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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presentan 2 casos de carcinoma broncog&#233;nico de c&#233;lulas peque&#241;as con secreci&#243;n ect&#243;pica de ACTH&#44; asociaci&#243;n conocida desde antiguo pero infrecuente&#44; de la que existen pocas series en la literatura&#44; la mayor&#237;a peque&#241;as y retrospectivas&#46; Se revisan los aspectos etiopatog&#233;nicos&#44; destacando la escasa sintomatolog&#237;a cl&#237;nica y los criterios bioqu&#237;micos necesarios para el diagn&#243;stico&#46; Se comenta su fatal pron&#243;stico a corto plazo y la necesidad de intentar un tratamiento del hipercortisolismo antes incluso de la terap&#233;utica citot&#243;xica&#46;</p></span>"
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Journal Information
Vol. 31. Issue 2.
Pages 86-88 (February 1995)
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Vol. 31. Issue 2.
Pages 86-88 (February 1995)
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Carcinoma broncogénico de células pequeñas con secreción ectópica de ACTH: a propósito de dos casos y revisión de la literatura
Small-cell bronchogenic carcinoma with ectopic ACTH secretion. Two cases and a review of the literature
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C. Fernández Estívariz, P. Martínez de Icaya Ortiz de Urbina, M.A. Juansolo Barranaechea
Sección de Endocrinología. Hospital Severo Ochoa. Leganés. Madrid
M. Yoldi Rodríguez*,1, R. Melchor Iñíguez*, C. Barbosa Ayúcar*
* Sección de Neumología. Hospital Severo Ochoa. Leganés. Madrid
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Se presentan 2 casos de carcinoma broncogénico de células pequeñas con secreción ectópica de ACTH, asociación conocida desde antiguo pero infrecuente, de la que existen pocas series en la literatura, la mayoría pequeñas y retrospectivas. Se revisan los aspectos etiopatogénicos, destacando la escasa sintomatología clínica y los criterios bioquímicos necesarios para el diagnóstico. Se comenta su fatal pronóstico a corto plazo y la necesidad de intentar un tratamiento del hipercortisolismo antes incluso de la terapéutica citotóxica.

Palabras clave:
Carcinoma broncogénico de células pequeñas
ACTH ectópica

Described in this report are 2 patients with small-cell bronchogenic carcinoma with ectopic secretion of ACTH, an association that has long been reported in the literature but that is nevertheless rare, with most authors describing small series of patients or reporting retrospetive studies. Pathogenic and etiological aspects are reviewed, with emphasis on the scarcity of clinical signs and the biochemical criteria needed for diagnosis. The poor prognosis of the disease is discussed along with the need to try to treat hypercortisolism even before cytotoxic therapy is initiated.

Key words:
Small-cell bronchogenic carcinoma
Ectopic ACTH
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Copyright © 1995. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
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