array:23 [
  "pii" => "S0300289604755441"
  "issn" => "03002896"
  "doi" => "10.1016/S0300-2896(04)75544-1"
  "estado" => "S300"
  "fechaPublicacion" => "2004-08-01"
  "aid" => "75544"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
  "copyrightAnyo" => "2004"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2004;40:355-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 17740
    "formatos" => array:3 [
      "EPUB" => 86
      "HTML" => 10468
      "PDF" => 7186
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0300289604755453"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(04)75545-3"
    "estado" => "S300"
    "fechaPublicacion" => "2004-08-01"
    "aid" => "75545"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2004;40:360-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5913
      "formatos" => array:3 [
        "EPUB" => 90
        "HTML" => 5171
        "PDF" => 652
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Sudación compensatoria secundaria a la simpaticólisis torácica superior. Estudio prospectivo de 123 casos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "360"
          "paginaFinal" => "363"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Compensatory Sweating After Upper Thoracic Sympathectomy. Prospective Study of 123 Cases"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J. Moya, R. Ramos, N. Vives, J. Pérez, R. Morera, V. Perna, R. Villalonga, G. Ferrer"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "J."
              "apellidos" => "Moya"
            ]
            1 => array:2 [
              "nombre" => "R."
              "apellidos" => "Ramos"
            ]
            2 => array:2 [
              "nombre" => "N."
              "apellidos" => "Vives"
            ]
            3 => array:2 [
              "nombre" => "J."
              "apellidos" => "Pérez"
            ]
            4 => array:2 [
              "nombre" => "R."
              "apellidos" => "Morera"
            ]
            5 => array:2 [
              "nombre" => "V."
              "apellidos" => "Perna"
            ]
            6 => array:2 [
              "nombre" => "R."
              "apellidos" => "Villalonga"
            ]
            7 => array:2 [
              "nombre" => "G."
              "apellidos" => "Ferrer"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289604755453?idApp=UINPBA00003Z"
    "url" => "/03002896/0000004000000008/v1_201307081405/S0300289604755453/v1_201307081405/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S030028960475543X"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(04)75543-X"
    "estado" => "S300"
    "fechaPublicacion" => "2004-08-01"
    "aid" => "75543"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2004;40:348-54"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6606
      "formatos" => array:3 [
        "EPUB" => 77
        "HTML" => 5714
        "PDF" => 815
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Abandono del consumo de tabaco en una cohorte de base poblacional"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "348"
          "paginaFinal" => "354"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Smoking Cessation in a Population-Based Cohort Study"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M. García, A. Schiaffino, J. Twose, C. Borrell, E. Saltó, M. Peris, E. Fernández"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "M."
              "apellidos" => "García"
            ]
            1 => array:2 [
              "nombre" => "A."
              "apellidos" => "Schiaffino"
            ]
            2 => array:2 [
              "nombre" => "J."
              "apellidos" => "Twose"
            ]
            3 => array:2 [
              "nombre" => "C."
              "apellidos" => "Borrell"
            ]
            4 => array:2 [
              "nombre" => "E."
              "apellidos" => "Saltó"
            ]
            5 => array:2 [
              "nombre" => "M."
              "apellidos" => "Peris"
            ]
            6 => array:2 [
              "nombre" => "E."
              "apellidos" => "Fernández"
            ]
            7 => array:1 [
              "colaborador" => "en representación de los investigadores del Estudio de Seguimiento de la Encuesta de Salud de Cornellà (Es.Esc)"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028960475543X?idApp=UINPBA00003Z"
    "url" => "/03002896/0000004000000008/v1_201307081405/S030028960475543X/v1_201307081405/es/main.assets"
  ]
  "es" => array:15 [
    "idiomaDefecto" => true
    "titulo" => "Acromegalia y apnea del sueño"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "355"
        "paginaFinal" => "359"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J.J. Blanco Pérez, M.A. Blanco-Ramos, C. Zamarrón Sanz, A. Souto Fernández, A. Mato Mato, J. Lamela López"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "J.J."
