Hemangiomatosis capilar pulmonar: una causa poco frecuente de hipertensión pulmonar
Pulmonary capillary hemangiomatosis: a rare cause of pulmonary hypertension
R. Bandrés Gimeno
, M.L. Torres Durán
Corresponding author
rafaelbandres@yahoo.es
Correspondencia: Dr. Rafael Bandrés Gimeno Servicio de Neumología. Complexo Hospitalario Xeral-Cíes.Pizarro 22. 36204 Vigo. Pontevedra
Correspondencia: Dr. Rafael Bandrés Gimeno Servicio de Neumología. Complexo Hospitalario Xeral-Cíes.Pizarro 22. 36204 Vigo. Pontevedra
Servicios de Neumología, Complexo Hospitalario Xeral-Cíes. Vigo.
a Servicios de Anatomía Patológica. Complexo Hospitalario Xeral-Cíes. Vigo
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"apellidos" => "Torres Durán" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicios de Neumología, Complexo Hospitalario Xeral-Cíes. Vigo." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. Rafael Bandrés Gimeno Servicio de Neumología. Complexo Hospitalario Xeral-Cíes.Pizarro 22. 36204 Vigo. Pontevedra" ] ] ] 1 => array:3 [ "autoresLista" => "J. González-Carreró, B. Iglesias, C. Vicente" "autores" => array:3 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "González-Carreró" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "Iglesias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Vicente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicios de Anatomía Patológica. Complexo Hospitalario Xeral-Cíes. Vigo" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pulmonary capillary hemangiomatosis: a rare cause of pulmonary hypertension" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-10-10" "fechaAceptado" => "2001-11-14" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec190572" "palabras" => array:2 [ 0 => "Hipertensión pulmonar" 1 => "Hemangiomatosis capi-lar pulmonar" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec190571" "palabras" => array:2 [ 0 => "Pulmonary hypertension" 1 => "Pulmonary capillary he-mangiomatosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La hemangiomatosis capilar pulmonar (HCP) es una cau-sa rara de hipertensión pulmonar, caracterizada por la proliferación de capilares que infiltran las estructuras del parénquima pulmonar, particularmente las vénulas, pero también los bronquiolos, el intersticio y otras. Presentamos un caso de hemangiomatosis capilar pulmonar en un varón de 70 años. Se demostró la existencia de una hipertensión arterial pulmonar mediante ecocardiografía y cateterismo. La tomografía axial computarizada (TAC) torácica evidenció que el enfermo presentaba un enfisema grave, a pesar de los valores de la espirometría que reflejaban una obstrucción al flujo aéreo de grado leve. Desarrolló una disnea progresiva y una insuficiencia respiratoria con efecto shunt marcado hasta el fallecimiento. El diagnóstico patológico se realizó en la autopsia. Se observó una proliferación capilar en las paredes alveolares, que formaba en ocasiones ovillos que protruían en los espacios aéreos o rodeaban pequeños vasos y bronquiolos. Las células endoteliales de los vasos neoformados no evidenciaban atipias y las mitosis eran esca-sas. La negatividad de la técnica inmunohistoquímica del antígeno p53 y la baja tasa de proliferación celular evaluada por Ki67 no apoyaban la naturaleza neoplásica de la HCP, como se ha sugerido en algunos trabajos</p>" ] "en" => array:1 [ "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Pulmonary capillary hemangiomatosis (PCH) is a rare cause of pulmonary hypertension characterized by capillary proliferation infiltrating the structures of the pulmonary parenchyma. Although veins are particularly involved, proliferation also affects bronchiolar, interstitial and other structures. We report a case of PCH in a 70-year-old man. Pulmonary artery hypertension was demonstrated by echocardiogram and angiography. Severe emphysema could be seen in a computed tomographic scan of the thorax, even though spirometric values indicated that airflow obstruction was mild. Dyspnea and respiratory insufficiency progressed with marked shunting until death. Tissue inspection at the autopsy revealed capillary proliferation in the alveolar walls with occasional oviform protrusions into air spaces or around small vessels and bronchioles. Endothelial cells in newly formed vessels were not atypical and mitosis was scarce; p53 expression was negative and Ki67 proliferation slight, indicating that PCH is not a neoplastic process as has sometimes been suggested</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Capillary haemangiomatosis of the lungs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.A. Wagenvoort" 1 => "A. Beetstra" 2 => "J. 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| 2023 July | 0 | 13 | 13 |
