Journal Information
Vol. 26. Issue 1.
Pages 12-16 (January - February 1990)
Share
Share
Download PDF
More article options
Vol. 26. Issue 1.
Pages 12-16 (January - February 1990)
Full text access
Carcinoides bronquiales: estudio clínico, histopatológico e inmunohistoquímico
Bronchial carcinoid: a clinical, histopathological and immunohistochemical study
Visits
3293
R. Rami Porta, R. Ledo Andión, M. Corbal Mosteiro, G. Calzadilla Martín
Servicios de Cirugía Torácica. Hospital General de Galicia-Clínico Universitario. Santiago de Compostela
M. Fraga Rodríguez*, M. Couce Matovelle*, M. Berdugo Oviedo**, E. Pérez Becerra*
* Servicios de Anatomía Patológica. Hospital General de Galicia-Clínico Universitario. Santiago de Compostela
** Servicios de Neumología. Hospital General de Galicia-Clínico Universitario. Santiago de Compostela
Related content
Arch Bronconeumol. 1990;26:27610.1016/S0300-2896(15)31596-9
Arch Bronconeumol. 1990;26:18010.1016/S0300-2896(15)31598-2
This item has received
Article information

Diez mujeres y 9 varones entre 18 y 65 años de edad fueron intervenidos por carcinoide broncopulmonar entre enero de 1978 y diciembre de 1988 en el Hospital General de Galicia. Se practicaron 13 lobectomías, 3 neumonectomías, 2 broncotomías con tumorectomía y una bilobectomía inferior y media. Los patrones histológicos fueron: mixto insular-trabecular (8), trabecular (7), insular (2) y mixto trabecular-glandular (2). Se realizó estudio inmunohistoquímico en 16 de los 19 carcinoides con anticuerpos dirigidos contra enolasa neuronal específica, cromogranina y LEU 7 (panmarcadores neuroendocrinos). Hubo tres hidroneumotórax residuales postoperatorios que requirieron drenaje. Un paciente fue perdido de seguimiento tras el alta hospitalaria y los restantes fueron seguidos entre un mes y 10 años (media, 3,2 años) y todos se encontraban vivos y sin signos de recidiva tumoral. Por tanto, a pesar de las características anatomopatológicas de malignidad, el carcinoide broncopulmonar tiene, tras la cirugía, una evolución favorable. No se ha observado ninguna diferencia en el comportamiento biológico del tumor según el patrón histopatológico exhibido. La inmunohistoquímica confirma la naturaleza neuroendocrina de estos tumores.

Ten females and 9 males aged 18-65 years underwent operation for bronchopulmonary carcinoid in the Hospital General de Galicia between January 1978 and December 1988; 13 lobectomies, 3 pneumectomies, 2 bronchotomies with tumorectomy and one mean and inferior bilobectomy «ere carried out. The histological patterns were: mixed insular-trabecular (8), trabecular (7), insular (2), and mixed trabecular-glandular (2). Immunohistochemical study was carried out in 16 of the 19 carcinoids with antibodies against neuore specifíc enolase, chromogramine and LEU 7 (panendocrine markers). There were three patients with residual postoperative hydropneumothorax required drainage. One patient was lost to follow up after hospital discharge, and the remaining patients were followed up for 1 month-10 years (mean 3, 2 years). All were alive and free from tumor relapse. Therefore, in spite the malignant pathological features, bronchopulmonary carcinoid has a good outcome after surgery. No difference in the biological behavior of the tumor was found between the different pathological behavior of the tumor was found between the different pathological patterns. Immunohistochemical study confirmed the neuroendocrine character of these tumors.