            "apellidos" => "Blanco Pérez"
            "email" => array:1 [
              0 => "xosej@tiscali.es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;A&#46;"
            "apellidos" => "Blanco-Ramos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Zamarr&#243;n Sanz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Souto Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Mato Mato"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Lamela L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#46; Complexo Hospitalario Ourense&#46; Ourense&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Investigaci&#243;n&#46; Complexo Hospitalario Ourense&#46; Ourense&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#46; Hospital Cl&#237;nico Universitario&#46; Santiago de Compostela&#46; A Coru&#241;a&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Endocrinolog&#237;a&#46; Complexo Hospitalario Ourense&#46; Ourense&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondencia&#58; Servicio de Neumolog&#237;a&#46; Complexo Hospitalario Ourense&#46;Ram&#243;n Puga&#44; 52&#8211;56&#46; 32005 Ourense&#46; Espa&#241;a"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Acromegaly and Sleep Apnea"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2003-11-11"
    "fechaAceptado" => "2004-02-17"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec189821"
          "palabras" => array:3 [
            0 => "S&#237;ndrome de apnea-hipopnea del sue&#241;o"
            1 => "Cefalo-metr&#237;a"
            2 => "Acromegalia"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec189822"
          "palabras" => array:3 [
            0 => "Sleep apnea-hypopnea syndrome"
            1 => "Cephalometry"
            2 => "Acromegaly"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La acromegalia se relaciona frecuentemente con el s&#237;ndrome de apnea-hipopnea del sue&#241;o &#40;SAHS&#41;&#46; El prop&#243;sito de este trabajo es conocer la prevalencia del SAHS en los pacientes con acromegalia y definir las caracter&#237;sticas de esta poblaci&#243;n con y sin SAHS</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 17 pacientes diagnosticados de acromegalia en la provincia de Ourense &#40;11 mujeres y 6 varones&#41;&#46; A todos ellos se les realiz&#243; polisomnograf&#237;a nocturna diagn&#243;stica en el laboratorio del sue&#241;o&#44; adem&#225;s de una determinaci&#243;n de hormona de crecimiento y de factor 1 de crecimiento insulinalike&#44; y a 16 se les efectu&#243; un estudio cefalom&#233;trico</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La edad media de los pacientes era de 58 a&#241;os &#40;intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 52-63&#41;&#46; La media del &#237;ndice de masa corporal era de 31 &#40;IC del 95&#37;&#44; 29-34&#41; y la del per&#237;metro del cuello&#44; de 41 &#40;IC del 95&#37;&#44; 39-43&#41;&#46; Diez pacientes &#40;58&#44;8&#37;&#41; ten&#237;an un &#237;ndice de apnea-hipopnea &#40;IAH&#41; mayor de 10&#59; 9 presentaban apnea obstructiva y 1&#44; central&#46; Del total de pacientes&#44; 7 &#40;5 con IAH &#62; 10 y 2 con IAH &#60; 10&#41; presentaban somnolencia diurna excesiva&#44; con un &#237;ndice de Epworth superior a 10 &#40;41&#44;2&#37;&#41;&#46; Presentaban SAHS &#40;IAH &#62; 10 y Epworth &#62; 10&#41; 5 pacientes &#40;29&#44;4&#37;&#41;&#46; No se encontr&#243; relaci&#243;n entre un IAH mayor de 10 y actividad hormonal &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;082&#41;&#46; Los sujetos con IAH mayor de 10 presentaban un valor medio de hormona de crecimiento de 4&#44;8 &#40;IC del 95&#37;&#44; 0&#44;5-9&#41; y en aquellos con IAH menor de 10 dicho valor era de 12 &#40;IC del 95&#37;&#44; 2&#8211;27&#41;&#46; Estaban tratados con an&#225;logos de la somatostatina el 50&#37; de los pacientes&#44; de los cuales la mitad presentaba apnea &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;302&#41;&#46; El estudio completo de las cefalometr&#237;as no evidenci&#243; diferencia en relaci&#243;n con la presencia de apneas</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Encontramos una alta prevalencia de apnea del sue&#241;o &#40;58&#44;8&#37;&#41; y de s&#237;ndrome de apnea del sue&#241;o &#40;29&#44;4&#37;&#41;&#44; y fue una rareza la presencia de apneas centrales&#46; No encontramos relaci&#243;n entre actividad hormonal y la presencia de SAHS&#46; Los pacientes tratados con an&#225;logos de la somatostatina presentaban la misma incidencia de SAHS que los no tratados&#46; Ning&#250;n par&#225;metro de cefalometr&#237;a result&#243; discriminador</p>"
      ]
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Acromegaly is often associated with sleep apnea-hypopnea syndrome &#40;SAHS&#41;&#46; The purpose of this study was to understand the prevalence of SAHS in patients with acromegaly and define the characteristics of acromegalic patients with and without SAHS</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The study enrolled 17 patients &#40;11 women and 6 men&#41; residing in the province of Ourense&#44; Spain&#44; who were diagnosed with acromegaly&#46; All patients underwent overnight polysomnography in a sleep laboratory&#46; In addition&#44; growth hormone and insulin-like growth factor 1 levels were assessed&#46; Sixteen of the patients underwent cephalometric study</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The average age of the patients was 58 years &#40;95&#37; confidence interval &#91;CI&#93;&#44; 52-63&#41;&#46; The average body mass index was 31 &#40;95&#37; CI&#44; 29&#8211;34&#41; and average neck circumference was 41 &#40;95&#37; CI&#44; 39-43&#41;&#46; Ten patients &#40;58&#46;8&#37;&#41; had an apnea-hypopnea index &#40;AHI&#41; greater than 10&#46; Nine had obstructive apnea and one had central apnea&#46; Seven &#40;5 with an AHI &#62; 10 and 2 with an AHI &#60; 10&#41; reported excessive daytime sleepiness with Epworth scores greater than 10 &#40;41&#46;2&#37;&#41;&#46; Five patients &#40;29&#46;4&#37;&#41; were diagnosed with SAHS &#40;AHI&#62;10 and Epworth&#62;10&#41;&#46; No correlation was found between an AHI greater than 10 and hormonal activity &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;082&#41;&#46; The mean growth hormone level for patients with an AHI greater than 10 was 4&#46;8 &#40;95&#37; CI&#44; 0&#46;5-9&#41; and the mean for those with an AHI less than 10 was 12 &#40;95&#37; CI&#44; 2&#8211;27&#41;&#46; Fifty percent of the patients were treated with a somatostatin analog and half of those treated exhibited apnea &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;302&#41;&#46; No cephalometric differences related to the presence of apneas were found</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We found a high prevalence of sleep apneas &#40;58&#46;8&#37;&#41; and SAHS &#40;29&#46;4&#37;&#41;&#44; and central apneas were rare&#46; We found no correlation between hormone activity level and the presence of SAHS&#46; The incidence of SAHS was the same in somatostatin analog treated and untreated patients&#46; Cephalometric variables did not distinguish between acromegalic patients with and without SAHS</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara">Estudio cefalom&#233;trico financiado por GASMEDI&#44; S&#46;A&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:22 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The occurrence of sleep-disordered breathing among middled-aged adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Young"
