Small Cel Carcinoma of the Lung. Experience with a six-drug Regimen
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Experience with a six-drug Regimen" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "135" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Treinta y siete enfermos con carcinoma de células pequeñas pulmonar, sin tratamiento previo, fueron tratados con un programa alternativo de dos regímenes de 3 drogas compuesto por agentes activos individualmente y con diferentes mecanismos de acción farmacológica. Las dos fases terapéuticas consistían’en: 1) ciclofosfamida 100 mg/m<span class="elsevierStyleSup">2</span>, adriamicina 30 mg/m<span class="elsevierStyleSup">2</span> y vincristina 1,4 mg/m<span class="elsevierStyleSup">2</span> administrados todos ellos por vía endovenosa en los días 1 y 22 (régimen CAV). El segundo régimen (BMP) consistía en BCNU 100 mg/m<span class="elsevierStyleSup">2</span> i.v., los días 43 y 44; methrotrexate, 30 mg/m<span class="elsevierStyleSup">2</span> i.v., los días 50 y 64, y procarbazina 100 mg/m<span class="elsevierStyleSup">2</span> per los de los días 51 a 64. Los tratamientos se «reciclaban » con CAV el día 85.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se usó radioterapia para controlar la extensión del tumor localmente que no respondía a la quimioterapia y para paliar las molestias focales del cáncer progresivo.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De los 31 enfermos valorables para un análisis de la respuesta a la quimioterapia y a la radiación, el 70% demostraron una regresión tumoral completa o parcial (más del 50%) con duración de la respuesta de 7 meses de media con rango de 1 2 25 o meses. El tiempo de superviviencia media desde el inicio del tratamiento fue de 11,5 meses para enfermos con enfermedad limitada y 7,5 meses con extensión tumoral.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La toxicidad incluyó: náuses y vómitos en todos los pacientes, leucopenia (menos de 3.000 elementos) en 29% del grupo CAV y 27% del BMP con dos episodios de infección y una muerte, trombopenia (menos de 50.000 elementos en 3% de grupo CAV y 42% en el BMP).</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Este programa de seis drogas no se mostró superior a otros protocolos conocidos de 4 drogas.</p></span>" ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000001600000003/v1_201509151256/S0300289615324844/v1_201509151256/es/main.assets" "Apartado" => array:4 [ "identificador" => "43822" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Referatas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000001600000003/v1_201509151256/S0300289615324844/v1_201509151256/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615324844?idApp=UINPBA00003Z" ]
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