Changes in bronchial epithelium in relation to cigarette smoking 1955-1960 vs. 1970-1977
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=> array:8 [ "idiomaDefecto" => true "titulo" => "Changes in bronchial epithelium in relation to cigarette smoking 1955-1960 vs. 1970-1977" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "147" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Para comprobar la hipótesis de que la reducción en el contenido de alquitrán y nicotina del humo de cigarrillos, iniciados en 1950, debería reflejarse en cambios histológicos del epitelio bronquial de los fumadores, se examinaron al microscopio 20.424 muestras obtenidas en autopsia de los bronquios de 445 hombres (no muertos de carcinoma bronquial).</p><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Docientos once murieron entre 19551960, de los que 154 eran fumadores regulares, y 234 que murieron entre 1970-1977, 181 fumadores regulares.</p><p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron los siguientes cambios histológicos: hiperplasia de células básales, pérdida de cilios y núcleos atípicos celulares.</p><p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">Estos cambios se dieron en ambos grupos y con mucha menos frecuencia en los no fumadores y aumentaban proporcionalmente a la cantidad de tabaco fumado.</p><p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">Muestras bronquiales con trastornos histológicos importantes entre el grupo 19551960 ocurrieron en 0% de los no fumadores, 2,6% de los fumadores de 1 a 19 cigarrillos al día, 13,2% en los que fumaban de 20 a 39 y en 22,5% en los fumadores de más de 40 cigarrillos al día.</p><p id="spar0140" class="elsevierStyleSimplePara elsevierViewall">En el grupo que murió entre 1970-1977 los porcentajes fueron 0, 0,1, 0,8 y 2,2 respectivamente.</p></span>" ] ] ] 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