                            1 => "M&#46; Palta"
                            2 => "J&#46; Dempsey"
                            3 => "J&#46; Skratrud"
                            4 => "S&#46; Weber"
                            5 => "S&#46; Bard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199304293281704"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1993"
                        "volumen" => "328"
                        "paginaInicial" => "1230"
                        "paginaFinal" => "1235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8464434"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obstructive sleep apnea hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Dur&#225;n"
                            1 => "S&#46; Esnaola"
                            2 => "R&#46; Rubio"
                            3 => "A&#46; Iztueta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.3.2005065"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "685"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11254524"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of acromegaly in the Newcastle region"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Alexander"
                            1 => "D&#46; Appleton"
                            2 => "R&#46; Hall"
                            3 => "W&#46;M&#46; Ross"
                            4 => "R&#46; Wilkinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1980"
                        "volumen" => "12"
                        "paginaInicial" => "71"
                        "paginaFinal" => "79"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and long-term survival in acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46;A&#46; Bengtsson"
                            1 => "S&#46; Eden"
                            2 => "I&#46; Ernst"
                            3 => "A&#46; Oden"
                            4 => "B&#46; Sjogren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Scand"
                        "fecha" => "1988"
                        "volumen" => "223"
                        "paginaInicial" => "327"
                        "paginaFinal" => "335"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3369313"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Melmed"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199004053221405"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1990"
                        "volumen" => "322"
                        "paginaInicial" => "966"
                        "paginaFinal" => "997"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2179724"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep apnea in acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;H&#46; Perks"
                            1 => "P&#46;M&#46; Horrocks"
                            2 => "R&#46;A&#46; Cooper"
                            3 => "S&#46; Bradbury"
                            4 => "A&#46; Allen"
                            5 => "N&#46; Baldock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br Med J"
                        "fecha" => "1980"
                        "volumen" => "280"
                        "paginaInicial" => "894"
                        "paginaFinal" => "897"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7388361"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep apnea in active acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46;B&#46; Hart"
                            1 => "S&#46;K&#46; Radow"
                            2 => "W&#46;G&#46; Blackard"
                            3 => "H&#46; st&#46; George Tucker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "1985"
                        "volumen" => "145"
                        "paginaInicial" => "865"
                        "paginaFinal" => "866"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3994462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep apnea in acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;R&#46; Grunstein"
                            1 => "K&#46; Ho"
                            2 => "C&#46;E&#46; Sullivan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1991"
                        "volumen" => "115"
                        "paginaInicial" => "527"
                        "paginaFinal" => "532"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1883121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of the sleep apnea syndrome in acromegaly population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Weiss"
                            1 => "K&#46; Sonka"
                            2 => "M&#46; Pretl"
                            3 => "S&#46; Dost&#225;lov&#225;"
                            4 => "J&#46; Klozar"
                            5 => "P&#46; Rambousek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03343767"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Endocrinol Invest"
                        "fecha" => "2000"
                        "volumen" => "23"
                        "paginaInicial" => "515"
                        "paginaFinal" => "519"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11021767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obstructive sleep apnea in acromegaly&#58; the role of craniofacial changes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46; Hochban"
                            1 => "K&#46; Ehlenz"
                            2 => "R&#46; Conradt"
                            3 => "U&#46; Brandeburg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "paginaInicial" => "196"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10489851"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of Sandostatin LAR on sleep apnea in acromegaly&#58; correlation with computerized tomographic cephalometry and hormonal activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;S&#46; Ip"
                            1 => "K&#46;C&#46; Tan"
                            2 => "W&#46;C&#46; Peh"
                            3 => "K&#46;S&#46; Lam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol &#40;Oxf&#41;"
                        "fecha" => "2001"
                        "volumen" => "55"