| 2023 June | 0 | 12 | 12 |
| 2023 April | 0 | 2 | 2 |
| 2023 March | 4 | 6 | 10 |
| 2023 February | 26 | 43 | 69 |
| 2023 January | 25 | 49 | 74 |
| 2022 December | 31 | 41 | 72 |
| 2022 November | 43 | 38 | 81 |
| 2022 October | 70 | 39 | 109 |
| 2022 September | 26 | 38 | 64 |
| 2022 August | 75 | 103 | 178 |
| 2022 July | 57 | 45 | 102 |
| 2022 June | 38 | 47 | 85 |
| 2022 May | 52 | 51 | 103 |
| 2022 April | 56 | 43 | 99 |
| 2022 March | 51 | 67 | 118 |
| 2022 February | 34 | 55 | 89 |
| 2022 January | 39 | 60 | 99 |
| 2021 December | 17 | 50 | 67 |
| 2021 November | 25 | 69 | 94 |
| 2021 October | 25 | 75 | 100 |
| 2021 September | 16 | 58 | 74 |
| 2021 August | 17 | 50 | 67 |
| 2021 July | 13 | 69 | 82 |
| 2021 June | 17 | 67 | 84 |
| 2021 May | 14 | 74 | 88 |
| 2021 April | 23 | 123 | 146 |
| 2021 March | 34 | 73 | 107 |
| 2021 February | 33 | 32 | 65 |
| 2021 January | 26 | 56 | 82 |
| 2020 December | 13 | 41 | 54 |
| 2020 November | 18 | 36 | 54 |
| 2020 October | 21 | 29 | 50 |
| 2020 September | 19 | 38 | 57 |
| 2020 August | 30 | 26 | 56 |
| 2020 July | 16 | 27 | 43 |
| 2020 June | 21 | 17 | 38 |
| 2020 May | 14 | 24 | 38 |
| 2020 April | 16 | 15 | 31 |
| 2020 March | 14 | 23 | 37 |
| 2020 February | 22 | 27 | 49 |
| 2020 January | 19 | 31 | 50 |
| 2019 December | 21 | 32 | 53 |
| 2019 November | 11 | 15 | 26 |
| 2019 October | 13 | 29 | 42 |
| 2019 September | 5 | 47 | 52 |
| 2019 August | 8 | 30 | 38 |
| 2019 July | 19 | 38 | 57 |
| 2019 June | 22 | 31 | 53 |
| 2019 May | 37 | 52 | 89 |
| 2019 April | 37 | 78 | 115 |
| 2019 March | 15 | 35 | 50 |
| 2019 February | 5 | 14 | 19 |
| 2019 January | 5 | 18 | 23 |
| 2018 December | 109 | 23 | 132 |
| 2018 November | 17 | 34 | 51 |
| 2018 October | 18 | 25 | 43 |
| 2018 September | 13 | 41 | 54 |
| 2018 May | 10 | 1 | 11 |
| 2018 April | 6 | 11 | 17 |
| 2018 March | 5 | 11 | 16 |
| 2018 February | 8 | 16 | 24 |
| 2018 January | 5 | 10 | 15 |
| 2017 December | 7 | 25 | 32 |
| 2017 November | 11 | 70 | 81 |
| 2017 October | 9 | 67 | 76 |
| 2017 September | 11 | 50 | 61 |
| 2017 August | 27 | 64 | 91 |
| 2017 July | 5 | 46 | 51 |
| 2017 June | 26 | 94 | 120 |
| 2017 May | 15 | 75 | 90 |
| 2017 April | 10 | 38 | 48 |
| 2017 March | 25 | 65 | 90 |
| 2017 February | 7 | 77 | 84 |
| 2017 January | 32 | 27 | 59 |
| 2016 December | 18 | 46 | 64 |
| 2016 November | 37 | 81 | 118 |
| 2016 October | 30 | 79 | 109 |
| 2016 September | 46 | 104 | 150 |
| 2016 August | 52 | 12 | 64 |
| 2016 July | 41 | 13 | 54 |
| 2016 June | 36 | 16 | 52 |
| 2016 May | 24 | 7 | 31 |
| 2016 April | 8 | 2 | 10 |
| 2016 March | 11 | 3 | 14 |
| 2016 February | 16 | 3 | 19 |
| 2016 January | 36 | 20 | 56 |
| 2015 December | 32 | 24 | 56 |
| 2015 November | 32 | 11 | 43 |
| 2015 October | 445 | 1 | 446 |
| 2015 September | 4017 | 0 | 4017 |
| 2015 August | 2049 | 0 | 2049 |
| 2015 July | 132 | 0 | 132 |
| 2015 June | 161 | 0 | 161 |
| 2015 May | 177 | 0 | 177 |
| 2015 April | 129 | 0 | 129 |
| 2015 March | 173 | 0 | 173 |
| 2015 February | 127 | 0 | 127 |
| 2015 January | 120 | 0 | 120 |
| 2014 December | 119 | 0 | 119 |
| 2014 November | 150 | 0 | 150 |
| 2014 October | 189 | 0 | 189 |
| 2014 September | 160 | 0 | 160 |
| 2014 August | 161 | 0 | 161 |
| 2014 July | 120 | 0 | 120 |
| 2014 June | 143 | 0 | 143 |
| 2014 May | 145 | 0 | 145 |
| 2014 April | 135 | 0 | 135 |
| 2014 March | 122 | 0 | 122 |
| 2014 February | 132 | 0 | 132 |
| 2014 January | 121 | 0 | 121 |
| 2013 December | 95 | 0 | 95 |
| 2013 November | 98 | 0 | 98 |
| 2013 October | 105 | 0 | 105 |
| 2013 September | 99 | 0 | 99 |
| 2013 August | 126 | 0 | 126 |
| 2013 July | 144 | 0 | 144 |
| 2013 June | 68 | 0 | 68 |
| 2013 May | 56 | 0 | 56 |
| 2013 April | 43 | 0 | 43 |
| 2013 March | 7 | 0 | 7 |
| 2000 January | 7916 | 0 | 7916 |
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