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Vol. 22. Issue 3.
Pages 140-144 (July - August 1986)
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Vol. 22. Issue 3.
Pages 140-144 (July - August 1986)
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Asma por acido acetilsalicilico, otros antiinflamatorios no esteroides y tartrazina
Asthma caused by aspirin and other non-steroid antiinflammatory agents and tartrazine
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J. De Gracia*, X. Carne**, F. Morell*
* Sección de Neumología, Ciudad Sanitaria Valle de Hebrón. Barcelona
** Servicio de Farmacología Clínica. Ciudad Sanitaria Valle de Hebrón. Barcelona
J.R. Laporte
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Asma inducido por ácido acetilsalicflico (AAS) y otros antiinflamatorios no esteroideos (AINE), ha sido descrito con una prevalencia entre el 16-19% de pacientes asmáticos. La inducción por tartrazina se ha hallado hasta en el 30% de pacientes con asma por AAS, aunque también puede encontrarse de forma aislada.

El diagnóstico de asma inducido por AINE o por tartrazina es difícil por historia clínica, debido a la aparición tardía de los síntomas tras la ingesta del fármaco desencadenante, a la variabilidad en la intensidad de las crisis, y a la dificultad en conocer si una especialidad farmacéutica o producto alimentario contienen tartrazina como excipiente. Es por ello que debe recurrirse en ocasiones al test de provocación oral. Como normal general, se evitará en pacientes asmáticos la administración de AINE y fármacos que contengan tartrazina en su excipiente. Se adjunta una tabla con la lista de presentaciones farmacéuticas que contienen tartrazina.

Asthma induced by acetilsalycilic acid and other nonsteroid antiinflamatory agents has been documented as prevalent in 16-19% of all asthmatic patients. Tertrazine induced asthma has been found in 30% of patients with ASA induced asthma, although it has also been seen alone.

The diagnosis of NSAI or tartrazine induced asthma is difficult to establish from the clinical history as the symptoms appear long intervals after ingestion of the causative drug, the varying intensity of the crisis and the difficulties inherent in discovering whether the drug or food responsible contained tartrazine as the excipient. For these reasons an oral challenge test may on occasion be required. As a rule NSAI and tartrazine containing drugs shoud be avoided in asthmatic patients. A table listing pharmaceutical products containing tartrazine is included.

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Copyright © 1986. Sociedad Española de Neumología y Cirugía Torácica
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