                        "paginaInicial" => "477"
                        "paginaFinal" => "483"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of octreotide&#44; a somatostanin analog&#44; on sleep apnea in patients with acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;R&#46; Grunstein"
                            1 => "K&#46; Ho"
                            2 => "C&#46;E&#46; Sullivan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1994"
                        "volumen" => "121"
                        "paginaInicial" => "478"
                        "paginaFinal" => "483"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8067645"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Atlas Task Force&#46; EEG arousals&#58; scoring rules and examples"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "American Sleep Disorders Association"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "1992"
                        "volumen" => "15"
                        "paginaInicial" => "174"
                        "paginaFinal" => "184"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new method of measuring daytime sleepiness&#58; the Epworth Sleepiness Scale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;W&#46; Johns"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "1991"
                        "volumen" => "14"
                        "paginaInicial" => "540"
                        "paginaFinal" => "545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1798888"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cephalometrics roentgenograms and computerized tomographic scans in obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Riley"
                            1 => "N&#46; Powell"
                            2 => "C&#46; Guillerminault"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "1986"
                        "volumen" => "9"
                        "paginaInicial" => "514"
                        "paginaFinal" => "515"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3809865"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pr&#225;cticas de ortodoncia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Su&#225;rez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "titulo" => "Grafinova Ediciones&#44;"
                        "fecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endocrine and metabolic disturbances in obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Grunstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Sleep and breathing"
                        "paginaInicial" => "449"
                        "paginaFinal" => "491"
                        "serieFecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Une observation de respiration &#233;riodique chez une acrom&#233;galie"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46; Laroche"
                            1 => "G&#46; Festal"
                            2 => "S&#46; Poenaru"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Med Intern"
                        "fecha" => "1976"
                        "volumen" => "127"
                        "paginaInicial" => "381"
                        "paginaFinal" => "385"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality in acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;D&#46; Wright"
                            1 => "D&#46;M&#46; Hill"
                            2 => "C&#46; Lowy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Q J Med"
                        "fecha" => "1970"
                        "volumen" => "39"
                        "paginaInicial" => "1"
                        "paginaFinal" => "16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5427331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep apnoea in treated acromegaly&#58; relative frecuency and predisposing factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Rosenow"
                            1 => "S&#46; Reuter"
                            2 => "U&#46; Deuss"
                            3 => "B&#46; Szelies"
                            4 => "R&#46;D&#46; Hilgers"
                            5 => "W&#46; Winkelmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1996"
                        "volumen" => "45"
                        "paginaInicial" => "563"
                        "paginaFinal" => "569"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endoscopic findings in sleep apnea associated with acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Cadieux"
                            1 => "A&#46; Kales"
                            2 => "R&#46; Santen"
                            3 => "E&#46; Bixler"
                            4 => "R&#46; Gordon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem-55-1-18"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1982"
                        "volumen" => "55"
                        "paginaInicial" => "18"
                        "paginaFinal" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7076804"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rapid improvement in sleep apnea of acromegaly after short term treatment with somatostatin analogue SMS 201-995"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Chanson"
                            1 => "J&#46; Timsit"
                            2 => "O&#46; Benoit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1986"
                        "volumen" => "2"
                        "paginaInicial" => "1270"
                        "paginaFinal" => "1271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2573774"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/03002896/0000004000000008/v1_201307081405/S0300289604755441/v1_201307081405/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9277"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03002896/0000004000000008/v1_201307081405/S0300289604755441/v1_201307081405/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289604755441?idApp=UINPBA00003Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Acromegalia y apnea del sueño
Acromegaly and Sleep Apnea
J.J. Blanco Péreza,
Corresponding author
xosej@tiscali.es

Correspondencia: Servicio de Neumología. Complexo Hospitalario Ourense.Ramón Puga, 52–56. 32005 Ourense. España
, M.A. Blanco-Ramosb, C. Zamarrón Sanzc, A. Souto Fernándeza, A. Mato Matod, J. Lamela Lópeza
a Servicio de Neumología. Complexo Hospitalario Ourense. Ourense. España
b Unidad de Investigación. Complexo Hospitalario Ourense. Ourense. España
c Servicio de Neumología. Hospital Clínico Universitario. Santiago de Compostela. A Coruña. España
d Servicio de Endocrinología. Complexo Hospitalario Ourense. Ourense. España
Read
21996
Times
was read the article
8854
Total PDF
13142
Total HTML
Share statistics
 array:23 [
  "pii" => "S0300289604755441"