Full text is only aviable in PDF
Bibliografía
[1.]
W.H. Warren, V.E. Gould, L.P. Faber, C.F. Kittle, V.A. Memoli.
Neuroendocrine neoplasms of the bronchopulmonary tract. A classification of the spectrum of carcinoid to small cell carcinoma and intervening variants.
J Thorac Cardiovasc Surg, 89 (1985), pp. 819-825
[2.]
D. Weissberg.
Bronchial non-adenoma.
Ann Thorac Surg, 41 (1986), pp. 702
[3.]
R. Hurt, M. Bates.
Carcinoid tumours of the bronchus: a 33 year experience.
Thorax, 39 (1984), pp. 617-623
[4.]
L.F. DeCaro, R. Paladugu, J.R. Benfield, L. Lovisatti, H. Pak, R.L. Teplitz.
Typical and atypical carcinoids within the pulmonary APUD tumor spectrum.
J Thorac Cardiovasc Surg, 86 (1983), pp. 528-536
[5.]
I.M.P. Dawson.
The endocrine cells of the gastro-intestinal tract and the neoplasms which arise from them.
Pathology of the gastro-intestinal tract: Current topics in pathology, pp. 225-258
[6.]
E.D. Martin, F. Potet.
Pathology of endocrine tumors of the gastrointestinal tract.
Clin Gastroenterol, 3 (1974), pp. 1-532
[7.]
J. Soga, K. Tazawa.
Pathologic analysis of carcinoids Histologic reevaluation of 62 cases.
Cancer, 28 (1971), pp. 990-998
[8.]
B. Brandt III, S.E. Heintz, E.F. Rose, J.L. Ehrenhaft.
Bronchial carcinoid tumors.
Ann Thorac Surg, 38 (1984), pp. 63-65
[9.]
E.W. Wilkins Jr., H.C. Grillo, A.C. Moncure, J.G. Scannell.
Changing times in surgical management of bronchopulmonary carcinoid tumor.
Ann Thorac Surg, 38 (1984), pp. 339-344
[10.]
B.C. McCaughan, N. Martini, M.S. Bains.
Bronchial carcinoids Review of 124 cases.
J Thorac Cardiovasc Surg, 89 (1985), pp. 8-17
[11.]
J. Rozeman, R. Pausner, Y. Lieberman, G. Gamsu.
Bronchial adenoma.
Chest, 92 (1987), pp. 145-147
[12.]
J.M. Rodríguez Paniagua, J. García Girón, M. Casillas Pajuelo, J. González Utrilla.
Carcinoide bronquial en pacientes jóvenes Revisión de la literatura.
Arch Bronconeumol, 24 (1988), pp. 182-185
[13.]
S. Attar, J.E. Miller, J. Hankins, B.W. Thompson, C.M. Suter, P.J. Kleger, J.S. McLaughlin.
Bronchial adenoma: a review of 51 patients.
Ann Thorac Surg, 40 (1985), pp. 126-132
[14.]
M. Alp, K. Uçanok, R. Dogan, S. Kaya, G. Çetin, M. Ünlü, F. Yorulmaz, B. Moldibi.
Surgical treatment of bronchial adenoma: results of 29 cases and review of the literature.
Thorac Cardiovasc Surgeon, 35 (1987), pp. 290-294
[15.]
T. Aberg, T. Blöndal, E. Nôu, J. Malmaeus.
The choice of operation for bronchial carcinoids.
Ann Thorac Surg, 32 (1981), pp. 19-22
[16.]
F. Serrano Muñoz, A. Alix Trueba, J.M. Borro.
Adenomas bronquiales.
Rev Clín Esp, 151 (1978), pp. 379-383
[17.]
L.A. Johnson, P. Lavin, C.G. Moertel, et al.
Carcinoids: the association of histologic growth pattern and survival.
Cancer, 51 (1983), pp. 882-889
[18.]
J.M. Polak, S.R. Bloom.
Immunocytochemistry of the diffuse neuroendocrine System.
Immunocytochemistry Modern methods applications, 2a ed., pp. 328-348
[19.]
V.E. Gould, I. Lee, W.H. Warren.
Immunohistochemical evaluation of neuroendocrine cells and neoplasms of the lung.
Pathol Res Pract, 183 (1988), pp. 200-213
[20.]
L. Mosca, M. Barbareschi, M.F. Mauri, et al.
Neuroendocrine lung structures and tumours: immunohistochemical study by specific markers.
Histol Histopathol, 3 (1988), pp. 367-376
[21.]
W.H. Warren, V.A. Memoli, V.E. Gould.
Immunohistochemical and ultrastructural analysis of bronchopulmonary neuroendocrine neoplasms I. Carcinoids.
Ultrastruct Pathol, 6 (1984), pp. 15-27
[22.]
P.U. Heitz.
Neuroendocrine tumor markers.
Morphological tumor markers. General aspects and diagnostic relevance. Current topics in pathology, pp. 279-306
Copyright © 1990. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?