjunto Laboratorio de Bioquímica. Instituto Nacional de Silicosis. Oviedo" "etiqueta" => "**" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Medico adjunto Fisiología Respiratoria. Instituto Nacional de Silicosis. Oviedo" "etiqueta" => "***" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Jefe Laboratorio Clínico. Instituto Nacional de Silicosis. Oviedo" "etiqueta" => "****" "identificador" => "aff0020" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Affinity of hemoblogin for oxygen in hypoxemia of obstructive patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1978-03-06" "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha estudiado la modificación de la afinidad de la Hb para el 0<span class="elsevierStyleInf">2</span> en 25 pacientes con obstrucción crónica de vías aéreas en insuficiencia respiratoria (P<span class="elsevierStyleInf">a</span>O<span class="elsevierStyleInf">2</span>, ≦ 61<span class="elsevierStyleHsp" style=""></span>mm. de Hg) con pH no inferior a 7,33. Se encontraron elevaciones ligeras, pero significativas, de la concentración intraeritrocitaria de 2,3 DPG. En 19 casos se determinó también la P50 por el método de Aberman y cois., encontrándose un valor medio ligeramente más alto de lo normal. No parece, sin embargo, que estas modificaciones contribuyan apreciablemente a mejorar el transporte de O<span class="elsevierStyleInf">2</span> en estos pacientes. Un análisis teórico de la influencia de la afinidad de la Hb muestra que una elevación de la P50 es beneficiosa sólo cuando la P<span class="elsevierStyleInf">a</span>O<span class="elsevierStyleInf">2</span> es normal o más alta de lo normal. Este beneficio se va perdiendo a medida que desciende la P<span class="elsevierStyleInf">a</span>O<span class="elsevierStyleInf">2</span> y puede decirse que es nulo en las hipoxemias severas.</p></span>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The authors have studied the modifícation of the affinity of Hb for O<span class="elsevierStyleInf">2</span> in 25 patients with chronic obstruction of airways in respiratory insufficiency (P<span class="elsevierStyleInf">a</span>O<span class="elsevierStyleInf">2</span> < 61<span class="elsevierStyleHsp" style=""></span>mmHg.) with a pH not inferior to 7.33. They found slight but signifícant elevations of the intraerythrocytic concentration of 2.3 DPG. The P50 was aiso determined in 19 cases by Aberman and colleagues method. The average valué was slightiy higher than normal. It wouid not seem, however, that these modifications contribute appreciably to improving the transport of O<span class="elsevierStyleInf">2</span> in these patients. A theoretical analysis of the influence of the affinity of the Hb shows that an elevation of P50 is beneficial oniy when the P<span class="elsevierStyleInf">a</span>O<span class="elsevierStyleInf">2</span> is normal or higher than normal. This benefit is lost as the P<span class="elsevierStyleInf">a</span>O<span class="elsevierStyleInf">2</span> decreases and it can be said to be nuil in severe hypoxemias.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 8 | 12 |
| 2024 October | 88 | 58 | 146 |
| 2024 September | 82 | 69 | 151 |
| 2024 August | 61 | 70 | 131 |