  "issn" => "03002896"
  "doi" => "10.1016/S0300-2896(04)75544-1"
  "estado" => "S300"
  "fechaPublicacion" => "2004-08-01"
  "aid" => "75544"
  "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica"
  "copyrightAnyo" => "2004"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2004;40:355-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 17740
    "formatos" => array:3 [
      "EPUB" => 86
      "HTML" => 10468
      "PDF" => 7186
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0300289604755453"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(04)75545-3"
    "estado" => "S300"
    "fechaPublicacion" => "2004-08-01"
    "aid" => "75545"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2004;40:360-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5913
      "formatos" => array:3 [
        "EPUB" => 90
        "HTML" => 5171
        "PDF" => 652
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Sudaci&#243;n compensatoria secundaria a la simpatic&#243;lisis tor&#225;cica superior&#46; Estudio prospectivo de 123 casos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "360"
          "paginaFinal" => "363"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Compensatory Sweating After Upper Thoracic Sympathectomy&#46; Prospective Study of 123 Cases"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Moya, R&#46; Ramos, N&#46; Vives, J&#46; P&#233;rez, R&#46; Morera, V&#46; Perna, R&#46; Villalonga, G&#46; Ferrer"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Moya"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ramos"
            ]
            2 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Vives"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "P&#233;rez"
            ]
            4 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Morera"
            ]
            5 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Perna"
            ]
            6 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Villalonga"
            ]
            7 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Ferrer"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289604755453?idApp=UINPBA00003Z"
    "url" => "/03002896/0000004000000008/v1_201307081405/S0300289604755453/v1_201307081405/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S030028960475543X"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(04)75543-X"
    "estado" => "S300"
    "fechaPublicacion" => "2004-08-01"
    "aid" => "75543"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2004;40:348-54"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6606
      "formatos" => array:3 [
        "EPUB" => 77
        "HTML" => 5714
        "PDF" => 815
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Abandono del consumo de tabaco en una cohorte de base poblacional"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "348"
          "paginaFinal" => "354"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Smoking Cessation in a Population-Based Cohort Study"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Garc&#237;a, A&#46; Schiaffino, J&#46; Twose, C&#46; Borrell, E&#46; Salt&#243;, M&#46; Peris, E&#46; Fern&#225;ndez"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Schiaffino"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Twose"
            ]
            3 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Borrell"
            ]
            4 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Salt&#243;"
            ]
            5 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Peris"
            ]
            6 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Fern&#225;ndez"
            ]
            7 => array:1 [
              "colaborador" => "en representaci&#243;n de los investigadores del Estudio de Seguimiento de la Encuesta de Salud de Cornell&#224; &#40;Es&#46;Esc&#41;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028960475543X?idApp=UINPBA00003Z"
    "url" => "/03002896/0000004000000008/v1_201307081405/S030028960475543X/v1_201307081405/es/main.assets"
  ]
  "es" => array:15 [
    "idiomaDefecto" => true
    "titulo" => "Acromegalia y apnea del sue&#241;o"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "355"
        "paginaFinal" => "359"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46;J&#46; Blanco P&#233;rez, M&#46;A&#46; Blanco-Ramos, C&#46; Zamarr&#243;n Sanz, A&#46; Souto Fern&#225;ndez, A&#46; Mato Mato, J&#46; Lamela L&#243;pez"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "J&#46;J&#46;"
            "apellidos" => "Blanco P&#233;rez"
            "email" => array:1 [
              0 => "xosej&#64;tiscali&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;A&#46;"
            "apellidos" => "Blanco-Ramos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Zamarr&#243;n Sanz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Souto Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Mato Mato"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Lamela L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#46; Complexo Hospitalario Ourense&#46; Ourense&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Investigaci&#243;n&#46; Complexo Hospitalario Ourense&#46; Ourense&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#46; Hospital Cl&#237;nico Universitario&#46; Santiago de Compostela&#46; A Coru&#241;a&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Endocrinolog&#237;a&#46; Complexo Hospitalario Ourense&#46; Ourense&#46; Espa&#241;a"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondencia&#58; Servicio de Neumolog&#237;a&#46; Complexo Hospitalario Ourense&#46;Ram&#243;n Puga&#44; 52&#8211;56&#46; 32005 Ourense&#46; Espa&#241;a"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Acromegaly and Sleep Apnea"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2003-11-11"
    "fechaAceptado" => "2004-02-17"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec189821"
          "palabras" => array:3 [
            0 => "S&#237;ndrome de apnea-hipopnea del sue&#241;o"
            1 => "Cefalo-metr&#237;a"
            2 => "Acromegalia"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec189822"
          "palabras" => array:3 [
            0 => "Sleep apnea-hypopnea syndrome"
            1 => "Cephalometry"
