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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetive</span><p class="elsevierStyleSimplePara elsevierViewall">To describe the clinical characteristics and survival of patients diagnosed with bronchogenic carcinoma during the years 2000 and 2001 in a tertiary level hospital&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Data were collected from our hospital&#39;s tumor registry and validated with independent sources&#46; Of all the patients diagnosed with or treated for bronchogenic carcinoma in our hospital&#44; only those from our health care area were selected&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">During the 2-year study period&#44; 482 patients were diagnosed&#46; Of those&#44; 90&#37; were men&#46; The mean &#40;SD&#41; age was 66&#46;6 &#40;9&#46;65&#41; years&#46; Large cell carcinomas accounted for 29&#46;4&#37; of cases&#46; Of all the cases of bronchogenic carcinoma&#44; 41&#46;3&#37; were diagnosed in stage IV&#46; Thirty percent of non-small cell carcinomas were classified as stage I&#44; compared to 6&#37; of small cell carcinomas &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; The most frequent treatment was chemotherapy &#40;42&#46;1&#37;&#41; and 20&#37; of patients underwent surgery&#46; The overall 5-year survival rate was 13&#37; &#40;95&#37; confidence interval &#91;CI&#93;&#44; 10&#37;&#8211;16&#37;&#41;&#44; while survival was significantly lower in patients aged 68 years or older &#40;95&#37; CI&#44; 3&#37;&#8211;15&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; and in patients with small cell carcinoma &#40;0&#37;&#44; <span class="elsevierStyleItalic">P</span>&#60;&#46;01&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Our recent experience &#40;2000-2001&#41; confirmed the advanced age of patients with bronchogenic carcinoma&#44; the frequency of diagnosis in advanced stages of the disease &#40;41&#37; in stage IV&#41;&#44; and the low overall 5-year survival rate &#40;13&#37;&#41;&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir las caracter&#237;sticas cl&#237;nicas y la super-vivencia de los carcinomas broncog&#233;nicos &#40;CB&#41; diagnosticados durante los a&#241;os 2000 y 2001 en un hospital terciario&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">La informaci&#243;n se recogi&#243; de la base de datos del Registro de Tumores del hospital y se valid&#243; con fuentes independientes&#46; De todos los pacientes con CB diagnosticados o tratados en nuestro centro&#44; se seleccion&#243; a los que proven&#237;an exclusivamente del &#225;rea de salud correspondiente&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se diagnosticaron 482 casos en los 2 a&#241;os del estudio&#59; un 90&#37; de los pacientes eran varones&#46; La edad media &#177; desviaci&#243;n est&#225;ndar fue de 66&#44;6 &#177; 9&#44;65 a&#241;os&#46; El 29&#44;4&#37; eran CB de c&#233;lulas grandes&#46; El 41&#44;3&#37; de todos los CB se diagnosticaron en estadio IV&#46; El 30&#37; de los CB no microc&#237;ticos se clasificaron en estadio I&#44; en comparaci&#243;n con el 6&#37; de los CB microc&#237;ticos &#40;p &#60; 0&#44;001&#41;&#46; El tratamiento m&#225;s frecuente fue la quimioterapia &#40;42&#44;1&#37;&#41;&#59; la cirug&#237;a se efectu&#243; en el 20&#37; de los casos&#46; La supervivencia global a los 5 a&#241;os fue de 13&#37; &#40;intervalo de confianza del 95&#37;&#44; 10&#8211;16&#37;&#41;&#44; y fue significativamente inferior &#40;p &#60; 0&#44;001&#41; en los pacientes con mayor edad &#40;&#8805; 68 a&#241;os&#41;&#44; en quienes se cifr&#243; en un 9&#37; &#40;intervalo de confianza del 95&#37;&#44; 3&#8211;15&#41;&#44; y en el CB microc&#237;tico &#40;0&#37;&#59; p &#60; 0&#44;01&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Se confirma en nuestra reciente experiencia &#40;2000-2001&#41; la elevada edad de los pacientes con CB&#44; el frecuente diagn&#243;stico en estadios avanzados &#40;estadio IV&#58; 41&#37;&#41; y la deficiente supervivencia global a los 5 a&#241;os &#40;el 13&#37; del global&#41;&#46;</p>"
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Vol. 43. Issue 11.
Pages 594-598 (January 2007)
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Vol. 43. Issue 11.
Pages 594-598 (January 2007)
Original Articles
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Bronchogenic Carcinoma 2000-2001: Characteristics and Overall Survival
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3599
Graciliano Estrada Triguerosa,
Corresponding author
graciestrada@hotmail.com