| 2024 July | 62 | 48 | 110 |
| 2024 June | 80 | 72 | 152 |
| 2024 May | 77 | 50 | 127 |
| 2024 April | 43 | 52 | 95 |
| 2024 March | 52 | 41 | 93 |
| 2024 February | 49 | 57 | 106 |
| 2023 December | 0 | 2 | 2 |
| 2023 November | 0 | 3 | 3 |
| 2023 October | 0 | 3 | 3 |
| 2023 August | 0 | 3 | 3 |
| 2023 July | 0 | 17 | 17 |
| 2023 June | 0 | 1 | 1 |
| 2023 May | 0 | 4 | 4 |
| 2023 April | 0 | 8 | 8 |
| 2023 March | 7 | 33 | 40 |
| 2023 February | 44 | 216 | 260 |
| 2023 January | 32 | 213 | 245 |
| 2022 December | 43 | 237 | 280 |
| 2022 November | 79 | 369 | 448 |
| 2022 October | 53 | 446 | 499 |
| 2022 September | 60 | 352 | 412 |
| 2022 August | 87 | 233 | 320 |
| 2022 July | 65 | 302 | 367 |
| 2022 June | 85 | 366 | 451 |
| 2022 May | 45 | 421 | 466 |
| 2022 April | 69 | 390 | 459 |
| 2022 March | 57 | 371 | 428 |
| 2022 February | 42 | 403 | 445 |
| 2022 January | 35 | 293 | 328 |
| 2021 December | 19 | 331 | 350 |
| 2021 November | 27 | 489 | 516 |
| 2021 October | 26 | 488 | 514 |
| 2021 September | 18 | 307 | 325 |
| 2021 August | 22 | 300 | 322 |
| 2021 July | 19 | 348 | 367 |
| 2021 June | 16 | 342 | 358 |
| 2021 May | 21 | 327 | 348 |
| 2021 April | 68 | 953 | 1021 |
| 2021 March | 84 | 474 | 558 |
| 2021 February | 36 | 399 | 435 |
| 2021 January | 34 | 323 | 357 |
| 2020 December | 32 | 437 | 469 |
| 2020 November | 37 | 691 | 728 |
| 2020 October | 29 | 455 | 484 |
| 2020 September | 14 | 518 | 532 |
| 2020 August | 24 | 306 | 330 |
| 2020 July | 44 | 474 | 518 |
| 2020 June | 20 | 474 | 494 |
| 2020 May | 22 | 493 | 515 |
| 2020 April | 23 | 526 | 549 |
| 2020 March | 21 | 327 | 348 |
| 2020 February | 26 | 244 | 270 |
| 2020 January | 13 | 101 | 114 |
| 2019 December | 29 | 174 | 203 |
| 2019 November | 19 | 281 | 300 |
| 2019 October | 11 | 195 | 206 |
| 2019 September | 13 | 219 | 232 |
| 2019 August | 8 | 79 | 87 |
| 2019 July | 12 | 72 | 84 |
| 2019 June | 16 | 106 | 122 |
| 2019 May | 11 | 123 | 134 |
| 2019 April | 35 | 60 | 95 |
| 2019 March | 7 | 70 | 77 |
| 2019 February | 3 | 34 | 37 |
| 2019 January | 2 | 24 | 26 |
| 2018 December | 10 | 13 | 23 |
| 2018 November | 7 | 7 | 14 |
| 2018 October | 10 | 11 | 21 |
| 2018 September | 11 | 15 | 26 |
| 2018 May | 3 | 1 | 4 |
| 2018 April | 8 | 5 | 13 |
| 2018 March | 6 | 6 | 12 |
| 2018 February | 9 | 14 | 23 |
| 2018 January | 5 | 5 | 10 |
| 2017 December | 6 | 10 | 16 |
| 2017 November | 9 | 13 | 22 |
| 2017 October | 7 | 10 | 17 |
| 2017 September | 4 | 8 | 12 |
| 2017 August | 11 | 15 | 26 |
| 2017 July | 3 | 6 | 9 |
| 2017 June | 9 | 8 | 17 |
| 2017 May | 19 | 18 | 37 |
| 2017 April | 8 | 25 | 33 |
| 2017 March | 8 | 23 | 31 |
| 2017 February | 6 | 7 | 13 |
| 2017 January | 4 | 3 | 7 |
| 2016 December | 6 | 7 | 13 |
| 2016 November | 18 | 10 | 28 |
| 2016 October | 21 | 14 | 35 |
| 2016 September | 11 | 4 | 15 |
| 2016 August | 15 | 6 | 21 |
| 2016 July | 19 | 4 | 23 |
| 2016 June | 21 | 9 | 30 |
| 2016 May | 19 | 9 | 28 |
| 2016 April | 8 | 0 | 8 |
| 2016 March | 13 | 0 | 13 |
| 2016 February | 12 | 2 | 14 |
| 2016 January | 13 | 8 | 21 |
| 2015 December | 21 | 11 | 32 |
| 2015 November | 24 | 8 | 32 |
| 2015 October | 5 | 1 | 6 |
| 2015 September | 1 | 0 | 1 |
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