            2 => "Acromegaly"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La acromegalia se relaciona frecuentemente con el s&#237;ndrome de apnea-hipopnea del sue&#241;o &#40;SAHS&#41;&#46; El prop&#243;sito de este trabajo es conocer la prevalencia del SAHS en los pacientes con acromegalia y definir las caracter&#237;sticas de esta poblaci&#243;n con y sin SAHS</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 17 pacientes diagnosticados de acromegalia en la provincia de Ourense &#40;11 mujeres y 6 varones&#41;&#46; A todos ellos se les realiz&#243; polisomnograf&#237;a nocturna diagn&#243;stica en el laboratorio del sue&#241;o&#44; adem&#225;s de una determinaci&#243;n de hormona de crecimiento y de factor 1 de crecimiento insulinalike&#44; y a 16 se les efectu&#243; un estudio cefalom&#233;trico</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La edad media de los pacientes era de 58 a&#241;os &#40;intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 52-63&#41;&#46; La media del &#237;ndice de masa corporal era de 31 &#40;IC del 95&#37;&#44; 29-34&#41; y la del per&#237;metro del cuello&#44; de 41 &#40;IC del 95&#37;&#44; 39-43&#41;&#46; Diez pacientes &#40;58&#44;8&#37;&#41; ten&#237;an un &#237;ndice de apnea-hipopnea &#40;IAH&#41; mayor de 10&#59; 9 presentaban apnea obstructiva y 1&#44; central&#46; Del total de pacientes&#44; 7 &#40;5 con IAH &#62; 10 y 2 con IAH &#60; 10&#41; presentaban somnolencia diurna excesiva&#44; con un &#237;ndice de Epworth superior a 10 &#40;41&#44;2&#37;&#41;&#46; Presentaban SAHS &#40;IAH &#62; 10 y Epworth &#62; 10&#41; 5 pacientes &#40;29&#44;4&#37;&#41;&#46; No se encontr&#243; relaci&#243;n entre un IAH mayor de 10 y actividad hormonal &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;082&#41;&#46; Los sujetos con IAH mayor de 10 presentaban un valor medio de hormona de crecimiento de 4&#44;8 &#40;IC del 95&#37;&#44; 0&#44;5-9&#41; y en aquellos con IAH menor de 10 dicho valor era de 12 &#40;IC del 95&#37;&#44; 2&#8211;27&#41;&#46; Estaban tratados con an&#225;logos de la somatostatina el 50&#37; de los pacientes&#44; de los cuales la mitad presentaba apnea &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;302&#41;&#46; El estudio completo de las cefalometr&#237;as no evidenci&#243; diferencia en relaci&#243;n con la presencia de apneas</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Encontramos una alta prevalencia de apnea del sue&#241;o &#40;58&#44;8&#37;&#41; y de s&#237;ndrome de apnea del sue&#241;o &#40;29&#44;4&#37;&#41;&#44; y fue una rareza la presencia de apneas centrales&#46; No encontramos relaci&#243;n entre actividad hormonal y la presencia de SAHS&#46; Los pacientes tratados con an&#225;logos de la somatostatina presentaban la misma incidencia de SAHS que los no tratados&#46; Ning&#250;n par&#225;metro de cefalometr&#237;a result&#243; discriminador</p>"
      ]
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Acromegaly is often associated with sleep apnea-hypopnea syndrome &#40;SAHS&#41;&#46; The purpose of this study was to understand the prevalence of SAHS in patients with acromegaly and define the characteristics of acromegalic patients with and without SAHS</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The study enrolled 17 patients &#40;11 women and 6 men&#41; residing in the province of Ourense&#44; Spain&#44; who were diagnosed with acromegaly&#46; All patients underwent overnight polysomnography in a sleep laboratory&#46; In addition&#44; growth hormone and insulin-like growth factor 1 levels were assessed&#46; Sixteen of the patients underwent cephalometric study</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The average age of the patients was 58 years &#40;95&#37; confidence interval &#91;CI&#93;&#44; 52-63&#41;&#46; The average body mass index was 31 &#40;95&#37; CI&#44; 29&#8211;34&#41; and average neck circumference was 41 &#40;95&#37; CI&#44; 39-43&#41;&#46; Ten patients &#40;58&#46;8&#37;&#41; had an apnea-hypopnea index &#40;AHI&#41; greater than 10&#46; Nine had obstructive apnea and one had central apnea&#46; Seven &#40;5 with an AHI &#62; 10 and 2 with an AHI &#60; 10&#41; reported excessive daytime sleepiness with Epworth scores greater than 10 &#40;41&#46;2&#37;&#41;&#46; Five patients &#40;29&#46;4&#37;&#41; were diagnosed with SAHS &#40;AHI&#62;10 and Epworth&#62;10&#41;&#46; No correlation was found between an AHI greater than 10 and hormonal activity &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;082&#41;&#46; The mean growth hormone level for patients with an AHI greater than 10 was 4&#46;8 &#40;95&#37; CI&#44; 0&#46;5-9&#41; and the mean for those with an AHI less than 10 was 12 &#40;95&#37; CI&#44; 2&#8211;27&#41;&#46; Fifty percent of the patients were treated with a somatostatin analog and half of those treated exhibited apnea &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;302&#41;&#46; No cephalometric differences related to the presence of apneas were found</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We found a high prevalence of sleep apneas &#40;58&#46;8&#37;&#41; and SAHS &#40;29&#46;4&#37;&#41;&#44; and central apneas were rare&#46; We found no correlation between hormone activity level and the presence of SAHS&#46; The incidence of SAHS was the same in somatostatin analog treated and untreated patients&#46; Cephalometric variables did not distinguish between acromegalic patients with and without SAHS</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara">Estudio cefalom&#233;trico financiado por GASMEDI&#44; S&#46;A&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:22 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The occurrence of sleep-disordered breathing among middled-aged adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Young"
                            1 => "M&#46; Palta"
                            2 => "J&#46; Dempsey"
                            3 => "J&#46; Skratrud"
                            4 => "S&#46; Weber"
                            5 => "S&#46; Bard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199304293281704"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1993"
                        "volumen" => "328"
                        "paginaInicial" => "1230"
                        "paginaFinal" => "1235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8464434"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obstructive sleep apnea hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Dur&#225;n"
                            1 => "S&#46; Esnaola"
                            2 => "R&#46; Rubio"
                            3 => "A&#46; Iztueta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.3.2005065"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "685"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11254524"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of acromegaly in the Newcastle region"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Alexander"
                            1 => "D&#46; Appleton"
                            2 => "R&#46; Hall"
                            3 => "W&#46;M&#46; Ross"
                            4 => "R&#46; Wilkinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1980"
                        "volumen" => "12"
                        "paginaInicial" => "71"