Correspondence: Dr. G. Estrada Trigueros. Servicio de Neumología. Hospital Universitario 12 de Octubre. Avda. de Córdoba, s/n. 28047 Madrid. España
, Lorena Comechea, Ángel López Encuentraa, Javier Montoro Zuluetaa, Fulgencio González Garridoa, Francisco Colinab
a Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, Spain
b Departamento de Anatomía Patológica, Hospital Universitario 12 de Octubre, Madrid, Spain
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Objetive

To describe the clinical characteristics and survival of patients diagnosed with bronchogenic carcinoma during the years 2000 and 2001 in a tertiary level hospital.

Patients and methods

Data were collected from our hospital's tumor registry and validated with independent sources. Of all the patients diagnosed with or treated for bronchogenic carcinoma in our hospital, only those from our health care area were selected.

Results

During the 2-year study period, 482 patients were diagnosed. Of those, 90% were men. The mean (SD) age was 66.6 (9.65) years. Large cell carcinomas accounted for 29.4% of cases. Of all the cases of bronchogenic carcinoma, 41.3% were diagnosed in stage IV. Thirty percent of non-small cell carcinomas were classified as stage I, compared to 6% of small cell carcinomas (P<.001). The most frequent treatment was chemotherapy (42.1%) and 20% of patients underwent surgery. The overall 5-year survival rate was 13% (95% confidence interval [CI], 10%–16%), while survival was significantly lower in patients aged 68 years or older (95% CI, 3%–15%; P<.001) and in patients with small cell carcinoma (0%, P<.01).

Conclusions

Our recent experience (2000-2001) confirmed the advanced age of patients with bronchogenic carcinoma, the frequency of diagnosis in advanced stages of the disease (41% in stage IV), and the low overall 5-year survival rate (13%).

Key words:
Carcinoma
bronchogenic
Survival
Staging
Prognosis
Objetivo

Describir las características clínicas y la super-vivencia de los carcinomas broncogénicos (CB) diagnosticados durante los años 2000 y 2001 en un hospital terciario.

Pacientes y métodos

La información se recogió de la base de datos del Registro de Tumores del hospital y se validó con fuentes independientes. De todos los pacientes con CB diagnosticados o tratados en nuestro centro, se seleccionó a los que provenían exclusivamente del área de salud correspondiente.

Resultados

Se diagnosticaron 482 casos en los 2 años del estudio; un 90% de los pacientes eran varones. La edad media ± desviación estándar fue de 66,6 ± 9,65 años. El 29,4% eran CB de células grandes. El 41,3% de todos los CB se diagnosticaron en estadio IV. El 30% de los CB no microcíticos se clasificaron en estadio I, en comparación con el 6% de los CB microcíticos (p < 0,001). El tratamiento más frecuente fue la quimioterapia (42,1%); la cirugía se efectuó en el 20% de los casos. La supervivencia global a los 5 años fue de 13% (intervalo de confianza del 95%, 10–16%), y fue significativamente inferior (p < 0,001) en los pacientes con mayor edad (≥ 68 años), en quienes se cifró en un 9% (intervalo de confianza del 95%, 3–15), y en el CB microcítico (0%; p < 0,01).

Conclusiones

Se confirma en nuestra reciente experiencia (2000-2001) la elevada edad de los pacientes con CB, el frecuente diagnóstico en estadios avanzados (estadio IV: 41%) y la deficiente supervivencia global a los 5 años (el 13% del global).

Palabras clave:
Carcinoma broncogénico
Supervivencia
Estadificación
Pronóstico
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This study was partially funded by RTIC-03/11-ISCIII-Red-Respira and by FIS grant 03/0046 from the Spanish Ministry of Health.

Copyright © 2007. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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