                        "paginaFinal" => "79"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and long-term survival in acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46;A&#46; Bengtsson"
                            1 => "S&#46; Eden"
                            2 => "I&#46; Ernst"
                            3 => "A&#46; Oden"
                            4 => "B&#46; Sjogren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Scand"
                        "fecha" => "1988"
                        "volumen" => "223"
                        "paginaInicial" => "327"
                        "paginaFinal" => "335"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3369313"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Melmed"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199004053221405"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1990"
                        "volumen" => "322"
                        "paginaInicial" => "966"
                        "paginaFinal" => "997"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2179724"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep apnea in acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;H&#46; Perks"
                            1 => "P&#46;M&#46; Horrocks"
                            2 => "R&#46;A&#46; Cooper"
                            3 => "S&#46; Bradbury"
                            4 => "A&#46; Allen"
                            5 => "N&#46; Baldock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br Med J"
                        "fecha" => "1980"
                        "volumen" => "280"
                        "paginaInicial" => "894"
                        "paginaFinal" => "897"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7388361"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep apnea in active acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46;B&#46; Hart"
                            1 => "S&#46;K&#46; Radow"
                            2 => "W&#46;G&#46; Blackard"
                            3 => "H&#46; st&#46; George Tucker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "1985"
                        "volumen" => "145"
                        "paginaInicial" => "865"
                        "paginaFinal" => "866"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3994462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep apnea in acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;R&#46; Grunstein"
                            1 => "K&#46; Ho"
                            2 => "C&#46;E&#46; Sullivan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1991"
                        "volumen" => "115"
                        "paginaInicial" => "527"
                        "paginaFinal" => "532"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1883121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of the sleep apnea syndrome in acromegaly population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Weiss"
                            1 => "K&#46; Sonka"
                            2 => "M&#46; Pretl"
                            3 => "S&#46; Dost&#225;lov&#225;"
                            4 => "J&#46; Klozar"
                            5 => "P&#46; Rambousek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03343767"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Endocrinol Invest"
                        "fecha" => "2000"
                        "volumen" => "23"
                        "paginaInicial" => "515"
                        "paginaFinal" => "519"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11021767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obstructive sleep apnea in acromegaly&#58; the role of craniofacial changes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46; Hochban"
                            1 => "K&#46; Ehlenz"
                            2 => "R&#46; Conradt"
                            3 => "U&#46; Brandeburg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "paginaInicial" => "196"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10489851"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of Sandostatin LAR on sleep apnea in acromegaly&#58; correlation with computerized tomographic cephalometry and hormonal activity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;S&#46; Ip"
                            1 => "K&#46;C&#46; Tan"
                            2 => "W&#46;C&#46; Peh"
                            3 => "K&#46;S&#46; Lam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol &#40;Oxf&#41;"
                        "fecha" => "2001"
                        "volumen" => "55"
                        "paginaInicial" => "477"
                        "paginaFinal" => "483"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of octreotide&#44; a somatostanin analog&#44; on sleep apnea in patients with acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;R&#46; Grunstein"
                            1 => "K&#46; Ho"
                            2 => "C&#46;E&#46; Sullivan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1994"
                        "volumen" => "121"
                        "paginaInicial" => "478"
                        "paginaFinal" => "483"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8067645"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Atlas Task Force&#46; EEG arousals&#58; scoring rules and examples"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "American Sleep Disorders Association"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "1992"
                        "volumen" => "15"
                        "paginaInicial" => "174"
                        "paginaFinal" => "184"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new method of measuring daytime sleepiness&#58; the Epworth Sleepiness Scale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;W&#46; Johns"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "1991"
                        "volumen" => "14"
                        "paginaInicial" => "540"
                        "paginaFinal" => "545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1798888"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cephalometrics roentgenograms and computerized tomographic scans in obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Riley"
                            1 => "N&#46; Powell"
                            2 => "C&#46; Guillerminault"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "1986"
                        "volumen" => "9"
                        "paginaInicial" => "514"
                        "paginaFinal" => "515"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3809865"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pr&#225;cticas de ortodoncia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Su&#225;rez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "titulo" => "Grafinova Ediciones&#44;"
                        "fecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endocrine and metabolic disturbances in obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Grunstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Sleep and breathing"
                        "paginaInicial" => "449"
                        "paginaFinal" => "491"
                        "serieFecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Une observation de respiration &#233;riodique chez une acrom&#233;galie"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46; Laroche"
                            1 => "G&#46; Festal"
                            2 => "S&#46; Poenaru"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Med Intern"
                        "fecha" => "1976"
                        "volumen" => "127"
                        "paginaInicial" => "381"
                        "paginaFinal" => "385"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality in acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;D&#46; Wright"
                            1 => "D&#46;M&#46; Hill"
                            2 => "C&#46; Lowy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Q J Med"
                        "fecha" => "1970"
                        "volumen" => "39"
                        "paginaInicial" => "1"
                        "paginaFinal" => "16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5427331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep apnoea in treated acromegaly&#58; relative frecuency and predisposing factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Rosenow"
                            1 => "S&#46; Reuter"
                            2 => "U&#46; Deuss"
                            3 => "B&#46; Szelies"
                            4 => "R&#46;D&#46; Hilgers"
                            5 => "W&#46; Winkelmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol"
                        "fecha" => "1996"
                        "volumen" => "45"
                        "paginaInicial" => "563"
                        "paginaFinal" => "569"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endoscopic findings in sleep apnea associated with acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Cadieux"
                            1 => "A&#46; Kales"
                            2 => "R&#46; Santen"
                            3 => "E&#46; Bixler"
                            4 => "R&#46; Gordon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem-55-1-18"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1982"
                        "volumen" => "55"
                        "paginaInicial" => "18"
                        "paginaFinal" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7076804"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rapid improvement in sleep apnea of acromegaly after short term treatment with somatostatin analogue SMS 201-995"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Chanson"
                            1 => "J&#46; Timsit"
                            2 => "O&#46; Benoit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1986"
                        "volumen" => "2"
                        "paginaInicial" => "1270"
                        "paginaFinal" => "1271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2573774"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/03002896/0000004000000008/v1_201307081405/S0300289604755441/v1_201307081405/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9277"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03002896/0000004000000008/v1_201307081405/S0300289604755441/v1_201307081405/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289604755441?idApp=UINPBA00003Z"
]
Article information
ISSN: 03002896
Original language: Spanish
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 5 3 8
2024 October 57 40 97
2024 September 73 27 100
2024 August 78 44 122
2024 July 72 29 101
2024 June 81 63 144
2024 May 71 32 103
2024 April 71 30 101
2024 March 60 32 92
2024 February 45 36 81
2023 December 0 3 3
2023 November 0 4 4
2023 October 0 3 3
2023 September 0 4 4
2023 August 1 5 6
2023 July 0 4 4
2023 May 1 0 1
2023 March 15 4 19
2023 February 70 27 97
2023 January 40 24 64
2022 December 62 25 87
2022 November 80 33 113
2022 October 71 30 101
2022 September 47 27 74
2022 August 51 48 99
2022 July 43 39 82
2022 June 51 30 81
2022 May 53 39 92
2022 April 59 26 85
2022 March 48 48 96
2022 February 58 40 98
2022 January 69 34 103
2021 December 32 53 85
2021 November 50 39 89
2021 October 68 57 125
2021 September 45 55 100
2021 August 51 54 105
2021 July 46 39 85
2021 June 51 62 113
2021 May 56 38 94
2021 April 120 66 186
2021 March 71 46 117
2021 February 64 26 90
2021 January 64 34 98
2020 December 62 35 97
2020 November 49 43 92
2020 October 84 18 102
2020 September 59 22 81
2020 August 51 22 73
2020 July 54 28 82
2020 June 31 16 47
2020 May 55 35 90
2020 April 34 12 46
2020 March 30 23 53
2020 February 35 22 57
2020 January 73 29 102
2019 December 76 33 109
2019 November 46 16 62
2019 October 46 18 64
2019 September 45 20 65
2019 August 38 12 50
2019 July 63 23 86
2019 June 52 22 74
2019 May 75 28 103
2019 April 82 51 133
2019 March 45 27 72
2019 February 28 16 44
2019 January 34 18 52
2018 December 35 37 72
2018 November 47 35 82
2018 October 66 19 85
2018 September 44 13 57
2018 May 15 2 17
2018 April 30 7 37
2018 March 27 6 33
2018 February 9 11 20
2018 January 8 12 20
2017 December 14 14 28
2017 November 16 7 23
2017 October 18 15 33
2017 September 48 24 72
2017 August 21 31 52
2017 July 11 16 27
2017 June 31 33 64
2017 May 15 33 48
2017 April 16 26 42
2017 March 39 38 77
2017 February 26 18 44
2017 January 21 9 30
2016 December 32 13 45
2016 November 55 30 85
2016 October 79 6229 6308
2016 September 34 41 75
2016 August 25 15 40
2016 July 29 14 43
2016 June 47 25 72
2016 May 38 18 56
2016 April 21 2 23
2016 March 18 2 20
2016 February 25 3 28
2016 January 41 29 70
2015 December 46 25 71
2015 November 38 9 47
2015 October 113 2 115
2015 September 92 0 92
2015 August 73 0 73
2015 July 94 0 94
2015 June 66 0 66
2015 May 97 0 97
2015 April 84 0 84
2015 March 47 0 47
2015 February 64 0 64
2015 January 58 0 58
2014 December 45 0 45
2014 November 67 0 67
2014 October 94 0 94
2014 September 71 0 71
2014 August 72 0 72
2014 July 68 0 68
2014 June 80 0 80
2014 May 86 0 86
2014 April 83 0 83
2014 March 94 0 94
2014 February 80 0 80
2014 January 56 0 56
2013 December 67 0 67
2013 November 75 0 75
2013 October 83 0 83
2013 September 89 0 89
2013 August 93 0 93
2013 July 84 0 84
2013 June 65 0 65
2013 May 61 0 61
2013 April 36 0 36
2013 March 8 0 8
2000 January 6315 0 6315
Show all

Follow this link to access the full text of the article

Archivos de Bronconeumología

Are you a health professional able to prescribe or dispense drugs?